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Protein

Cholecystokinin

Gene

Cck

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

GO - Molecular functioni

  • hormone activity Source: MGI
  • neuropeptide hormone activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin
Short name:
CCK
Cleaved into the following 3 chains:
Cholecystokinin-33
Short name:
CCK33
Cholecystokinin-12
Short name:
CCK12
Cholecystokinin-8
Short name:
CCK8
Gene namesi
Name:Cck
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88297 Cck

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001055221 – 115CholecystokininAdd BLAST95
PropeptideiPRO_000001055321 – 70Add BLAST50
PeptideiPRO_000001055471 – 103Cholecystokinin-33Add BLAST33
PeptideiPRO_000001055592 – 103Cholecystokinin-12Add BLAST12
PeptideiPRO_000001055696 – 103Cholecystokinin-88
PropeptideiPRO_0000010557107 – 1159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97SulfotyrosineBy similarity1
Modified residuei103Phenylalanine amide1 Publication1
Modified residuei111SulfotyrosineBy similarity1
Modified residuei113SulfotyrosineBy similarity1

Post-translational modificationi

The precursor is cleaved by proteases to produce a number of active cholecystokinins.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Sulfation

Proteomic databases

PaxDbiP09240
PeptideAtlasiP09240
PRIDEiP09240

PTM databases

PhosphoSitePlusiP09240

Expressioni

Gene expression databases

BgeeiENSMUSG00000032532 Expressed in 155 organ(s), highest expression level in cingulate cortex
CleanExiMM_CCK
ExpressionAtlasiP09240 baseline and differential
GenevisibleiP09240 MM

Interactioni

Subunit structurei

Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035120

Structurei

3D structure databases

SMRiP09240
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gastrin/cholecystokinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQ9 Eukaryota
ENOG411211F LUCA
GeneTreeiENSGT00390000003571
HOGENOMiHOG000073533
HOVERGENiHBG005806
InParanoidiP09240
KOiK05226
OMAiDGEPRAH
OrthoDBiEOG091G11B3
PhylomeDBiP09240
TreeFamiTF333419

Family and domain databases

InterProiView protein in InterPro
IPR015499 CCK-like
IPR001651 Gastrin/CCK
IPR013152 Gastrin/cholecystokinin_CS
PANTHERiPTHR10786 PTHR10786, 1 hit
PfamiView protein in Pfam
PF00918 Gastrin, 1 hit
PROSITEiView protein in PROSITE
PS00259 GASTRIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P09240-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSGVCLCVV MAVLAAGALA QPVVPAEATD PVEQRAQEAP RRQLRAVLRT
60 70 80 90 100
DGEPRARLGA LLARYIQQVR KAPSGRMSVL KNLQSLDPSH RISDRDYMGW
110
MDFGRRSAED YEYPS
Length:115
Mass (Da):12,770
Last modified:April 8, 2008 - v3
Checksum:i7841B11D39BB52DA
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8R041Q8R041_MOUSE
Cck protein
Cck
134Annotation score:
A0A1L1SRD3A0A1L1SRD3_MOUSE
Cholecystokinin
Cck
85Annotation score:
A0A1L1SQR9A0A1L1SQR9_MOUSE
Cholecystokinin
Cck
42Annotation score:
A0A1L1SU12A0A1L1SU12_MOUSE
Cholecystokinin
Cck
68Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37Q → E in CAB94216 (PubMed:2011497).Curated1
Sequence conflicti50T → P in CAB94216 (PubMed:2011497).Curated1
Sequence conflicti52G → R in CAB94216 (PubMed:2011497).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59521, X59522 Genomic DNA Translation: CAB94216.1
AK002677 mRNA Translation: BAB22279.1
M11739 mRNA Translation: AAA37382.1
CCDSiCCDS23631.1
PIRiS22563
RefSeqiNP_001271437.1, NM_001284508.2
NP_112438.1, NM_031161.4
XP_017168605.1, XM_017313116.1
UniGeneiMm.2619

Genome annotation databases

EnsembliENSMUST00000035120; ENSMUSP00000035120; ENSMUSG00000032532
ENSMUST00000215228; ENSMUSP00000149679; ENSMUSG00000032532
GeneIDi12424
KEGGimmu:12424
UCSCiuc009sdg.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59521, X59522 Genomic DNA Translation: CAB94216.1
AK002677 mRNA Translation: BAB22279.1
M11739 mRNA Translation: AAA37382.1
CCDSiCCDS23631.1
PIRiS22563
RefSeqiNP_001271437.1, NM_001284508.2
NP_112438.1, NM_031161.4
XP_017168605.1, XM_017313116.1
UniGeneiMm.2619

3D structure databases

SMRiP09240
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035120

PTM databases

PhosphoSitePlusiP09240

Proteomic databases

PaxDbiP09240
PeptideAtlasiP09240
PRIDEiP09240

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035120; ENSMUSP00000035120; ENSMUSG00000032532
ENSMUST00000215228; ENSMUSP00000149679; ENSMUSG00000032532
GeneIDi12424
KEGGimmu:12424
UCSCiuc009sdg.3 mouse

Organism-specific databases

CTDi885
MGIiMGI:88297 Cck

Phylogenomic databases

eggNOGiENOG410IXQ9 Eukaryota
ENOG411211F LUCA
GeneTreeiENSGT00390000003571
HOGENOMiHOG000073533
HOVERGENiHBG005806
InParanoidiP09240
KOiK05226
OMAiDGEPRAH
OrthoDBiEOG091G11B3
PhylomeDBiP09240
TreeFamiTF333419

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events

Miscellaneous databases

ChiTaRSiCck mouse
PROiPR:P09240
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032532 Expressed in 155 organ(s), highest expression level in cingulate cortex
CleanExiMM_CCK
ExpressionAtlasiP09240 baseline and differential
GenevisibleiP09240 MM

Family and domain databases

InterProiView protein in InterPro
IPR015499 CCK-like
IPR001651 Gastrin/CCK
IPR013152 Gastrin/cholecystokinin_CS
PANTHERiPTHR10786 PTHR10786, 1 hit
PfamiView protein in Pfam
PF00918 Gastrin, 1 hit
PROSITEiView protein in PROSITE
PS00259 GASTRIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCKN_MOUSE
AccessioniPrimary (citable) accession number: P09240
Secondary accession number(s): Q53WS9, Q9DCL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 8, 2008
Last modified: October 10, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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