UniProtKB - P09424 (MTLD_ECOLI)
Protein
Mannitol-1-phosphate 5-dehydrogenase
Gene
mtlD
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalytic activityi
- EC:1.1.1.17
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 3 – 14 | NADBy similarityAdd BLAST | 12 |
GO - Molecular functioni
- mannitol-1-phosphate 5-dehydrogenase activity Source: EcoCyc
GO - Biological processi
- mannitol catabolic process Source: EcoCyc
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | EcoCyc:MANNPDEHYDROG-MONOMER MetaCyc:MANNPDEHYDROG-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:mtlD Ordered Locus Names:b3600, JW3574 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000170703 | 1 – 382 | Mannitol-1-phosphate 5-dehydrogenaseAdd BLAST | 382 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 269 | N6-acetyllysine1 Publication | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | P09424 |
PaxDbi | P09424 |
PRIDEi | P09424 |
PTM databases
iPTMneti | P09424 |
Interactioni
Subunit structurei
Monomer.
Protein-protein interaction databases
BioGRIDi | 4261273, 9 interactors |
DIPi | DIP-10268N |
IntActi | P09424, 11 interactors |
STRINGi | 511145.b3600 |
Family & Domainsi
Sequence similaritiesi
Belongs to the mannitol dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | COG0246, Bacteria |
HOGENOMi | CLU_036089_2_0_6 |
InParanoidi | P09424 |
PhylomeDBi | P09424 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
HAMAPi | MF_00196, Mannitol_dehydrog, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR023028, Mannitol_1_phos_5_DH IPR000669, Mannitol_DH IPR013118, Mannitol_DH_C IPR023027, Mannitol_DH_CS IPR013131, Mannitol_DH_N IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01232, Mannitol_dh, 1 hit PF08125, Mannitol_dh_C, 1 hit |
PRINTSi | PR00084, MTLDHDRGNASE |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00974, MANNITOL_DHGENASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P09424-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKALHFGAGN IGRGFIGKLL ADAGIQLTFA DVNQVVLDAL NARHSYQVHV
60 70 80 90 100
VGETEQVDTV SGVNAVSSIG DDVVDLIAQV DLVTTAVGPV VLERIAPAIA
110 120 130 140 150
KGQVKRKEQG NESPLNIIAC ENMVRGTTQL KGHVMNALPE DAKAWVEEHV
160 170 180 190 200
GFVDSAVDRI VPPSASATND PLEVTVETFS EWIVDKTQFK GALPNIPGME
210 220 230 240 250
LTDNLMAFVE RKLFTLNTGH AITAYLGKLA GHQTIRDAIL DEKIRAVVKG
260 270 280 290 300
AMEESGAVLI KRYGFDADKH AAYIQKILGR FENPYLKDDV ERVGRQPLRK
310 320 330 340 350
LSAGDRLIKP LLGTLEYGLP HKNLIEGIAA AMHFRSEDDP QAQELAALIA
360 370 380
DKGPQAALAQ ISGLDANSEV VSEAVTAYKA MQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5 | H → V AA sequence (PubMed:8899705).Curated | 1 | |
Sequence conflicti | 14 – 15 | GF → SL AA sequence (PubMed:8899705).Curated | 2 | |
Sequence conflicti | 86 | A → R (PubMed:3135464).Curated | 1 | |
Sequence conflicti | 86 | A → R (PubMed:1964486).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51359 Genomic DNA Translation: CAA35744.1 U00039 Genomic DNA Translation: AAB18577.1 U00096 Genomic DNA Translation: AAC76624.1 AP009048 Genomic DNA Translation: BAE77693.1 X06794 Genomic DNA Translation: CAA29954.1 Sequence problems. U03845 Genomic DNA Translation: AAA92661.1 |
PIRi | B65160 |
RefSeqi | NP_418057.1, NC_000913.3 WP_000645439.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC76624; AAC76624; b3600 BAE77693; BAE77693; BAE77693 |
GeneIDi | 948117 |
KEGGi | ecj:JW3574 eco:b3600 |
PATRICi | fig|1411691.4.peg.3107 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51359 Genomic DNA Translation: CAA35744.1 U00039 Genomic DNA Translation: AAB18577.1 U00096 Genomic DNA Translation: AAC76624.1 AP009048 Genomic DNA Translation: BAE77693.1 X06794 Genomic DNA Translation: CAA29954.1 Sequence problems. U03845 Genomic DNA Translation: AAA92661.1 |
PIRi | B65160 |
RefSeqi | NP_418057.1, NC_000913.3 WP_000645439.1, NZ_LN832404.1 |
3D structure databases
SMRi | P09424 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261273, 9 interactors |
DIPi | DIP-10268N |
IntActi | P09424, 11 interactors |
STRINGi | 511145.b3600 |
PTM databases
iPTMneti | P09424 |
Proteomic databases
jPOSTi | P09424 |
PaxDbi | P09424 |
PRIDEi | P09424 |
Genome annotation databases
EnsemblBacteriai | AAC76624; AAC76624; b3600 BAE77693; BAE77693; BAE77693 |
GeneIDi | 948117 |
KEGGi | ecj:JW3574 eco:b3600 |
PATRICi | fig|1411691.4.peg.3107 |
Organism-specific databases
EchoBASEi | EB0611 |
Phylogenomic databases
eggNOGi | COG0246, Bacteria |
HOGENOMi | CLU_036089_2_0_6 |
InParanoidi | P09424 |
PhylomeDBi | P09424 |
Enzyme and pathway databases
BioCyci | EcoCyc:MANNPDEHYDROG-MONOMER MetaCyc:MANNPDEHYDROG-MONOMER |
Miscellaneous databases
PROi | PR:P09424 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
HAMAPi | MF_00196, Mannitol_dehydrog, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR023028, Mannitol_1_phos_5_DH IPR000669, Mannitol_DH IPR013118, Mannitol_DH_C IPR023027, Mannitol_DH_CS IPR013131, Mannitol_DH_N IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01232, Mannitol_dh, 1 hit PF08125, Mannitol_dh_C, 1 hit |
PRINTSi | PR00084, MTLDHDRGNASE |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00974, MANNITOL_DHGENASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MTLD_ECOLI | |
Accessioni | P09424Primary (citable) accession number: P09424 Secondary accession number(s): Q2M7R3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | October 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 169 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families