Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alcohol dehydrogenase 2

Gene

Adh2

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.PROSITE-ProRule annotation
A secondary alcohol + NAD+ = a ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 33NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 2 (EC:1.1.1.1)
Gene namesi
Name:Adh2
ORF Names:GI17643
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000009192 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0012567 Dmoj\Adh2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000544792 – 254Alcohol dehydrogenase 2Add BLAST253

Expressioni

Gene expression databases

BgeeiFBgn0012567

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP09369
SMRiP09369
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiP09369
KOiK00001
OMAiWSKHWDS
OrthoDBiEOG091G0OC9
PhylomeDBiP09369

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09369-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIANKNIIF VAGLGGIGFD TSREIVKRGP KNLVILDRIE NPAAIAELKA
60 70 80 90 100
LNPKVTVTFY PYDVTVSVAE TTKLLKTIFD KLKTVDLLIN GAGILDDHQI
110 120 130 140 150
ERTIAVNFTG TVNTITAIMS FWDKRKGGPG GVIANVCSVT GFNAIYQVPV
160 170 180 190 200
YSASKAAALS FTNSLARLAP ITGVTAYSIN PGITKTTLVH KFNSWLDVEP
210 220 230 240 250
RVAELLLEHP TQTTLQCAQN FVKAIEANQN GAIWKVDLGT LEAIEWTKHW

DSHI
Length:254
Mass (Da):27,605
Last modified:October 14, 2008 - v3
Checksum:iDE52DEA5DA7508D2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti28R → S in strain: MJBC 95.1, MJS 93 and VRF. 4 Publications1
Natural varianti71T → S in strain: MJBC 33.3. 1 Publication1
Natural varianti92A → T in strain: VRF. 2 Publications1
Natural varianti98H → Y in strain: MJS 115, MJS 147.2F, MJS 16F, MJS 122, MJS 127, MJS 132, MJS 14, MJS 154, MJS 36, MJS 58.2, MJS 68, MJS 84 and MJS 87. 1 Publication1
Natural varianti112V → L in strain: VRF. 2 Publications1
Natural varianti115I → T in strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 133, MJS 14, MJS 147.2F, MJS 154, MJS 16F, MJS 36, MJS 58.2, MJS 68, MJS 84, MJS 87, MJS 93 and VRF. 3 Publications1
Natural varianti136V → I in strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 133, MJS 14, MJS 147.2F, MJS 154, MJS 16F, MJS 36, MJS 58.2, MJS 68, MJS 84, MJS 87, MJS 93 and VRF. 3 Publications1
Natural varianti146Y → L in strain: VRF. 2 Publications1
Natural varianti147Q → P in strain: VRF. 2 Publications1
Natural varianti226E → Q in strain: VRF. 2 Publications1
Natural varianti236V → L in strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 133, MJS 14, MJS 147.2F, MJS 154, MJS 16F, MJS 36, MJS 58.2, MJS 68, MJS 84, MJS 87, MJS 93 and VRF. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37276 Genomic DNA Translation: AAA28334.1
X12536 Genomic DNA Translation: CAA31054.1
AY154864 Genomic DNA Translation: AAN86900.1
AY154865 Genomic DNA Translation: AAN86901.1
AY154866 Genomic DNA Translation: AAN86902.1
AY154867 Genomic DNA Translation: AAN86903.1
AY154868 Genomic DNA Translation: AAN86904.1
AY154869 Genomic DNA Translation: AAN86905.1
AY154870 Genomic DNA Translation: AAN86906.1
AY154871 Genomic DNA Translation: AAN86907.1
AY154872 Genomic DNA Translation: AAN86908.1
AY154873 Genomic DNA Translation: AAN86909.1
AY154874 Genomic DNA Translation: AAN86910.1
AY154875 Genomic DNA Translation: AAN86911.1
AY154876 Genomic DNA Translation: AAN86912.1
AY364508 Genomic DNA Translation: AAR21255.1
AY364509 Genomic DNA Translation: AAR21256.1
AY364510 Genomic DNA Translation: AAR21257.1
AY364511 Genomic DNA Translation: AAR21258.1
AY364512 Genomic DNA Translation: AAR21259.1
AY364513 Genomic DNA Translation: AAR21260.1
AY364514 Genomic DNA Translation: AAR21261.1
AY364515 Genomic DNA Translation: AAR21262.1
AY364516 Genomic DNA Translation: AAR21263.1
AY364517 Genomic DNA Translation: AAR21264.1
AY364518 Genomic DNA Translation: AAR21265.1
AY364519 Genomic DNA Translation: AAR21266.1
AY364520 Genomic DNA Translation: AAR21267.1
AY364521 Genomic DNA Translation: AAR21268.1
AY364522 Genomic DNA Translation: AAR21269.1
CH933807 Genomic DNA Translation: EDW12371.1
PIRiS01901
RefSeqiXP_002002929.1, XM_002002893.2

Genome annotation databases

EnsemblMetazoaiFBtr0168368; FBpp0166860; FBgn0012567
GeneIDi6576952
KEGGidmo:Dmoj_GI17643

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiADH2_DROMO
AccessioniPrimary (citable) accession number: P09369
Secondary accession number(s): Q6YFE3, Q867G0, Q86LV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 14, 2008
Last modified: November 22, 2017
This is version 106 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health