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UniProtKB - P09348 (MOTA_ECOLI)

Entry version 162 (10 Feb 2021)
Sequence version 1 (01 Jul 1989)
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Protein

Motility protein A

Gene

motA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

MotA and MotB comprise the stator element of the flagellar motor complex. Required for rotation of the flagellar motor. Probable transmembrane proton channel. Overexpression of MotA, with or without MotB, restores motility in a pdeH disruption, (a c-di-GMP phosphodiesterase) suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein YcgR and the flagellar stator.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processChemotaxis, Flagellar rotation, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:MOTA-FLAGELLAR-MOTOR-STATOR-PROTEIN

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.30.1.1, the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Motility protein A
Alternative name(s):
Chemotaxis protein MotA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:motA
Synonyms:flaJ
Ordered Locus Names:b1890, JW1879
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2 – 21HelicalSequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 33PeriplasmicSequence analysisAdd BLAST12
Transmembranei34 – 51HelicalSequence analysisAdd BLAST18
Topological domaini52 – 170CytoplasmicSequence analysisAdd BLAST119
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 200PeriplasmicSequence analysis9
Transmembranei201 – 222HelicalSequence analysisAdd BLAST22
Topological domaini223 – 295CytoplasmicSequence analysisAdd BLAST73

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi93G → E: Suppresses pdeH disruption motility mutant, swimming velocity is wild-type. 1 Publication1
Mutagenesisi93G → R: Suppresses pdeH disruption motility mutant, swimming velocity is between disruption and wild-type. 1 Publication1
Mutagenesisi93G → V: Suppresses pdeH disruption motility mutant, swimming velocity is between disruption and wild-type. In the wt background velocity is reduced. 1 Publication1
Mutagenesisi96S → L: Suppresses pdeH disruption motility mutant, swimming velocity is between disruption and wild-type. In the wt background velocity is reduced. 1 Publication1

Miscellaneous databases

Pathogen-Host Interaction database

More...PHI-basei		PHI:6533

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001895721 – 295Motility protein AAdd BLAST295

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P09348

PRoteomics IDEntifications database

More...PRIDEi		P09348

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Each stator complex is composed of 4 MotA and 2 MotB subunits; in E.coli 11 to 12 stator complexes can be involved in flagellar rotation. 2 A subunits and 1 B subunit are thought to form a single ion channel, so that each stator complex contains two channels.

Interacts with FliG.

Interacts with flagellar brake protein YcgR in the flagellar basal bodies (PubMed:20303158). In another study (PubMed:20346719) YcgR was not seen to interact with MotA, but instead with FliM and FliG, also in the flagellar basal body.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4262245, 486 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5884, Flagellar motor stator complex

Database of interacting proteins

More...DIPi		DIP-10244N

Protein interaction database and analysis system

More...IntActi		P09348, 3 interactors

STRING: functional protein association networks

More...STRINGi		511145.b1890

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P09348

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MotA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1291, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_068213_0_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P09348

Database for complete collections of gene phylogenies

More...PhylomeDBi		P09348

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000540, Flag_MotA_CS
IPR022522, Flagellar_motor_stator_MotA
IPR002898, MotA_ExbB_proton_chnl

The PANTHER Classification System

More...PANTHERi		PTHR30433:SF4, PTHR30433:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01618, MotA_ExbB, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR03818, MotA1, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01307, MOTA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P09348-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLILLGYLVV LGTVFGGYLM TGGSLGALYQ PAELVIIAGA GIGSFIVGNN 
        60         70         80         90        100
GKAIKGTLKA LPLLFRRSKY TKAMYMDLLA LLYRLMAKSR QMGMFSLERD 
       110        120        130        140        150
IENPRESEIF ASYPRILADS VMLDFIVDYL RLIISGHMNT FEIEALMDEE 
       160        170        180        190        200
IETHESEAEV PANSLALVGD SLPAFGIVAA VMGVVHALGS ADRPAAELGA 
       210        220        230        240        250
LIAHAMVGTF LGILLAYGFI SPLATVLRQK SAETSKMMQC VKVTLLSNLN 
       260        270        280        290 
GYAPPIAVEF GRKTLYSSER PSFIELEEHV RAVKNPQQQT TTEEA
Length:295
Mass (Da):32,011
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i355DC13EF63DD7D8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J01652 Genomic DNA Translation: AAA24177.1
U00096 Genomic DNA Translation: AAC74960.1
AP009048 Genomic DNA Translation: BAA15711.1

Protein sequence database of the Protein Information Resource

More...PIRi		A30279, QRECMA

NCBI Reference Sequences

More...RefSeqi		NP_416404.1, NC_000913.3
WP_000906340.1, NZ_STEB01000026.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC74960; AAC74960; b1890
BAA15711; BAA15711; BAA15711

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57731289
947564

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW1879
eco:b1890

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.357

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01652 Genomic DNA Translation: AAA24177.1
U00096 Genomic DNA Translation: AAC74960.1
AP009048 Genomic DNA Translation: BAA15711.1
PIRiA30279, QRECMA
RefSeqiNP_416404.1, NC_000913.3
WP_000906340.1, NZ_STEB01000026.1

3D structure databases

SMRiP09348
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4262245, 486 interactors
ComplexPortaliCPX-5884, Flagellar motor stator complex
DIPiDIP-10244N
IntActiP09348, 3 interactors
STRINGi511145.b1890

Protein family/group databases

TCDBi1.A.30.1.1, the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily

Proteomic databases

PaxDbiP09348
PRIDEiP09348

Genome annotation databases

EnsemblBacteriaiAAC74960; AAC74960; b1890
BAA15711; BAA15711; BAA15711
GeneIDi57731289
947564
KEGGiecj:JW1879
eco:b1890
PATRICifig|1411691.4.peg.357

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0596

Phylogenomic databases

eggNOGiCOG1291, Bacteria
HOGENOMiCLU_068213_0_0_6
InParanoidiP09348
PhylomeDBiP09348

Enzyme and pathway databases

BioCyciEcoCyc:MOTA-FLAGELLAR-MOTOR-STATOR-PROTEIN

Miscellaneous databases

PHI-baseiPHI:6533

Protein Ontology

More...PROi		PR:P09348

Family and domain databases

InterProiView protein in InterPro
IPR000540, Flag_MotA_CS
IPR022522, Flagellar_motor_stator_MotA
IPR002898, MotA_ExbB_proton_chnl
PANTHERiPTHR30433:SF4, PTHR30433:SF4, 1 hit
PfamiView protein in Pfam
PF01618, MotA_ExbB, 1 hit
TIGRFAMsiTIGR03818, MotA1, 1 hit
PROSITEiView protein in PROSITE
PS01307, MOTA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOTA_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09348
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 10, 2021
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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