Neuronal acetylcholine receptor subunit alpha-4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• acetylcholine binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells."
    Xiao Y., Kellar K.J.
    J. Pharmacol. Exp. Ther. 310:98-107(2004) [PubMed] [Europe PMC] [Abstract]
  • "Formation of oligomers containing the beta3 and beta4 subunits of the rat nicotinic receptor."
    Forsayeth J.R., Kobrin E.
    J. Neurosci. 17:1531-1538(1997) [PubMed] [Europe PMC] [Abstract]
• acetylcholine-gated cation-selective channel activity Source: RGDInferred from direct assayⁱ
  • "The calcium sensor protein visinin-like protein-1 modulates the surface expression and agonist sensitivity of the alpha 4beta 2 nicotinic acetylcholine receptor."
    Lin L., Jeanclos E.M., Treuil M., Braunewell K.H., Gundelfinger E.D., Anand R.
    J. Biol. Chem. 277:41872-41878(2002) [PubMed] [Europe PMC] [Abstract]
• acetylcholine receptor activity Source: RGDInferred from sequence orthologyⁱ
  • "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."
    Elliott K.J., Ellis S.B., Berckhan K.J., Urrutia A., Chavez-Noriega L.E., Johnson E.C., Velicelebi G., Harpold M.M.
    J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract]
• drug binding Source: RGDInferred from direct assayⁱ
  • "The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells."
    Xiao Y., Kellar K.J.
    J. Pharmacol. Exp. Ther. 310:98-107(2004) [PubMed] [Europe PMC] [Abstract]
  • "Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes."
    Marritt A.M., Cox B.C., Yasuda R.P., McIntosh J.M., Xiao Y., Wolfe B.B., Kellar K.J.
    Mol. Pharmacol. 68:1656-1668(2005) [PubMed] [Europe PMC] [Abstract]
  • "Varenicline is a potent partial agonist at alpha6beta2* nicotinic acetylcholine receptors in rat and monkey striatum."
    Bordia T., Hrachova M., Chin M., McIntosh J.M., Quik M.
    J. Pharmacol. Exp. Ther. 342:327-334(2012) [PubMed] [Europe PMC] [Abstract]
• ion channel activity Source: RGDInferred from sequence orthologyⁱ
  • "Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1."
    Ibanez-Tallon I., Miwa J.M., Wang H.L., Adams N.C., Crabtree G.W., Sine S.M., Heintz N.
    Neuron 33:893-903(2002) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGDInferred from direct assayⁱ
  • "Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes."
    Marritt A.M., Cox B.C., Yasuda R.P., McIntosh J.M., Xiao Y., Wolfe B.B., Kellar K.J.
    Mol. Pharmacol. 68:1656-1668(2005) [PubMed] [Europe PMC] [Abstract]
  • "Quantitative analysis of the heteromeric neuronal nicotinic receptors in the rat hippocampus."
    Lomazzo E., MacArthur L., Yasuda R.P., Wolfe B.B., Kellar K.J.
    J. Neurochem. 115:625-634(2010) [PubMed] [Europe PMC] [Abstract]
• transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: SynGOInferred from direct assayⁱ
  • "Postsynaptic alpha 4 beta 2 and alpha 7 type nicotinic acetylcholine receptors contribute to the local and endogenous acetylcholine-mediated synaptic transmissions in nigral dopaminergic neurons."
    Matsubayashi H., Amano T., Seki T., Sasa M., Sakai N.
    Brain Res. 1005:1-8(2004) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• acetylcholine receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Mechanisms of inhibition and potentiation of alpha4beta2 nicotinic acetylcholine receptors by members of the Ly6 protein family."
    Wu M., Puddifoot C.A., Taylor P., Joiner W.J.
    J. Biol. Chem. 290:24509-24518(2015) [PubMed] [Europe PMC] [Abstract]
• action potential Source: RGDInferred from sequence orthologyⁱ
  • "Reduced antinociception in mice lacking neuronal nicotinic receptor subunits."
    Marubio L.M., del Mar Arroyo-Jimenez M., Cordero-Erausquin M., Lena C., Le Novere N., de Kerchove d'Exaerde A., Huchet M., Damaj M.I., Changeux J.P.
    Nature 398:805-810(1999) [PubMed] [Europe PMC] [Abstract]
• B cell activation Source: RGDInferred from sequence orthologyⁱ
  • "Nicotinic receptors regulate B lymphocyte activation and immune response."
    Skok M., Grailhe R., Changeux J.P.
    Eur. J. Pharmacol. 517:246-251(2005) [PubMed] [Europe PMC] [Abstract]
• behavioral response to nicotine Source: RGDInferred from sequence orthologyⁱ
  • "Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization."
    Tapper A.R., McKinney S.L., Nashmi R., Schwarz J., Deshpande P., Labarca C., Whiteaker P., Marks M.J., Collins A.C., Lester H.A.
    Science 306:1029-1032(2004) [PubMed] [Europe PMC] [Abstract]
  • "Gene-environment interactions in the development of combined type ADHD: evidence for a synapse-based model."
    Todd R.D., Neuman R.J.
    Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B:971-975(2007) [PubMed] [Europe PMC] [Abstract]
• calcium ion transport Source: RGDInferred from sequence orthologyⁱ
  • "Functional characterization of mouse alpha4beta2 nicotinic acetylcholine receptors stably expressed in HEK293T cells."
    Karadsheh M.S., Shah M.S., Tang X., Macdonald R.L., Stitzel J.A.
    J. Neurochem. 91:1138-1150(2004) [PubMed] [Europe PMC] [Abstract]
• chemical synaptic transmission Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cognition Source: RGDInferred from sequence orthologyⁱ
  • "A Korean kindred with autosomal dominant nocturnal frontal lobe epilepsy and mental retardation."
    Cho Y.-W., Motamedi G.K., Laufenberg I., Sohn S.-I., Lim J.-G., Lee H., Yi S.-D., Lee J.-H., Kim D.-K., Reba R., Gaillard W.D., Theodore W.H., Lesser R.P., Steinlein O.K.
    Arch. Neurol. 60:1625-1632(2003) [PubMed] [Europe PMC] [Abstract]
• DNA repair Source: RGDInferred from sequence orthologyⁱ
  • "Polymorphisms of the CHRNA4 gene encoding the alpha4 subunit of nicotinic acetylcholine receptor as related to the oxidative DNA damage and the level of apoptotic proteins in lymphocytes of the patients with Alzheimer's disease."
    Dorszewska J., Florczak J., Rozycka A., Jaroszewska-Kolecka J., Trzeciak W.H., Kozubski W.
    DNA Cell Biol. 24:786-794(2005) [PubMed] [Europe PMC] [Abstract]
• exploration behavior Source: RGDInferred from sequence orthologyⁱ
  • "Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse."
    Ross S.A., Wong J.Y., Clifford J.J., Kinsella A., Massalas J.S., Horne M.K., Scheffer I.E., Kola I., Waddington J.L., Berkovic S.F., Drago J.
    J. Neurosci. 20:6431-6441(2000) [PubMed] [Europe PMC] [Abstract]
• inhibitory postsynaptic potential Source: RGDInferred from sequence orthologyⁱ
  • "Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy."
    Klaassen A., Glykys J., Maguire J., Labarca C., Mody I., Boulter J.
    Proc. Natl. Acad. Sci. U.S.A. 103:19152-19157(2006) [PubMed] [Europe PMC] [Abstract]
• ion transmembrane transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• locomotory behavior Source: RGDInferred from sequence orthologyⁱ
  • "Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety."
    Labarca C., Schwarz J., Deshpande P., Schwarz S., Nowak M.W., Fonck C., Nashmi R., Kofuji P., Dang H., Shi W., Fidan M., Khakh B.S., Chen Z., Bowers B.J., Boulter J., Wehner J.M., Lester H.A.
    Proc. Natl. Acad. Sci. U.S.A. 98:2786-2791(2001) [PubMed] [Europe PMC] [Abstract]
• membrane depolarization Source: RGDInferred from sequence orthologyⁱ
  • "Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei."
    Klink R., de Kerchove d'Exaerde A., Zoli M., Changeux J.P.
    J. Neurosci. 21:1452-1463(2001) [PubMed] [Europe PMC] [Abstract]
  • "Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety."
    Labarca C., Schwarz J., Deshpande P., Schwarz S., Nowak M.W., Fonck C., Nashmi R., Kofuji P., Dang H., Shi W., Fidan M., Khakh B.S., Chen Z., Bowers B.J., Boulter J., Wehner J.M., Lester H.A.
    Proc. Natl. Acad. Sci. U.S.A. 98:2786-2791(2001) [PubMed] [Europe PMC] [Abstract]
  • "Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice."
    Champtiaux N., Gotti C., Cordero-Erausquin M., David D.J., Przybylski C., Lena C., Clementi F., Moretti M., Rossi F.M., Le Novere N., McIntosh J.M., Gardier A.M., Changeux J.P.
    J. Neurosci. 23:7820-7829(2003) [PubMed] [Europe PMC] [Abstract]
  • "Exocytic trafficking is required for nicotine-induced up-regulation of alpha 4 beta 2 nicotinic acetylcholine receptors."
    Darsow T., Booker T.K., Pina-Crespo J.C., Heinemann S.F.
    J. Biol. Chem. 280:18311-18320(2005) [PubMed] [Europe PMC] [Abstract]
• nervous system process Source: RGDInferred from sequence orthologyⁱ
  • "Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy."
    Klaassen A., Glykys J., Maguire J., Labarca C., Mody I., Boulter J.
    Proc. Natl. Acad. Sci. U.S.A. 103:19152-19157(2006) [PubMed] [Europe PMC] [Abstract]
  • "Association of attentional network function with exon 5 variations of the CHRNA4 gene."
    Winterer G., Musso F., Konrad A., Vucurevic G., Stoeter P., Sander T., Gallinat J.
    Hum. Mol. Genet. 16:2165-2174(2007) [PubMed] [Europe PMC] [Abstract]
  • "A missense mutation in the neuronal nicotinic acetylcholine receptor alpha-4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy."
    Steinlein O.K., Mulley J.C., Propping P., Wallace R.H., Phillips H.A., Sutherland G.R., Scheffer I.E., Berkovic S.F.
    Nat. Genet. 11:201-203(1995) [PubMed] [Europe PMC] [Abstract]
• neuromuscular synaptic transmission Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of dopamine secretion Source: RGDInferred from direct assayⁱ
  • "Varenicline is a potent partial agonist at alpha6beta2* nicotinic acetylcholine receptors in rat and monkey striatum."
    Bordia T., Hrachova M., Chin M., McIntosh J.M., Quik M.
    J. Pharmacol. Exp. Ther. 342:327-334(2012) [PubMed] [Europe PMC] [Abstract]
• regulation of acetylcholine-gated cation channel activity Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Mutation (Ser284Leu) of neuronal nicotinic acetylcholine receptor alpha 4 subunit associated with frontal lobe epilepsy causes faster desensitization of the rat receptor expressed in oocytes."
    Matsushima N., Hirose S., Iwata H., Fukuma G., Yonetani M., Nagayama C., Hamanaka W., Matsunaka Y., Ito M., Kaneko S., Mitsudome A., Sugiyama H.
    Epilepsy Res. 48:181-186(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of dopamine secretion Source: RGDInferred from sequence orthologyⁱ
  • "Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice."
    Champtiaux N., Gotti C., Cordero-Erausquin M., David D.J., Przybylski C., Lena C., Clementi F., Moretti M., Rossi F.M., Le Novere N., McIntosh J.M., Gardier A.M., Changeux J.P.
    J. Neurosci. 23:7820-7829(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of membrane potential Source: RGDInferred from sequence orthologyⁱ
  • "Functional characterization of mouse alpha4beta2 nicotinic acetylcholine receptors stably expressed in HEK293T cells."
    Karadsheh M.S., Shah M.S., Tang X., Macdonald R.L., Stitzel J.A.
    J. Neurochem. 91:1138-1150(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of synaptic vesicle exocytosis Source: RGDInferred from sequence orthologyⁱ
  • "Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice."
    Champtiaux N., Gotti C., Cordero-Erausquin M., David D.J., Przybylski C., Lena C., Clementi F., Moretti M., Rossi F.M., Le Novere N., McIntosh J.M., Gardier A.M., Changeux J.P.
    J. Neurosci. 23:7820-7829(2003) [PubMed] [Europe PMC] [Abstract]
• respiratory gaseous exchange by respiratory system Source: RGDInferred from sequence orthologyⁱ
  • "Cholinergic chemosensory cells in the trachea regulate breathing."
    Krasteva G., Canning B.J., Hartmann P., Veres T.Z., Papadakis T., Muhlfeld C., Schliecker K., Tallini Y.N., Braun A., Hackstein H., Baal N., Weihe E., Schutz B., Kotlikoff M., Ibanez-Tallon I., Kummer W.
    Proc. Natl. Acad. Sci. U.S.A. 108:9478-9483(2011) [PubMed] [Europe PMC] [Abstract]
• response to hypoxia Source: RGDInferred from sequence orthologyⁱ
  • "A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors."
    Heeschen C., Weis M., Aicher A., Dimmeler S., Cooke J.P.
    J. Clin. Invest. 110:527-536(2002) [PubMed] [Europe PMC] [Abstract]
• response to nicotine Source: RGDInferred from sequence orthologyⁱ
  • "Reduced antinociception in mice lacking neuronal nicotinic receptor subunits."
    Marubio L.M., del Mar Arroyo-Jimenez M., Cordero-Erausquin M., Lena C., Le Novere N., de Kerchove d'Exaerde A., Huchet M., Damaj M.I., Changeux J.P.
    Nature 398:805-810(1999) [PubMed] [Europe PMC] [Abstract]
  • "A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors."
    Heeschen C., Weis M., Aicher A., Dimmeler S., Cooke J.P.
    J. Clin. Invest. 110:527-536(2002) [PubMed] [Europe PMC] [Abstract]
  • "The mouse Chrna4 A529T polymorphism alters the ratio of high to low affinity alpha 4 beta 2 nAChRs."
    Kim H., Flanagin B.A., Qin C., Macdonald R.L., Stitzel J.A.
    Neuropharmacology 45:345-354(2003) [PubMed] [Europe PMC] [Abstract]
  • "Exocytic trafficking is required for nicotine-induced up-regulation of alpha 4 beta 2 nicotinic acetylcholine receptors."
    Darsow T., Booker T.K., Pina-Crespo J.C., Heinemann S.F.
    J. Biol. Chem. 280:18311-18320(2005) [PubMed] [Europe PMC] [Abstract]
• response to oxidative stress Source: RGDInferred from sequence orthologyⁱ
  • "Polymorphisms of the CHRNA4 gene encoding the alpha4 subunit of nicotinic acetylcholine receptor as related to the oxidative DNA damage and the level of apoptotic proteins in lymphocytes of the patients with Alzheimer's disease."
    Dorszewska J., Florczak J., Rozycka A., Jaroszewska-Kolecka J., Trzeciak W.H., Kozubski W.
    DNA Cell Biol. 24:786-794(2005) [PubMed] [Europe PMC] [Abstract]
• sensory perception of pain Source: RGDInferred from sequence orthologyⁱ
  • "Reduced antinociception in mice lacking neuronal nicotinic receptor subunits."
    Marubio L.M., del Mar Arroyo-Jimenez M., Cordero-Erausquin M., Lena C., Le Novere N., de Kerchove d'Exaerde A., Huchet M., Damaj M.I., Changeux J.P.
    Nature 398:805-810(1999) [PubMed] [Europe PMC] [Abstract]
• signal transduction Source: RGDInferred from sequence orthologyⁱ
  • "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."
    Elliott K.J., Ellis S.B., Berckhan K.J., Urrutia A., Chavez-Noriega L.E., Johnson E.C., Velicelebi G., Harpold M.M.
    J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract]
• synaptic transmission, cholinergic Source: RGDInferred from mutant phenotypeⁱ
  • "Rat nicotinic acetylcholine receptor alpha2beta2 channels: comparison of functional properties with alpha4beta2 channels in Xenopus oocytes."
    Khiroug S.S., Khiroug L., Yakel J.L.
    Neuroscience 124:817-822(2004) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MANSGTGAPP PLLLLPLLLL LGTGLLPASS HIETRAHAEE RLLKRLFSGY 
        60         70         80         90        100
NKWSRPVANI SDVVLVRFGL SIAQLIDVDE KNQMMTTNVW VKQEWHDYKL 
       110        120        130        140        150
RWDPGDYENV TSIRIPSELI WRPDIVLYNN ADGDFAVTHL TKAHLFYDGR 
       160        170        180        190        200
VQWTPPAIYK SSCSIDVTFF PFDQQNCTMK FGSWTYDKAK IDLVSMHSRV 
       210        220        230        240        250
DQLDFWESGE WVIVDAVGTY NTRKYECCAE IYPDITYAFI IRRLPLFYTI 
       260        270        280        290        300
NLIIPCLLIS CLTVLVFYLP SECGEKVTLC ISVLLSLTVF LLLITEIIPS 
       310        320        330        340        350
PTSLVIPLIG EYLLFTMIFV TLSIVITVFV LNVHHRSPRT HTMPAWVRRV 
       360        370        380        390        400
FLDIVPRLLF MKRPSVVKDN CRRLIESMHK MANAPRFWPE PVGEPGILSD 
       410        420        430        440        450
ICNQGLSPAP TFCNPTDTAV ETQPTCRSPP LEVPDLKTSE VEKASPCPSP 
       460        470        480        490        500
GSCPPPKSSS GAPMLIKARS LSVQHVPSSQ EAAEDGIRCR SRSIQYCVSQ 
       510        520        530        540        550
DGAASLADSK PTSSPTSLKA RPSQLPVSDQ ASPCKCTCKE PSPVSPVTVL 
       560        570        580        590        600
KAGGTKAPPQ HLPLSPALTR AVEGVQYIAD HLKAEDTDFS VKEDWKYVAM 
       610        620        630
VIDRIFLWMF IIVCLLGTVG LFLPPWLAAC                       

        10         20         30         40         50
MANSGTGAPP PLLLLPLLLL LGTGLLPASS HIETRAHAEE RLLKRLFSGY 
        60         70         80         90        100
NKWSRPVANI SDVVLVRFGL SIAQLIDVDE KNQMMTTNVW VKQEWHDYKL 
       110        120        130        140        150
RWDPGDYENV TSIRIPSELI WRPDIVLYNN ADGDFAVTHL TKAHLFYDGR 
       160        170        180        190        200
VQWTPPAIYK SSCSIDVTFF PFDQQNCTMK FGSWTYDKAK IDLVSMHSRV 
       210        220        230        240        250
DQLDFWESGE WVIVDAVGTY NTRKYECCAE IYPDITYAFI IRRLPLFYTI 
       260        270        280        290        300
NLIIPCLLIS CLTVLVFYLP SECGEKVTLC ISVLLSLTVF LLLITEIIPS 
       310        320        330        340        350
PTSLVIPLIG EYLLFTMIFV TLSIVITVFV LNVHHRSPRT HTMPAWVRRV 
       360        370        380        390        400
FLDIVPRLLF MKRPSVVKDN CRRLIESMHK MANAPRFWPE PVGEPGILSD 
       410        420        430        440        450
ICNQGLSPAP TFCNPTDTAV ETQPTCRSPP LEVPDLKTSE VEKASPCPSP 
       460        470        480        490        500
GSCPPPKSSS GAPMLIKARS LSVQHVPSSQ EAAEDGIRCR SRSIQYCVSQ 
       510        520        530        540        550
DGAASLADSK PTSSPTSLKA RPSQLPVSDQ ASPCKCTCKE PSPVSPVTVL 
       560        570        580        590        600
KAGGTKAPPQ HLPLSPALTR AVEGVQYIAD HLKAEDTDFS VKEDWKYVAM 
       610        620        630 
VIDRIFLWMF IIVCLLGTVG LFLPPWLAGM I                     

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families