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Protein

Alcohol dehydrogenase 1

Gene

Adh1

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.PROSITE-ProRule annotation
A secondary alcohol + NAD+ = a ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 33NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Gene namesi
Name:Adh1
ORF Names:GI17644
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000009192 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0012566 Dmoj\Adh1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000544782 – 254Alcohol dehydrogenase 1Add BLAST253

Proteomic databases

PRIDEiP09370

Expressioni

Gene expression databases

BgeeiFBgn0012566 Expressed in 2 organ(s), highest expression level in adult organism

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP09370
SMRiP09370
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiP09370
KOiK00001
OMAiPLACAEN
OrthoDBiEOG091G0OC9
PhylomeDBiP09370

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09370-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIANKNIIF VAGLGGIGFD TSREIVKKGP KNLVILDRIE NPAAIAELKA
60 70 80 90 100
LNPKVTVTFY LYDVTVSVAE STKLLQKIFD QLKTVDLLIN GAGILDDHQI
110 120 130 140 150
ERTIAVNFTG TVNTITAIMS FWDKRKGGPG GVIANVCSVT GFNAIYQVPV
160 170 180 190 200
YSASKAAALS FTNSLAKLAP ITGVTAYSIN PGITKTPLLH KFNSWLDVEP
210 220 230 240 250
RVGELLLEHP TQTSLECAQN FVKAIEANQN GAIWKVDLGT LEAIEWTKHW

DSHI
Length:254
Mass (Da):27,561
Last modified:October 14, 2008 - v3
Checksum:i4ECDEF98EB9A99ED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti187P → T in strain: VRF. 2 Publications1
Natural varianti189L → V in strain: VRF. 2 Publications1
Natural varianti236V → L in strain: VRF. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37276 Genomic DNA Translation: AAA28335.1
X12536 Genomic DNA Translation: CAA31055.1
AY154827 Genomic DNA Translation: AAN86863.1
AY154828 Genomic DNA Translation: AAN86864.1
AY154829 Genomic DNA Translation: AAN86865.1
AY154830 Genomic DNA Translation: AAN86866.1
AY154831 Genomic DNA Translation: AAN86867.1
AY154832 Genomic DNA Translation: AAN86868.1
AY154833 Genomic DNA Translation: AAN86869.1
AY154834 Genomic DNA Translation: AAN86870.1
AY154835 Genomic DNA Translation: AAN86871.1
AY154836 Genomic DNA Translation: AAN86872.1
AY154837 Genomic DNA Translation: AAN86873.1
AY154838 Genomic DNA Translation: AAN86874.1
AY154839 Genomic DNA Translation: AAN86875.1
AY364493 Genomic DNA Translation: AAR12927.1
AY364494 Genomic DNA Translation: AAR12928.1
AY364495 Genomic DNA Translation: AAR12929.1
AY364496 Genomic DNA Translation: AAR12930.1
AY364497 Genomic DNA Translation: AAR12931.1
AY364498 Genomic DNA Translation: AAR12932.1
AY364499 Genomic DNA Translation: AAR12933.1
AY364500 Genomic DNA Translation: AAR12934.1
AY364501 Genomic DNA Translation: AAR12935.1
AY364502 Genomic DNA Translation: AAR12936.1
AY364503 Genomic DNA Translation: AAR12937.1
AY364504 Genomic DNA Translation: AAR12938.1
AY364505 Genomic DNA Translation: AAR12939.1
AY364506 Genomic DNA Translation: AAR12940.1
AY364507 Genomic DNA Translation: AAR12941.1
CH933807 Genomic DNA Translation: EDW12372.1
PIRiS01902
RefSeqiXP_002002930.1, XM_002002894.2

Genome annotation databases

EnsemblMetazoaiFBtr0168369; FBpp0166861; FBgn0012566
GeneIDi6576953
KEGGidmo:Dmoj_GI17644

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiADH1_DROMO
AccessioniPrimary (citable) accession number: P09370
Secondary accession number(s): Q6UPV9
, Q6UPW6, Q6UPX2, Q867T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 14, 2008
Last modified: September 12, 2018
This is version 109 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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