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Protein

Transcription factor jun-B

Gene

Junb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor jun-B
Alternative name(s):
MyD21
Gene namesi
Name:Junb
Synonyms:Jun-b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:96647 Junb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764391 – 344Transcription factor jun-BAdd BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki36Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki81Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei102PhosphothreonineBy similarity1
Modified residuei104PhosphothreonineBy similarity1
Modified residuei117PhosphoserineBy similarity1
Cross-linki138Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei237N6-acetyllysine; alternateCombined sources1
Cross-linki237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei248PhosphoserineCombined sources1
Modified residuei252PhosphothreonineCombined sources1
Modified residuei256PhosphoserineCombined sources1
Cross-linki340Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Ubiquitinated by ITCH, leading to its degradation.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP09450
PaxDbiP09450
PeptideAtlasiP09450
PRIDEiP09450

PTM databases

iPTMnetiP09450
PhosphoSitePlusiP09450

Expressioni

Inductioni

By growth factors.

Gene expression databases

BgeeiENSMUSG00000052837 Expressed in 169 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiMM_JUNB
ExpressionAtlasiP09450 baseline and differential
GenevisibleiP09450 MM

Interactioni

Subunit structurei

Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with NFE2 (via its WW domains).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MDV005Q9DGW52EBI-5347760,EBI-10889526From Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987).

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200872, 104 interactors
CORUMiP09450
DIPiDIP-1069N
ELMiP09450
IntActiP09450, 103 interactors
STRINGi10090.ENSMUSP00000064680

Structurei

3D structure databases

ProteinModelPortaliP09450
SMRiP09450
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini265 – 328bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni265 – 292Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni293 – 321Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated

Phylogenomic databases

eggNOGiKOG0837 Eukaryota
ENOG410XRWH LUCA
GeneTreeiENSGT00390000009929
HOGENOMiHOG000006648
HOVERGENiHBG001722
InParanoidiP09450
KOiK09028
OMAiSHHFQHS
OrthoDBiEOG091G0N0L
PhylomeDBiP09450

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR005643 JNK
IPR029822 JunB
IPR002112 Leuzip_Jun
IPR008917 TF_DNA-bd_sf
PANTHERiPTHR11462:SF37 PTHR11462:SF37, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PF03957 Jun, 1 hit
PRINTSiPR00043 LEUZIPPRJUN
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

P09450-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCTKMEQPFY HDDSYAAAGY GRSPGSLSLH DYKLLKPTLA LNLADPYRGL
60 70 80 90 100
KGPGARGPGP EGSGAGSYFS GQGSDTGASL KLASTELERL IVPNSNGVIT
110 120 130 140 150
TTPTPPGQYF YPRGGGSGGG TGGGVTEEQE GFADGFVKAL DDLHKMNHVT
160 170 180 190 200
PPNVSLGASG GPQAGPGGVY AGPEPPPVYT NLSSYSPASA PSGGSGTAVG
210 220 230 240 250
TGSSYPTATI SYLPHAPPFA GGHPAQLGLS RGASAFKEEP QTVPEARSRD
260 270 280 290 300
ATPPVSPINM EDQERIKVER KRLRNRLAAT KCRKRKLERI ARLEDKVKTL
310 320 330 340
KAENAGLSSA AGLLREQVAQ LKQKVMTHVS NGCQLLLGVK GHAF
Length:344
Mass (Da):35,765
Last modified:July 1, 1989 - v1
Checksum:i6F52D4FECC32E234
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53P → S in BAC40473 (PubMed:16141072).Curated1
Sequence conflicti200G → R in AAA74916 (PubMed:8530030).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03236 mRNA Translation: AAA39343.1
U20735 Genomic DNA Translation: AAA74916.1
AK088643 mRNA Translation: BAC40473.1
BC003790 mRNA Translation: AAH03790.1
X54332 mRNA No translation available.
CCDSiCCDS22488.1
PIRiA28963 TVMSJB
RefSeqiNP_032442.1, NM_008416.3
UniGeneiMm.1167

Genome annotation databases

EnsembliENSMUST00000064922; ENSMUSP00000064680; ENSMUSG00000052837
GeneIDi16477
KEGGimmu:16477
UCSCiuc009mop.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03236 mRNA Translation: AAA39343.1
U20735 Genomic DNA Translation: AAA74916.1
AK088643 mRNA Translation: BAC40473.1
BC003790 mRNA Translation: AAH03790.1
X54332 mRNA No translation available.
CCDSiCCDS22488.1
PIRiA28963 TVMSJB
RefSeqiNP_032442.1, NM_008416.3
UniGeneiMm.1167

3D structure databases

ProteinModelPortaliP09450
SMRiP09450
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200872, 104 interactors
CORUMiP09450
DIPiDIP-1069N
ELMiP09450
IntActiP09450, 103 interactors
STRINGi10090.ENSMUSP00000064680

PTM databases

iPTMnetiP09450
PhosphoSitePlusiP09450

Proteomic databases

EPDiP09450
PaxDbiP09450
PeptideAtlasiP09450
PRIDEiP09450

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064922; ENSMUSP00000064680; ENSMUSG00000052837
GeneIDi16477
KEGGimmu:16477
UCSCiuc009mop.1 mouse

Organism-specific databases

CTDi3726
MGIiMGI:96647 Junb

Phylogenomic databases

eggNOGiKOG0837 Eukaryota
ENOG410XRWH LUCA
GeneTreeiENSGT00390000009929
HOGENOMiHOG000006648
HOVERGENiHBG001722
InParanoidiP09450
KOiK09028
OMAiSHHFQHS
OrthoDBiEOG091G0N0L
PhylomeDBiP09450

Miscellaneous databases

PROiPR:P09450
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052837 Expressed in 169 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiMM_JUNB
ExpressionAtlasiP09450 baseline and differential
GenevisibleiP09450 MM

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR005643 JNK
IPR029822 JunB
IPR002112 Leuzip_Jun
IPR008917 TF_DNA-bd_sf
PANTHERiPTHR11462:SF37 PTHR11462:SF37, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PF03957 Jun, 1 hit
PRINTSiPR00043 LEUZIPPRJUN
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJUNB_MOUSE
AccessioniPrimary (citable) accession number: P09450
Secondary accession number(s): Q8C2G9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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