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Protein

Glutathione S-transferase P

Gene

GSTP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei8Glutathione7 Publications1
Binding sitei14Glutathione7 Publications1
Binding sitei39Glutathione7 Publications1
Binding sitei45Glutathione7 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.5.1.18 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-156590 Glutathione conjugation
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-6798695 Neutrophil degranulation

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P09211

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P09211

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001615

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutathione S-transferase P (EC:2.5.1.18)
Alternative name(s):
GST class-pi
GSTP1-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GSTP1
Synonyms:FAEES3, GST3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000084207.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4638 GSTP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
134660 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P09211

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi8Y → F: Reduces catalytic activity about 50-fold. 2 Publications1
Mutagenesisi99D → A: Reduces affinity for glutathione. Slightly reduced catalytic activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
2950

Open Targets

More...
OpenTargetsi
ENSG00000084207

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29028

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3902

Drug and drug target database

More...
DrugBanki
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB01008 Busulfan
DB04972 Canfosfamide
DB04339 Carbocisteine
DB00958 Carboplatin
DB00291 Chlorambucil
DB02633 Cibacron Blue
DB00515 Cisplatin
DB01242 Clomipramine
DB00773 Etoposide
DB00143 Glutathione
DB03003 Glutathione Sulfonic Acid
DB04077 Glycerol
DB00526 Oxaliplatin
DB08370 S-(4-BROMOBENZYL)CYSTEINE
DB03686 S-(P-Nitrobenzyl)Glutathione
DB04132 S-Hexylglutathione
DB01915 S-Hydroxycysteine
DB07849 S-NONYL-CYSTEINE
DB05460 TLK-199
DB00163 Vitamin E

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GSTP1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources5 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001859002 – 210Glutathione S-transferase PAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4Phosphotyrosine; by EGFR1 Publication1
Modified residuei62PhosphothreonineCombined sources1
Modified residuei103N6-succinyllysineBy similarity1
Modified residuei116N6-succinyllysineBy similarity1
Modified residuei128N6-acetyllysineCombined sources1
Modified residuei199Phosphotyrosine; by EGFR1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P09211

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P09211

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P09211

PeptideAtlas

More...
PeptideAtlasi
P09211

PRoteomics IDEntifications database

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PRIDEi
P09211

ProteomicsDB human proteome resource

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ProteomicsDBi
12638
52207

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P09211

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P09211

USC-OGP 2-DE database

More...
OGPi
P09211

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00219757

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P09211

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P09211

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P09211

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P09211

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P09211

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P09211

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000084207 Expressed in 229 organ(s), highest expression level in esophagus mucosa

CleanEx database of gene expression profiles

More...
CleanExi
HS_GSTP1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P09211 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P09211 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019779
HPA019869

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with CDK5.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109205, 54 interactors

Protein interaction database and analysis system

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IntActi
P09211, 59 interactors

Molecular INTeraction database

More...
MINTi
P09211

STRING: functional protein association networks

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STRINGi
9606.ENSP00000381607

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P09211

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
10GSX-ray2.20A/B2-210[»]
11GSX-ray2.30A/B1-210[»]
12GSX-ray2.10A/B1-210[»]
13GSX-ray1.90A/B1-210[»]
14GSX-ray2.80A/B1-210[»]
16GSX-ray1.90A/B1-210[»]
17GSX-ray1.90A/B1-210[»]
18GSX-ray1.90A/B1-210[»]
19GSX-ray1.90A/B2-210[»]
1AQVX-ray1.94A/B2-210[»]
1AQWX-ray1.80A/B/C/D2-210[»]
1AQXX-ray2.00A/B/C/D2-210[»]
1EOGX-ray2.10A/B3-210[»]
1EOHX-ray2.50A/B/C/D/E/F/G/H2-210[»]
1GSSX-ray2.80A/B2-210[»]
1KBNX-ray2.00A/B2-210[»]
1LBKX-ray1.86A/B2-203[»]
1MD3X-ray2.03A/B2-210[»]
1MD4X-ray2.10A/B2-210[»]
1PGTX-ray1.80A/B1-210[»]
1PX6X-ray2.10A/B2-210[»]
1PX7X-ray2.03A/B2-210[»]
1ZGNX-ray2.10A/B2-210[»]
20GSX-ray2.45A/B2-210[»]
22GSX-ray1.90A/B1-210[»]
2A2RX-ray1.40A/B1-210[»]
2A2SX-ray1.70A/B1-210[»]
2GSSX-ray1.90A/B2-210[»]
2J9HX-ray2.40A/B2-210[»]
2PGTX-ray1.90A/B1-210[»]
3CSHX-ray1.55A/B2-210[»]
3CSIX-ray1.90A/B/C/D2-210[»]
3CSJX-ray1.90A/B2-210[»]
3DD3X-ray2.25A/B1-210[»]
3DGQX-ray1.60A/B1-210[»]
3GSSX-ray1.90A/B2-210[»]
3GUSX-ray1.53A/B2-210[»]
3HJMX-ray2.10A/B/C/D2-210[»]
3HJOX-ray1.95A/B2-210[»]
3HKRX-ray1.80A/B2-210[»]
3IE3X-ray1.80A/B2-210[»]
3KM6X-ray2.10A/B2-210[»]
3KMNX-ray1.80A/B2-210[»]
3KMOX-ray2.60A/B2-210[»]
3N9JX-ray1.85A/B1-210[»]
3PGTX-ray2.14A/B1-210[»]
4GSSX-ray2.50A/B2-210[»]
4PGTX-ray2.10A/B1-210[»]
5DAKX-ray2.11A/B1-210[»]
5DALX-ray1.50A/B1-210[»]
5DCGX-ray2.01A/B1-210[»]
5DDLX-ray1.98A/B1-210[»]
5DJLX-ray1.80A/B1-210[»]
5DJMX-ray1.90A/B1-210[»]
5GSSX-ray1.95A/B2-210[»]
5J41X-ray1.19A/B2-210[»]
5JCWX-ray1.95A/B1-210[»]
5L6XX-ray2.00A/B1-210[»]
5X79X-ray1.90A/B1-210[»]
6AP9X-ray1.55A/B1-210[»]
6GSSX-ray1.90A/B2-210[»]
7GSSX-ray2.20A/B2-210[»]
8GSSX-ray1.90A/B/C2-210[»]
9GSSX-ray1.97A/B2-210[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P09211

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P09211

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P09211

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 81GST N-terminalAdd BLAST80
Domaini83 – 204GST C-terminalAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni52 – 53Glutathione binding7 Publications2
Regioni65 – 66Glutathione binding7 Publications2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GST superfamily. Pi family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1695 Eukaryota
ENOG4111VAU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162460

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115733

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108324

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P09211

KEGG Orthology (KO)

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KOi
K00799

Identification of Orthologs from Complete Genome Data

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OMAi
LRCKYAT

Database of Orthologous Groups

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OrthoDBi
1162336at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P09211

TreeFam database of animal gene trees

More...
TreeFami
TF105321

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR003082 GST_pi
IPR036249 Thioredoxin-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01268 GSTRNSFRASEP

Structure-Function Linkage Database

More...
SFLDi
SFLDS00019 Glutathione_Transferase_(cytos, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P09211-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPYTVVYFP VRGRCAALRM LLADQGQSWK EEVVTVETWQ EGSLKASCLY
60 70 80 90 100
GQLPKFQDGD LTLYQSNTIL RHLGRTLGLY GKDQQEAALV DMVNDGVEDL
110 120 130 140 150
RCKYISLIYT NYEAGKDDYV KALPGQLKPF ETLLSQNQGG KTFIVGDQIS
160 170 180 190 200
FADYNLLDLL LIHEVLAPGC LDAFPLLSAY VGRLSARPKL KAFLASPEYV
210
NLPINGNGKQ
Length:210
Mass (Da):23,356
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i409E33FFAA338396
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MX94A8MX94_HUMAN
Glutathione S-transferase P
GSTP1
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X2E9A0A087X2E9_HUMAN
Glutathione S-transferase P
GSTP1
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X243A0A087X243_HUMAN
Glutathione S-transferase P
GSTP1
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5E5A0A2R8Y5E5_HUMAN
Glutathione S-transferase P
GSTP1
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti186A → P in CAA30894 (PubMed:3196325).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014499105I → V in allele GSTP1*B and allele GSTP1*C. 3 PublicationsCorresponds to variant dbSNP:rs1695EnsemblClinVar.1
Natural variantiVAR_014500114A → V in allele GSTP1*C. 2 PublicationsCorresponds to variant dbSNP:rs1138272Ensembl.1
Natural variantiVAR_049493169G → D. Corresponds to variant dbSNP:rs41462048Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X06547 mRNA Translation: CAA29794.1
M24485 Genomic DNA Translation: AAA56823.1
X08058 Genomic DNA Translation: CAA30847.1
X08094, X08095, X08096 Genomic DNA Translation: CAA30894.1
X15480 mRNA Translation: CAA33508.1
U12472 Genomic DNA Translation: AAA64919.1
U30897 mRNA Translation: AAC51280.1
U62589 mRNA Translation: AAC51237.1
U21689 Genomic DNA Translation: AAC13869.1
BT019949 mRNA Translation: AAV38752.1
BT019950 mRNA Translation: AAV38753.1
CR450361 mRNA Translation: CAG29357.1
AY324387 Genomic DNA Translation: AAP72967.1
BC010915 mRNA Translation: AAH10915.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41679.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A41177
JS0153 A37378

NCBI Reference Sequences

More...
RefSeqi
NP_000843.1, NM_000852.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.523836

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000398606; ENSP00000381607; ENSG00000084207
ENST00000642444; ENSP00000493538; ENSG00000084207

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2950

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2950

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06547 mRNA Translation: CAA29794.1
M24485 Genomic DNA Translation: AAA56823.1
X08058 Genomic DNA Translation: CAA30847.1
X08094, X08095, X08096 Genomic DNA Translation: CAA30894.1
X15480 mRNA Translation: CAA33508.1
U12472 Genomic DNA Translation: AAA64919.1
U30897 mRNA Translation: AAC51280.1
U62589 mRNA Translation: AAC51237.1
U21689 Genomic DNA Translation: AAC13869.1
BT019949 mRNA Translation: AAV38752.1
BT019950 mRNA Translation: AAV38753.1
CR450361 mRNA Translation: CAG29357.1
AY324387 Genomic DNA Translation: AAP72967.1
BC010915 mRNA Translation: AAH10915.1
CCDSiCCDS41679.1
PIRiA41177
JS0153 A37378
RefSeqiNP_000843.1, NM_000852.3
UniGeneiHs.523836

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
10GSX-ray2.20A/B2-210[»]
11GSX-ray2.30A/B1-210[»]
12GSX-ray2.10A/B1-210[»]
13GSX-ray1.90A/B1-210[»]
14GSX-ray2.80A/B1-210[»]
16GSX-ray1.90A/B1-210[»]
17GSX-ray1.90A/B1-210[»]
18GSX-ray1.90A/B1-210[»]
19GSX-ray1.90A/B2-210[»]
1AQVX-ray1.94A/B2-210[»]
1AQWX-ray1.80A/B/C/D2-210[»]
1AQXX-ray2.00A/B/C/D2-210[»]
1EOGX-ray2.10A/B3-210[»]
1EOHX-ray2.50A/B/C/D/E/F/G/H2-210[»]
1GSSX-ray2.80A/B2-210[»]
1KBNX-ray2.00A/B2-210[»]
1LBKX-ray1.86A/B2-203[»]
1MD3X-ray2.03A/B2-210[»]
1MD4X-ray2.10A/B2-210[»]
1PGTX-ray1.80A/B1-210[»]
1PX6X-ray2.10A/B2-210[»]
1PX7X-ray2.03A/B2-210[»]
1ZGNX-ray2.10A/B2-210[»]
20GSX-ray2.45A/B2-210[»]
22GSX-ray1.90A/B1-210[»]
2A2RX-ray1.40A/B1-210[»]
2A2SX-ray1.70A/B1-210[»]
2GSSX-ray1.90A/B2-210[»]
2J9HX-ray2.40A/B2-210[»]
2PGTX-ray1.90A/B1-210[»]
3CSHX-ray1.55A/B2-210[»]
3CSIX-ray1.90A/B/C/D2-210[»]
3CSJX-ray1.90A/B2-210[»]
3DD3X-ray2.25A/B1-210[»]
3DGQX-ray1.60A/B1-210[»]
3GSSX-ray1.90A/B2-210[»]
3GUSX-ray1.53A/B2-210[»]
3HJMX-ray2.10A/B/C/D2-210[»]
3HJOX-ray1.95A/B2-210[»]
3HKRX-ray1.80A/B2-210[»]
3IE3X-ray1.80A/B2-210[»]
3KM6X-ray2.10A/B2-210[»]
3KMNX-ray1.80A/B2-210[»]
3KMOX-ray2.60A/B2-210[»]
3N9JX-ray1.85A/B1-210[»]
3PGTX-ray2.14A/B1-210[»]
4GSSX-ray2.50A/B2-210[»]
4PGTX-ray2.10A/B1-210[»]
5DAKX-ray2.11A/B1-210[»]
5DALX-ray1.50A/B1-210[»]
5DCGX-ray2.01A/B1-210[»]
5DDLX-ray1.98A/B1-210[»]
5DJLX-ray1.80A/B1-210[»]
5DJMX-ray1.90A/B1-210[»]
5GSSX-ray1.95A/B2-210[»]
5J41X-ray1.19A/B2-210[»]
5JCWX-ray1.95A/B1-210[»]
5L6XX-ray2.00A/B1-210[»]
5X79X-ray1.90A/B1-210[»]
6AP9X-ray1.55A/B1-210[»]
6GSSX-ray1.90A/B2-210[»]
7GSSX-ray2.20A/B2-210[»]
8GSSX-ray1.90A/B/C2-210[»]
9GSSX-ray1.97A/B2-210[»]
ProteinModelPortaliP09211
SMRiP09211
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109205, 54 interactors
IntActiP09211, 59 interactors
MINTiP09211
STRINGi9606.ENSP00000381607

Chemistry databases

BindingDBiP09211
ChEMBLiCHEMBL3902
DrugBankiDB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB01008 Busulfan
DB04972 Canfosfamide
DB04339 Carbocisteine
DB00958 Carboplatin
DB00291 Chlorambucil
DB02633 Cibacron Blue
DB00515 Cisplatin
DB01242 Clomipramine
DB00773 Etoposide
DB00143 Glutathione
DB03003 Glutathione Sulfonic Acid
DB04077 Glycerol
DB00526 Oxaliplatin
DB08370 S-(4-BROMOBENZYL)CYSTEINE
DB03686 S-(P-Nitrobenzyl)Glutathione
DB04132 S-Hexylglutathione
DB01915 S-Hydroxycysteine
DB07849 S-NONYL-CYSTEINE
DB05460 TLK-199
DB00163 Vitamin E
SwissLipidsiSLP:000001615

PTM databases

iPTMnetiP09211
PhosphoSitePlusiP09211
SwissPalmiP09211

Polymorphism and mutation databases

BioMutaiGSTP1

2D gel databases

DOSAC-COBS-2DPAGEiP09211
OGPiP09211
REPRODUCTION-2DPAGEiIPI00219757
SWISS-2DPAGEiP09211
UCD-2DPAGEiP09211

Proteomic databases

EPDiP09211
jPOSTiP09211
PaxDbiP09211
PeptideAtlasiP09211
PRIDEiP09211
ProteomicsDBi12638
52207
TopDownProteomicsiP09211

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2950
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398606; ENSP00000381607; ENSG00000084207
ENST00000642444; ENSP00000493538; ENSG00000084207
GeneIDi2950
KEGGihsa:2950

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2950
DisGeNETi2950
EuPathDBiHostDB:ENSG00000084207.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GSTP1
HGNCiHGNC:4638 GSTP1
HPAiHPA019779
HPA019869
MIMi134660 gene
neXtProtiNX_P09211
OpenTargetsiENSG00000084207
PharmGKBiPA29028

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
GeneTreeiENSGT00940000162460
HOGENOMiHOG000115733
HOVERGENiHBG108324
InParanoidiP09211
KOiK00799
OMAiLRCKYAT
OrthoDBi1162336at2759
PhylomeDBiP09211
TreeFamiTF105321

Enzyme and pathway databases

BRENDAi2.5.1.18 2681
ReactomeiR-HSA-156590 Glutathione conjugation
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-6798695 Neutrophil degranulation
SABIO-RKiP09211
SIGNORiP09211

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GSTP1 human
EvolutionaryTraceiP09211

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GSTP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2950
PMAP-CutDBiP09211

Protein Ontology

More...
PROi
PR:P09211

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000084207 Expressed in 229 organ(s), highest expression level in esophagus mucosa
CleanExiHS_GSTP1
ExpressionAtlasiP09211 baseline and differential
GenevisibleiP09211 HS

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR003082 GST_pi
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01268 GSTRNSFRASEP
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGSTP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09211
Secondary accession number(s): O00460, Q15690, Q5TZY3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 220 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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