rhaS

Protein namesⁱ	Recommended name: HTH-type transcriptional activator RhaS Alternative name(s): L-rhamnose operon regulatory protein RhaS
Gene namesⁱ	Name:rhaS Synonyms:rhaC2 Ordered Locus Names:b3905, JW3876
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG10843 rhaS

EcoGeneⁱ

EG10843 rhaS

Subcellular locationⁱ

Cytoplasm

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	201	L → A: 48% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	202	R → A: 4% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	205	H → A: 28% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	206	R → A: 0.1% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	246	C → A: 66% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	247	G → A: 6.2% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	247	G → R: 0.9% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	248	F → A: 0.9% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	248	F → V: 3.3% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	249	S → G: 93% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	250	D → A: 8.3% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	251	S → G: 87% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	252	N → A: 31% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	252	N → H: 0.4% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	252	N → I: 0.3% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	252	N → S: 37% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	253	H → A: 48% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	253	H → Q: 32% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	254	F → A: 1.2% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	255	S → A: 80% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	256	T → A: 61% of wild-type activity. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000194563	1 – 278	HTH-type transcriptional activator RhaSAdd BLAST		278

Proteomic databases

PaxDbⁱ	P09377
PRIDEⁱ	P09377

Expressionⁱ

Inductionⁱ

Induced by RhaR in response to L-rhamnose. Binding of the cAMP receptor protein (CRP) is required for full expression.1 Publication

Interactionⁱ

Subunit structureⁱ

Binds DNA as a dimer.Curated

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	241	Interaction with sigma-70		1
Siteⁱ	250	Interaction with sigma-70		1

Protein-protein interaction databases

BioGridⁱ	4260998, 4 interactors
Database of interacting proteins More...DIPⁱ	DIP-10694N
IntActⁱ	P09377, 24 interactors
STRINGⁱ	316385.ECDH10B_4095

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P09377
SMRⁱ	P09377
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG4107S4Z Bacteria ENOG410XT8S LUCA
HOGENOMⁱ	HOG000290513
InParanoidⁱ	P09377
KEGG Orthology (KO) More...KOⁱ	K02855
PhylomeDBⁱ	P09377

Family and domain databases

Gene3Dⁱ	2.60.120.10, 1 hit
HAMAPⁱ	MF_01534 HTH_type_RhaS, 1 hit
InterProⁱ	View protein in InterPro IPR003313 AraC-bd IPR009057 Homeobox-like_sf IPR037923 HTH-like IPR018060 HTH_AraC IPR018062 HTH_AraC-typ_CS IPR014710 RmlC-like_jellyroll IPR020449 Tscrpt_reg_HTH_AraC-type IPR023609 Tscrpt_reg_HTH_RhaS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02311 AraC_binding, 1 hit PF12833 HTH_18, 1 hit
PRINTSⁱ	PR00032 HTHARAC
SMARTⁱ	View protein in SMART SM00342 HTH_ARAC, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 2 hits SSF51215 SSF51215, 1 hit
PROSITEⁱ	View protein in PROSITE PS00041 HTH_ARAC_FAMILY_1, 1 hit PS01124 HTH_ARAC_FAMILY_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P09377-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTVLHSVDFF PSGNASVAIE PRLPQADFPE HHHDFHEIVI VEHGTGIHVF 
        60         70         80         90        100
NGQPYTITGG TVCFVRDHDR HLYEHTDNLC LTNVLYRSPD RFQFLAGLNQ 
       110        120        130        140        150
LLPQELDGQY PSHWRVNHSV LQQVRQLVAQ MEQQEGENDL PSTASREILF 
       160        170        180        190        200
MQLLLLLRKS SLQENLENSA SRLNLLLAWL EDHFADEVNW DAVADQFSLS 
       210        220        230        240        250
LRTLHRQLKQ QTGLTPQRYL NRLRLMKARH LLRHSEASVT DIAYRCGFSD 
       260        270 
SNHFSTLFRR EFNWSPRDIR QGRDGFLQ

Length:278

Mass (Da):32,315

Last modified:July 1, 1989 - v1

Checksum:ⁱ64264514484C0D2A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X06058 Genomic DNA Translation: CAA29452.1 L19201 Genomic DNA Translation: AAB03038.1 U00096 Genomic DNA Translation: AAC76887.1 AP009048 Genomic DNA Translation: BAE77404.1
PIRⁱ	S40849
NCBI Reference Sequences More...RefSeqⁱ	NP_418341.1, NC_000913.3 WP_000217137.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC76887; AAC76887; b3905 BAE77404; BAE77404; BAE77404
GeneIDⁱ	948397
KEGGⁱ	ecj:JW3876 eco:b3905
PATRICⁱ	fig\|1411691.4.peg.2800

Protein	Similar proteins		Species	Score	Length	Source
P09377	HTH-type transcriptional activator RhaS		ECO55		278	UniRef100_B7L9G1
HTH-type transcriptional activator RhaS		ECO8A		278
HTH-type transcriptional activator RhaS		ECOBW		278
HTH-type transcriptional activator RhaS		ECODH		278
HTH-type transcriptional activator RhaS		ECOHS		278
+40

Protein	Similar proteins		Species	Score	Length	Source
P09377	HTH-type transcriptional activator RhaS		ECO57		278	UniRef90_Q8X897
HTH-type transcriptional activator RhaS		ECO5E		278
HTH-type transcriptional activator RhaS		ECO24		278
HTH-type transcriptional activator RhaS		ECO27		278
HTH-type transcriptional activator RhaS		ECOL5		278
+537

Protein	Similar proteins		Species	Score	Length	Source
P09377	HTH-type transcriptional activator RhaS		PECAS		279	UniRef50_Q6DA22
HTH-type transcriptional activator RhaS		PECCP		279
HTH-type transcriptional activator RhaS		ESCF3		278
HTH-type transcriptional activator RhaS		ENT38		278
HTH-type transcriptional activator RhaS		SALA4		278
+1497

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X06058 Genomic DNA Translation: CAA29452.1 L19201 Genomic DNA Translation: AAB03038.1 U00096 Genomic DNA Translation: AAC76887.1 AP009048 Genomic DNA Translation: BAE77404.1
PIRⁱ	S40849
RefSeqⁱ	NP_418341.1, NC_000913.3 WP_000217137.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P09377
SMRⁱ	P09377
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4260998, 4 interactors
DIPⁱ	DIP-10694N
IntActⁱ	P09377, 24 interactors
STRINGⁱ	316385.ECDH10B_4095

Proteomic databases

PaxDbⁱ	P09377
PRIDEⁱ	P09377

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC76887; AAC76887; b3905 BAE77404; BAE77404; BAE77404
GeneIDⁱ	948397
KEGGⁱ	ecj:JW3876 eco:b3905
PATRICⁱ	fig\|1411691.4.peg.2800

Organism-specific databases

EchoBASEⁱ	EB0836
EcoGeneⁱ	EG10843 rhaS

Phylogenomic databases

eggNOGⁱ	ENOG4107S4Z Bacteria ENOG410XT8S LUCA
HOGENOMⁱ	HOG000290513
InParanoidⁱ	P09377
KOⁱ	K02855
PhylomeDBⁱ	P09377

Enzyme and pathway databases

BioCycⁱ	EcoCyc:PD00221

BioCycⁱ

EcoCyc:PD00221

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P09377

PROⁱ

PR:P09377

Family and domain databases

Gene3Dⁱ	2.60.120.10, 1 hit
HAMAPⁱ	MF_01534 HTH_type_RhaS, 1 hit
InterProⁱ	View protein in InterPro IPR003313 AraC-bd IPR009057 Homeobox-like_sf IPR037923 HTH-like IPR018060 HTH_AraC IPR018062 HTH_AraC-typ_CS IPR014710 RmlC-like_jellyroll IPR020449 Tscrpt_reg_HTH_AraC-type IPR023609 Tscrpt_reg_HTH_RhaS
Pfamⁱ	View protein in Pfam PF02311 AraC_binding, 1 hit PF12833 HTH_18, 1 hit
PRINTSⁱ	PR00032 HTHARAC
SMARTⁱ	View protein in SMART SM00342 HTH_ARAC, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 2 hits SSF51215 SSF51215, 1 hit
PROSITEⁱ	View protein in PROSITE PS00041 HTH_ARAC_FAMILY_1, 1 hit PS01124 HTH_ARAC_FAMILY_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RHAS_ECOLI
Accessionⁱ	P09377Primary (citable) accession number: P09377 Secondary accession number(s): Q2M8K2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 1, 1989
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

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Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P09377 (RHAS_ECOLI)

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HTH-type transcriptional activator RhaS

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ