Transcription factor jun-B

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 12220541
• DNA-binding transcription factor activity Source: MGI
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• double-stranded DNA binding Source: MGI
• proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 11818961
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SBInferred from mutant phenotypeⁱ
  • 11818961
• RNA polymerase II regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • 19289495
• sequence-specific DNA binding Source: MGI
• transcription coactivator activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635

GO - Biological processⁱ

• cellular process Source: MGIInferred from direct assayⁱ
  • 11818961
• cellular response to calcium ion Source: MGIInferred from direct assayⁱ
  • 19303854
• cellular response to hormone stimulus Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• decidualization Source: MGIInferred from mutant phenotypeⁱ
  • 10022836
• embryonic process involved in female pregnancy Source: MGIInferred from mutant phenotypeⁱ
  • 10022836
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • 10022836
• labyrinthine layer blood vessel development Source: MGIInferred from mutant phenotypeⁱ
  • 10022836
• negative regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• osteoblast differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 14769860
• osteoblast proliferation Source: MGIInferred from mutant phenotypeⁱ
  • 14769860
• osteoclast differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 14769860
• positive regulation of cell differentiation Source: MGIInferred from direct assayⁱ
  • 11456449
• positive regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from mutant phenotypeⁱ
  • 11818961
• regulation of cell cycle Source: MGIInferred from direct assayⁱ
  • 11818961
• regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • 11818961
• response to cAMP Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to cytokine Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to drug Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to lipopolysaccharide Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to mechanical stimulus Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to organic substance Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to radiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• transcription by RNA polymerase II Source: MGI
• trophectodermal cell differentiation Source: MGIInferred from direct assayⁱ
  • 11456449
• vasculogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 10022836

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MCTKMEQPFY HDDSYAAAGY GRSPGSLSLH DYKLLKPTLA LNLADPYRGL 
        60         70         80         90        100
KGPGARGPGP EGSGAGSYFS GQGSDTGASL KLASTELERL IVPNSNGVIT 
       110        120        130        140        150
TTPTPPGQYF YPRGGGSGGG TGGGVTEEQE GFADGFVKAL DDLHKMNHVT 
       160        170        180        190        200
PPNVSLGASG GPQAGPGGVY AGPEPPPVYT NLSSYSPASA PSGGSGTAVG 
       210        220        230        240        250
TGSSYPTATI SYLPHAPPFA GGHPAQLGLS RGASAFKEEP QTVPEARSRD 
       260        270        280        290        300
ATPPVSPINM EDQERIKVER KRLRNRLAAT KCRKRKLERI ARLEDKVKTL 
       310        320        330        340 
KAENAGLSSA AGLLREQVAQ LKQKVMTHVS NGCQLLLGVK GHAF       

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot