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Protein

Galectin-1

Gene

LGALS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53Beta-galactoside1
Binding sitei62Beta-galactoside1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiP09382

Protein family/group databases

MoonDBiP09382 Curated
UniLectiniP09382

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-1
Short name:
Gal-1
Alternative name(s):
14 kDa laminin-binding protein
Short name:
HLBP14
14 kDa lectin
Beta-galactoside-binding lectin L-14-I
Galaptin
HBL
HPL
Lactose-binding lectin 1
Lectin galactoside-binding soluble 1
Putative MAPK-activating protein PM12
S-Lac lectin 1
Gene namesi
Name:LGALS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100097.11
HGNCiHGNC:6561 LGALS1
MIMi150570 gene
neXtProtiNX_P09382

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3956
OpenTargetsiENSG00000100097
PharmGKBiPA30337

Chemistry databases

ChEMBLiCHEMBL4915
DrugBankiDB03345 Beta-Mercaptoethanol
DB04396 Thiodigalactoside

Polymorphism and mutation databases

BioMutaiLGALS1
DMDMi126155

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources3 Publications
ChainiPRO_00000769172 – 135Galectin-1Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei13N6-acetyllysineBy similarity1
Modified residuei29N6-acetyllysineCombined sources1
Modified residuei30Phosphoserine; by FAM20C1 Publication1
Modified residuei108N6-acetyllysine; alternateBy similarity1
Modified residuei108N6-succinyllysine; alternateBy similarity1
Modified residuei128N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP09382
MaxQBiP09382
PaxDbiP09382
PeptideAtlasiP09382
PRIDEiP09382
ProteomicsDBi52215
TopDownProteomicsiP09382

2D gel databases

DOSAC-COBS-2DPAGEiP09382
REPRODUCTION-2DPAGEiIPI00219219
P09382
SWISS-2DPAGEiP09382
UCD-2DPAGEiP09382

PTM databases

GlyConnecti1255
iPTMnetiP09382
PhosphoSitePlusiP09382
SwissPalmiP09382

Miscellaneous databases

PMAP-CutDBiP09382

Expressioni

Tissue specificityi

Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.2 Publications

Gene expression databases

BgeeiENSG00000100097 Expressed in 230 organ(s), highest expression level in adipose tissue
CleanExiHS_LGALS1
ExpressionAtlasiP09382 baseline and differential
GenevisibleiP09382 HS

Organism-specific databases

HPAiCAB002157
HPA000646
HPA000687
HPA001130

Interactioni

Subunit structurei

Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD6, CD7, CD43, ALCAM and CD45. Interacts with laminin (via poly-N-acetyllactosamine). Interacts with SUSD2.6 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110147, 111 interactors
ComplexPortaliCPX-92 Galectin-1 complex
CORUMiP09382
DIPiDIP-46153N
IntActiP09382, 25 interactors
MINTiP09382
STRINGi9606.ENSP00000215909

Chemistry databases

BindingDBiP09382

Structurei

Secondary structure

1135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP09382
SMRiP09382
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09382

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 135GalectinPROSITE-ProRule annotationAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 49Beta-galactoside binding5
Regioni69 – 72Beta-galactoside binding4

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00440000034263
HOGENOMiHOG000059539
HOVERGENiHBG006255
InParanoidiP09382
KOiK06830
OMAiCNSKEDG
OrthoDBiEOG091G0S7H
PhylomeDBiP09382
TreeFamiTF315551

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001079 Galectin_CRD
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P09382-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACGLVASNL NLKPGECLRV RGEVAPDAKS FVLNLGKDSN NLCLHFNPRF
60 70 80 90 100
NAHGDANTIV CNSKDGGAWG TEQREAVFPF QPGSVAEVCI TFDQANLTVK
110 120 130
LPDGYEFKFP NRLNLEAINY MAADGDFKIK CVAFD
Length:135
Mass (Da):14,716
Last modified:January 23, 2007 - v2
Checksum:i2FBB8D7A1FC0F1F9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WEI7F8WEI7_HUMAN
Galectin-1
LGALS1
38Annotation score:
F8WCQ5F8WCQ5_HUMAN
Galectin-1
LGALS1
69Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14829 mRNA Translation: CAA32938.1
J04456 mRNA Translation: AAA36170.1
X15256 mRNA Translation: CAA33328.1
EU363770 mRNA Translation: ACA58297.1
M57678 Genomic DNA Translation: AAB00777.1
AB097036 mRNA Translation: BAC77389.1
CR456511 mRNA Translation: CAG30397.1
AK312161 mRNA Translation: BAG35095.1
BT006775 mRNA Translation: AAP35421.1
Z83844 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60178.1
BC001693 mRNA Translation: AAH01693.1
BC020675 mRNA Translation: AAH20675.1
CCDSiCCDS13954.1
PIRiA37134 LNHUGB
RefSeqiNP_002296.1, NM_002305.3
UniGeneiHs.445351

Genome annotation databases

EnsembliENST00000215909; ENSP00000215909; ENSG00000100097
GeneIDi3956
KEGGihsa:3956
UCSCiuc003atn.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14829 mRNA Translation: CAA32938.1
J04456 mRNA Translation: AAA36170.1
X15256 mRNA Translation: CAA33328.1
EU363770 mRNA Translation: ACA58297.1
M57678 Genomic DNA Translation: AAB00777.1
AB097036 mRNA Translation: BAC77389.1
CR456511 mRNA Translation: CAG30397.1
AK312161 mRNA Translation: BAG35095.1
BT006775 mRNA Translation: AAP35421.1
Z83844 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60178.1
BC001693 mRNA Translation: AAH01693.1
BC020675 mRNA Translation: AAH20675.1
CCDSiCCDS13954.1
PIRiA37134 LNHUGB
RefSeqiNP_002296.1, NM_002305.3
UniGeneiHs.445351

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GZWX-ray1.70A/B2-135[»]
1W6MX-ray2.30A/B2-135[»]
1W6NX-ray1.65A/B2-135[»]
1W6OX-ray1.90A/B2-135[»]
1W6PX-ray1.80A/B2-135[»]
1W6QX-ray2.10A/B2-135[»]
2KM2NMR-A/B2-135[»]
2ZKNX-ray1.86A/B2-135[»]
3OY8X-ray2.19A/B2-135[»]
3OYWX-ray2.50A/B2-135[»]
3T2TX-ray1.90A/B1-135[»]
3W58X-ray1.58A/B/C/D2-135[»]
3W59X-ray2.10A/B/C/D2-135[»]
4Q1PX-ray1.46A/B1-135[»]
4Q1RX-ray1.47A/B1-135[»]
4Q26X-ray1.40A/B/G/H1-135[»]
4Q27X-ray1.20A/B1-135[»]
4Q2FX-ray1.40A/B1-135[»]
4XBLX-ray1.93A/B1-135[»]
4Y1UX-ray1.76A/B3-135[»]
4Y1VX-ray2.32A/B3-135[»]
4Y1XX-ray2.45A/B3-135[»]
4Y1YX-ray1.86A/B4-135[»]
4Y1ZX-ray2.23A/B3-135[»]
4Y20X-ray2.20A/B3-135[»]
4Y22X-ray2.50A/B3-135[»]
4Y24X-ray2.32A/B3-135[»]
5MWTX-ray1.71A/B3-135[»]
5MWXX-ray1.29A/B3-135[»]
ProteinModelPortaliP09382
SMRiP09382
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110147, 111 interactors
ComplexPortaliCPX-92 Galectin-1 complex
CORUMiP09382
DIPiDIP-46153N
IntActiP09382, 25 interactors
MINTiP09382
STRINGi9606.ENSP00000215909

Chemistry databases

BindingDBiP09382
ChEMBLiCHEMBL4915
DrugBankiDB03345 Beta-Mercaptoethanol
DB04396 Thiodigalactoside

Protein family/group databases

MoonDBiP09382 Curated
UniLectiniP09382

PTM databases

GlyConnecti1255
iPTMnetiP09382
PhosphoSitePlusiP09382
SwissPalmiP09382

Polymorphism and mutation databases

BioMutaiLGALS1
DMDMi126155

2D gel databases

DOSAC-COBS-2DPAGEiP09382
REPRODUCTION-2DPAGEiIPI00219219
P09382
SWISS-2DPAGEiP09382
UCD-2DPAGEiP09382

Proteomic databases

EPDiP09382
MaxQBiP09382
PaxDbiP09382
PeptideAtlasiP09382
PRIDEiP09382
ProteomicsDBi52215
TopDownProteomicsiP09382

Protocols and materials databases

DNASUi3956
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215909; ENSP00000215909; ENSG00000100097
GeneIDi3956
KEGGihsa:3956
UCSCiuc003atn.4 human

Organism-specific databases

CTDi3956
DisGeNETi3956
EuPathDBiHostDB:ENSG00000100097.11
GeneCardsiLGALS1
HGNCiHGNC:6561 LGALS1
HPAiCAB002157
HPA000646
HPA000687
HPA001130
MIMi150570 gene
neXtProtiNX_P09382
OpenTargetsiENSG00000100097
PharmGKBiPA30337
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00440000034263
HOGENOMiHOG000059539
HOVERGENiHBG006255
InParanoidiP09382
KOiK06830
OMAiCNSKEDG
OrthoDBiEOG091G0S7H
PhylomeDBiP09382
TreeFamiTF315551

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiP09382

Miscellaneous databases

ChiTaRSiLGALS1 human
EvolutionaryTraceiP09382
GeneWikiiGalectin-1
LGALS1
GenomeRNAii3956
PMAP-CutDBiP09382
PROiPR:P09382
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100097 Expressed in 230 organ(s), highest expression level in adipose tissue
CleanExiHS_LGALS1
ExpressionAtlasiP09382 baseline and differential
GenevisibleiP09382 HS

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001079 Galectin_CRD
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLEG1_HUMAN
AccessioniPrimary (citable) accession number: P09382
Secondary accession number(s): B2R5E8, Q9UDK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 222 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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