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UniProtKB - P09384 (CHEA_SALTY)

Entry version 159 (23 Feb 2022)
Sequence version 1 (01 Jul 1989)
Previous versions | rss
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Protein

Chemotaxis protein CheA

Gene

cheA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. EC:2.7.13.3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processChemotaxis, Two-component regulatory system
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.13.3, 5542

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chemotaxis protein CheA (EC:2.7.13.3)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cheA
Ordered Locus Names:STM1921
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99287 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001014 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000747101 – 671Chemotaxis protein CheAAdd BLAST671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei48Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P09384

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Trimer or tetramer.

Protein-protein interaction databases

Database of interacting proteins

More...DIPi		DIP-61270N

Protein interaction database and analysis system

More...IntActi		P09384, 2 interactors

STRING: functional protein association networks

More...STRINGi		99287.STM1921

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1671
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P09384

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P09384

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 105HPtPROSITE-ProRule annotationAdd BLAST105
Domaini274 – 526Histidine kinasePROSITE-ProRule annotationAdd BLAST253
Domaini528 – 663CheW-likePROSITE-ProRule annotationAdd BLAST136

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni256 – 278DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi262 – 278Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

May have three functional domains: one for interaction with CheB and CheY, a second for regulating phosphorylation and controlling the stability of the protein, and a third for receiving input signals regulating CheA activity.

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000650_3_6_6

Identification of Orthologs from Complete Genome Data

More...OMAi		MMDMAKS

Database for complete collections of gene phylogenies

More...PhylomeDBi		P09384

Family and domain databases

Conserved Domains Database

More...CDDi		cd00088, HPT, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.287.560, 1 hit
1.20.120.160, 1 hit
3.30.565.10, 1 hit
3.30.70.400, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004105, CheA-like_dim
IPR037006, CheA-like_homodim_sf
IPR036061, CheW-like_dom_sf
IPR002545, CheW-lke_dom
IPR015162, CheY-binding
IPR035891, CheY-binding_CheA
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR036097, HisK_dim/P_sf
IPR036641, HPT_dom_sf
IPR004358, Sig_transdc_His_kin-like_C
IPR008207, Sig_transdc_His_kin_Hpt_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01584, CheW, 1 hit
PF09078, CheY-binding, 1 hit
PF02895, H-kinase_dim, 1 hit
PF02518, HATPase_c, 1 hit
PF01627, Hpt, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00344, BCTRLSENSOR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00260, CheW, 1 hit
SM01231, H-kinase_dim, 1 hit
SM00387, HATPase_c, 1 hit
SM00073, HPT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47226, SSF47226, 1 hit
SSF47384, SSF47384, 1 hit
SSF50341, SSF50341, 1 hit
SSF55052, SSF55052, 1 hit
SSF55874, SSF55874, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50851, CHEW, 1 hit
PS50109, HIS_KIN, 1 hit
PS50894, HPT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P09384-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMDISDFYQ TFFDEADELL ADMEQHLLDL VPESPDAEQL NAIFRAAHSI 
        60         70         80         90        100
KGGAGTFGFT ILQETTHLME NLLDEARRGE MQLNTDIINL FLETKDIMQE 
       110        120        130        140        150
QLDAYKNSEE PDAASFEYIC NALRQLALEA KGETTPAVVE TAALSAAIQE 
       160        170        180        190        200
ESVAETESPR DESKLRIVLS RLKANEVDLL EEELGNLATL TDVVKGADSL 
       210        220        230        240        250
SATLDGSVAE DDIVAVLCFV IEADQIAFEK VVAAPVEKAQ EKTEVAPVAP 
       260        270        280        290        300
PAVVAPAAKS AAHEHHAGRE KPARERESTS IRVAVEKVDQ LINLVGELVI 
       310        320        330        340        350
TQSMLAQRSN ELDPVNHGDL ITSMGQLQRN ARDLQESVMS IRMMPMEYVF 
       360        370        380        390        400
SRFPRLVRDL AGKLGKQVEL TLVGSSTELD KSLIERIIDP LTHLVRNSLD 
       410        420        430        440        450
HGIEMPEKRL EAGKNVVGNL ILSAEHQGGN ICIEVTDDGA GLNRERILAK 
       460        470        480        490        500
AMSQGMAVNE NMTDDEVGML IFAPGFSTAE QVTDVSGRGV GMDVVKRNIQ 
       510        520        530        540        550
EMGGHVEIQS KQGSGTTIRI LLPLTLAILD GMSVRVAGEV FILPLNAVME 
       560        570        580        590        600
SLQPREEDLH PLAGGERVLE VRGEYLPLVE LWKVFDVDGA KTEATQGIVV 
       610        620        630        640        650
ILQSAGRRYA LLVDQLIGQH QVVVKNLESN YRKVPGISAA TILGDGSVAL 
       660        670 
IVDVSALQGL NREQRMAITA A
Length:671
Mass (Da):73,013
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07AFFC34FBA5DB01
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J03611 Genomic DNA Translation: AAA27034.1
AE006468 Genomic DNA Translation: AAL20837.1

Protein sequence database of the Protein Information Resource

More...PIRi		A28959

NCBI Reference Sequences

More...RefSeqi		NP_460878.1, NC_003197.2
WP_000061302.1, NC_003197.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAL20837; AAL20837; STM1921

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1253442

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		stm:STM1921

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|99287.12.peg.2038

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03611 Genomic DNA Translation: AAA27034.1
AE006468 Genomic DNA Translation: AAL20837.1
PIRiA28959
RefSeqiNP_460878.1, NC_003197.2
WP_000061302.1, NC_003197.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I5NX-ray2.14A/B/C/D1-138[»]
SMRiP09384
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-61270N
IntActiP09384, 2 interactors
STRINGi99287.STM1921

Proteomic databases

PaxDbiP09384

Genome annotation databases

EnsemblBacteriaiAAL20837; AAL20837; STM1921
GeneIDi1253442
KEGGistm:STM1921
PATRICifig|99287.12.peg.2038

Phylogenomic databases

HOGENOMiCLU_000650_3_6_6
OMAiMMDMAKS
PhylomeDBiP09384

Enzyme and pathway databases

BRENDAi2.7.13.3, 5542

Miscellaneous databases

EvolutionaryTraceiP09384

Family and domain databases

CDDicd00088, HPT, 1 hit
Gene3Di1.10.287.560, 1 hit
1.20.120.160, 1 hit
3.30.565.10, 1 hit
3.30.70.400, 1 hit
InterProiView protein in InterPro
IPR004105, CheA-like_dim
IPR037006, CheA-like_homodim_sf
IPR036061, CheW-like_dom_sf
IPR002545, CheW-lke_dom
IPR015162, CheY-binding
IPR035891, CheY-binding_CheA
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR036097, HisK_dim/P_sf
IPR036641, HPT_dom_sf
IPR004358, Sig_transdc_His_kin-like_C
IPR008207, Sig_transdc_His_kin_Hpt_dom
PfamiView protein in Pfam
PF01584, CheW, 1 hit
PF09078, CheY-binding, 1 hit
PF02895, H-kinase_dim, 1 hit
PF02518, HATPase_c, 1 hit
PF01627, Hpt, 1 hit
PRINTSiPR00344, BCTRLSENSOR
SMARTiView protein in SMART
SM00260, CheW, 1 hit
SM01231, H-kinase_dim, 1 hit
SM00387, HATPase_c, 1 hit
SM00073, HPT, 1 hit
SUPFAMiSSF47226, SSF47226, 1 hit
SSF47384, SSF47384, 1 hit
SSF50341, SSF50341, 1 hit
SSF55052, SSF55052, 1 hit
SSF55874, SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50851, CHEW, 1 hit
PS50109, HIS_KIN, 1 hit
PS50894, HPT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHEA_SALTY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09384
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 23, 2022
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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