PAEP

Functionⁱ

Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260). Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671). Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155).5 Publications

GO - Molecular functionⁱ

small molecule binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process
Source: CACAO
Inferred from direct assayⁱ
- 18996219
multicellular organism development
Source: ProtInc
Traceable author statementⁱ
- 3194393
negative regulation of sperm capacitation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15883155
positive regulation of granulocyte macrophage colony-stimulating factor production
Source: CACAO
Inferred from direct assayⁱ
- 19945098
positive regulation of interleukin-13 secretion
Source: CACAO
Inferred from direct assayⁱ
- 19945098
positive regulation of interleukin-6 secretion
Source: CACAO
Inferred from direct assayⁱ
- 19945098
regulation of binding of sperm to zona pellucida
Source: UniProtKB
Inferred from direct assayⁱ
- 17192260

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glycodelin Short name: GD Alternative name(s): Placental protein 142 Publications Short name: PP14 Pregnancy-associated endometrial alpha-2 globulin1 Publication Short name: PAEG Short name: PEG Progestagen-associated endometrial protein Progesterone-associated endometrial protein Zona-binding inhibitory factor-11 Publication Short name: ZIF-11 Publication
Gene namesⁱ	Name:PAEP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000122133.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8573 PAEP
MIMⁱ	173310 gene
neXtProtⁱ	NX_P09466

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5047
Open Targets More...OpenTargetsⁱ	ENSG00000122133
PharmGKBⁱ	PA32904

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB02405 12-Bromododecanoic Acid DB04077 Glycerol DB03796 Palmitic Acid

DrugBankⁱ

DB02405 12-Bromododecanoic Acid
DB04077 Glycerol
DB03796 Palmitic Acid

Polymorphism and mutation databases

BioMutaⁱ	PAEP
DMDMⁱ	130701

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	3 PublicationsAdd BLAST		18
ChainⁱPRO_0000017953	19 – 180	GlycodelinAdd BLAST		162

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
GlycosylationⁱCAR_000123	46	N-linked (GlcNAc...) (complex) asparagine1 Publication	1
GlycosylationⁱCAR_000124	81	N-linked (GlcNAc...) (complex) asparagine1 Publication	1
Disulfide bondⁱ	84 ↔ 178	Combined sources1 Publication
Disulfide bondⁱ	124 ↔ 137	Combined sources1 Publication

Post-translational modificationⁱ

Four distinct glycoforms A, C, F and S arise from different N-linked oligosaccharide chains at amino acid residues Asn-46 and Asn-81. Glycodelin-A and -F are taken up by the cumulus cells in which partial deglycosylation takes place to produce glycodelin-C.4 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P09466
PeptideAtlas More...PeptideAtlasⁱ	P09466
PRIDEⁱ	P09466
ProteomicsDBⁱ	52220 52221 [P09466-2] 52222 [P09466-3]

PTM databases

GlyConnectⁱ	177
iPTMnetⁱ	P09466
PhosphoSitePlusⁱ	P09466
UniCarbKBⁱ	P09466

Expressionⁱ

Tissue specificityⁱ

This protein is, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy (PubMed:3667877). Glycodelin-A is expressed in amniotic fluid, endometrium/decidua and maternal serum (at protein level) (PubMed:3194393). Glycodelin-F is expressed in follicular fluid, luteinized granulosa cells and the oviduct (at protein level) (PubMed:12672671). Glycodelin-S is expressed in seminal plasma and seminal vesicles (at protein level) (PubMed:9239694). Glycodelin-C is detected in cumulus cells (at protein level), but cumulus cells do not synthesize Glycodelin-C but take up and convert glycodelin-A and -F vis glycan remodeling (PubMed:17192260).5 Publications

Gene expression databases

Bgeeⁱ	ENSG00000122133 Expressed in 60 organ(s), highest expression level in decidua
CleanExⁱ	HS_PAEP
ExpressionAtlasⁱ	P09466 baseline and differential
Genevisibleⁱ	P09466 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016762 HPA020108 HPA029473

HPAⁱ

CAB016762
HPA020108
HPA029473

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GRAMD2B	Q96HH9	5	EBI-465167,EBI-2832937

With

Entry

#Exp.

IntAct

Notes

GRAMD2B

Q96HH9

5

EBI-465167,EBI-2832937

Protein-protein interaction databases

BioGridⁱ	111084, 19 interactors
IntActⁱ	P09466, 22 interactors
Molecular INTeraction database More...MINTⁱ	P09466
STRINGⁱ	9606.ENSP00000277508

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	30 – 33	Combined sources	4
Beta strandⁱ	38 – 46	Combined sources	9
Helixⁱ	47 – 49	Combined sources	3
Beta strandⁱ	60 – 66	Combined sources	7
Beta strandⁱ	72 – 79	Combined sources	8
Beta strandⁱ	81 – 93	Combined sources	13
Beta strandⁱ	99 – 104	Combined sources	6
Beta strandⁱ	107 – 115	Combined sources	9
Beta strandⁱ	117 – 127	Combined sources	11
Beta strandⁱ	129 – 132	Combined sources	4
Beta strandⁱ	134 – 144	Combined sources	11
Helixⁱ	148 – 158	Combined sources	11
Beta strandⁱ	159 – 162	Combined sources	4
Beta strandⁱ	167 – 170	Combined sources	4
Turnⁱ	173 – 175	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P09466
SMRⁱ	P09466
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410JCG3 Eukaryota ENOG4111386 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00620000088158
HOGENOMⁱ	HOG000113272
HOVERGENⁱ	HBG104361
InParanoidⁱ	P09466
OMAⁱ	CMENSAS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0M2T
PhylomeDBⁱ	P09466
TreeFamⁱ	TF342475

Family and domain databases

Gene3Dⁱ	2.40.128.20, 1 hit
InterProⁱ	View protein in InterPro IPR002447 Blactoglobulin IPR012674 Calycin IPR002345 Lipocalin IPR022272 Lipocalin_CS IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERⁱ	PTHR11430 PTHR11430, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00061 Lipocalin, 1 hit
PRINTSⁱ	PR01172 BLCTOGLOBULN
SUPFAMⁱ	SSF50814 SSF50814, 1 hit
PROSITEⁱ	View protein in PROSITE PS00213 LIPOCALIN, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P09466-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCLLLTLGV ALVCGVPAMD IPQTKQDLEL PKLAGTWHSM AMATNNISLM 
        60         70         80         90        100
ATLKAPLRVH ITSLLPTPED NLEIVLHRWE NNSCVEKKVL GEKTENPKKF 
       110        120        130        140        150
KINYTVANEA TLLDTDYDNF LFLCLQDTTT PIQSMMCQYL ARVLVEDDEI 
       160        170        180
MQGFIRAFRP LPRHLWYLLD LKQMEEPCRF

Length:180

Mass (Da):20,624

Last modified:March 1, 1992 - v2

Checksum:ⁱ0813A74A4231149E

GO

Isoform 2 (identifier: P09466-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
33-54: Missing.

« Hide

        10         20         30         40         50
MLCLLLTLGV ALVCGVPAMD IPQTKQDLEL PKAPLRVHIT SLLPTPEDNL 
        60         70         80         90        100
EIVLHRWENN SCVEKKVLGE KTENPKKFKI NYTVANEATL LDTDYDNFLF 
       110        120        130        140        150
LCLQDTTTPI QSMMCQYLAR VLVEDDEIMQ GFIRAFRPLP RHLWYLLDLK 

QMEEPCRF

Show »

Length:158

Mass (Da):18,279

Checksum:ⁱFEB77A0B313F33C8

GO

Isoform 3 (identifier: P09466-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
33-126: Missing.

« Hide

        10         20         30         40         50
MLCLLLTLGV ALVCGVPAMD IPQTKQDLEL PKDTTTPIQS MMCQYLARVL 
        60         70         80 
VEDDEIMQGF IRAFRPLPRH LWYLLDLKQM EEPCRF

Show »

Length:86

Mass (Da):9,953

Checksum:ⁱ01C203BBE8D26652

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A6XNE0	A6XNE0_HUMAN	Glycodelin Glycodelin	PAEP	143	Annotation score:
F2Z349	F2Z349_HUMAN	Glycodelin Glycodelin	PAEP	169	Annotation score:
Q5T6T6	Q5T6T6_HUMAN	Glycodelin Glycodelin	PAEP	132	Annotation score:
H0Y6A4	H0Y6A4_HUMAN	Glycodelin Glycodelin	PAEP	126	Annotation score:
H0Y4U4	H0Y4U4_HUMAN	Glycodelin Glycodelin	PAEP	131	Annotation score:
H0Y530	H0Y530_HUMAN	Glycodelin Glycodelin	PAEP	33	Annotation score:

Sequence cautionⁱ

The sequence AAA60147 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAB43305 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	35 – 37	GTW → VTA AA sequence (PubMed:11278680).Curated	3
Sequence conflictⁱ	36	T → K AA sequence (PubMed:3667877).Curated	1
Sequence conflictⁱ	95	E → G (PubMed:3194393).Curated	1
Sequence conflictⁱ	152	Q → E (PubMed:3194393).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050178	28	L → V. Corresponds to variant dbSNP:rs34284195Ensembl.		1
Natural variantⁱVAR_034355	126	Q → K. Corresponds to variant dbSNP:rs3748210Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_003141	33 – 126	Missing in isoform 3. CuratedAdd BLAST		94
Alternative sequenceⁱVSP_003140	33 – 54	Missing in isoform 2. CuratedAdd BLAST		22

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04129 mRNA Translation: AAA60147.1 Different initiation. M34046 Genomic DNA Translation: AAA60148.1 M61886 mRNA Translation: AAA35801.1 M61886 mRNA Translation: AAA35802.1 AL050169 mRNA Translation: CAB43305.1 Different initiation. AL354761 Genomic DNA No translation available. BC069451 mRNA Translation: AAH69451.1 BC069562 mRNA Translation: AAH69562.1 BC112304 mRNA Translation: AAI12305.1 BC113728 mRNA Translation: AAI13729.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35173.1 [P09466-1]
PIRⁱ	A35570 A39167
NCBI Reference Sequences More...RefSeqⁱ	NP_001018058.1, NM_001018048.1 [P09466-2] NP_001018059.1, NM_001018049.2 [P09466-1] NP_002562.2, NM_002571.3 [P09466-1] XP_011517051.1, XM_011518749.2 [P09466-1] XP_011517053.1, XM_011518751.1 [P09466-2]
UniGeneⁱ	Hs.532325

Genome annotation databases

Ensemblⁱ	ENST00000277508; ENSP00000277508; ENSG00000122133 [P09466-1] ENST00000371766; ENSP00000360831; ENSG00000122133 [P09466-1] ENST00000479141; ENSP00000417898; ENSG00000122133 [P09466-1]
GeneIDⁱ	5047
KEGGⁱ	hsa:5047
UCSC genome browser More...UCSCⁱ	uc004cgd.2 human [P09466-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P09466	Progestagen-associated endometrial protein (Placental protein 14, pregnancy-associated endometrial alpha-2-globulin, alpha uterine protein), isoform CRA_d		HUMAN		180	UniRef100_P09466
Glycodelin (Fragment)		HUMAN		132

Protein	Similar proteins		Species	Score	Length	Source
P09466	Progestagen-associated endometrial protein (Placental protein 14, pregnancy-associated endometrial alpha-2-globulin, alpha uterine protein), isoform CRA_d		HUMAN		180	UniRef90_P09466
Uncharacterized protein		PANPA		225
PAEP isoform 1		PANTR		180
PAEP isoform 1		PONAB		180
Progestagen associated endometrial protein		GORGO		180
+2
P09466-2	cDNA FLJ52183, highly similar to Glycodelin		HUMAN		158	UniRef90_P09466-2
UPI00020E3952		PANPA		158
UPI00029D9222		GORGO		158

Protein	Similar proteins		Species	Score	Length	Source
P09466	Progestagen-associated endometrial protein (Placental protein 14, pregnancy-associated endometrial alpha-2-globulin, alpha uterine protein), isoform CRA_d		HUMAN		180	UniRef50_P09466
Uncharacterized protein		PANPA		225
PAEP isoform 1		PANTR		180
Progestagen associated endometrial protein		GORGO		180
PAEP isoform 1		PONAB		180
+23
P09466-2	cDNA FLJ52183, highly similar to Glycodelin		HUMAN		158	UniRef50_P09466-2
Progestagen associated endometrial protein		PANTR		182
PAEP isoform 9 (Fragment)		PONAB		132
UPI00029D9222		GORGO		158
UPI00020E3952		PANPA		158
+7

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04129 mRNA Translation: AAA60147.1 Different initiation. M34046 Genomic DNA Translation: AAA60148.1 M61886 mRNA Translation: AAA35801.1 M61886 mRNA Translation: AAA35802.1 AL050169 mRNA Translation: CAB43305.1 Different initiation. AL354761 Genomic DNA No translation available. BC069451 mRNA Translation: AAH69451.1 BC069562 mRNA Translation: AAH69562.1 BC112304 mRNA Translation: AAI12305.1 BC113728 mRNA Translation: AAI13729.1
CCDSⁱ	CCDS35173.1 [P09466-1]
PIRⁱ	A35570 A39167
RefSeqⁱ	NP_001018058.1, NM_001018048.1 [P09466-2] NP_001018059.1, NM_001018049.2 [P09466-1] NP_002562.2, NM_002571.3 [P09466-1] XP_011517051.1, XM_011518749.2 [P09466-1] XP_011517053.1, XM_011518751.1 [P09466-2]
UniGeneⁱ	Hs.532325

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4R0B	X-ray	2.45	A	20-180	[»]
ProteinModelPortalⁱ	P09466
SMRⁱ	P09466
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111084, 19 interactors
IntActⁱ	P09466, 22 interactors
MINTⁱ	P09466
STRINGⁱ	9606.ENSP00000277508

Chemistry databases

DrugBankⁱ	DB02405 12-Bromododecanoic Acid DB04077 Glycerol DB03796 Palmitic Acid

DrugBankⁱ

DB02405 12-Bromododecanoic Acid
DB04077 Glycerol
DB03796 Palmitic Acid

PTM databases

GlyConnectⁱ	177
iPTMnetⁱ	P09466
PhosphoSitePlusⁱ	P09466
UniCarbKBⁱ	P09466

Polymorphism and mutation databases

BioMutaⁱ	PAEP
DMDMⁱ	130701

Proteomic databases

PaxDbⁱ	P09466
PeptideAtlasⁱ	P09466
PRIDEⁱ	P09466
ProteomicsDBⁱ	52220 52221 [P09466-2] 52222 [P09466-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5047
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000277508; ENSP00000277508; ENSG00000122133 [P09466-1] ENST00000371766; ENSP00000360831; ENSG00000122133 [P09466-1] ENST00000479141; ENSP00000417898; ENSG00000122133 [P09466-1]
GeneIDⁱ	5047
KEGGⁱ	hsa:5047
UCSCⁱ	uc004cgd.2 human [P09466-1]

Organism-specific databases

CTDⁱ	5047
DisGeNETⁱ	5047
EuPathDBⁱ	HostDB:ENSG00000122133.16
GeneCardsⁱ	PAEP
HGNCⁱ	HGNC:8573 PAEP
HPAⁱ	CAB016762 HPA020108 HPA029473
MIMⁱ	173310 gene
neXtProtⁱ	NX_P09466
OpenTargetsⁱ	ENSG00000122133
PharmGKBⁱ	PA32904
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410JCG3 Eukaryota ENOG4111386 LUCA
GeneTreeⁱ	ENSGT00620000088158
HOGENOMⁱ	HOG000113272
HOVERGENⁱ	HBG104361
InParanoidⁱ	P09466
OMAⁱ	CMENSAS
OrthoDBⁱ	EOG091G0M2T
PhylomeDBⁱ	P09466
TreeFamⁱ	TF342475

Miscellaneous databases

ChiTaRSⁱ	PAEP human
GeneWikiⁱ	PAEP
GenomeRNAiⁱ	5047
Protein Ontology More...PROⁱ	PR:P09466
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000122133 Expressed in 60 organ(s), highest expression level in decidua
CleanExⁱ	HS_PAEP
ExpressionAtlasⁱ	P09466 baseline and differential
Genevisibleⁱ	P09466 HS

Family and domain databases

Gene3Dⁱ	2.40.128.20, 1 hit
InterProⁱ	View protein in InterPro IPR002447 Blactoglobulin IPR012674 Calycin IPR002345 Lipocalin IPR022272 Lipocalin_CS IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERⁱ	PTHR11430 PTHR11430, 1 hit
Pfamⁱ	View protein in Pfam PF00061 Lipocalin, 1 hit
PRINTSⁱ	PR01172 BLCTOGLOBULN
SUPFAMⁱ	SSF50814 SSF50814, 1 hit
PROSITEⁱ	View protein in PROSITE PS00213 LIPOCALIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PAEP_HUMAN
Accessionⁱ	P09466Primary (citable) accession number: P09466 Secondary accession number(s): Q5T6T1, Q9UG92
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	March 1, 1992
	Last modified:	November 7, 2018
	This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P09466 (PAEP_HUMAN)

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Glycodelin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ