UniProtKB - P09245 (MCP_VZVD)
Protein
Major capsid protein
Gene
MCP
Organism
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
Status
Functioni
Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.UniRule annotation
GO - Molecular functioni
- structural molecule activity Source: UniProtKB-UniRule
Names & Taxonomyi
Protein namesi | Recommended name: Major capsid proteinUniRule annotationShort name: MCPUniRule annotation |
Gene namesi | Name:MCPUniRule annotation Synonyms:40 |
Organismi | Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) |
Taxonomic identifieri | 10338 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Virion UniRule annotation
- Host nucleus UniRule annotation
GO - Cellular componenti
- host cell nucleus Source: UniProtKB-SubCell
- T=16 icosahedral viral capsid Source: UniProtKB-UniRule
Keywords - Cellular componenti
Capsid protein, Host nucleus, T=16 icosahedral capsid protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000115707 | 1 – 1396 | Major capsid proteinAdd BLAST | 1396 |
Proteomic databases
PRIDEi | P09245 |
Interactioni
Subunit structurei
Homomultimer. Makes the hexons and eleven out of twelve pentons.
Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2.
Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus.
Interacts with capsid vertex component 2/CVC2.
Interacts with the small capsomere-interacting protein/SCP.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Belongs to the herpesviridae major capsid protein family.UniRule annotation
Family and domain databases
HAMAPi | MF_04016, HSV_MCP, 1 hit |
InterProi | View protein in InterPro IPR000912, Herpes_MCP IPR023233, Herpes_MCP_upper_sf |
Pfami | View protein in Pfam PF03122, Herpes_MCP, 1 hit |
PRINTSi | PR00235, HSVCAPSIDMCP |
SUPFAMi | SSF103417, SSF103417, 1 hit |
i Sequence
Sequence statusi: Complete.
P09245-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTVSCPANV ITTTESDRIA GLFNIPAGII PTGNVLSTIE VCAHRCIFDF
60 70 80 90 100
FKQIRSDDNS LYSAQFDILL GTYCNTLNFV RFLELGLSVA CICTKFPELA
110 120 130 140 150
YVRDGVIQFE VQQPMIARDG PHPVDQPVHN YMVKRIHKRS LSAAFAIASE
160 170 180 190 200
ALSLLSNTYV DGTEIDSSLR IRAIQQMARN LRTVLDSFER GTADQLLGVL
210 220 230 240 250
LEKAPPLSLL SPINKFQPEG HLNRVARAAL LSDLKRRVCA DMFFMTRHAR
260 270 280 290 300
EPRLISAYLS DMVSCTQPSV MVSRITHTNT RGRQVDGVLV TTATLKRQLL
310 320 330 340 350
QGILQIDDTA ADVPVTYGEM VLQGTNLVTA LVMGKAVRGM DDVARHLLDI
360 370 380 390 400
TDPNTLNIPS IPPQSNSDST TAGLPVNARV PADLVIVGDK LVFLEALERR
410 420 430 440 450
VYQATRVAYP LIGNIDITFI MPMGVFQANS MDRYTRHAGD FSTVSEQDPR
460 470 480 490 500
QFPPQGIFFY NKDGILTQLT LRDAMGTICH SSLLDVEATL VALRQQHLDR
510 520 530 540 550
QCYFGVYVAE GTEDTLDVQM GRFMETWADM MPHHPHWVNE HLTILQFIAP
560 570 580 590 600
SNPRLRFELN PAFDFFVAPG DVDLPGPQRP PEAMPTVNAT LRIINGNIPV
610 620 630 640 650
PLCPISFRDC RGTQLGLGRH TMTPATIKAV KDTFEDRAYP TIFYMLEAVI
660 670 680 690 700
HGNERNFCAL LRLLTQCIRG YWEQSHRVAF VNNFHMLMYI TTYLGNGELP
710 720 730 740 750
EVCINIYRDL LQHVRALRQT ITDFTIQGEG HNGETSEALN NILTDDTFIA
760 770 780 790 800
PILWDCDALI YRDEAARDRL PAIRVSGRNG YQALHFVDMA GHNFQRRDNV
810 820 830 840 850
LIHGRPVRGD TGQGIPITPH HDREWGILSK IYYYIVIPAF SRGSCCTMGV
860 870 880 890 900
RYDRLYPALQ AVIVPEIPAD EEAPTTPEDP RHPLHAHQLV PNSLNVYFHN
910 920 930 940 950
AHLTVDGDAL LTLQELMGDM AERTTAILVS SAPDAGAATA TTRNMRIYDG
960 970 980 990 1000
ALYHGLIMMA YQAYDETIAT GTFFYPVPVN PLFACPEHLA SLRGMTNARR
1010 1020 1030 1040 1050
VLAKMVPPIP PFLGANHHAT IRQPVAYHVT HSKSDFNTLT YSLLGGYFKF
1060 1070 1080 1090 1100
TPISLTHQLR TGFHPGIAFT VVRQDRFATE QLLYAERASE SYFVGQIQVH
1110 1120 1130 1140 1150
HHDAIGGVNF TLTQPRAHVD LGVGYTAVCA TAALRCPLTD MGNTAQNLFF
1160 1170 1180 1190 1200
SRGGVPMLHD NVTESLRRIT ASGGRLNPTE PLPIFGGLRP ATSAGIARGQ
1210 1220 1230 1240 1250
ASVCEFVAMP VSTDLQYFRT ACNPRGRASG MLYMGDRDAD IEAIMFDHTQ
1260 1270 1280 1290 1300
SDVAYTDRAT LNPWASQKHS YGDRLYNGTY NLTGASPIYS PCFKFFTPAE
1310 1320 1330 1340 1350
VNTNCNTLDR LLMEAKAVAS QSSTDTEYQF KRPPGSTEMT QDPCGLFQEA
1360 1370 1380 1390
YPPLCSSDAA MLRTAHAGET GADEVHLAQY LIRDASPLRG CLPLPR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04370 Genomic DNA Translation: CAA27923.1 |
PIRi | E27341, VCBE40 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04370 Genomic DNA Translation: CAA27923.1 |
PIRi | E27341, VCBE40 |
3D structure databases
SMRi | P09245 |
ModBasei | Search... |
Proteomic databases
PRIDEi | P09245 |
Family and domain databases
HAMAPi | MF_04016, HSV_MCP, 1 hit |
InterProi | View protein in InterPro IPR000912, Herpes_MCP IPR023233, Herpes_MCP_upper_sf |
Pfami | View protein in Pfam PF03122, Herpes_MCP, 1 hit |
PRINTSi | PR00235, HSVCAPSIDMCP |
SUPFAMi | SSF103417, SSF103417, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MCP_VZVD | |
Accessioni | P09245Primary (citable) accession number: P09245 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families