UniProtKB - P09234 (RU1C_HUMAN)
U1 small nuclear ribonucleoprotein C
SNRPC
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 4 – 36 | Matrin-typeUniRule annotationAdd BLAST | 33 |
GO - Molecular functioni
- mRNA binding Source: UniProtKB-UniRule
- pre-mRNA 5'-splice site binding Source: GO_Central
- protein homodimerization activity Source: UniProtKB
- RNA binding Source: UniProtKB
- single-stranded RNA binding Source: UniProtKB
- U1 snRNP binding Source: Ensembl
- zinc ion binding Source: UniProtKB
GO - Biological processi
- mRNA 5'-splice site recognition Source: GO_Central
- mRNA splicing, via spliceosome Source: UniProtKB
- spliceosomal snRNP assembly Source: UniProtKB
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P09234 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: U1 small nuclear ribonucleoprotein CUniRule annotationShort name: U1 snRNP CUniRule annotation Short name: U1-CUniRule annotation Short name: U1CUniRule annotation |
Gene namesi | Name:SNRPCUniRule annotation |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000124562.9 |
HGNCi | HGNC:11157, SNRPC |
MIMi | 603522, gene |
neXtProti | NX_P09234 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation1 Publication
Nucleus
- Cajal body Source: UniProtKB
- commitment complex Source: UniProtKB-UniRule
- nucleoplasm Source: HPA
- U1 snRNP Source: UniProtKB
- U2-type prespliceosome Source: UniProtKB-UniRule
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 6 | C → S: Abolishes the binding to U1 snRNP. 1 Publication | 1 | |
Mutagenesisi | 9 | C → S: Abolishes the binding to U1 snRNP. 1 Publication | 1 | |
Mutagenesisi | 24 | H → Q: Abolishes the binding to U1 snRNP. 1 Publication | 1 | |
Mutagenesisi | 25 | C → S: No effect. 1 Publication | 1 | |
Mutagenesisi | 30 | H → Q: Abolishes the binding to U1 snRNP. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6631 |
OpenTargetsi | ENSG00000124562 |
PharmGKBi | PA35998 |
Miscellaneous databases
Pharosi | P09234, Tbio |
Polymorphism and mutation databases
BioMutai | SNRPC |
DMDMi | 134093 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097525 | 1 – 159 | U1 small nuclear ribonucleoprotein CAdd BLAST | 159 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 8 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 17 | PhosphoserineCombined sources | 1 | |
Modified residuei | 52 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-947 |
EPDi | P09234 |
jPOSTi | P09234 |
MassIVEi | P09234 |
PaxDbi | P09234 |
PeptideAtlasi | P09234 |
PRIDEi | P09234 |
ProteomicsDBi | 52209 |
PTM databases
iPTMneti | P09234 |
PhosphoSitePlusi | P09234 |
SwissPalmi | P09234 |
Expressioni
Gene expression databases
Bgeei | ENSG00000124562, Expressed in apex of heart and 247 other tissues |
ExpressionAtlasi | P09234, baseline and differential |
Genevisiblei | P09234, HS |
Organism-specific databases
HPAi | ENSG00000124562, Low tissue specificity |
Interactioni
Subunit structurei
Component of the U1 snRNP (PubMed:2136774). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.
UniRule annotation5 PublicationsBinary interactionsi
P09234
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112515, 167 interactors |
CORUMi | P09234 |
DIPi | DIP-34235N |
IntActi | P09234, 100 interactors |
MINTi | P09234 |
STRINGi | 9606.ENSP00000244520 |
Miscellaneous databases
RNActi | P09234, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P09234 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P09234 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 63 – 157 | Met/Pro-richAdd BLAST | 95 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 4 – 36 | Matrin-typeUniRule annotationAdd BLAST | 33 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3454, Eukaryota |
GeneTreei | ENSGT00730000110997 |
HOGENOMi | CLU_079697_3_0_1 |
InParanoidi | P09234 |
OrthoDBi | 1594407at2759 |
TreeFami | TF313578 |
Family and domain databases
HAMAPi | MF_03153, U1_C, 1 hit |
IDEALi | IID00139 |
InterProi | View protein in InterPro IPR000690, Matrin/U1-C_Znf_C2H2 IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR013085, U1-CZ_Znf_C2H2 IPR017340, U1_snRNP-C IPR036236, Znf_C2H2_sf |
PANTHERi | PTHR31148, PTHR31148, 1 hit |
Pfami | View protein in Pfam PF06220, zf-U1, 1 hit |
PIRSFi | PIRSF037969, U1_snRNP-C, 1 hit |
SMARTi | View protein in SMART SM00451, ZnF_U1, 1 hit |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50171, ZF_MATRIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MPKFYCDYCD TYLTHDSPSV RKTHCSGRKH KENVKDYYQK WMEEQAQSLI
60 70 80 90 100
DKTTAAFQQG KIPPTPFSAP PPAGAMIPPP PSLPGPPRPG MMPAPHMGGP
110 120 130 140 150
PMMPMMGPPP PGMMPVGPAP GMRPPMGGHM PMMPGPPMMR PPARPMMVPT
RPGMTRPDR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MRR7 | A0A0A0MRR7_HUMAN | U1 small nuclear ribonucleoprotein ... | SNRPC | 180 | Annotation score: | ||
Q5TAL2 | Q5TAL2_HUMAN | U1 small nuclear ribonucleoprotein ... | SNRPC | 118 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 25 – 27 | CSG → RSR in AAA36618 (PubMed:2961811).Curated | 3 | |
Sequence conflicti | 94 – 98 | APHMG → TPIW in AAA36618 (PubMed:2961811).Curated | 5 | |
Sequence conflicti | 101 | P → S in AAA36618 (PubMed:2961811).Curated | 1 | |
Sequence conflicti | 129 – 131 | HMP → ICQ in AAA36618 (PubMed:2961811).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12517 mRNA Translation: CAA31037.1 AL139100 Genomic DNA No translation available. M18465 mRNA Translation: AAA36618.1 |
CCDSi | CCDS34436.1 |
PIRi | S01387 |
RefSeqi | NP_003084.1, NM_003093.2 |
Genome annotation databases
Ensembli | ENST00000244520; ENSP00000244520; ENSG00000124562 |
GeneIDi | 6631 |
KEGGi | hsa:6631 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12517 mRNA Translation: CAA31037.1 AL139100 Genomic DNA No translation available. M18465 mRNA Translation: AAA36618.1 |
CCDSi | CCDS34436.1 |
PIRi | S01387 |
RefSeqi | NP_003084.1, NM_003093.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2VRD | NMR | - | A | 1-61 | [»] | |
3CW1 | X-ray | 5.49 | 0/9/L/l | 1-77 | [»] | |
4PJO | X-ray | 3.30 | L/M/l/m | 1-61 | [»] | |
6ELD | X-ray | 2.48 | A | 30-61 | [»] | |
6QX9 | electron microscopy | 3.28 | 1C | 1-159 | [»] | |
SMRi | P09234 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112515, 167 interactors |
CORUMi | P09234 |
DIPi | DIP-34235N |
IntActi | P09234, 100 interactors |
MINTi | P09234 |
STRINGi | 9606.ENSP00000244520 |
PTM databases
iPTMneti | P09234 |
PhosphoSitePlusi | P09234 |
SwissPalmi | P09234 |
Polymorphism and mutation databases
BioMutai | SNRPC |
DMDMi | 134093 |
Proteomic databases
CPTACi | CPTAC-947 |
EPDi | P09234 |
jPOSTi | P09234 |
MassIVEi | P09234 |
PaxDbi | P09234 |
PeptideAtlasi | P09234 |
PRIDEi | P09234 |
ProteomicsDBi | 52209 |
Protocols and materials databases
Antibodypediai | 45711, 68 antibodies |
Genome annotation databases
Ensembli | ENST00000244520; ENSP00000244520; ENSG00000124562 |
GeneIDi | 6631 |
KEGGi | hsa:6631 |
Organism-specific databases
CTDi | 6631 |
DisGeNETi | 6631 |
EuPathDBi | HostDB:ENSG00000124562.9 |
GeneCardsi | SNRPC |
HGNCi | HGNC:11157, SNRPC |
HPAi | ENSG00000124562, Low tissue specificity |
MIMi | 603522, gene |
neXtProti | NX_P09234 |
OpenTargetsi | ENSG00000124562 |
PharmGKBi | PA35998 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3454, Eukaryota |
GeneTreei | ENSGT00730000110997 |
HOGENOMi | CLU_079697_3_0_1 |
InParanoidi | P09234 |
OrthoDBi | 1594407at2759 |
TreeFami | TF313578 |
Enzyme and pathway databases
PathwayCommonsi | P09234 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
Miscellaneous databases
BioGRID-ORCSi | 6631, 555 hits in 852 CRISPR screens |
ChiTaRSi | SNRPC, human |
EvolutionaryTracei | P09234 |
GeneWikii | Small_nuclear_ribonucleoprotein_polypeptide_C |
GenomeRNAii | 6631 |
Pharosi | P09234, Tbio |
PROi | PR:P09234 |
RNActi | P09234, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124562, Expressed in apex of heart and 247 other tissues |
ExpressionAtlasi | P09234, baseline and differential |
Genevisiblei | P09234, HS |
Family and domain databases
HAMAPi | MF_03153, U1_C, 1 hit |
IDEALi | IID00139 |
InterProi | View protein in InterPro IPR000690, Matrin/U1-C_Znf_C2H2 IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR013085, U1-CZ_Znf_C2H2 IPR017340, U1_snRNP-C IPR036236, Znf_C2H2_sf |
PANTHERi | PTHR31148, PTHR31148, 1 hit |
Pfami | View protein in Pfam PF06220, zf-U1, 1 hit |
PIRSFi | PIRSF037969, U1_snRNP-C, 1 hit |
SMARTi | View protein in SMART SM00451, ZnF_U1, 1 hit |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50171, ZF_MATRIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RU1C_HUMAN | |
Accessioni | P09234Primary (citable) accession number: P09234 Secondary accession number(s): Q5TAL3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 189 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families