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Protein

Glutathione S-transferase P

Gene

GSTP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8Glutathione7 Publications1
Binding sitei14Glutathione7 Publications1
Binding sitei39Glutathione7 Publications1
Binding sitei45Glutathione7 Publications1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BRENDAi2.5.1.18 2681
ReactomeiR-HSA-156590 Glutathione conjugation
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-6798695 Neutrophil degranulation
SABIO-RKiP09211
SIGNORiP09211

Chemistry databases

SwissLipidsiSLP:000001615

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase P (EC:2.5.1.18)
Alternative name(s):
GST class-pi
GSTP1-1
Gene namesi
Name:GSTP1
Synonyms:FAEES3, GST3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000084207.15
HGNCiHGNC:4638 GSTP1
MIMi134660 gene
neXtProtiNX_P09211

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi8Y → F: Reduces catalytic activity about 50-fold. 2 Publications1
Mutagenesisi99D → A: Reduces affinity for glutathione. Slightly reduced catalytic activity. 1 Publication1

Organism-specific databases

DisGeNETi2950
OpenTargetsiENSG00000084207
PharmGKBiPA29028

Chemistry databases

ChEMBLiCHEMBL3902
DrugBankiDB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB01008 Busulfan
DB04972 Canfosfamide
DB04339 Carbocisteine
DB00958 Carboplatin
DB00291 Chlorambucil
DB02633 Cibacron Blue
DB00515 Cisplatin
DB01242 Clomipramine
DB00773 Etoposide
DB00143 Glutathione
DB03003 Glutathione Sulfonic Acid
DB04077 Glycerol
DB00526 Oxaliplatin
DB08370 S-(4-BROMOBENZYL)CYSTEINE
DB03686 S-(P-Nitrobenzyl)Glutathione
DB04132 S-Hexylglutathione
DB01915 S-Hydroxycysteine
DB07849 S-NONYL-CYSTEINE
DB05460 TLK-199
DB00163 Vitamin E

Polymorphism and mutation databases

BioMutaiGSTP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources5 Publications
ChainiPRO_00001859002 – 210Glutathione S-transferase PAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4Phosphotyrosine; by EGFR1 Publication1
Modified residuei62PhosphothreonineCombined sources1
Modified residuei103N6-succinyllysineBy similarity1
Modified residuei116N6-succinyllysineBy similarity1
Modified residuei128N6-acetyllysineCombined sources1
Modified residuei199Phosphotyrosine; by EGFR1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP09211
PaxDbiP09211
PeptideAtlasiP09211
PRIDEiP09211
ProteomicsDBi12638
52207
TopDownProteomicsiP09211

2D gel databases

DOSAC-COBS-2DPAGEiP09211
OGPiP09211
REPRODUCTION-2DPAGEiIPI00219757
SWISS-2DPAGEiP09211
UCD-2DPAGEiP09211

PTM databases

iPTMnetiP09211
PhosphoSitePlusiP09211
SwissPalmiP09211

Miscellaneous databases

PMAP-CutDBiP09211

Expressioni

Gene expression databases

BgeeiENSG00000084207 Expressed in 229 organ(s), highest expression level in esophagus mucosa
CleanExiHS_GSTP1
ExpressionAtlasiP09211 baseline and differential
GenevisibleiP09211 HS

Organism-specific databases

HPAiHPA019779
HPA019869

Interactioni

Subunit structurei

Homodimer. Interacts with CDK5.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109205, 52 interactors
IntActiP09211, 59 interactors
MINTiP09211
STRINGi9606.ENSP00000381607

Chemistry databases

BindingDBiP09211

Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP09211
SMRiP09211
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09211

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 81GST N-terminalAdd BLAST80
Domaini83 – 204GST C-terminalAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 53Glutathione binding7 Publications2
Regioni65 – 66Glutathione binding7 Publications2

Sequence similaritiesi

Belongs to the GST superfamily. Pi family.Curated

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
GeneTreeiENSGT00550000074559
HOGENOMiHOG000115733
HOVERGENiHBG108324
InParanoidiP09211
KOiK00799
OMAiLRCKYAT
OrthoDBiEOG091G0K2E
PhylomeDBiP09211
TreeFamiTF105321

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR003082 GST_pi
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01268 GSTRNSFRASEP
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P09211-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPYTVVYFP VRGRCAALRM LLADQGQSWK EEVVTVETWQ EGSLKASCLY
60 70 80 90 100
GQLPKFQDGD LTLYQSNTIL RHLGRTLGLY GKDQQEAALV DMVNDGVEDL
110 120 130 140 150
RCKYISLIYT NYEAGKDDYV KALPGQLKPF ETLLSQNQGG KTFIVGDQIS
160 170 180 190 200
FADYNLLDLL LIHEVLAPGC LDAFPLLSAY VGRLSARPKL KAFLASPEYV
210
NLPINGNGKQ
Length:210
Mass (Da):23,356
Last modified:January 23, 2007 - v2
Checksum:i409E33FFAA338396
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MX94A8MX94_HUMAN
Glutathione S-transferase P
GSTP1
174Annotation score:
A0A087X2E9A0A087X2E9_HUMAN
Glutathione S-transferase P
GSTP1
79Annotation score:
A0A087X243A0A087X243_HUMAN
Glutathione S-transferase P
GSTP1
69Annotation score:
A0A2R8Y5E5A0A2R8Y5E5_HUMAN
Glutathione S-transferase P
GSTP1
58Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186A → P in CAA30894 (PubMed:3196325).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014499105I → V in allele GSTP1*B and allele GSTP1*C. 3 PublicationsCorresponds to variant dbSNP:rs1695EnsemblClinVar.1
Natural variantiVAR_014500114A → V in allele GSTP1*C. 2 PublicationsCorresponds to variant dbSNP:rs1138272Ensembl.1
Natural variantiVAR_049493169G → D. Corresponds to variant dbSNP:rs41462048Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06547 mRNA Translation: CAA29794.1
M24485 Genomic DNA Translation: AAA56823.1
X08058 Genomic DNA Translation: CAA30847.1
X08094, X08095, X08096 Genomic DNA Translation: CAA30894.1
X15480 mRNA Translation: CAA33508.1
U12472 Genomic DNA Translation: AAA64919.1
U30897 mRNA Translation: AAC51280.1
U62589 mRNA Translation: AAC51237.1
U21689 Genomic DNA Translation: AAC13869.1
BT019949 mRNA Translation: AAV38752.1
BT019950 mRNA Translation: AAV38753.1
CR450361 mRNA Translation: CAG29357.1
AY324387 Genomic DNA Translation: AAP72967.1
BC010915 mRNA Translation: AAH10915.1
CCDSiCCDS41679.1
PIRiA41177
JS0153 A37378
RefSeqiNP_000843.1, NM_000852.3
UniGeneiHs.523836

Genome annotation databases

EnsembliENST00000398606; ENSP00000381607; ENSG00000084207
ENST00000642444; ENSP00000493538; ENSG00000084207
GeneIDi2950
KEGGihsa:2950

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06547 mRNA Translation: CAA29794.1
M24485 Genomic DNA Translation: AAA56823.1
X08058 Genomic DNA Translation: CAA30847.1
X08094, X08095, X08096 Genomic DNA Translation: CAA30894.1
X15480 mRNA Translation: CAA33508.1
U12472 Genomic DNA Translation: AAA64919.1
U30897 mRNA Translation: AAC51280.1
U62589 mRNA Translation: AAC51237.1
U21689 Genomic DNA Translation: AAC13869.1
BT019949 mRNA Translation: AAV38752.1
BT019950 mRNA Translation: AAV38753.1
CR450361 mRNA Translation: CAG29357.1
AY324387 Genomic DNA Translation: AAP72967.1
BC010915 mRNA Translation: AAH10915.1
CCDSiCCDS41679.1
PIRiA41177
JS0153 A37378
RefSeqiNP_000843.1, NM_000852.3
UniGeneiHs.523836

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
10GSX-ray2.20A/B2-210[»]
11GSX-ray2.30A/B1-210[»]
12GSX-ray2.10A/B1-210[»]
13GSX-ray1.90A/B1-210[»]
14GSX-ray2.80A/B1-210[»]
16GSX-ray1.90A/B1-210[»]
17GSX-ray1.90A/B1-210[»]
18GSX-ray1.90A/B1-210[»]
19GSX-ray1.90A/B2-210[»]
1AQVX-ray1.94A/B2-210[»]
1AQWX-ray1.80A/B/C/D2-210[»]
1AQXX-ray2.00A/B/C/D2-210[»]
1EOGX-ray2.10A/B3-210[»]
1EOHX-ray2.50A/B/C/D/E/F/G/H2-210[»]
1GSSX-ray2.80A/B2-210[»]
1KBNX-ray2.00A/B2-210[»]
1LBKX-ray1.86A/B2-203[»]
1MD3X-ray2.03A/B2-210[»]
1MD4X-ray2.10A/B2-210[»]
1PGTX-ray1.80A/B1-210[»]
1PX6X-ray2.10A/B2-210[»]
1PX7X-ray2.03A/B2-210[»]
1ZGNX-ray2.10A/B2-210[»]
20GSX-ray2.45A/B2-210[»]
22GSX-ray1.90A/B1-210[»]
2A2RX-ray1.40A/B1-210[»]
2A2SX-ray1.70A/B1-210[»]
2GSSX-ray1.90A/B2-210[»]
2J9HX-ray2.40A/B2-210[»]
2PGTX-ray1.90A/B1-210[»]
3CSHX-ray1.55A/B2-210[»]
3CSIX-ray1.90A/B/C/D2-210[»]
3CSJX-ray1.90A/B2-210[»]
3DD3X-ray2.25A/B1-210[»]
3DGQX-ray1.60A/B1-210[»]
3GSSX-ray1.90A/B2-210[»]
3GUSX-ray1.53A/B2-210[»]
3HJMX-ray2.10A/B/C/D2-210[»]
3HJOX-ray1.95A/B2-210[»]
3HKRX-ray1.80A/B2-210[»]
3IE3X-ray1.80A/B2-210[»]
3KM6X-ray2.10A/B2-210[»]
3KMNX-ray1.80A/B2-210[»]
3KMOX-ray2.60A/B2-210[»]
3N9JX-ray1.85A/B1-210[»]
3PGTX-ray2.14A/B1-210[»]
4GSSX-ray2.50A/B2-210[»]
4PGTX-ray2.10A/B1-210[»]
5DAKX-ray2.11A/B1-210[»]
5DALX-ray1.50A/B1-210[»]
5DCGX-ray2.01A/B1-210[»]
5DDLX-ray1.98A/B1-210[»]
5DJLX-ray1.80A/B1-210[»]
5DJMX-ray1.90A/B1-210[»]
5GSSX-ray1.95A/B2-210[»]
5J41X-ray1.19A/B2-210[»]
5JCWX-ray1.95A/B1-210[»]
5L6XX-ray2.00A/B1-210[»]
5X79X-ray1.90A/B1-210[»]
6AP9X-ray1.55A/B1-210[»]
6GSSX-ray1.90A/B2-210[»]
7GSSX-ray2.20A/B2-210[»]
8GSSX-ray1.90A/B/C2-210[»]
9GSSX-ray1.97A/B2-210[»]
ProteinModelPortaliP09211
SMRiP09211
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109205, 52 interactors
IntActiP09211, 59 interactors
MINTiP09211
STRINGi9606.ENSP00000381607

Chemistry databases

BindingDBiP09211
ChEMBLiCHEMBL3902
DrugBankiDB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB01008 Busulfan
DB04972 Canfosfamide
DB04339 Carbocisteine
DB00958 Carboplatin
DB00291 Chlorambucil
DB02633 Cibacron Blue
DB00515 Cisplatin
DB01242 Clomipramine
DB00773 Etoposide
DB00143 Glutathione
DB03003 Glutathione Sulfonic Acid
DB04077 Glycerol
DB00526 Oxaliplatin
DB08370 S-(4-BROMOBENZYL)CYSTEINE
DB03686 S-(P-Nitrobenzyl)Glutathione
DB04132 S-Hexylglutathione
DB01915 S-Hydroxycysteine
DB07849 S-NONYL-CYSTEINE
DB05460 TLK-199
DB00163 Vitamin E
SwissLipidsiSLP:000001615

PTM databases

iPTMnetiP09211
PhosphoSitePlusiP09211
SwissPalmiP09211

Polymorphism and mutation databases

BioMutaiGSTP1

2D gel databases

DOSAC-COBS-2DPAGEiP09211
OGPiP09211
REPRODUCTION-2DPAGEiIPI00219757
SWISS-2DPAGEiP09211
UCD-2DPAGEiP09211

Proteomic databases

EPDiP09211
PaxDbiP09211
PeptideAtlasiP09211
PRIDEiP09211
ProteomicsDBi12638
52207
TopDownProteomicsiP09211

Protocols and materials databases

DNASUi2950
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398606; ENSP00000381607; ENSG00000084207
ENST00000642444; ENSP00000493538; ENSG00000084207
GeneIDi2950
KEGGihsa:2950

Organism-specific databases

CTDi2950
DisGeNETi2950
EuPathDBiHostDB:ENSG00000084207.15
GeneCardsiGSTP1
HGNCiHGNC:4638 GSTP1
HPAiHPA019779
HPA019869
MIMi134660 gene
neXtProtiNX_P09211
OpenTargetsiENSG00000084207
PharmGKBiPA29028
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
GeneTreeiENSGT00550000074559
HOGENOMiHOG000115733
HOVERGENiHBG108324
InParanoidiP09211
KOiK00799
OMAiLRCKYAT
OrthoDBiEOG091G0K2E
PhylomeDBiP09211
TreeFamiTF105321

Enzyme and pathway databases

BRENDAi2.5.1.18 2681
ReactomeiR-HSA-156590 Glutathione conjugation
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-6798695 Neutrophil degranulation
SABIO-RKiP09211
SIGNORiP09211

Miscellaneous databases

ChiTaRSiGSTP1 human
EvolutionaryTraceiP09211
GeneWikiiGSTP1
GenomeRNAii2950
PMAP-CutDBiP09211
PROiPR:P09211
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000084207 Expressed in 229 organ(s), highest expression level in esophagus mucosa
CleanExiHS_GSTP1
ExpressionAtlasiP09211 baseline and differential
GenevisibleiP09211 HS

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR003082 GST_pi
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01268 GSTRNSFRASEP
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGSTP1_HUMAN
AccessioniPrimary (citable) accession number: P09211
Secondary accession number(s): O00460, Q15690, Q5TZY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 218 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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