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Entry version 197 (05 Jun 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Nucleolin

Gene

Ncl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, RNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolin
Alternative name(s):
Protein C23
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ncl
Synonyms:Nuc
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:97286 Ncl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000816932 – 707NucleolinAdd BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9N6-acetyllysineCombined sources1
Modified residuei15N6-acetyllysineCombined sources1
Modified residuei16N6-acetyllysineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei41PhosphoserineCombined sources1
Modified residuei67PhosphoserineBy similarity1
Modified residuei69PhosphothreonineBy similarity1
Modified residuei76PhosphothreonineBy similarity1
Modified residuei84PhosphothreonineBy similarity1
Modified residuei92PhosphothreonineBy similarity1
Modified residuei96N6-acetyllysineCombined sources1
Modified residuei99PhosphothreonineBy similarity1
Modified residuei102N6-acetyllysineCombined sources1
Modified residuei106PhosphothreonineBy similarity1
Modified residuei109N6-acetyllysineCombined sources1
Modified residuei116N6-acetyllysineCombined sources1
Modified residuei121PhosphothreonineBy similarity1
Modified residuei124N6-acetyllysineBy similarity1
Modified residuei145PhosphoserineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei212PhosphoserineCombined sources1
Modified residuei220PhosphothreonineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki299Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki299Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei303PhosphoserineCombined sources1
Modified residuei320N6-acetyllysineBy similarity1
Cross-linki326Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki326Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei350N6-acetyllysineCombined sources1
Modified residuei358PhosphoserineBy similarity1
Modified residuei369PhosphothreonineBy similarity1
Cross-linki372Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei379N6-acetyllysine; alternateBy similarity1
Cross-linki379Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei400N6-acetyllysineBy similarity1
Modified residuei403PhosphoserineCombined sources1
Modified residuei407PhosphothreonineBy similarity1
Modified residuei429N6-acetyllysineCombined sources1
Modified residuei446N6-acetyllysineCombined sources1
Modified residuei460PhosphoserineCombined sources1
Modified residuei462PhosphoserineBy similarity1
Modified residuei469N6-acetyllysineCombined sources1
Modified residuei478N6-acetyllysineCombined sources1
Modified residuei514N6-acetyllysine; alternateBy similarity1
Cross-linki514Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei522N6-acetyllysineCombined sources1
Modified residuei569N6-acetyllysineBy similarity1
Modified residuei574N6-acetyllysine; alternateCombined sources1
Cross-linki574Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei577PhosphoserineBy similarity1
Cross-linki586Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki586Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei588PhosphoserineBy similarity1
Modified residuei616PhosphoserineCombined sources1
Cross-linki621Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei643N6-acetyllysineCombined sources1
Modified residuei653Asymmetric dimethylarginineBy similarity1
Modified residuei657Asymmetric dimethylarginineBy similarity1
Modified residuei663Asymmetric dimethylarginineBy similarity1
Modified residuei667Asymmetric dimethylarginineBy similarity1
Modified residuei670Asymmetric dimethylarginineBy similarity1
Modified residuei676Asymmetric dimethylarginineBy similarity1
Modified residuei678Asymmetric dimethylarginineBy similarity1
Modified residuei684Asymmetric dimethylarginineBy similarity1
Modified residuei688Asymmetric dimethylarginineBy similarity1
Modified residuei691Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei691Omega-N-methylarginine; alternateCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group.
Symmetrically methylated by PRMT5.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P09405

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P09405

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P09405

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P09405

PeptideAtlas

More...
PeptideAtlasi
P09405

PRoteomics IDEntifications database

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PRIDEi
P09405

Consortium for Top Down Proteomics

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TopDownProteomicsi
P09405

2D gel databases

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
P09405

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P09405

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P09405

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P09405

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
P09405

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in B-cells that have been induced to switch to various Ig isotypes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000026234 Expressed in 292 organ(s), highest expression level in placenta

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P09405 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P09405 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (By similarity). Component of the SWAP complex that consists of NPM1, NCL/nucleolin, PARP1 and SWAP70 (PubMed:9642267). Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin (By similarity). Interacts with AICDA (PubMed:21518874). Interacts with APTX (By similarity). Interacts with C1QBP (By similarity). Interacts with ERBB4 (By similarity). Interacts (via C-terminus) with FMR1 isoform 6 (via N-terminus) (By similarity). Interacts with GZF1; this interaction is important for nucleolar localization of GZF1 (By similarity). Interacts with NSUN2 (By similarity). Interacts with NVL (PubMed:21474449). Interacts (via N-terminus domain) with SETX (By similarity). Interacts (via RRM1 and C-terminal RRM4/Arg/Gly-rich domains) with TERT; the interaction is important for nucleolar localization of TERT (By similarity). Interacts with WDR46 (By similarity). Interacts with ZFP36 (By similarity). Interacts with LRRC34 (PubMed:24991885). Interacts with RRP1B (By similarity). Interacts with HNRNPU; this interaction occurs during mitosis (By similarity). Interacts with RIOK1; RIOK1 recruits NCL to PRMT5 for symmetrically methylation (By similarity). Interacts with ZBTB7B (PubMed:28784777). Interacts with MDK; this interaction promotes NCL clustering and lateral movements of this complex into lipid rafts leading to MDK internalization (By similarity).By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
201706, 15 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P09405

Protein interaction database and analysis system

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IntActi
P09405, 17 interactors

Molecular INTeraction database

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MINTi
P09405

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000027438

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P09405

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati58 – 6518
Repeati75 – 8228
Repeati83 – 9038
Repeati91 – 9848
Repeati99 – 1045; truncated6
Repeati105 – 11268
Repeati120 – 12778
Repeati128 – 13588
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini309 – 385RRM 1PROSITE-ProRule annotationAdd BLAST77
Domaini395 – 468RRM 2PROSITE-ProRule annotationAdd BLAST74
Domaini487 – 561RRM 3PROSITE-ProRule annotationAdd BLAST75
Domaini569 – 644RRM 4PROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni58 – 1358 X 8 AA tandem repeats of X-T-P-X-K-K-X-XAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi143 – 170Asp/Glu-rich (acidic)Add BLAST28
Compositional biasi190 – 215Asp/Glu-rich (acidic)Add BLAST26
Compositional biasi241 – 273Asp/Glu-rich (acidic)Add BLAST33
Compositional biasi646 – 697Arg/Gly/Phe-richAdd BLAST52

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IRS7 Eukaryota
ENOG410XSFV LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157437

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113885

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P09405

KEGG Orthology (KO)

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KOi
K11294

Identification of Orthologs from Complete Genome Data

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OMAi
SNQNQAT

Database of Orthologous Groups

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OrthoDBi
1174365at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P09405

TreeFam database of animal gene trees

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TreeFami
TF328499

Family and domain databases

Conserved Domains Database

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CDDi
cd12403 RRM1_NCL, 1 hit
cd12404 RRM2_NCL, 1 hit
cd12405 RRM3_NCL, 1 hit
cd12406 RRM4_NCL, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 4 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR034230 Nucleolin_RRM1
IPR034233 Nucleolin_RRM2
IPR034234 Nucleolin_RRM3
IPR034235 Nucleolin_RRM4
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

Pfam protein domain database

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Pfami
View protein in Pfam
PF00076 RRM_1, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00360 RRM, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54928 SSF54928, 4 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50102 RRM, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P09405-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKLAKAGKT HGEAKKMAPP PKEVEEDSED EEMSEDEDDS SGEEEVVIPQ
60 70 80 90 100
KKGKKATTTP AKKVVVSQTK KAAVPTPAKK AAVTPGKKAV ATPAKKNITP
110 120 130 140 150
AKVIPTPGKK GAAQAKALVP TPGKKGAATP AKGAKNGKNA KKEDSDEDED
160 170 180 190 200
EEDEDDSDED EDDEEEDEFE PPIVKGVKPA KAAPAAPASE DEEDDEDEDD
210 220 230 240 250
EEDDDEEEED DSEEEVMEIT TAKGKKTPAK VVPMKAKSVA EEEDDEEEDE
260 270 280 290 300
DDEDEDDEEE DDEDDDEEEE EEEPVKAAPG KRKKEMTKQK EAPEAKKQKV
310 320 330 340 350
EGSEPTTPFN LFIGNLNPNK SVNELKFAIS ELFAKNDLAV VDVRTGTNRK
360 370 380 390 400
FGYVDFESAE DLEKALELTG LKVFGNEIKL EKPKGRDSKK VRAARTLLAK
410 420 430 440 450
NLSFNITEDE LKEVFEDAME IRLVSQDGKS KGIAYIEFKS EADAEKNLEE
460 470 480 490 500
KQGAEIDGRS VSLYYTGEKG QRQERTGKTS TWSGESKTLV LSNLSYSATK
510 520 530 540 550
ETLEEVFEKA TFIKVPQNPH GKPKGYAFIE FASFEDAKEA LNSCNKMEIE
560 570 580 590 600
GRTIRLELQG SNSRSQPSKT LFVKGLSEDT TEETLKESFE GSVRARIVTD
610 620 630 640 650
RETGSSKGFG FVDFNSEEDA KAAKEAMEDG EIDGNKVTLD WAKPKGEGGF
660 670 680 690 700
GGRGGGRGGF GGRGGGRGGR GGFGGRGRGG FGGRGGFRGG RGGGGDFKPQ

GKKTKFE
Length:707
Mass (Da):76,723
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE2CE2ACDBF54CD4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WRM5A0A087WRM5_MOUSE
Nucleolin
Ncl
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti155D → E in AAH05460 (PubMed:15489334).Curated1
Sequence conflicti203 – 204DD → EE in AAH05460 (PubMed:15489334).Curated2
Sequence conflicti245D → E in AAH05460 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X07699 Genomic DNA Translation: CAA30538.1
AF318184 mRNA Translation: AAK07920.1
AK050958 mRNA Translation: BAC34476.1
AK083307 mRNA Translation: BAC38858.1
AK144894 mRNA Translation: BAE26119.1
AK161706 mRNA Translation: BAE36542.1
AK163275 mRNA Translation: BAE37270.1
BC005460 mRNA Translation: AAH05460.1
M22089 Genomic DNA Translation: AAA39841.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS35646.1

Protein sequence database of the Protein Information Resource

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PIRi
A29958 DNMS

NCBI Reference Sequences

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RefSeqi
NP_035010.3, NM_010880.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000027438; ENSMUSP00000027438; ENSMUSG00000026234

Database of genes from NCBI RefSeq genomes

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GeneIDi
17975

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:17975

UCSC genome browser

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UCSCi
uc007bvl.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07699 Genomic DNA Translation: CAA30538.1
AF318184 mRNA Translation: AAK07920.1
AK050958 mRNA Translation: BAC34476.1
AK083307 mRNA Translation: BAC38858.1
AK144894 mRNA Translation: BAE26119.1
AK161706 mRNA Translation: BAE36542.1
AK163275 mRNA Translation: BAE37270.1
BC005460 mRNA Translation: AAH05460.1
M22089 Genomic DNA Translation: AAA39841.1
CCDSiCCDS35646.1
PIRiA29958 DNMS
RefSeqiNP_035010.3, NM_010880.3

3D structure databases

SMRiP09405
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201706, 15 interactors
CORUMiP09405
IntActiP09405, 17 interactors
MINTiP09405
STRINGi10090.ENSMUSP00000027438

PTM databases

iPTMnetiP09405
PhosphoSitePlusiP09405
SwissPalmiP09405

2D gel databases

REPRODUCTION-2DPAGEiP09405

Proteomic databases

EPDiP09405
jPOSTiP09405
MaxQBiP09405
PaxDbiP09405
PeptideAtlasiP09405
PRIDEiP09405
TopDownProteomicsiP09405

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027438; ENSMUSP00000027438; ENSMUSG00000026234
GeneIDi17975
KEGGimmu:17975
UCSCiuc007bvl.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4691
MGIiMGI:97286 Ncl

Phylogenomic databases

eggNOGiENOG410IRS7 Eukaryota
ENOG410XSFV LUCA
GeneTreeiENSGT00940000157437
HOGENOMiHOG000113885
InParanoidiP09405
KOiK11294
OMAiSNQNQAT
OrthoDBi1174365at2759
PhylomeDBiP09405
TreeFamiTF328499

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ncl mouse
PMAP-CutDBiP09405

Protein Ontology

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PROi
PR:P09405

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026234 Expressed in 292 organ(s), highest expression level in placenta
ExpressionAtlasiP09405 baseline and differential
GenevisibleiP09405 MM

Family and domain databases

CDDicd12403 RRM1_NCL, 1 hit
cd12404 RRM2_NCL, 1 hit
cd12405 RRM3_NCL, 1 hit
cd12406 RRM4_NCL, 1 hit
Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR034230 Nucleolin_RRM1
IPR034233 Nucleolin_RRM2
IPR034234 Nucleolin_RRM3
IPR034235 Nucleolin_RRM4
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 4 hits
SMARTiView protein in SMART
SM00360 RRM, 4 hits
SUPFAMiSSF54928 SSF54928, 4 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUCL_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09405
Secondary accession number(s): Q548M9
, Q61991, Q8BQD8, Q99K50
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: June 5, 2019
This is version 197 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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