Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cystatin-SA

Gene

CST2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thiol protease inhibitor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei32Reactive site1

GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.009

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-SA
Alternative name(s):
Cystatin-2
Cystatin-S5
Gene namesi
Name:CST2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000170369.3
HGNCiHGNC:2474 CST2
MIMi123856 gene
neXtProtiNX_P09228

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1470
OpenTargetsiENSG00000170369
PharmGKBiPA26975

Polymorphism and mutation databases

BioMutaiCST2
DMDMi118192

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 202 PublicationsAdd BLAST20
ChainiPRO_000000665221 – 141Cystatin-SAAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 1041 Publication
Disulfide bondi118 ↔ 1381 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP09228
PaxDbiP09228
PeptideAtlasiP09228
PRIDEiP09228
ProteomicsDBi52208

Expressioni

Tissue specificityi

Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in submandibular gland and parotid gland.2 Publications

Gene expression databases

BgeeiENSG00000170369 Expressed in 108 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_CST2
GenevisibleiP09228 HS

Organism-specific databases

HPAiCAB024963
HPA043706
HPA044763

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi107852, 30 interactors
IntActiP09228, 8 interactors
STRINGi9606.ENSP00000307540

Structurei

3D structure databases

ProteinModelPortaliP09228
SMRiP09228
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi76 – 80Secondary area of contact5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZZH Eukaryota
ENOG4112CFJ LUCA
GeneTreeiENSGT00900000140934
HOGENOMiHOG000231754
HOVERGENiHBG009556
InParanoidiP09228
KOiK13898
OMAiKIARTMC
OrthoDBiEOG091G0TP1
PhylomeDBiP09228

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
IPR018073 Prot_inh_cystat_CS
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 1 hit
PROSITEiView protein in PROSITE
PS00287 CYSTATIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09228-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWPLCTLLL LLATQAVALA WSPQEEDRII EGGIYDADLN DERVQRALHF
60 70 80 90 100
VISEYNKATE DEYYRRLLRV LRAREQIVGG VNYFFDIEVG RTICTKSQPN
110 120 130 140
LDTCAFHEQP ELQKKQLCSF QIYEVPWEDR MSLVNSRCQE A
Length:141
Mass (Da):16,445
Last modified:July 1, 1989 - v1
Checksum:iEB54915B1B977AA2
GO

Mass spectrometryi

Molecular mass is 14336.9856±0.0158 Da from positions 21 - 141. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19673, M19671, M19672 Genomic DNA Translation: AAA36116.1
AF319564 Genomic DNA Translation: AAK11570.1
AL591074 Genomic DNA No translation available.
BC062679 mRNA Translation: AAH62679.1
CCDSiCCDS13161.1
PIRiB29632
RefSeqiNP_001313.1, NM_001322.2
UniGeneiHs.669305

Genome annotation databases

EnsembliENST00000304725; ENSP00000307540; ENSG00000170369
GeneIDi1470
KEGGihsa:1470
UCSCiuc002wtq.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19673, M19671, M19672 Genomic DNA Translation: AAA36116.1
AF319564 Genomic DNA Translation: AAK11570.1
AL591074 Genomic DNA No translation available.
BC062679 mRNA Translation: AAH62679.1
CCDSiCCDS13161.1
PIRiB29632
RefSeqiNP_001313.1, NM_001322.2
UniGeneiHs.669305

3D structure databases

ProteinModelPortaliP09228
SMRiP09228
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107852, 30 interactors
IntActiP09228, 8 interactors
STRINGi9606.ENSP00000307540

Protein family/group databases

MEROPSiI25.009

Polymorphism and mutation databases

BioMutaiCST2
DMDMi118192

Proteomic databases

EPDiP09228
PaxDbiP09228
PeptideAtlasiP09228
PRIDEiP09228
ProteomicsDBi52208

Protocols and materials databases

DNASUi1470
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304725; ENSP00000307540; ENSG00000170369
GeneIDi1470
KEGGihsa:1470
UCSCiuc002wtq.2 human

Organism-specific databases

CTDi1470
DisGeNETi1470
EuPathDBiHostDB:ENSG00000170369.3
GeneCardsiCST2
HGNCiHGNC:2474 CST2
HPAiCAB024963
HPA043706
HPA044763
MIMi123856 gene
neXtProtiNX_P09228
OpenTargetsiENSG00000170369
PharmGKBiPA26975
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZZH Eukaryota
ENOG4112CFJ LUCA
GeneTreeiENSGT00900000140934
HOGENOMiHOG000231754
HOVERGENiHBG009556
InParanoidiP09228
KOiK13898
OMAiKIARTMC
OrthoDBiEOG091G0TP1
PhylomeDBiP09228

Miscellaneous databases

ChiTaRSiCST2 human
GeneWikiiCST2
GenomeRNAii1470
PROiPR:P09228
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170369 Expressed in 108 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_CST2
GenevisibleiP09228 HS

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
IPR018073 Prot_inh_cystat_CS
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 1 hit
PROSITEiView protein in PROSITE
PS00287 CYSTATIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYTT_HUMAN
AccessioniPrimary (citable) accession number: P09228
Secondary accession number(s): Q9UCQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again