UniProtKB - P09435 (HSP73_YEAST)
Protein
Heat shock protein SSA3
Gene
SSA3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Miscellaneous
Present with 6440 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- ATPase activity Source: SGD
- ATP binding Source: GO_Central
- heat shock protein binding Source: GO_Central
- misfolded protein binding Source: GO_Central
- protein folding chaperone Source: GO_Central
- unfolded protein binding Source: SGD
GO - Biological processi
- cellular response to unfolded protein Source: GO_Central
- chaperone cofactor-dependent protein refolding Source: GO_Central
- protein folding Source: SGD
- protein quality control for misfolded or incompletely synthesized proteins Source: SGD
- protein refolding Source: GO_Central
- SRP-dependent cotranslational protein targeting to membrane, translocation Source: SGD
- vesicle-mediated transport Source: GO_Central
Keywordsi
Biological process | Stress response |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SCE-3371453, Regulation of HSF1-mediated heat shock response R-SCE-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-SCE-3371571, HSF1-dependent transactivation R-SCE-6798695, Neutrophil degranulation R-SCE-8856828, Clathrin-mediated endocytosis R-SCE-8876725, Protein methylation |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock protein SSA3 |
Gene namesi | Name:SSA3 Ordered Locus Names:YBL075C ORF Names:YBL06.07, YBL0610 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000171, SSA3 |
VEuPathDBi | FungiDB:YBL075C |
Subcellular locationi
Cytoplasm and Cytosol
Cytosol
- cytosol Source: SGD
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000078387 | 1 – 649 | Heat shock protein SSA3Add BLAST | 649 |
Proteomic databases
MaxQBi | P09435 |
PaxDbi | P09435 |
PRIDEi | P09435 |
2D gel databases
UCD-2DPAGEi | P09435 |
PTM databases
iPTMneti | P09435 |
Interactioni
GO - Molecular functioni
- heat shock protein binding Source: GO_Central
- misfolded protein binding Source: GO_Central
- unfolded protein binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 32627, 142 interactors |
DIPi | DIP-2266N |
IntActi | P09435, 61 interactors |
MINTi | P09435 |
STRINGi | 4932.YBL075C |
Miscellaneous databases
RNActi | P09435, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the heat shock protein 70 family.Curated
Phylogenomic databases
eggNOGi | KOG0101, Eukaryota |
GeneTreei | ENSGT00940000176322 |
HOGENOMi | CLU_005965_3_0_1 |
InParanoidi | P09435 |
OMAi | CTGPSCG |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR029048, HSP70_C_sf IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF100934, SSF100934, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P09435-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRAVGIDLG TTYSCVAHFS NDRVEIIAND QGNRTTPSYV AFTDTERLIG
60 70 80 90 100
DAAKNQAAIN PHNTVFDAKR LIGRKFDDPE VTTDAKHFPF KVISRDGKPV
110 120 130 140 150
VQVEYKGETK TFTPEEISSM VLSKMKETAE NYLGTTVNDA VVTVPAYFND
160 170 180 190 200
SQRQATKDAG TIAGMNVLRI INEPTAAAIA YGLDKKGRAE HNVLIFDLGG
210 220 230 240 250
GTFDVSLLSI DEGVFEVKAT AGDTHLGGED FDNRLVNHLA TEFKRKTKKD
260 270 280 290 300
ISNNQRSLRR LRTAAERAKR ALSSSSQTSI EIDSLFEGMD FYTSLTRARF
310 320 330 340 350
EELCADLFRS TLEPVEKVLK DSKLDKSQID EIVLVGGSTR IPKIQKLVSD
360 370 380 390 400
FFNGKEPNRS INPDEAVAYG AAVQAAILTG DQSTKTQDLL LLDVAPLSLG
410 420 430 440 450
IETAGGIMTK LIPRNSTIPT KKSETFSTYA DNQPGVLIQV FEGERTRTKD
460 470 480 490 500
NNLLGKFELS GIPPAPRGVP QIDVTFDIDA NGILNVSALE KGTGKSNKIT
510 520 530 540 550
ITNDKGRLSK DDIDRMVSEA EKYRADDERE AERVQAKNQL ESYAFTLKNT
560 570 580 590 600
INEASFKEKV GEDDAKRLET ASQETIDWLD ASQAASTDEY KDRQKELEGI
610 620 630 640
ANPIMTKFYG AGAGAGPGAG ESGGFPGSMP NSGATGGGED TGPTVEEVD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 620 | G → A in CAA30732 (PubMed:2663194).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M97225 Unassigned DNA Translation: AAC37398.1 Z35836 Genomic DNA Translation: CAA84896.1 Z26879 Genomic DNA Translation: CAA81523.1 D90455 Genomic DNA No translation available. M36115 Genomic DNA Translation: AAA35097.1 X07886 Genomic DNA Translation: CAA30732.1 Sequence problems. BK006936 Genomic DNA Translation: DAA07047.1 |
PIRi | S36753 |
RefSeqi | NP_009478.1, NM_001178315.1 |
Genome annotation databases
EnsemblFungii | YBL075C_mRNA; YBL075C; YBL075C |
GeneIDi | 852203 |
KEGGi | sce:YBL075C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M97225 Unassigned DNA Translation: AAC37398.1 Z35836 Genomic DNA Translation: CAA84896.1 Z26879 Genomic DNA Translation: CAA81523.1 D90455 Genomic DNA No translation available. M36115 Genomic DNA Translation: AAA35097.1 X07886 Genomic DNA Translation: CAA30732.1 Sequence problems. BK006936 Genomic DNA Translation: DAA07047.1 |
PIRi | S36753 |
RefSeqi | NP_009478.1, NM_001178315.1 |
3D structure databases
SMRi | P09435 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 32627, 142 interactors |
DIPi | DIP-2266N |
IntActi | P09435, 61 interactors |
MINTi | P09435 |
STRINGi | 4932.YBL075C |
PTM databases
iPTMneti | P09435 |
2D gel databases
UCD-2DPAGEi | P09435 |
Proteomic databases
MaxQBi | P09435 |
PaxDbi | P09435 |
PRIDEi | P09435 |
Genome annotation databases
EnsemblFungii | YBL075C_mRNA; YBL075C; YBL075C |
GeneIDi | 852203 |
KEGGi | sce:YBL075C |
Organism-specific databases
SGDi | S000000171, SSA3 |
VEuPathDBi | FungiDB:YBL075C |
Phylogenomic databases
eggNOGi | KOG0101, Eukaryota |
GeneTreei | ENSGT00940000176322 |
HOGENOMi | CLU_005965_3_0_1 |
InParanoidi | P09435 |
OMAi | CTGPSCG |
Enzyme and pathway databases
Reactomei | R-SCE-3371453, Regulation of HSF1-mediated heat shock response R-SCE-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-SCE-3371571, HSF1-dependent transactivation R-SCE-6798695, Neutrophil degranulation R-SCE-8856828, Clathrin-mediated endocytosis R-SCE-8876725, Protein methylation |
Miscellaneous databases
PROi | PR:P09435 |
RNActi | P09435, protein |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR029048, HSP70_C_sf IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF100934, SSF100934, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HSP73_YEAST | |
Accessioni | P09435Primary (citable) accession number: P09435 Secondary accession number(s): D6VPS7, P18862 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | October 1, 1993 | |
Last modified: | April 7, 2021 | |
This is version 196 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome II
Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names - SIMILARITY comments
Index of protein domains and families