UniProtKB - P09466 (PAEP_HUMAN)
Protein
Glycodelin
Gene
PAEP
Organism
Homo sapiens (Human)
Status
Functioni
Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260). Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671). Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155).5 Publications
GO - Molecular functioni
- odorant binding Source: GO_Central
- small molecule binding Source: InterPro
GO - Biological processi
- apoptotic process Source: CACAO
- multicellular organism development Source: ProtInc
- negative regulation of sperm capacitation Source: UniProtKB
- positive regulation of granulocyte macrophage colony-stimulating factor production Source: CACAO
- regulation of binding of sperm to zona pellucida Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | P09466 |
Names & Taxonomyi
Protein namesi | Recommended name: GlycodelinShort name: GD Alternative name(s): Placental protein 142 Publications Short name: PP14 Pregnancy-associated endometrial alpha-2 globulin1 Publication Short name: PAEG Short name: PEG Progestagen-associated endometrial protein Progesterone-associated endometrial protein Zona-binding inhibitory factor-11 Publication Short name: ZIF-11 Publication |
Gene namesi | Name:PAEP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000122133.16 |
HGNCi | HGNC:8573, PAEP |
MIMi | 173310, gene |
neXtProti | NX_P09466 |
Subcellular locationi
Extracellular region or secreted
- Secreted 3 Publications
Extracellular region or secreted
- extracellular region Source: UniProtKB
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 5047 |
MalaCardsi | PAEP |
OpenTargetsi | ENSG00000122133 |
PharmGKBi | PA32904 |
Miscellaneous databases
Pharosi | P09466, Tbio |
Chemistry databases
DrugBanki | DB02405, 12-Bromododecanoic Acid DB09462, Glycerin DB03796, Palmitic Acid |
Polymorphism and mutation databases
BioMutai | PAEP |
DMDMi | 130701 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | 3 PublicationsAdd BLAST | 18 | |
ChainiPRO_0000017953 | 19 – 180 | GlycodelinAdd BLAST | 162 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
GlycosylationiCAR_000123 | 46 | N-linked (GlcNAc...) (complex) asparagine1 Publication | 1 | |
GlycosylationiCAR_000124 | 81 | N-linked (GlcNAc...) (complex) asparagine1 Publication | 1 | |
Disulfide bondi | 84 ↔ 178 | Combined sources1 Publication | ||
Disulfide bondi | 124 ↔ 137 | Combined sources1 Publication |
Post-translational modificationi
Four distinct glycoforms A, C, F and S arise from different N-linked oligosaccharide chains at amino acid residues Asn-46 and Asn-81. Glycodelin-A and -F are taken up by the cumulus cells in which partial deglycosylation takes place to produce glycodelin-C.4 Publications
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P09466 |
MassIVEi | P09466 |
PaxDbi | P09466 |
PeptideAtlasi | P09466 |
PRIDEi | P09466 |
ProteomicsDBi | 52220 [P09466-1] 52221 [P09466-2] 52222 [P09466-3] |
PTM databases
GlyConnecti | 177, 20 N-Linked glycans (2 sites) |
GlyGeni | P09466, 3 sites, 22 N-linked glycans (3 sites) |
iPTMneti | P09466 |
PhosphoSitePlusi | P09466 |
UniCarbKBi | P09466 |
Expressioni
Tissue specificityi
This protein is, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy (PubMed:3667877). Glycodelin-A is expressed in amniotic fluid, endometrium/decidua and maternal serum (at protein level) (PubMed:3194393). Glycodelin-F is expressed in follicular fluid, luteinized granulosa cells and the oviduct (at protein level) (PubMed:12672671). Glycodelin-S is expressed in seminal plasma and seminal vesicles (at protein level) (PubMed:9239694). Glycodelin-C is detected in cumulus cells (at protein level), but cumulus cells do not synthesize Glycodelin-C but take up and convert glycodelin-A and -F vis glycan remodeling (PubMed:17192260).5 Publications
Gene expression databases
Bgeei | ENSG00000122133, Expressed in decidua and 84 other tissues |
ExpressionAtlasi | P09466, baseline and differential |
Genevisiblei | P09466, HS |
Organism-specific databases
HPAi | ENSG00000122133, Group enriched (ductus deferens, endometrium, placenta) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP09466
Protein-protein interaction databases
BioGRIDi | 111084, 30 interactors |
IntActi | P09466, 25 interactors |
MINTi | P09466 |
STRINGi | 9606.ENSP00000417898 |
Miscellaneous databases
RNActi | P09466, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P09466 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502T0EI, Eukaryota |
GeneTreei | ENSGT00960000186645 |
InParanoidi | P09466 |
OMAi | KWEDNRC |
OrthoDBi | 1551422at2759 |
PhylomeDBi | P09466 |
TreeFami | TF342475 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR002447, Blactoglobulin IPR012674, Calycin IPR002345, Lipocalin IPR022272, Lipocalin_CS IPR000566, Lipocln_cytosolic_FA-bd_dom |
PANTHERi | PTHR11430, PTHR11430, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR01172, BLCTOGLOBULN |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00213, LIPOCALIN, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P09466-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLCLLLTLGV ALVCGVPAMD IPQTKQDLEL PKLAGTWHSM AMATNNISLM
60 70 80 90 100
ATLKAPLRVH ITSLLPTPED NLEIVLHRWE NNSCVEKKVL GEKTENPKKF
110 120 130 140 150
KINYTVANEA TLLDTDYDNF LFLCLQDTTT PIQSMMCQYL ARVLVEDDEI
160 170 180
MQGFIRAFRP LPRHLWYLLD LKQMEEPCRF
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA6XNE0 | A6XNE0_HUMAN | Glycodelin | PAEP | 143 | Annotation score: | ||
F2Z349 | F2Z349_HUMAN | Glycodelin | PAEP | 169 | Annotation score: | ||
H0Y4U4 | H0Y4U4_HUMAN | Glycodelin | PAEP | 131 | Annotation score: | ||
H0Y6A4 | H0Y6A4_HUMAN | Glycodelin | PAEP | 126 | Annotation score: | ||
Q5T6T6 | Q5T6T6_HUMAN | Glycodelin | PAEP | 132 | Annotation score: | ||
H0Y530 | H0Y530_HUMAN | Glycodelin | PAEP | 33 | Annotation score: |
Sequence cautioni
The sequence AAA60147 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB43305 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 35 – 37 | GTW → VTA AA sequence (PubMed:11278680).Curated | 3 | |
Sequence conflicti | 36 | T → K AA sequence (PubMed:3667877).Curated | 1 | |
Sequence conflicti | 95 | E → G (PubMed:3194393).Curated | 1 | |
Sequence conflicti | 152 | Q → E (PubMed:3194393).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050178 | 28 | L → V. Corresponds to variant dbSNP:rs34284195Ensembl. | 1 | |
Natural variantiVAR_034355 | 126 | Q → K. Corresponds to variant dbSNP:rs3748210Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003141 | 33 – 126 | Missing in isoform 3. CuratedAdd BLAST | 94 | |
Alternative sequenceiVSP_003140 | 33 – 54 | Missing in isoform 2. CuratedAdd BLAST | 22 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04129 mRNA Translation: AAA60147.1 Different initiation. M34046 Genomic DNA Translation: AAA60148.1 M61886 mRNA Translation: AAA35801.1 M61886 mRNA Translation: AAA35802.1 AL050169 mRNA Translation: CAB43305.1 Different initiation. AL354761 Genomic DNA No translation available. BC069451 mRNA Translation: AAH69451.1 BC069562 mRNA Translation: AAH69562.1 BC112304 mRNA Translation: AAI12305.1 BC113728 mRNA Translation: AAI13729.1 |
CCDSi | CCDS35173.1 [P09466-1] |
PIRi | A35570, A39167 |
RefSeqi | NP_001018058.1, NM_001018048.1 [P09466-2] NP_001018059.1, NM_001018049.2 [P09466-1] NP_002562.2, NM_002571.3 [P09466-1] XP_011517051.1, XM_011518749.2 [P09466-1] XP_011517053.1, XM_011518751.1 [P09466-2] |
Genome annotation databases
Ensembli | ENST00000277508; ENSP00000277508; ENSG00000122133 [P09466-1] ENST00000371766; ENSP00000360831; ENSG00000122133 [P09466-1] ENST00000479141; ENSP00000417898; ENSG00000122133 [P09466-1] |
GeneIDi | 5047 |
KEGGi | hsa:5047 |
UCSCi | uc004cgd.2, human [P09466-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04129 mRNA Translation: AAA60147.1 Different initiation. M34046 Genomic DNA Translation: AAA60148.1 M61886 mRNA Translation: AAA35801.1 M61886 mRNA Translation: AAA35802.1 AL050169 mRNA Translation: CAB43305.1 Different initiation. AL354761 Genomic DNA No translation available. BC069451 mRNA Translation: AAH69451.1 BC069562 mRNA Translation: AAH69562.1 BC112304 mRNA Translation: AAI12305.1 BC113728 mRNA Translation: AAI13729.1 |
CCDSi | CCDS35173.1 [P09466-1] |
PIRi | A35570, A39167 |
RefSeqi | NP_001018058.1, NM_001018048.1 [P09466-2] NP_001018059.1, NM_001018049.2 [P09466-1] NP_002562.2, NM_002571.3 [P09466-1] XP_011517051.1, XM_011518749.2 [P09466-1] XP_011517053.1, XM_011518751.1 [P09466-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4R0B | X-ray | 2.45 | A | 20-180 | [»] | |
SMRi | P09466 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111084, 30 interactors |
IntActi | P09466, 25 interactors |
MINTi | P09466 |
STRINGi | 9606.ENSP00000417898 |
Chemistry databases
DrugBanki | DB02405, 12-Bromododecanoic Acid DB09462, Glycerin DB03796, Palmitic Acid |
PTM databases
GlyConnecti | 177, 20 N-Linked glycans (2 sites) |
GlyGeni | P09466, 3 sites, 22 N-linked glycans (3 sites) |
iPTMneti | P09466 |
PhosphoSitePlusi | P09466 |
UniCarbKBi | P09466 |
Polymorphism and mutation databases
BioMutai | PAEP |
DMDMi | 130701 |
Proteomic databases
jPOSTi | P09466 |
MassIVEi | P09466 |
PaxDbi | P09466 |
PeptideAtlasi | P09466 |
PRIDEi | P09466 |
ProteomicsDBi | 52220 [P09466-1] 52221 [P09466-2] 52222 [P09466-3] |
Protocols and materials databases
Antibodypediai | 3391, 369 antibodies |
DNASUi | 5047 |
Genome annotation databases
Ensembli | ENST00000277508; ENSP00000277508; ENSG00000122133 [P09466-1] ENST00000371766; ENSP00000360831; ENSG00000122133 [P09466-1] ENST00000479141; ENSP00000417898; ENSG00000122133 [P09466-1] |
GeneIDi | 5047 |
KEGGi | hsa:5047 |
UCSCi | uc004cgd.2, human [P09466-1] |
Organism-specific databases
CTDi | 5047 |
DisGeNETi | 5047 |
EuPathDBi | HostDB:ENSG00000122133.16 |
GeneCardsi | PAEP |
HGNCi | HGNC:8573, PAEP |
HPAi | ENSG00000122133, Group enriched (ductus deferens, endometrium, placenta) |
MalaCardsi | PAEP |
MIMi | 173310, gene |
neXtProti | NX_P09466 |
OpenTargetsi | ENSG00000122133 |
PharmGKBi | PA32904 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502T0EI, Eukaryota |
GeneTreei | ENSGT00960000186645 |
InParanoidi | P09466 |
OMAi | KWEDNRC |
OrthoDBi | 1551422at2759 |
PhylomeDBi | P09466 |
TreeFami | TF342475 |
Enzyme and pathway databases
PathwayCommonsi | P09466 |
Miscellaneous databases
BioGRID-ORCSi | 5047, 8 hits in 842 CRISPR screens |
ChiTaRSi | PAEP, human |
GeneWikii | PAEP |
GenomeRNAii | 5047 |
Pharosi | P09466, Tbio |
PROi | PR:P09466 |
RNActi | P09466, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122133, Expressed in decidua and 84 other tissues |
ExpressionAtlasi | P09466, baseline and differential |
Genevisiblei | P09466, HS |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR002447, Blactoglobulin IPR012674, Calycin IPR002345, Lipocalin IPR022272, Lipocalin_CS IPR000566, Lipocln_cytosolic_FA-bd_dom |
PANTHERi | PTHR11430, PTHR11430, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR01172, BLCTOGLOBULN |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00213, LIPOCALIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PAEP_HUMAN | |
Accessioni | P09466Primary (citable) accession number: P09466 Secondary accession number(s): Q5T6T1, Q9UG92 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | March 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 198 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations