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UniProtKB - P09234 (RU1C_HUMAN)

Entry version 189 (02 Dec 2020)
Sequence version 1 (01 Jul 1989)
Previous versions | rss
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Protein

U1 small nuclear ribonucleoprotein C

Gene

SNRPC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.UniRule annotation4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri4 – 36Matrin-typeUniRule annotationAdd BLAST33

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P09234

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-72163, mRNA Splicing - Major Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
U1 small nuclear ribonucleoprotein CUniRule annotation
Short name:
U1 snRNP CUniRule annotation
Short name:
U1-CUniRule annotation
Short name:
U1CUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNRPCUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000124562.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:11157, SNRPC

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603522, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P09234

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi6C → S: Abolishes the binding to U1 snRNP. 1 Publication1
Mutagenesisi9C → S: Abolishes the binding to U1 snRNP. 1 Publication1
Mutagenesisi24H → Q: Abolishes the binding to U1 snRNP. 1 Publication1
Mutagenesisi25C → S: No effect. 1 Publication1
Mutagenesisi30H → Q: Abolishes the binding to U1 snRNP. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		6631

Open Targets

More...OpenTargetsi		ENSG00000124562

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35998

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P09234, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SNRPC

Domain mapping of disease mutations (DMDM)

More...DMDMi		134093

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000975251 – 159U1 small nuclear ribonucleoprotein CAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8PhosphotyrosineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei52N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-947

Encyclopedia of Proteome Dynamics

More...EPDi		P09234

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P09234

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P09234

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P09234

PeptideAtlas

More...PeptideAtlasi		P09234

PRoteomics IDEntifications database

More...PRIDEi		P09234

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52209

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P09234

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P09234

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P09234

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000124562, Expressed in apex of heart and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P09234, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P09234, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000124562, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the U1 snRNP (PubMed:2136774). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

UniRule annotation5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P09234
With#Exp.IntAct
AKAP8L [Q9ULX6]3EBI-766589,EBI-357530
ANKRD10 - isoform 2 [Q9NXR5-2]3EBI-766589,EBI-12102070
ARHGAP9 [Q9BRR9]3EBI-766589,EBI-750254
BAG4 [O95429]3EBI-766589,EBI-2949658
BCAS2 [O75934]3EBI-766589,EBI-1050106
BOLL - isoform 4 [Q8N9W6-4]3EBI-766589,EBI-11983447
C19orf54 - isoform 3 [Q5BKX5-3]3EBI-766589,EBI-11976299
CREM - isoform 22 [Q03060-25]3EBI-766589,EBI-12884642
CYSRT1 [A8MQ03]3EBI-766589,EBI-3867333
DAZAP2 [Q15038]3EBI-766589,EBI-724310
ECM1 [Q16610]3EBI-766589,EBI-947964
EXOSC8 [Q96B26]3EBI-766589,EBI-371922
EYA2 - isoform 2 [O00167-2]3EBI-766589,EBI-12807776
FAM168B - isoform 2 [A1KXE4-2]3EBI-766589,EBI-12193763
FHL3 [Q13643]3EBI-766589,EBI-741101
FUBP1 - isoform 2 [Q96AE4-2]3EBI-766589,EBI-12121668
GIGYF1 [O75420]3EBI-766589,EBI-947774
HNRNPDL [O14979]3EBI-766589,EBI-299727
HNRNPH1 [P31943]3EBI-766589,EBI-351590
HOXA1 [P49639]5EBI-766589,EBI-740785
HSD17B14 [Q9BPX1]3EBI-766589,EBI-742664
INTS11 [Q5TA45]3EBI-766589,EBI-748258
JMJD7 [P0C870]5EBI-766589,EBI-9090173
KLF1 [Q13351]3EBI-766589,EBI-8284732
KRTAP11-1 [Q8IUC1]3EBI-766589,EBI-1052037
KRTAP13-2 [Q52LG2]3EBI-766589,EBI-11953846
KRTAP19-2 [Q3LHN2]3EBI-766589,EBI-12196745
KRTAP19-5 [Q3LI72]3EBI-766589,EBI-1048945
KRTAP19-6 [Q3LI70]3EBI-766589,EBI-12805508
KRTAP21-2 [Q3LI59]3EBI-766589,EBI-18395721
KRTAP6-2 [Q3LI66]5EBI-766589,EBI-11962084
KRTAP7-1 [Q8IUC3]3EBI-766589,EBI-18394498
KRTAP8-1 [Q8IUC2]3EBI-766589,EBI-10261141
MAGED1 [Q9Y5V3]3EBI-766589,EBI-716006
METTL27 [Q8N6F8]3EBI-766589,EBI-8487781
MKRN3 [Q13064]3EBI-766589,EBI-2340269
NCKIPSD - isoform 3 [Q9NZQ3-3]3EBI-766589,EBI-10963850
ODAM [A1E959]3EBI-766589,EBI-5774125
PLA2G10 [O15496]3EBI-766589,EBI-726466
PRDM14 [Q9GZV8]3EBI-766589,EBI-3957793
PRR20D [P86480]3EBI-766589,EBI-12754095
RAMAC [Q9BTL3]3EBI-766589,EBI-744023
RBM10 [P98175]2EBI-766589,EBI-721525
RBPMS - isoform C [Q93062-3]3EBI-766589,EBI-740343
RERE [Q9P2R6]3EBI-766589,EBI-948076
RUNX1 - isoform AML-1G [Q01196-8]3EBI-766589,EBI-12001422
SEC23B [Q15437]3EBI-766589,EBI-742673
SPAG8 - isoform 2 [Q99932-2]3EBI-766589,EBI-11959123
STH [Q8IWL8]3EBI-766589,EBI-12843506
TIA1 [P31483]6EBI-766589,EBI-1387216
TLE5 - isoform 2 [Q08117-2]3EBI-766589,EBI-11741437
TRIB3 [Q96RU7]3EBI-766589,EBI-492476
UFSP1 [Q6NVU6]3EBI-766589,EBI-12068150
WDR83 [Q9BRX9]2EBI-766589,EBI-7705033
WWOX - isoform 5 [Q9NZC7-5]3EBI-766589,EBI-12040603
WWP2 [O00308]3EBI-766589,EBI-743923

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112515, 167 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P09234

Database of interacting proteins

More...DIPi		DIP-34235N

Protein interaction database and analysis system

More...IntActi		P09234, 100 interactors

Molecular INTeraction database

More...MINTi		P09234

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000244520

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P09234, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1159
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P09234

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P09234

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi63 – 157Met/Pro-richAdd BLAST95

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the U1 small nuclear ribonucleoprotein C family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 36Matrin-typeUniRule annotationAdd BLAST33

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3454, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00730000110997

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_079697_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P09234

Database of Orthologous Groups

More...OrthoDBi		1594407at2759

TreeFam database of animal gene trees

More...TreeFami		TF313578

Family and domain databases

HAMAP database of protein families

More...HAMAPi		MF_03153, U1_C, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00139

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000690, Matrin/U1-C_Znf_C2H2
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR013085, U1-CZ_Znf_C2H2
IPR017340, U1_snRNP-C
IPR036236, Znf_C2H2_sf

The PANTHER Classification System

More...PANTHERi		PTHR31148, PTHR31148, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06220, zf-U1, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037969, U1_snRNP-C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00451, ZnF_U1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50171, ZF_MATRIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P09234-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKFYCDYCD TYLTHDSPSV RKTHCSGRKH KENVKDYYQK WMEEQAQSLI 
        60         70         80         90        100
DKTTAAFQQG KIPPTPFSAP PPAGAMIPPP PSLPGPPRPG MMPAPHMGGP 
       110        120        130        140        150
PMMPMMGPPP PGMMPVGPAP GMRPPMGGHM PMMPGPPMMR PPARPMMVPT 

RPGMTRPDR
Length:159
Mass (Da):17,394
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC313A57DEC79D95
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRR7A0A0A0MRR7_HUMAN
U1 small nuclear ribonucleoprotein ...
SNRPC
180Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TAL2Q5TAL2_HUMAN
U1 small nuclear ribonucleoprotein ...
SNRPC
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25 – 27CSG → RSR in AAA36618 (PubMed:2961811).Curated3
Sequence conflicti94 – 98APHMG → TPIW in AAA36618 (PubMed:2961811).Curated5
Sequence conflicti101P → S in AAA36618 (PubMed:2961811).Curated1
Sequence conflicti129 – 131HMP → ICQ in AAA36618 (PubMed:2961811).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X12517 mRNA Translation: CAA31037.1
AL139100 Genomic DNA No translation available.
M18465 mRNA Translation: AAA36618.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34436.1

Protein sequence database of the Protein Information Resource

More...PIRi		S01387

NCBI Reference Sequences

More...RefSeqi		NP_003084.1, NM_003093.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000244520; ENSP00000244520; ENSG00000124562

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6631

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6631

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12517 mRNA Translation: CAA31037.1
AL139100 Genomic DNA No translation available.
M18465 mRNA Translation: AAA36618.1
CCDSiCCDS34436.1
PIRiS01387
RefSeqiNP_003084.1, NM_003093.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VRDNMR-A1-61[»]
3CW1X-ray5.490/9/L/l1-77[»]
4PJOX-ray3.30L/M/l/m1-61[»]
6ELDX-ray2.48A30-61[»]
6QX9electron microscopy3.281C1-159[»]
SMRiP09234
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112515, 167 interactors
CORUMiP09234
DIPiDIP-34235N
IntActiP09234, 100 interactors
MINTiP09234
STRINGi9606.ENSP00000244520

PTM databases

iPTMnetiP09234
PhosphoSitePlusiP09234
SwissPalmiP09234

Polymorphism and mutation databases

BioMutaiSNRPC
DMDMi134093

Proteomic databases

CPTACiCPTAC-947
EPDiP09234
jPOSTiP09234
MassIVEiP09234
PaxDbiP09234
PeptideAtlasiP09234
PRIDEiP09234
ProteomicsDBi52209

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		45711, 68 antibodies

Genome annotation databases

EnsembliENST00000244520; ENSP00000244520; ENSG00000124562
GeneIDi6631
KEGGihsa:6631

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6631
DisGeNETi6631
EuPathDBiHostDB:ENSG00000124562.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		SNRPC
HGNCiHGNC:11157, SNRPC
HPAiENSG00000124562, Low tissue specificity
MIMi603522, gene
neXtProtiNX_P09234
OpenTargetsiENSG00000124562
PharmGKBiPA35998

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3454, Eukaryota
GeneTreeiENSGT00730000110997
HOGENOMiCLU_079697_3_0_1
InParanoidiP09234
OrthoDBi1594407at2759
TreeFamiTF313578

Enzyme and pathway databases

PathwayCommonsiP09234
ReactomeiR-HSA-72163, mRNA Splicing - Major Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6631, 555 hits in 852 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SNRPC, human
EvolutionaryTraceiP09234

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Small_nuclear_ribonucleoprotein_polypeptide_C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6631
PharosiP09234, Tbio

Protein Ontology

More...PROi		PR:P09234
RNActiP09234, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000124562, Expressed in apex of heart and 247 other tissues
ExpressionAtlasiP09234, baseline and differential
GenevisibleiP09234, HS

Family and domain databases

HAMAPiMF_03153, U1_C, 1 hit
IDEALiIID00139
InterProiView protein in InterPro
IPR000690, Matrin/U1-C_Znf_C2H2
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR013085, U1-CZ_Znf_C2H2
IPR017340, U1_snRNP-C
IPR036236, Znf_C2H2_sf
PANTHERiPTHR31148, PTHR31148, 1 hit
PfamiView protein in Pfam
PF06220, zf-U1, 1 hit
PIRSFiPIRSF037969, U1_snRNP-C, 1 hit
SMARTiView protein in SMART
SM00451, ZnF_U1, 1 hit
SUPFAMiSSF57667, SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50171, ZF_MATRIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRU1C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09234
Secondary accession number(s): Q5TAL3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: December 2, 2020
This is version 189 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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