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Protein

Tyrosine-protein kinase Yes

Gene

YES1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, differentiation, G2/M progression and cytokinesis.By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei303ATPPROSITE-ProRule annotation1
Active sitei394Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi281 – 289ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 1306
ReactomeiR-GGA-1227986 Signaling by ERBB2
R-GGA-1433557 Signaling by SCF-KIT
R-GGA-1433559 Regulation of KIT signaling
R-GGA-389356 CD28 co-stimulation
R-GGA-389513 CTLA4 inhibitory signaling
R-GGA-3928662 EPHB-mediated forward signaling
R-GGA-3928663 EPHA-mediated growth cone collapse
R-GGA-3928665 EPH-ephrin mediated repulsion of cells
R-GGA-912631 Regulation of signaling by CBL

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Yes (EC:2.7.10.2)
Alternative name(s):
p61-Yes
Gene namesi
Name:YES1
Synonyms:YES
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000881832 – 541Tyrosine-protein kinase YesAdd BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi3S-palmitoyl cysteine; in membrane formBy similarity1
Modified residuei424Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei535Phosphotyrosine; by CSKBy similarity1

Post-translational modificationi

Autophosphorylation at Tyr-424 maintains enzyme activity.By similarity
Palmitoylation at Cys-3 promotes membrane localization.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP09324
PRIDEiP09324

Expressioni

Gene expression databases

BgeeiENSGALG00000014860

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023934

Structurei

3D structure databases

ProteinModelPortaliP09324
SMRiP09324
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 150SH3PROSITE-ProRule annotationAdd BLAST62
Domaini156 – 253SH2PROSITE-ProRule annotationAdd BLAST98
Domaini275 – 528Protein kinasePROSITE-ProRule annotationAdd BLAST254

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118938
HOGENOMiHOG000233858
HOVERGENiHBG008761
InParanoidiP09324
KOiK05705
OMAiHVGHYGP
OrthoDBiEOG091G0D46
PhylomeDBiP09324

Family and domain databases

CDDicd12007 SH3_Yes, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR035751 Yes_SH3
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCIKSKEDK GPAMKYRTDN TPEPISSHVS HYGSDSSQAT QSPAIKGSAV
60 70 80 90 100
NFNSHSMTPF GGPSGMTPFG GASSSFSAVP SPYPSTLTGG VTVFVALYDY
110 120 130 140 150
EARTTDDLSF KKGERFQIIN NTEGDWWEAR SIATGKTGYI PSNYVAPADS
160 170 180 190 200
IQAEEWYFGK MGRKDAERLL LNPGNQRGIF LVRESETTKG AYSLSIRDWD
210 220 230 240 250
EVRGDNVKHY KIRKLDNGGY YITTRAQFES LQKLVKHYRE HADGLCHKLT
260 270 280 290 300
TVCPTVKPQT QGLAKDAWEI PRESLRLEVK LGQGCFGEVW MGTWNGTTKV
310 320 330 340 350
AIKTLKPGTM MPEAFLQEAQ IMKKLRHDKL VPLYAVVSEE PIYIVTEFMT
360 370 380 390 400
KGSLLDFLKE GEGKFLKLPQ LVDMAAQIAD GMAYIERMNY IHRDLRAANI
410 420 430 440 450
LVGDNLVCKI ADFGLARLIE DNEYTARQGA KFPIKWTAPE AALYGRFTIK
460 470 480 490 500
SDVWSFGILL TELVTKGRVP YPGMVNREVL EQVERGYRMP CPQGCPESLH
510 520 530 540
ELMKLCWKKD PDERPTFEYI QSFLEDYFTA TEPQYQPGDN L
Length:541
Mass (Da):60,792
Last modified:January 23, 2007 - v3
Checksum:iBEA849CC7D1755AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67 – 71TPFGG → IHPLR in CAA31595 (PubMed:2464785).Curated5
Sequence conflicti82P → Q in CAA31595 (PubMed:2464785).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12461 mRNA Translation: CAA31002.1
X13207 mRNA Translation: CAA31595.1
X69695 mRNA Translation: CAA49365.1
PIRiS03324 TVCHYS
RefSeqiNP_990632.1, NM_205301.1
UniGeneiGga.1891

Genome annotation databases

EnsembliENSGALT00000023980; ENSGALP00000023934; ENSGALG00000014860
GeneIDi396238
KEGGigga:396238

Similar proteinsi

Entry informationi

Entry nameiYES_CHICK
AccessioniPrimary (citable) accession number: P09324
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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