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UniProtKB - P09466 (PAEP_HUMAN)

Entry version 201 (02 Jun 2021)
Sequence version 2 (01 Mar 1992)
Previous versions | rss
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Protein

Glycodelin

Gene

PAEP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163).

Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260).

Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671).

Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155).

5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P09466

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycodelin
Short name:
GD
Alternative name(s):
Placental protein 142 Publications
Short name:
PP14
Pregnancy-associated endometrial alpha-2 globulin1 Publication
Short name:
PAEG
Short name:
PEG
Progestagen-associated endometrial protein
Progesterone-associated endometrial protein
Zona-binding inhibitory factor-11 Publication
Short name:
ZIF-11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PAEP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8573, PAEP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		173310, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P09466

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000122133.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5047

MalaCards human disease database

More...MalaCardsi		PAEP

Open Targets

More...OpenTargetsi		ENSG00000122133

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA32904

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P09466, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB02405, 12-Bromododecanoic Acid
DB09462, Glycerin
DB03796, Palmitic Acid

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PAEP

Domain mapping of disease mutations (DMDM)

More...DMDMi		130701

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 183 PublicationsAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001795319 – 180GlycodelinAdd BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_00012346N-linked (GlcNAc...) (complex) asparagine1 Publication1
GlycosylationiCAR_00012481N-linked (GlcNAc...) (complex) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi84 ↔ 178Combined sources1 Publication
Disulfide bondi124 ↔ 137Combined sources1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Four distinct glycoforms A, C, F and S arise from different N-linked oligosaccharide chains at amino acid residues Asn-46 and Asn-81. Glycodelin-A and -F are taken up by the cumulus cells in which partial deglycosylation takes place to produce glycodelin-C.4 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P09466

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P09466

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P09466

PeptideAtlas

More...PeptideAtlasi		P09466

PRoteomics IDEntifications database

More...PRIDEi		P09466

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52220 [P09466-1]
52221 [P09466-2]
52222 [P09466-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		177, 20 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P09466, 3 sites, 22 N-linked glycans (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P09466

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P09466

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

This protein is, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy (PubMed:3667877). Glycodelin-A is expressed in amniotic fluid, endometrium/decidua and maternal serum (at protein level) (PubMed:3194393). Glycodelin-F is expressed in follicular fluid, luteinized granulosa cells and the oviduct (at protein level) (PubMed:12672671). Glycodelin-S is expressed in seminal plasma and seminal vesicles (at protein level) (PubMed:9239694). Glycodelin-C is detected in cumulus cells (at protein level), but cumulus cells do not synthesize Glycodelin-C but take up and convert glycodelin-A and -F vis glycan remodeling (PubMed:17192260).5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000122133, Expressed in decidua and 85 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P09466, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P09466, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000122133, Group enriched (ductus deferens, endometrium, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:25422905, PubMed:9239694).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111084, 30 interactors

Protein interaction database and analysis system

More...IntActi		P09466, 25 interactors

Molecular INTeraction database

More...MINTi		P09466

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000417898

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P09466, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P09466

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502T0EI, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00960000186645

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P09466

Identification of Orthologs from Complete Genome Data

More...OMAi		KWEDNRC

Database of Orthologous Groups

More...OrthoDBi		1551422at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P09466

TreeFam database of animal gene trees

More...TreeFami		TF342475

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.128.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002447, Blactoglobulin
IPR012674, Calycin
IPR002345, Lipocalin
IPR022272, Lipocalin_CS
IPR000566, Lipocln_cytosolic_FA-bd_dom

The PANTHER Classification System

More...PANTHERi		PTHR11430, PTHR11430, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00061, Lipocalin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01172, BLCTOGLOBULN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50814, SSF50814, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00213, LIPOCALIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P09466-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLCLLLTLGV ALVCGVPAMD IPQTKQDLEL PKLAGTWHSM AMATNNISLM 
        60         70         80         90        100
ATLKAPLRVH ITSLLPTPED NLEIVLHRWE NNSCVEKKVL GEKTENPKKF 
       110        120        130        140        150
KINYTVANEA TLLDTDYDNF LFLCLQDTTT PIQSMMCQYL ARVLVEDDEI 
       160        170        180
MQGFIRAFRP LPRHLWYLLD LKQMEEPCRF
Length:180
Mass (Da):20,624
Last modified:March 1, 1992 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0813A74A4231149E
GO
Isoform 2 (identifier: P09466-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-54: Missing.

Show »
Length:158
Mass (Da):18,279
Checksum:iFEB77A0B313F33C8
GO
Isoform 3 (identifier: P09466-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-126: Missing.

Show »
Length:86
Mass (Da):9,953
Checksum:i01C203BBE8D26652
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6XNE0A6XNE0_HUMAN
Glycodelin
PAEP
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z349F2Z349_HUMAN
Glycodelin
PAEP
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4U4H0Y4U4_HUMAN
Glycodelin
PAEP
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6A4H0Y6A4_HUMAN
Glycodelin
PAEP
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T6T6Q5T6T6_HUMAN
Glycodelin
PAEP
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y530H0Y530_HUMAN
Glycodelin
PAEP
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA60147 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB43305 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti35 – 37GTW → VTA AA sequence (PubMed:11278680).Curated3
Sequence conflicti36T → K AA sequence (PubMed:3667877).Curated1
Sequence conflicti95E → G (PubMed:3194393).Curated1
Sequence conflicti152Q → E (PubMed:3194393).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05017828L → V. Corresponds to variant dbSNP:rs34284195Ensembl.1
Natural variantiVAR_034355126Q → K. Corresponds to variant dbSNP:rs3748210Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00314133 – 126Missing in isoform 3. CuratedAdd BLAST94
Alternative sequenceiVSP_00314033 – 54Missing in isoform 2. CuratedAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J04129 mRNA Translation: AAA60147.1 Different initiation.
M34046 Genomic DNA Translation: AAA60148.1
M61886 mRNA Translation: AAA35801.1
M61886 mRNA Translation: AAA35802.1
AL050169 mRNA Translation: CAB43305.1 Different initiation.
AL354761 Genomic DNA No translation available.
BC069451 mRNA Translation: AAH69451.1
BC069562 mRNA Translation: AAH69562.1
BC112304 mRNA Translation: AAI12305.1
BC113728 mRNA Translation: AAI13729.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35173.1 [P09466-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A35570, A39167

NCBI Reference Sequences

More...RefSeqi		NP_001018058.1, NM_001018048.1 [P09466-2]
NP_001018059.1, NM_001018049.2 [P09466-1]
NP_002562.2, NM_002571.3 [P09466-1]
XP_011517051.1, XM_011518749.2 [P09466-1]
XP_011517053.1, XM_011518751.1 [P09466-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000277508; ENSP00000277508; ENSG00000122133 [P09466-1]
ENST00000371766; ENSP00000360831; ENSG00000122133 [P09466-1]
ENST00000479141; ENSP00000417898; ENSG00000122133 [P09466-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5047

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5047

UCSC genome browser

More...UCSCi		uc004cgd.2, human [P09466-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04129 mRNA Translation: AAA60147.1 Different initiation.
M34046 Genomic DNA Translation: AAA60148.1
M61886 mRNA Translation: AAA35801.1
M61886 mRNA Translation: AAA35802.1
AL050169 mRNA Translation: CAB43305.1 Different initiation.
AL354761 Genomic DNA No translation available.
BC069451 mRNA Translation: AAH69451.1
BC069562 mRNA Translation: AAH69562.1
BC112304 mRNA Translation: AAI12305.1
BC113728 mRNA Translation: AAI13729.1
CCDSiCCDS35173.1 [P09466-1]
PIRiA35570, A39167
RefSeqiNP_001018058.1, NM_001018048.1 [P09466-2]
NP_001018059.1, NM_001018049.2 [P09466-1]
NP_002562.2, NM_002571.3 [P09466-1]
XP_011517051.1, XM_011518749.2 [P09466-1]
XP_011517053.1, XM_011518751.1 [P09466-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4R0BX-ray2.45A20-180[»]
SMRiP09466
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111084, 30 interactors
IntActiP09466, 25 interactors
MINTiP09466
STRINGi9606.ENSP00000417898

Chemistry databases

DrugBankiDB02405, 12-Bromododecanoic Acid
DB09462, Glycerin
DB03796, Palmitic Acid

PTM databases

GlyConnecti177, 20 N-Linked glycans (2 sites)
GlyGeniP09466, 3 sites, 22 N-linked glycans (3 sites)
iPTMnetiP09466
PhosphoSitePlusiP09466

Genetic variation databases

BioMutaiPAEP
DMDMi130701

Proteomic databases

jPOSTiP09466
MassIVEiP09466
PaxDbiP09466
PeptideAtlasiP09466
PRIDEiP09466
ProteomicsDBi52220 [P09466-1]
52221 [P09466-2]
52222 [P09466-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3391, 376 antibodies

The DNASU plasmid repository

More...DNASUi		5047

Genome annotation databases

EnsembliENST00000277508; ENSP00000277508; ENSG00000122133 [P09466-1]
ENST00000371766; ENSP00000360831; ENSG00000122133 [P09466-1]
ENST00000479141; ENSP00000417898; ENSG00000122133 [P09466-1]
GeneIDi5047
KEGGihsa:5047
UCSCiuc004cgd.2, human [P09466-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5047
DisGeNETi5047

GeneCards: human genes, protein and diseases

More...GeneCardsi		PAEP
HGNCiHGNC:8573, PAEP
HPAiENSG00000122133, Group enriched (ductus deferens, endometrium, placenta)
MalaCardsiPAEP
MIMi173310, gene
neXtProtiNX_P09466
OpenTargetsiENSG00000122133
PharmGKBiPA32904
VEuPathDBiHostDB:ENSG00000122133.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502T0EI, Eukaryota
GeneTreeiENSGT00960000186645
InParanoidiP09466
OMAiKWEDNRC
OrthoDBi1551422at2759
PhylomeDBiP09466
TreeFamiTF342475

Enzyme and pathway databases

PathwayCommonsiP09466

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5047, 8 hits in 985 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PAEP, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PAEP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5047
PharosiP09466, Tbio

Protein Ontology

More...PROi		PR:P09466
RNActiP09466, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000122133, Expressed in decidua and 85 other tissues
ExpressionAtlasiP09466, baseline and differential
GenevisibleiP09466, HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR002447, Blactoglobulin
IPR012674, Calycin
IPR002345, Lipocalin
IPR022272, Lipocalin_CS
IPR000566, Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11430, PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061, Lipocalin, 1 hit
PRINTSiPR01172, BLCTOGLOBULN
SUPFAMiSSF50814, SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213, LIPOCALIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAEP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09466
Secondary accession number(s): Q5T6T1, Q9UG92
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: March 1, 1992
Last modified: June 2, 2021
This is version 201 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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