SNRPC

Functionⁱ

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.UniRule annotation4 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	4 – 36	Matrin-typeUniRule annotationAdd BLAST		33

GO - Molecular functionⁱ

mRNA binding Source: UniProtKB-UniRule
pre-mRNA 5'-splice site binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein homodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 8532530
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889
single-stranded RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 8798632
U1 snRNP binding Source: Ensembl
zinc ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15312772

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA 5'-splice site recognition
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mRNA splicing, via spliceosome
Source: UniProtKB
Inferred from direct assayⁱ
- 8972845
spliceosomal snRNP assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 8972845

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, RNA-binding
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: U1 small nuclear ribonucleoprotein CUniRule annotation Short name: U1 snRNP CUniRule annotation Short name: U1-CUniRule annotation Short name: U1CUniRule annotation
Gene namesⁱ	Name:SNRPCUniRule annotation
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000124562.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11157 SNRPC
MIMⁱ	603522 gene
neXtProtⁱ	NX_P09234

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	6	C → S: Abolishes the binding to U1 snRNP. 1 Publication	1
Mutagenesisⁱ	9	C → S: Abolishes the binding to U1 snRNP. 1 Publication	1
Mutagenesisⁱ	24	H → Q: Abolishes the binding to U1 snRNP. 1 Publication	1
Mutagenesisⁱ	25	C → S: No effect. 1 Publication	1
Mutagenesisⁱ	30	H → Q: Abolishes the binding to U1 snRNP. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6631
Open Targets More...OpenTargetsⁱ	ENSG00000124562
PharmGKBⁱ	PA35998

Polymorphism and mutation databases

BioMutaⁱ	SNRPC
DMDMⁱ	134093

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000097525	1 – 159	U1 small nuclear ribonucleoprotein CAdd BLAST		159

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	8	PhosphotyrosineCombined sources	1
Modified residueⁱ	17	PhosphoserineCombined sources	1
Modified residueⁱ	52	N6-acetyllysineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P09234
PaxDbⁱ	P09234
PeptideAtlas More...PeptideAtlasⁱ	P09234
PRIDEⁱ	P09234
ProteomicsDBⁱ	52209

PTM databases

iPTMnetⁱ	P09234
PhosphoSitePlusⁱ	P09234
SwissPalmⁱ	P09234

Miscellaneous databases

PMAP-CutDBⁱ	P09234

PMAP-CutDBⁱ

P09234

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000124562 Expressed in 232 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_SNRPC
ExpressionAtlasⁱ	P09234 baseline and differential
Genevisibleⁱ	P09234 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB034338 HPA055490

HPAⁱ

CAB034338
HPA055490

Interactionⁱ

Subunit structureⁱ

Component of the U1 snRNP (PubMed:2136774). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.UniRule annotation5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
RBM10	P98175	2	EBI-766589,EBI-721525
WDR83	Q9BRX9	2	EBI-766589,EBI-7705033

GO - Molecular functionⁱ

protein homodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 8532530

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112515, 94 interactors
CORUMⁱ	P09234
Database of interacting proteins More...DIPⁱ	DIP-34235N
IntActⁱ	P09234, 85 interactors
Molecular INTeraction database More...MINTⁱ	P09234
STRINGⁱ	9606.ENSP00000244520

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	4 – 6	Combined sources	3
Turnⁱ	7 – 10	Combined sources	4
Beta strandⁱ	11 – 15	Combined sources	5
Helixⁱ	18 – 25	Combined sources	8
Helixⁱ	28 – 53	Combined sources	26
Beta strandⁱ	56 – 59	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P09234
SMRⁱ	P09234
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P09234

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	63 – 157	Met/Pro-richAdd BLAST		95

Sequence similaritiesⁱ

Belongs to the U1 small nuclear ribonucleoprotein C family.UniRule annotation

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	4 – 36	Matrin-typeUniRule annotationAdd BLAST		33

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3454 Eukaryota COG5136 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110997
HOGENOMⁱ	HOG000238970
HOVERGENⁱ	HBG017763
InParanoidⁱ	P09234
KEGG Orthology (KO) More...KOⁱ	K11095
TreeFamⁱ	TF313578

Family and domain databases

HAMAPⁱ	MF_03153 U1_C, 1 hit
InterProⁱ	View protein in InterPro IPR000690 Matrin/U1-C_Znf_C2H2 IPR003604 Matrin/U1-like-C_Znf_C2H2 IPR013085 U1-CZ_Znf_C2H2 IPR017340 U1_snRNP-C IPR036236 Znf_C2H2_sf
PANTHERⁱ	PTHR31148 PTHR31148, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06220 zf-U1, 1 hit
PIRSFⁱ	PIRSF037969 U1_snRNP-C, 1 hit
SMARTⁱ	View protein in SMART SM00451 ZnF_U1, 1 hit
SUPFAMⁱ	SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS50171 ZF_MATRIN, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P09234-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPKFYCDYCD TYLTHDSPSV RKTHCSGRKH KENVKDYYQK WMEEQAQSLI 
        60         70         80         90        100
DKTTAAFQQG KIPPTPFSAP PPAGAMIPPP PSLPGPPRPG MMPAPHMGGP 
       110        120        130        140        150
PMMPMMGPPP PGMMPVGPAP GMRPPMGGHM PMMPGPPMMR PPARPMMVPT 

RPGMTRPDR

Length:159

Mass (Da):17,394

Last modified:July 1, 1989 - v1

Checksum:ⁱEC313A57DEC79D95

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0A0MRR7	A0A0A0MRR7_HUMAN	U1 small nuclear ribonucleoprotein ... U1 small nuclear ribonucleoprotein C, U1 snRNP C, U1-C, U1C	SNRPC	180	Annotation score:
Q5TAL2	Q5TAL2_HUMAN	U1 small nuclear ribonucleoprotein ... U1 small nuclear ribonucleoprotein C	SNRPC	118	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	25 – 27	CSG → RSR in AAA36618 (PubMed:2961811).Curated	3
Sequence conflictⁱ	94 – 98	APHMG → TPIW in AAA36618 (PubMed:2961811).Curated	5
Sequence conflictⁱ	101	P → S in AAA36618 (PubMed:2961811).Curated	1
Sequence conflictⁱ	129 – 131	HMP → ICQ in AAA36618 (PubMed:2961811).Curated	3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X12517 mRNA Translation: CAA31037.1 AL139100 Genomic DNA No translation available. M18465 mRNA Translation: AAA36618.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34436.1
PIRⁱ	S01387
NCBI Reference Sequences More...RefSeqⁱ	NP_003084.1, NM_003093.2
UniGeneⁱ	Hs.1063

Genome annotation databases

Ensemblⁱ	ENST00000244520; ENSP00000244520; ENSG00000124562
GeneIDⁱ	6631
KEGGⁱ	hsa:6631

Protein	Similar proteins		Species	Score	Length	Source
P09234	U1 small nuclear ribonucleoprotein C		BOVIN		159	UniRef100_P09234
U1 small nuclear ribonucleoprotein C		CANLF		159
U1 small nuclear ribonucleoprotein C		MACMU		159
U1 small nuclear ribonucleoprotein C		HUMAN		118
SNRPC isoform 2		PONAB		118
+51

Protein	Similar proteins		Species	Score	Length	Source
P09234	U1 small nuclear ribonucleoprotein C		BOVIN		159	UniRef90_P09234
U1 small nuclear ribonucleoprotein C		CANLF		159
U1 small nuclear ribonucleoprotein C		MACMU		159
U1 small nuclear ribonucleoprotein C		HUMAN		118
SNRPC isoform 2		PONAB		118
+51

Protein	Similar proteins		Species	Score	Length	Source
P09234	U1 small nuclear ribonucleoprotein C		BOVIN		159	UniRef50_P09234
U1 small nuclear ribonucleoprotein C		CANLF		159
U1 small nuclear ribonucleoprotein C		MACMU		159
U1 small nuclear ribonucleoprotein C		HUMAN		118
SNRPC isoform 2		PONAB		118
+51

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X12517 mRNA Translation: CAA31037.1 AL139100 Genomic DNA No translation available. M18465 mRNA Translation: AAA36618.1
CCDSⁱ	CCDS34436.1
PIRⁱ	S01387
RefSeqⁱ	NP_003084.1, NM_003093.2
UniGeneⁱ	Hs.1063

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2VRD	NMR	-	A	1-61	[»]
	3CW1	X-ray	5.49	0/9/L/l	1-77	[»]
	4PJO	X-ray	3.30	L/M/l/m	1-61	[»]
ProteinModelPortalⁱ	P09234
SMRⁱ	P09234
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112515, 94 interactors
CORUMⁱ	P09234
DIPⁱ	DIP-34235N
IntActⁱ	P09234, 85 interactors
MINTⁱ	P09234
STRINGⁱ	9606.ENSP00000244520

PTM databases

iPTMnetⁱ	P09234
PhosphoSitePlusⁱ	P09234
SwissPalmⁱ	P09234

Polymorphism and mutation databases

BioMutaⁱ	SNRPC
DMDMⁱ	134093

Proteomic databases

EPDⁱ	P09234
PaxDbⁱ	P09234
PeptideAtlasⁱ	P09234
PRIDEⁱ	P09234
ProteomicsDBⁱ	52209

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000244520; ENSP00000244520; ENSG00000124562
GeneIDⁱ	6631
KEGGⁱ	hsa:6631

Organism-specific databases

CTDⁱ	6631
DisGeNETⁱ	6631
EuPathDBⁱ	HostDB:ENSG00000124562.9
GeneCardsⁱ	SNRPC
H-InvDBⁱ	HIX0010405 HIX0171661
HGNCⁱ	HGNC:11157 SNRPC
HPAⁱ	CAB034338 HPA055490
MIMⁱ	603522 gene
neXtProtⁱ	NX_P09234
OpenTargetsⁱ	ENSG00000124562
PharmGKBⁱ	PA35998
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3454 Eukaryota COG5136 LUCA
GeneTreeⁱ	ENSGT00730000110997
HOGENOMⁱ	HOG000238970
HOVERGENⁱ	HBG017763
InParanoidⁱ	P09234
KOⁱ	K11095
TreeFamⁱ	TF313578

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

EvolutionaryTraceⁱ	P09234
GeneWikiⁱ	Small_nuclear_ribonucleoprotein_polypeptide_C
GenomeRNAiⁱ	6631
PMAP-CutDBⁱ	P09234
Protein Ontology More...PROⁱ	PR:P09234
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000124562 Expressed in 232 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_SNRPC
ExpressionAtlasⁱ	P09234 baseline and differential
Genevisibleⁱ	P09234 HS

Family and domain databases

HAMAPⁱ	MF_03153 U1_C, 1 hit
InterProⁱ	View protein in InterPro IPR000690 Matrin/U1-C_Znf_C2H2 IPR003604 Matrin/U1-like-C_Znf_C2H2 IPR013085 U1-CZ_Znf_C2H2 IPR017340 U1_snRNP-C IPR036236 Znf_C2H2_sf
PANTHERⁱ	PTHR31148 PTHR31148, 1 hit
Pfamⁱ	View protein in Pfam PF06220 zf-U1, 1 hit
PIRSFⁱ	PIRSF037969 U1_snRNP-C, 1 hit
SMARTⁱ	View protein in SMART SM00451 ZnF_U1, 1 hit
SUPFAMⁱ	SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS50171 ZF_MATRIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RU1C_HUMAN
Accessionⁱ	P09234Primary (citable) accession number: P09234 Secondary accession number(s): Q5TAL3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 1, 1989
	Last modified:	November 7, 2018
	This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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UniProtKB - P09234 (RU1C_HUMAN)

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U1 small nuclear ribonucleoprotein C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ