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Protein

Glutathione S-transferase A2

Gene

GSTA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9Glutathione1 Publication1
Binding sitei45Glutathione1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyciMetaCyc:HS01846-MONOMER
BRENDAi2.5.1.18 2681
ReactomeiR-HSA-156590 Glutathione conjugation
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SABIO-RKiP09210

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase A2 (EC:2.5.1.18)
Alternative name(s):
GST HA subunit 2
GST class-alpha member 2
GST-gamma
GSTA2-2
GTH2
Gene namesi
Name:GSTA2
Synonyms:GST2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000244067.2
HGNCiHGNC:4627 GSTA2
MIMi138360 gene
neXtProtiNX_P09210

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi2939
OpenTargetsiENSG00000244067
PharmGKBiPA29017

Chemistry databases

ChEMBLiCHEMBL2241
DrugBankiDB00993 Azathioprine
DB01008 Busulfan
DB00608 Chloroquine
DB00636 Clofibrate
DB00903 Etacrynic acid
DB00143 Glutathione
DB00163 Vitamin E

Polymorphism and mutation databases

BioMutaiGSTA2
DMDMi126302551

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity1 Publication
ChainiPRO_00001857842 – 222Glutathione S-transferase A2Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei4N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP09210
PaxDbiP09210
PeptideAtlasiP09210
PRIDEiP09210
ProteomicsDBi52206

2D gel databases

REPRODUCTION-2DPAGEiIPI00745233

PTM databases

iPTMnetiP09210
PhosphoSitePlusiP09210

Expressioni

Tissue specificityi

Liver.

Gene expression databases

BgeeiENSG00000244067 Expressed in 53 organ(s), highest expression level in body of pancreas
CleanExiHS_GSTA2
ExpressionAtlasiP09210 baseline and differential

Organism-specific databases

HPAiHPA004342
HPA048934
HPA053817

Interactioni

Subunit structurei

Homodimer or heterodimer of GSTA1 and GSTA2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GSTA4O152178EBI-10196201,EBI-752440

Protein-protein interaction databases

BioGridi109194, 5 interactors
IntActiP09210, 2 interactors
STRINGi9606.ENSP00000420168

Chemistry databases

BindingDBiP09210

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP09210
SMRiP09210
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09210

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 83GST N-terminalAdd BLAST81
Domaini85 – 207GST C-terminalAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 55Glutathione binding1 Publication2
Regioni67 – 68Glutathione binding1 Publication2

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
GeneTreeiENSGT00670000097856
HOGENOMiHOG000115734
HOVERGENiHBG053749
InParanoidiP09210
KOiK00799
OMAiCPPAEKD
OrthoDBiEOG091G0O3D
PhylomeDBiP09210
TreeFamiTF105321

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR003080 GST_alpha
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01266 GSTRNSFRASEA
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09210-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEKPKLHYS NIRGRMESIR WLLAAAGVEF EEKFIKSAED LDKLRNDGYL
60 70 80 90 100
MFQQVPMVEI DGMKLVQTRA ILNYIASKYN LYGKDIKEKA LIDMYIEGIA
110 120 130 140 150
DLGEMILLLP FSQPEEQDAK LALIQEKTKN RYFPAFEKVL KSHGQDYLVG
160 170 180 190 200
NKLSRADIHL VELLYYVEEL DSSLISSFPL LKALKTRISN LPTVKKFLQP
210 220
GSPRKPPMDE KSLEESRKIF RF
Length:222
Mass (Da):25,664
Last modified:February 20, 2007 - v4
Checksum:i2823565A693A30AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10 – 12SNI → FNA AA sequence (PubMed:8431482).Curated3
Sequence conflicti12I → T in CAA46642 (PubMed:1497629).Curated1
Sequence conflicti19I → T AA sequence (PubMed:8431482).Curated1
Sequence conflicti89K → R AA sequence (PubMed:8431482).Curated1
Sequence conflicti128T → I AA sequence (PubMed:8431482).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014495110P → S. Corresponds to variant dbSNP:rs2234951Ensembl.1
Natural variantiVAR_012205112S → TCombined sources3 PublicationsCorresponds to variant dbSNP:rs2180314Ensembl.1
Natural variantiVAR_014496149V → A. Corresponds to variant dbSNP:rs2266631Ensembl.1
Natural variantiVAR_012206210E → A3 PublicationsCorresponds to variant dbSNP:rs6577Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16594 mRNA Translation: AAA52616.1
S45640
, S45627, S45629, S45636, S45637, S45639 Genomic DNA Translation: AAB23672.1
X65727
, X65728, X65729, X65730, X65731, X65732 Genomic DNA Translation: CAA46642.1
AL109918 Genomic DNA No translation available.
BC002895 mRNA Translation: AAH02895.1
CCDSiCCDS4944.1
PIRiS24330
S29658
RefSeqiNP_000837.3, NM_000846.4
XP_011512834.1, XM_011514532.2
UniGeneiHs.94107

Genome annotation databases

EnsembliENST00000493422; ENSP00000420168; ENSG00000244067
GeneIDi2939
KEGGihsa:2939
UCSCiuc003pay.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16594 mRNA Translation: AAA52616.1
S45640
, S45627, S45629, S45636, S45637, S45639 Genomic DNA Translation: AAB23672.1
X65727
, X65728, X65729, X65730, X65731, X65732 Genomic DNA Translation: CAA46642.1
AL109918 Genomic DNA No translation available.
BC002895 mRNA Translation: AAH02895.1
CCDSiCCDS4944.1
PIRiS24330
S29658
RefSeqiNP_000837.3, NM_000846.4
XP_011512834.1, XM_011514532.2
UniGeneiHs.94107

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AGSX-ray2.50A/B2-222[»]
2VCTX-ray2.10A/B/C/D/E/F/G/H1-222[»]
2WJUX-ray2.30A/B/C/D/E/F/G/H1-222[»]
4ACSX-ray2.10A/B/C/D1-221[»]
ProteinModelPortaliP09210
SMRiP09210
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109194, 5 interactors
IntActiP09210, 2 interactors
STRINGi9606.ENSP00000420168

Chemistry databases

BindingDBiP09210
ChEMBLiCHEMBL2241
DrugBankiDB00993 Azathioprine
DB01008 Busulfan
DB00608 Chloroquine
DB00636 Clofibrate
DB00903 Etacrynic acid
DB00143 Glutathione
DB00163 Vitamin E

PTM databases

iPTMnetiP09210
PhosphoSitePlusiP09210

Polymorphism and mutation databases

BioMutaiGSTA2
DMDMi126302551

2D gel databases

REPRODUCTION-2DPAGEiIPI00745233

Proteomic databases

MaxQBiP09210
PaxDbiP09210
PeptideAtlasiP09210
PRIDEiP09210
ProteomicsDBi52206

Protocols and materials databases

DNASUi2939
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000493422; ENSP00000420168; ENSG00000244067
GeneIDi2939
KEGGihsa:2939
UCSCiuc003pay.4 human

Organism-specific databases

CTDi2939
DisGeNETi2939
EuPathDBiHostDB:ENSG00000244067.2
GeneCardsiGSTA2
H-InvDBiHIX0200871
HGNCiHGNC:4627 GSTA2
HPAiHPA004342
HPA048934
HPA053817
MIMi138360 gene
neXtProtiNX_P09210
OpenTargetsiENSG00000244067
PharmGKBiPA29017
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
GeneTreeiENSGT00670000097856
HOGENOMiHOG000115734
HOVERGENiHBG053749
InParanoidiP09210
KOiK00799
OMAiCPPAEKD
OrthoDBiEOG091G0O3D
PhylomeDBiP09210
TreeFamiTF105321

Enzyme and pathway databases

BioCyciMetaCyc:HS01846-MONOMER
BRENDAi2.5.1.18 2681
ReactomeiR-HSA-156590 Glutathione conjugation
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SABIO-RKiP09210

Miscellaneous databases

EvolutionaryTraceiP09210
GeneWikiiGSTA2
GenomeRNAii2939
PROiPR:P09210
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000244067 Expressed in 53 organ(s), highest expression level in body of pancreas
CleanExiHS_GSTA2
ExpressionAtlasiP09210 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR003080 GST_alpha
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01266 GSTRNSFRASEA
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGSTA2_HUMAN
AccessioniPrimary (citable) accession number: P09210
Secondary accession number(s): Q12759, Q16491, Q9NTY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 196 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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