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Protein

Stromelysin-2

Gene

MMP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.

Catalytic activityi

Similar to stromelysin 1, but action on collagen types III, IV and V is weak.1 Publication

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi91Zinc; in inhibited formBy similarity1
Metal bindingi167Zinc 11
Metal bindingi169Zinc 11
Metal bindingi182Zinc 11
Metal bindingi195Zinc 11
Metal bindingi217Zinc 2; catalytic1
Active sitei218PROSITE-ProRule annotation1 Publication1
Metal bindingi221Zinc 2; catalytic1
Metal bindingi227Zinc 2; catalytic1

GO - Molecular functioni

  • metalloendopeptidase activity Source: Reactome
  • serine-type endopeptidase activity Source: Reactome
  • zinc ion binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processCollagen degradation
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.24.22 2681
ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1592389 Activation of Matrix Metalloproteinases
SIGNORiP09238

Protein family/group databases

MEROPSiM10.006

Names & Taxonomyi

Protein namesi
Recommended name:
Stromelysin-2 (EC:3.4.24.22)
Short name:
SL-2
Alternative name(s):
Matrix metalloproteinase-10
Short name:
MMP-10
Transin-2
Gene namesi
Name:MMP10
Synonyms:STMY2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166670.9
HGNCiHGNC:7156 MMP10
MIMi185260 gene
neXtProtiNX_P09238

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4319
OpenTargetsiENSG00000166670
PharmGKBiPA30868

Chemistry databases

ChEMBLiCHEMBL4270
DrugBankiDB00786 Marimastat
DB08271 N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID
GuidetoPHARMACOLOGYi1634

Polymorphism and mutation databases

BioMutaiMMP10
DMDMi116869

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17CuratedAdd BLAST17
PropeptideiPRO_000002876418 – 98Activation peptideAdd BLAST81
ChainiPRO_000002876599 – 476Stromelysin-2Add BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi289 ↔ 476By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP09238
PeptideAtlasiP09238
PRIDEiP09238
ProteomicsDBi52211
TopDownProteomicsiP09238

PTM databases

iPTMnetiP09238
PhosphoSitePlusiP09238

Expressioni

Gene expression databases

BgeeiENSG00000166670 Expressed in 79 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_MMP10
ExpressionAtlasiP09238 baseline and differential
GenevisibleiP09238 HS

Organism-specific databases

HPAiCAB002159

Interactioni

Protein-protein interaction databases

BioGridi110462, 15 interactors
STRINGi9606.ENSP00000279441

Chemistry databases

BindingDBiP09238

Structurei

Secondary structure

1476
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP09238
SMRiP09238
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09238

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati286 – 335Hemopexin 1Add BLAST50
Repeati336 – 382Hemopexin 2Add BLAST47
Repeati384 – 432Hemopexin 3Add BLAST49
Repeati433 – 476Hemopexin 4Add BLAST44

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi89 – 96Cysteine switchBy similarity8

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Belongs to the peptidase M10A family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00760000118870
HOGENOMiHOG000217927
HOVERGENiHBG052484
InParanoidiP09238
KOiK01396
OMAiSNSWLLC
OrthoDBiEOG091G03DP
PhylomeDBiP09238
TreeFamiTF315428

Family and domain databases

CDDicd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di2.110.10.10, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
PfamiView protein in Pfam
PF00045 Hemopexin, 4 hits
PF00413 Peptidase_M10, 1 hit
PF01471 PG_binding_1, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF50923 SSF50923, 1 hit
PROSITEiView protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 4 hits
PS00142 ZINC_PROTEASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P09238-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMHLAFLVLL CLPVCSAYPL SGAAKEEDSN KDLAQQYLEK YYNLEKDVKQ
60 70 80 90 100
FRRKDSNLIV KKIQGMQKFL GLEVTGKLDT DTLEVMRKPR CGVPDVGHFS
110 120 130 140 150
SFPGMPKWRK THLTYRIVNY TPDLPRDAVD SAIEKALKVW EEVTPLTFSR
160 170 180 190 200
LYEGEADIMI SFAVKEHGDF YSFDGPGHSL AHAYPPGPGL YGDIHFDDDE
210 220 230 240 250
KWTEDASGTN LFLVAAHELG HSLGLFHSAN TEALMYPLYN SFTELAQFRL
260 270 280 290 300
SQDDVNGIQS LYGPPPASTE EPLVPTKSVP SGSEMPAKCD PALSFDAIST
310 320 330 340 350
LRGEYLFFKD RYFWRRSHWN PEPEFHLISA FWPSLPSYLD AAYEVNSRDT
360 370 380 390 400
VFIFKGNEFW AIRGNEVQAG YPRGIHTLGF PPTIRKIDAA VSDKEKKKTY
410 420 430 440 450
FFAADKYWRF DENSQSMEQG FPRLIADDFP GVEPKVDAVL QAFGFFYFFS
460 470
GSSQFEFDPN ARMVTHILKS NSWLHC
Length:476
Mass (Da):54,151
Last modified:July 1, 1989 - v1
Checksum:i516DCDDFEF92A0D6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GYX7F5GYX7_HUMAN
Matrix metalloproteinase
MMP10
181Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0209494L → V1 PublicationCorresponds to variant dbSNP:rs17435959Ensembl.1
Natural variantiVAR_02095053R → K2 PublicationsCorresponds to variant dbSNP:rs486055Ensembl.1
Natural variantiVAR_02095165G → R1 PublicationCorresponds to variant dbSNP:rs17293607Ensembl.1
Natural variantiVAR_036139142E → Q in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_020952226F → L1 PublicationCorresponds to variant dbSNP:rs17860971Ensembl.1
Natural variantiVAR_020953282G → E1 PublicationCorresponds to variant dbSNP:rs17860973Ensembl.1
Natural variantiVAR_020954440L → F1 PublicationCorresponds to variant dbSNP:rs17860996Ensembl.1
Natural variantiVAR_020955475H → L1 PublicationCorresponds to variant dbSNP:rs17861009Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07820 mRNA Translation: CAA30679.1
BT007442 mRNA Translation: AAP36110.1
AK222601 mRNA Translation: BAD96321.1
AK313960 mRNA Translation: BAG36676.1
AY744675 Genomic DNA Translation: AAU21039.1
CH471065 Genomic DNA Translation: EAW67029.1
BC002591 mRNA Translation: AAH02591.1
CCDSiCCDS8321.1
PIRiA28816 KCHUS2
RefSeqiNP_002416.1, NM_002425.2
UniGeneiHs.2258

Genome annotation databases

EnsembliENST00000279441; ENSP00000279441; ENSG00000166670
GeneIDi4319
KEGGihsa:4319
UCSCiuc001phg.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07820 mRNA Translation: CAA30679.1
BT007442 mRNA Translation: AAP36110.1
AK222601 mRNA Translation: BAD96321.1
AK313960 mRNA Translation: BAG36676.1
AY744675 Genomic DNA Translation: AAU21039.1
CH471065 Genomic DNA Translation: EAW67029.1
BC002591 mRNA Translation: AAH02591.1
CCDSiCCDS8321.1
PIRiA28816 KCHUS2
RefSeqiNP_002416.1, NM_002425.2
UniGeneiHs.2258

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q3AX-ray2.10A/B/C99-263[»]
3V96X-ray1.90B99-263[»]
4ILWX-ray2.10D/F99-263[»]
ProteinModelPortaliP09238
SMRiP09238
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110462, 15 interactors
STRINGi9606.ENSP00000279441

Chemistry databases

BindingDBiP09238
ChEMBLiCHEMBL4270
DrugBankiDB00786 Marimastat
DB08271 N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID
GuidetoPHARMACOLOGYi1634

Protein family/group databases

MEROPSiM10.006

PTM databases

iPTMnetiP09238
PhosphoSitePlusiP09238

Polymorphism and mutation databases

BioMutaiMMP10
DMDMi116869

Proteomic databases

PaxDbiP09238
PeptideAtlasiP09238
PRIDEiP09238
ProteomicsDBi52211
TopDownProteomicsiP09238

Protocols and materials databases

DNASUi4319
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279441; ENSP00000279441; ENSG00000166670
GeneIDi4319
KEGGihsa:4319
UCSCiuc001phg.3 human

Organism-specific databases

CTDi4319
DisGeNETi4319
EuPathDBiHostDB:ENSG00000166670.9
GeneCardsiMMP10
HGNCiHGNC:7156 MMP10
HPAiCAB002159
MIMi185260 gene
neXtProtiNX_P09238
OpenTargetsiENSG00000166670
PharmGKBiPA30868
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00760000118870
HOGENOMiHOG000217927
HOVERGENiHBG052484
InParanoidiP09238
KOiK01396
OMAiSNSWLLC
OrthoDBiEOG091G03DP
PhylomeDBiP09238
TreeFamiTF315428

Enzyme and pathway databases

BRENDAi3.4.24.22 2681
ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1592389 Activation of Matrix Metalloproteinases
SIGNORiP09238

Miscellaneous databases

EvolutionaryTraceiP09238
GeneWikiiMMP10
GenomeRNAii4319
PROiPR:P09238
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166670 Expressed in 79 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_MMP10
ExpressionAtlasiP09238 baseline and differential
GenevisibleiP09238 HS

Family and domain databases

CDDicd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di2.110.10.10, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
PfamiView protein in Pfam
PF00045 Hemopexin, 4 hits
PF00413 Peptidase_M10, 1 hit
PF01471 PG_binding_1, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF50923 SSF50923, 1 hit
PROSITEiView protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 4 hits
PS00142 ZINC_PROTEASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMMP10_HUMAN
AccessioniPrimary (citable) accession number: P09238
Secondary accession number(s): B2R9X9, Q53HH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 188 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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