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Protein

Spermatid nuclear transition protein 1

Gene

TNP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid nuclear transition protein 1
Short name:
STP-1
Short name:
TP-1
Gene namesi
Name:TNP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000118245.2
HGNCiHGNC:11951 TNP1
MIMi190231 gene
neXtProtiNX_P09430

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7141
OpenTargetsiENSG00000118245
PharmGKBiPA36640

Polymorphism and mutation databases

BioMutaiTNP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001914171 – 55Spermatid nuclear transition protein 1Add BLAST55

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1
Modified residuei40PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP09430
PRIDEiP09430
ProteomicsDBi52218

PTM databases

iPTMnetiP09430
PhosphoSitePlusiP09430

Expressioni

Tissue specificityi

Expressed by spermatids (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000118245 Expressed in 108 organ(s), highest expression level in sperm
CleanExiHS_TNP1
ExpressionAtlasiP09430 baseline and differential
GenevisibleiP09430 HS

Organism-specific databases

HPAiHPA044387

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SDCBP2Q9H1903EBI-10196343,EBI-742426

Protein-protein interaction databases

BioGridi112995, 9 interactors
IntActiP09430, 2 interactors
STRINGi9606.ENSP00000236979

Structurei

3D structure databases

ProteinModelPortaliP09430
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410JJTU Eukaryota
ENOG4111B50 LUCA
GeneTreeiENSGT00390000000539
HOGENOMiHOG000136637
HOVERGENiHBG004485
InParanoidiP09430
OMAiRTPHKGV
PhylomeDBiP09430
TreeFamiTF338391

Family and domain databases

InterProiView protein in InterPro
IPR001319 Nuclear_transition_prot1
IPR020062 Nuclear_transition_prot1_CS
PANTHERiPTHR17486 PTHR17486, 1 hit
PfamiView protein in Pfam
PF02079 TP1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010292 TP1, 1 hit
PROSITEiView protein in PROSITE
PS00541 TP1, 1 hit

Sequencei

Sequence statusi: Complete.

P09430-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTSRKLKSH GMRRSKSRSP HKGVKRGGSK RKYRKGNLKS RKRGDDANRN

YRSHL
Length:55
Mass (Da):6,424
Last modified:January 23, 2007 - v2
Checksum:iE29C58EB2AADF3BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59924 Genomic DNA Translation: AAA61202.1
X07948 mRNA Translation: CAA30774.1
BC029516 mRNA Translation: AAH29516.1
CCDSiCCDS2406.1
PIRiA37106 BGHU
RefSeqiNP_003275.1, NM_003284.3
UniGeneiHs.3017

Genome annotation databases

EnsembliENST00000236979; ENSP00000236979; ENSG00000118245
GeneIDi7141
KEGGihsa:7141

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59924 Genomic DNA Translation: AAA61202.1
X07948 mRNA Translation: CAA30774.1
BC029516 mRNA Translation: AAH29516.1
CCDSiCCDS2406.1
PIRiA37106 BGHU
RefSeqiNP_003275.1, NM_003284.3
UniGeneiHs.3017

3D structure databases

ProteinModelPortaliP09430
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112995, 9 interactors
IntActiP09430, 2 interactors
STRINGi9606.ENSP00000236979

PTM databases

iPTMnetiP09430
PhosphoSitePlusiP09430

Polymorphism and mutation databases

BioMutaiTNP1

Proteomic databases

PaxDbiP09430
PRIDEiP09430
ProteomicsDBi52218

Protocols and materials databases

DNASUi7141
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000236979; ENSP00000236979; ENSG00000118245
GeneIDi7141
KEGGihsa:7141

Organism-specific databases

CTDi7141
DisGeNETi7141
EuPathDBiHostDB:ENSG00000118245.2
GeneCardsiTNP1
HGNCiHGNC:11951 TNP1
HPAiHPA044387
MIMi190231 gene
neXtProtiNX_P09430
OpenTargetsiENSG00000118245
PharmGKBiPA36640
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JJTU Eukaryota
ENOG4111B50 LUCA
GeneTreeiENSGT00390000000539
HOGENOMiHOG000136637
HOVERGENiHBG004485
InParanoidiP09430
OMAiRTPHKGV
PhylomeDBiP09430
TreeFamiTF338391

Miscellaneous databases

GeneWikiiTNP1
GenomeRNAii7141
PROiPR:P09430
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118245 Expressed in 108 organ(s), highest expression level in sperm
CleanExiHS_TNP1
ExpressionAtlasiP09430 baseline and differential
GenevisibleiP09430 HS

Family and domain databases

InterProiView protein in InterPro
IPR001319 Nuclear_transition_prot1
IPR020062 Nuclear_transition_prot1_CS
PANTHERiPTHR17486 PTHR17486, 1 hit
PfamiView protein in Pfam
PF02079 TP1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010292 TP1, 1 hit
PROSITEiView protein in PROSITE
PS00541 TP1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTP1_HUMAN
AccessioniPrimary (citable) accession number: P09430
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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