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Protein

Growth-regulated alpha protein

Gene

CXCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.1 Publication

GO - Molecular functioni

  • chemokine activity Source: GO_Central
  • enzyme activator activity Source: ProtInc
  • growth factor activity Source: UniProtKB-KW
  • signaling receptor binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processInflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6798695 Neutrophil degranulation
SIGNORiP09341

Names & Taxonomyi

Protein namesi
Recommended name:
Growth-regulated alpha protein
Alternative name(s):
C-X-C motif chemokine 1
GRO-alpha(1-73)
Melanoma growth stimulatory activity
Short name:
MGSA
Neutrophil-activating protein 3
Short name:
NAP-3
Cleaved into the following 3 chains:
Gene namesi
Name:CXCL1
Synonyms:GRO, GRO1, GROA, MGSA, SCYB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000163739.4
HGNCiHGNC:4602 CXCL1
MIMi155730 gene
neXtProtiNX_P09341

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2919
OpenTargetsiENSG00000163739
PharmGKBiPA35050

Polymorphism and mutation databases

BioMutaiCXCL1
DMDMi121622

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 345 PublicationsAdd BLAST34
ChainiPRO_000000504935 – 107Growth-regulated alpha proteinAdd BLAST73
ChainiPRO_000000505038 – 107GRO-alpha(4-73)Add BLAST70
ChainiPRO_000000505139 – 107GRO-alpha(5-73)Add BLAST69
ChainiPRO_000000505240 – 107GRO-alpha(6-73)Add BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 69
Disulfide bondi45 ↔ 85

Post-translational modificationi

N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP09341
MaxQBiP09341
PaxDbiP09341
PeptideAtlasiP09341
PRIDEiP09341
ProteomicsDBi52214

PTM databases

PhosphoSitePlusiP09341
SwissPalmiP09341

Miscellaneous databases

PMAP-CutDBiP09341

Expressioni

Gene expression databases

BgeeiENSG00000163739 Expressed in 176 organ(s), highest expression level in smooth muscle tissue
CleanExiHS_CXCL1
GenevisibleiP09341 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109176, 10 interactors
DIPiDIP-5896N
IntActiP09341, 9 interactors
MINTiP09341
STRINGi9606.ENSP00000379110

Structurei

Secondary structure

1107
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP09341
SMRiP09341
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09341

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE Eukaryota
ENOG410ZT1C LUCA
GeneTreeiENSGT00530000062901
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP09341
KOiK05505
OMAiLNCDKSN
OrthoDBiEOG091G14TE
PhylomeDBiP09341
TreeFamiTF333433

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09341-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARAALSAAP SNPRLLRVAL LLLLLVAAGR RAAGASVATE LRCQCLQTLQ
60 70 80 90 100
GIHPKNIQSV NVKSPGPHCA QTEVIATLKN GRKACLNPAS PIVKKIIEKM

LNSDKSN
Length:107
Mass (Da):11,301
Last modified:July 1, 1989 - v1
Checksum:i17048A6B4D765CA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03561 mRNA Translation: AAA35933.1
X12510 mRNA Translation: CAA31027.1
X54489 Genomic DNA Translation: CAA38361.1
BT006880 mRNA Translation: AAP35526.1
BC011976 mRNA Translation: AAH11976.1
CCDSiCCDS47074.1
PIRiS13669 A28414
RefSeqiNP_001502.1, NM_001511.3
UniGeneiHs.708652
Hs.789

Genome annotation databases

EnsembliENST00000395761; ENSP00000379110; ENSG00000163739
GeneIDi2919
KEGGihsa:2919
UCSCiuc003hhh.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CXCL1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03561 mRNA Translation: AAA35933.1
X12510 mRNA Translation: CAA31027.1
X54489 Genomic DNA Translation: CAA38361.1
BT006880 mRNA Translation: AAP35526.1
BC011976 mRNA Translation: AAH11976.1
CCDSiCCDS47074.1
PIRiS13669 A28414
RefSeqiNP_001502.1, NM_001511.3
UniGeneiHs.708652
Hs.789

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MGSNMR-A/B35-107[»]
1MSGNMR-A/B35-106[»]
1MSHNMR-A/B35-106[»]
1RODNMR-A/B40-62[»]
A/B89-107[»]
ProteinModelPortaliP09341
SMRiP09341
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109176, 10 interactors
DIPiDIP-5896N
IntActiP09341, 9 interactors
MINTiP09341
STRINGi9606.ENSP00000379110

PTM databases

PhosphoSitePlusiP09341
SwissPalmiP09341

Polymorphism and mutation databases

BioMutaiCXCL1
DMDMi121622

Proteomic databases

EPDiP09341
MaxQBiP09341
PaxDbiP09341
PeptideAtlasiP09341
PRIDEiP09341
ProteomicsDBi52214

Protocols and materials databases

DNASUi2919
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395761; ENSP00000379110; ENSG00000163739
GeneIDi2919
KEGGihsa:2919
UCSCiuc003hhh.4 human

Organism-specific databases

CTDi2919
DisGeNETi2919
EuPathDBiHostDB:ENSG00000163739.4
GeneCardsiCXCL1
H-InvDBiHIX0120073
HGNCiHGNC:4602 CXCL1
MIMi155730 gene
neXtProtiNX_P09341
OpenTargetsiENSG00000163739
PharmGKBiPA35050
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3WE Eukaryota
ENOG410ZT1C LUCA
GeneTreeiENSGT00530000062901
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP09341
KOiK05505
OMAiLNCDKSN
OrthoDBiEOG091G14TE
PhylomeDBiP09341
TreeFamiTF333433

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6798695 Neutrophil degranulation
SIGNORiP09341

Miscellaneous databases

ChiTaRSiCXCL1 human
EvolutionaryTraceiP09341
GeneWikiiCXCL1
GenomeRNAii2919
PMAP-CutDBiP09341
PROiPR:P09341
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163739 Expressed in 176 organ(s), highest expression level in smooth muscle tissue
CleanExiHS_CXCL1
GenevisibleiP09341 HS

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGROA_HUMAN
AccessioniPrimary (citable) accession number: P09341
Secondary accession number(s): Q9UCR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 188 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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