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Entry version 112 (16 Oct 2019)
Sequence version 3 (14 Oct 2008)
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Protein

Alcohol dehydrogenase 2

Gene

Adh2

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei138SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 33NADBy similarityAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNAD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alcohol dehydrogenase 2 (EC:1.1.1.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Adh2
ORF Names:GI17643
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila mojavensis (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7230 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009192 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000544792 – 254Alcohol dehydrogenase 2Add BLAST253

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0012567 Expressed in 2 organ(s), highest expression level in head

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7230.FBpp0166860

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P09369

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P09369

KEGG Orthology (KO)

More...
KOi
K00001

Identification of Orthologs from Complete Genome Data

More...
OMAi
WSKHWDS

Database of Orthologous Groups

More...
OrthoDBi
1053465at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P09369

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002425 ADH_Drosophila-type
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00106 adh_short, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01168 ALCDHDRGNASE
PR00080 SDRFAMILY

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00061 ADH_SHORT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P09369-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIANKNIIF VAGLGGIGFD TSREIVKRGP KNLVILDRIE NPAAIAELKA
60 70 80 90 100
LNPKVTVTFY PYDVTVSVAE TTKLLKTIFD KLKTVDLLIN GAGILDDHQI
110 120 130 140 150
ERTIAVNFTG TVNTITAIMS FWDKRKGGPG GVIANVCSVT GFNAIYQVPV
160 170 180 190 200
YSASKAAALS FTNSLARLAP ITGVTAYSIN PGITKTTLVH KFNSWLDVEP
210 220 230 240 250
RVAELLLEHP TQTTLQCAQN FVKAIEANQN GAIWKVDLGT LEAIEWTKHW

DSHI
Length:254
Mass (Da):27,605
Last modified:October 14, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE52DEA5DA7508D2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti28R → S in strain: MJBC 95.1, MJS 93 and VRF. 4 Publications1
Natural varianti71T → S in strain: MJBC 33.3. 1 Publication1
Natural varianti92A → T in strain: VRF. 2 Publications1
Natural varianti98H → Y in strain: MJS 115, MJS 147.2F, MJS 16F, MJS 122, MJS 127, MJS 132, MJS 14, MJS 154, MJS 36, MJS 58.2, MJS 68, MJS 84 and MJS 87. 1 Publication1
Natural varianti112V → L in strain: VRF. 2 Publications1
Natural varianti115I → T in strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 133, MJS 14, MJS 147.2F, MJS 154, MJS 16F, MJS 36, MJS 58.2, MJS 68, MJS 84, MJS 87, MJS 93 and VRF. 3 Publications1
Natural varianti136V → I in strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 133, MJS 14, MJS 147.2F, MJS 154, MJS 16F, MJS 36, MJS 58.2, MJS 68, MJS 84, MJS 87, MJS 93 and VRF. 3 Publications1
Natural varianti146Y → L in strain: VRF. 2 Publications1
Natural varianti147Q → P in strain: VRF. 2 Publications1
Natural varianti226E → Q in strain: VRF. 2 Publications1
Natural varianti236V → L in strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 133, MJS 14, MJS 147.2F, MJS 154, MJS 16F, MJS 36, MJS 58.2, MJS 68, MJS 84, MJS 87, MJS 93 and VRF. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M37276 Genomic DNA Translation: AAA28334.1
X12536 Genomic DNA Translation: CAA31054.1
AY154864 Genomic DNA Translation: AAN86900.1
AY154865 Genomic DNA Translation: AAN86901.1
AY154866 Genomic DNA Translation: AAN86902.1
AY154867 Genomic DNA Translation: AAN86903.1
AY154868 Genomic DNA Translation: AAN86904.1
AY154869 Genomic DNA Translation: AAN86905.1
AY154870 Genomic DNA Translation: AAN86906.1
AY154871 Genomic DNA Translation: AAN86907.1
AY154872 Genomic DNA Translation: AAN86908.1
AY154873 Genomic DNA Translation: AAN86909.1
AY154874 Genomic DNA Translation: AAN86910.1
AY154875 Genomic DNA Translation: AAN86911.1
AY154876 Genomic DNA Translation: AAN86912.1
AY364508 Genomic DNA Translation: AAR21255.1
AY364509 Genomic DNA Translation: AAR21256.1
AY364510 Genomic DNA Translation: AAR21257.1
AY364511 Genomic DNA Translation: AAR21258.1
AY364512 Genomic DNA Translation: AAR21259.1
AY364513 Genomic DNA Translation: AAR21260.1
AY364514 Genomic DNA Translation: AAR21261.1
AY364515 Genomic DNA Translation: AAR21262.1
AY364516 Genomic DNA Translation: AAR21263.1
AY364517 Genomic DNA Translation: AAR21264.1
AY364518 Genomic DNA Translation: AAR21265.1
AY364519 Genomic DNA Translation: AAR21266.1
AY364520 Genomic DNA Translation: AAR21267.1
AY364521 Genomic DNA Translation: AAR21268.1
AY364522 Genomic DNA Translation: AAR21269.1
CH933807 Genomic DNA Translation: EDW12371.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S01901

NCBI Reference Sequences

More...
RefSeqi
XP_002002929.1, XM_002002893.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0168368; FBpp0166860; FBgn0012567

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6576952

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dmo:Dmoj_GI17643

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37276 Genomic DNA Translation: AAA28334.1
X12536 Genomic DNA Translation: CAA31054.1
AY154864 Genomic DNA Translation: AAN86900.1
AY154865 Genomic DNA Translation: AAN86901.1
AY154866 Genomic DNA Translation: AAN86902.1
AY154867 Genomic DNA Translation: AAN86903.1
AY154868 Genomic DNA Translation: AAN86904.1
AY154869 Genomic DNA Translation: AAN86905.1
AY154870 Genomic DNA Translation: AAN86906.1
AY154871 Genomic DNA Translation: AAN86907.1
AY154872 Genomic DNA Translation: AAN86908.1
AY154873 Genomic DNA Translation: AAN86909.1
AY154874 Genomic DNA Translation: AAN86910.1
AY154875 Genomic DNA Translation: AAN86911.1
AY154876 Genomic DNA Translation: AAN86912.1
AY364508 Genomic DNA Translation: AAR21255.1
AY364509 Genomic DNA Translation: AAR21256.1
AY364510 Genomic DNA Translation: AAR21257.1
AY364511 Genomic DNA Translation: AAR21258.1
AY364512 Genomic DNA Translation: AAR21259.1
AY364513 Genomic DNA Translation: AAR21260.1
AY364514 Genomic DNA Translation: AAR21261.1
AY364515 Genomic DNA Translation: AAR21262.1
AY364516 Genomic DNA Translation: AAR21263.1
AY364517 Genomic DNA Translation: AAR21264.1
AY364518 Genomic DNA Translation: AAR21265.1
AY364519 Genomic DNA Translation: AAR21266.1
AY364520 Genomic DNA Translation: AAR21267.1
AY364521 Genomic DNA Translation: AAR21268.1
AY364522 Genomic DNA Translation: AAR21269.1
CH933807 Genomic DNA Translation: EDW12371.1
PIRiS01901
RefSeqiXP_002002929.1, XM_002002893.2

3D structure databases

SMRiP09369
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7230.FBpp0166860

Genome annotation databases

EnsemblMetazoaiFBtr0168368; FBpp0166860; FBgn0012567
GeneIDi6576952
KEGGidmo:Dmoj_GI17643

Phylogenomic databases

InParanoidiP09369
KOiK00001
OMAiWSKHWDS
OrthoDBi1053465at2759
PhylomeDBiP09369

Gene expression databases

BgeeiFBgn0012567 Expressed in 2 organ(s), highest expression level in head

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADH2_DROMO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09369
Secondary accession number(s): Q6YFE3, Q867G0, Q86LV9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 14, 2008
Last modified: October 16, 2019
This is version 112 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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