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Protein

Galectin-1

Gene

LGALS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei53Beta-galactoside1
Binding sitei62Beta-galactoside1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis
LigandLectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P09382

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
P09382 Curated

UniLectin database of carbohydrate-binding proteins

More...
UniLectini
P09382

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Galectin-1
Short name:
Gal-1
Alternative name(s):
14 kDa laminin-binding protein
Short name:
HLBP14
14 kDa lectin
Beta-galactoside-binding lectin L-14-I
Galaptin
HBL
HPL
Lactose-binding lectin 1
Lectin galactoside-binding soluble 1
Putative MAPK-activating protein PM12
S-Lac lectin 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LGALS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100097.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6561 LGALS1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
150570 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P09382

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3956

Open Targets

More...
OpenTargetsi
ENSG00000100097

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30337

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4915

Drug and drug target database

More...
DrugBanki
DB03345 Beta-Mercaptoethanol
DB04396 Thiodigalactoside

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LGALS1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126155

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources3 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000769172 – 135Galectin-1Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei13N6-acetyllysineBy similarity1
Modified residuei29N6-acetyllysineCombined sources1
Modified residuei30Phosphoserine; by FAM20C1 Publication1
Modified residuei108N6-acetyllysine; alternateBy similarity1
Modified residuei108N6-succinyllysine; alternateBy similarity1
Modified residuei128N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P09382

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P09382

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P09382

PeptideAtlas

More...
PeptideAtlasi
P09382

PRoteomics IDEntifications database

More...
PRIDEi
P09382

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52215

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P09382

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P09382

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00219219
P09382

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P09382

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P09382

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1255

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P09382

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P09382

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P09382

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P09382

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100097 Expressed in 230 organ(s), highest expression level in adipose tissue

CleanEx database of gene expression profiles

More...
CleanExi
HS_LGALS1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P09382 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P09382 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002157
HPA000646
HPA000687
HPA001130

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD6, CD7, CD43, ALCAM and CD45. Interacts with laminin (via poly-N-acetyllactosamine). Interacts with SUSD2.6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110147, 111 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-92 Galectin-1 complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P09382

Database of interacting proteins

More...
DIPi
DIP-46153N

Protein interaction database and analysis system

More...
IntActi
P09382, 25 interactors

Molecular INTeraction database

More...
MINTi
P09382

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000215909

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P09382

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P09382

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P09382

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P09382

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 135GalectinPROSITE-ProRule annotationAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni45 – 49Beta-galactoside binding5
Regioni69 – 72Beta-galactoside binding4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3587 Eukaryota
ENOG4111EA0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155534

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059539

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006255

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P09382

KEGG Orthology (KO)

More...
KOi
K06830

Identification of Orthologs from Complete Genome Data

More...
OMAi
CNSKEDG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0S7H

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P09382

TreeFam database of animal gene trees

More...
TreeFami
TF315551

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00070 GLECT, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001079 Galectin_CRD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00337 Gal-bind_lectin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51304 GALECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P09382-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACGLVASNL NLKPGECLRV RGEVAPDAKS FVLNLGKDSN NLCLHFNPRF
60 70 80 90 100
NAHGDANTIV CNSKDGGAWG TEQREAVFPF QPGSVAEVCI TFDQANLTVK
110 120 130
LPDGYEFKFP NRLNLEAINY MAADGDFKIK CVAFD
Length:135
Mass (Da):14,716
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FBB8D7A1FC0F1F9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WEI7F8WEI7_HUMAN
Galectin-1
LGALS1
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCQ5F8WCQ5_HUMAN
Galectin-1
LGALS1
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X14829 mRNA Translation: CAA32938.1
J04456 mRNA Translation: AAA36170.1
X15256 mRNA Translation: CAA33328.1
EU363770 mRNA Translation: ACA58297.1
M57678 Genomic DNA Translation: AAB00777.1
AB097036 mRNA Translation: BAC77389.1
CR456511 mRNA Translation: CAG30397.1
AK312161 mRNA Translation: BAG35095.1
BT006775 mRNA Translation: AAP35421.1
Z83844 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60178.1
BC001693 mRNA Translation: AAH01693.1
BC020675 mRNA Translation: AAH20675.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13954.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A37134 LNHUGB

NCBI Reference Sequences

More...
RefSeqi
NP_002296.1, NM_002305.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.445351

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000215909; ENSP00000215909; ENSG00000100097

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3956

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3956

UCSC genome browser

More...
UCSCi
uc003atn.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14829 mRNA Translation: CAA32938.1
J04456 mRNA Translation: AAA36170.1
X15256 mRNA Translation: CAA33328.1
EU363770 mRNA Translation: ACA58297.1
M57678 Genomic DNA Translation: AAB00777.1
AB097036 mRNA Translation: BAC77389.1
CR456511 mRNA Translation: CAG30397.1
AK312161 mRNA Translation: BAG35095.1
BT006775 mRNA Translation: AAP35421.1
Z83844 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60178.1
BC001693 mRNA Translation: AAH01693.1
BC020675 mRNA Translation: AAH20675.1
CCDSiCCDS13954.1
PIRiA37134 LNHUGB
RefSeqiNP_002296.1, NM_002305.3
UniGeneiHs.445351

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GZWX-ray1.70A/B2-135[»]
1W6MX-ray2.30A/B2-135[»]
1W6NX-ray1.65A/B2-135[»]
1W6OX-ray1.90A/B2-135[»]
1W6PX-ray1.80A/B2-135[»]
1W6QX-ray2.10A/B2-135[»]
2KM2NMR-A/B2-135[»]
2ZKNX-ray1.86A/B2-135[»]
3OY8X-ray2.19A/B2-135[»]
3OYWX-ray2.50A/B2-135[»]
3T2TX-ray1.90A/B1-135[»]
3W58X-ray1.58A/B/C/D2-135[»]
3W59X-ray2.10A/B/C/D2-135[»]
4Q1PX-ray1.46A/B1-135[»]
4Q1RX-ray1.47A/B1-135[»]
4Q26X-ray1.40A/B/G/H1-135[»]
4Q27X-ray1.20A/B1-135[»]
4Q2FX-ray1.40A/B1-135[»]
4XBLX-ray1.93A/B1-135[»]
4Y1UX-ray1.76A/B3-135[»]
4Y1VX-ray2.32A/B3-135[»]
4Y1XX-ray2.45A/B3-135[»]
4Y1YX-ray1.86A/B4-135[»]
4Y1ZX-ray2.23A/B3-135[»]
4Y20X-ray2.20A/B3-135[»]
4Y22X-ray2.50A/B3-135[»]
4Y24X-ray2.32A/B3-135[»]
5MWTX-ray1.71A/B3-135[»]
5MWXX-ray1.29A/B3-135[»]
6B94X-ray1.80A/B2-135[»]
ProteinModelPortaliP09382
SMRiP09382
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110147, 111 interactors
ComplexPortaliCPX-92 Galectin-1 complex
CORUMiP09382
DIPiDIP-46153N
IntActiP09382, 25 interactors
MINTiP09382
STRINGi9606.ENSP00000215909

Chemistry databases

BindingDBiP09382
ChEMBLiCHEMBL4915
DrugBankiDB03345 Beta-Mercaptoethanol
DB04396 Thiodigalactoside

Protein family/group databases

MoonDBiP09382 Curated
UniLectiniP09382

PTM databases

GlyConnecti1255
iPTMnetiP09382
PhosphoSitePlusiP09382
SwissPalmiP09382

Polymorphism and mutation databases

BioMutaiLGALS1
DMDMi126155

2D gel databases

DOSAC-COBS-2DPAGEiP09382
REPRODUCTION-2DPAGEiIPI00219219
P09382
SWISS-2DPAGEiP09382
UCD-2DPAGEiP09382

Proteomic databases

EPDiP09382
MaxQBiP09382
PaxDbiP09382
PeptideAtlasiP09382
PRIDEiP09382
ProteomicsDBi52215
TopDownProteomicsiP09382

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3956
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215909; ENSP00000215909; ENSG00000100097
GeneIDi3956
KEGGihsa:3956
UCSCiuc003atn.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3956
DisGeNETi3956
EuPathDBiHostDB:ENSG00000100097.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LGALS1
HGNCiHGNC:6561 LGALS1
HPAiCAB002157
HPA000646
HPA000687
HPA001130
MIMi150570 gene
neXtProtiNX_P09382
OpenTargetsiENSG00000100097
PharmGKBiPA30337

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00940000155534
HOGENOMiHOG000059539
HOVERGENiHBG006255
InParanoidiP09382
KOiK06830
OMAiCNSKEDG
OrthoDBiEOG091G0S7H
PhylomeDBiP09382
TreeFamiTF315551

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiP09382

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LGALS1 human
EvolutionaryTraceiP09382

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Galectin-1
LGALS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3956
PMAP-CutDBiP09382

Protein Ontology

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PROi
PR:P09382

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100097 Expressed in 230 organ(s), highest expression level in adipose tissue
CleanExiHS_LGALS1
ExpressionAtlasiP09382 baseline and differential
GenevisibleiP09382 HS

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001079 Galectin_CRD
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLEG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09382
Secondary accession number(s): B2R5E8, Q9UDK5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 223 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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