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UniProtKB - P09210 (GSTA2_HUMAN)
Protein
Glutathione S-transferase A2
Gene
GSTA2
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the conjugation of glutathione to a large variety of electrophilic compounds.
By similarityCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 9 | Glutathione1 Publication | 1 | |
Binding sitei | 45 | Glutathione1 Publication | 1 |
GO - Molecular functioni
- glutathione transferase activity Source: UniProtKB
GO - Biological processi
- epithelial cell differentiation Source: UniProtKB
- glutathione metabolic process Source: UniProtKB
- xenobiotic metabolic process Source: GO_Central
Keywordsi
Molecular function | Transferase |
Enzyme and pathway databases
BRENDAi | 2.5.1.18, 2681 |
PathwayCommonsi | P09210 |
Reactomei | R-HSA-156590, Glutathione conjugation R-HSA-8950505, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
SABIO-RKi | P09210 |
SignaLinki | P09210 |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione S-transferase A2 (EC:2.5.1.18By similarity)Alternative name(s): GST HA subunit 2 GST class-alpha member 2 GST-gamma GSTA2-2 GTH2 |
Gene namesi | Name:GSTA2 Synonyms:GST2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4627, GSTA2 |
MIMi | 138360, gene |
neXtProti | NX_P09210 |
VEuPathDBi | HostDB:ENSG00000244067 |
Subcellular locationi
Cytoplasm and Cytosol
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 2939 |
OpenTargetsi | ENSG00000244067 |
PharmGKBi | PA29017 |
Miscellaneous databases
Pharosi | P09210, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2241 |
DrugBanki | DB14001, alpha-Tocopherol succinate DB00993, Azathioprine DB01008, Busulfan DB00608, Chloroquine DB00636, Clofibrate DB14002, D-alpha-Tocopherol acetate DB00903, Etacrynic acid DB00143, Glutathione DB03310, Glutathione disulfide DB00163, Vitamin E |
Genetic variation databases
BioMutai | GSTA2 |
DMDMi | 126302551 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity1 Publication | |||
ChainiPRO_0000185784 | 2 – 222 | Glutathione S-transferase A2Add BLAST | 221 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 4 | N6-succinyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | P09210 |
MassIVEi | P09210 |
MaxQBi | P09210 |
PaxDbi | P09210 |
PeptideAtlasi | P09210 |
PRIDEi | P09210 |
ProteomicsDBi | 52206 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00745233 |
PTM databases
GlyGeni | P09210, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P09210 |
PhosphoSitePlusi | P09210 |
Expressioni
Tissue specificityi
Liver.1 Publication
Gene expression databases
Bgeei | ENSG00000244067, Expressed in adult mammalian kidney and 71 other tissues |
ExpressionAtlasi | P09210, baseline and differential |
Organism-specific databases
HPAi | ENSG00000244067, Group enriched (kidney, liver) |
Interactioni
Subunit structurei
Homodimer or heterodimer of GSTA1 and GSTA2.
2 PublicationsBinary interactionsi
P09210
With | #Exp. | IntAct |
---|---|---|
GSTA4 [O15217] | 11 | EBI-10196201,EBI-752440 |
GSTA5 [Q7RTV2] | 4 | EBI-10196201,EBI-13328621 |
Protein-protein interaction databases
BioGRIDi | 109194, 9 interactors |
IntActi | P09210, 5 interactors |
STRINGi | 9606.ENSP00000420168 |
Chemistry databases
BindingDBi | P09210 |
Miscellaneous databases
RNActi | P09210, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P09210 |
SMRi | P09210 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P09210 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 83 | GST N-terminalAdd BLAST | 81 | |
Domaini | 85 – 207 | GST C-terminalAdd BLAST | 123 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 54 – 55 | Glutathione binding1 Publication | 2 | |
Regioni | 67 – 68 | Glutathione binding1 Publication | 2 | |
Regioni | 199 – 222 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 207 – 222 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1695, Eukaryota |
GeneTreei | ENSGT00940000164034 |
HOGENOMi | CLU_039475_4_0_1 |
InParanoidi | P09210 |
OMAi | KERAXID |
OrthoDBi | 1162336at2759 |
PhylomeDBi | P09210 |
TreeFami | TF105321 |
Family and domain databases
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR003080, GST_alpha IPR004046, GST_C IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF14497, GST_C_3, 1 hit PF02798, GST_N, 1 hit |
PRINTSi | PR01266, GSTRNSFRASEA |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P09210-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEKPKLHYS NIRGRMESIR WLLAAAGVEF EEKFIKSAED LDKLRNDGYL
60 70 80 90 100
MFQQVPMVEI DGMKLVQTRA ILNYIASKYN LYGKDIKEKA LIDMYIEGIA
110 120 130 140 150
DLGEMILLLP FSQPEEQDAK LALIQEKTKN RYFPAFEKVL KSHGQDYLVG
160 170 180 190 200
NKLSRADIHL VELLYYVEEL DSSLISSFPL LKALKTRISN LPTVKKFLQP
210 220
GSPRKPPMDE KSLEESRKIF RF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 – 12 | SNI → FNA AA sequence (PubMed:8431482).Curated | 3 | |
Sequence conflicti | 12 | I → T in CAA46642 (PubMed:1497629).Curated | 1 | |
Sequence conflicti | 19 | I → T AA sequence (PubMed:8431482).Curated | 1 | |
Sequence conflicti | 89 | K → R AA sequence (PubMed:8431482).Curated | 1 | |
Sequence conflicti | 128 | T → I AA sequence (PubMed:8431482).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014495 | 110 | P → S. Corresponds to variant dbSNP:rs2234951Ensembl. | 1 | |
Natural variantiVAR_012205 | 112 | S → TCombined sources3 PublicationsCorresponds to variant dbSNP:rs2180314Ensembl. | 1 | |
Natural variantiVAR_014496 | 149 | V → A. Corresponds to variant dbSNP:rs2266631Ensembl. | 1 | |
Natural variantiVAR_012206 | 210 | E → A3 PublicationsCorresponds to variant dbSNP:rs6577Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M16594 mRNA Translation: AAA52616.1 S45640 , S45627, S45629, S45636, S45637, S45639 Genomic DNA Translation: AAB23672.1 X65727 , X65728, X65729, X65730, X65731, X65732 Genomic DNA Translation: CAA46642.1 AL109918 Genomic DNA No translation available. BC002895 mRNA Translation: AAH02895.1 |
CCDSi | CCDS4944.1 |
PIRi | S24330 S29658 |
RefSeqi | NP_000837.3, NM_000846.4 XP_011512834.1, XM_011514532.2 |
Genome annotation databases
Ensembli | ENST00000493422.3; ENSP00000420168.1; ENSG00000244067.3 |
GeneIDi | 2939 |
KEGGi | hsa:2939 |
MANE-Selecti | ENST00000493422.3; ENSP00000420168.1; NM_000846.5; NP_000837.3 |
UCSCi | uc003pay.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M16594 mRNA Translation: AAA52616.1 S45640 , S45627, S45629, S45636, S45637, S45639 Genomic DNA Translation: AAB23672.1 X65727 , X65728, X65729, X65730, X65731, X65732 Genomic DNA Translation: CAA46642.1 AL109918 Genomic DNA No translation available. BC002895 mRNA Translation: AAH02895.1 |
CCDSi | CCDS4944.1 |
PIRi | S24330 S29658 |
RefSeqi | NP_000837.3, NM_000846.4 XP_011512834.1, XM_011514532.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AGS | X-ray | 2.50 | A/B | 2-222 | [»] | |
2VCT | X-ray | 2.10 | A/B/C/D/E/F/G/H | 1-222 | [»] | |
2WJU | X-ray | 2.30 | A/B/C/D/E/F/G/H | 1-222 | [»] | |
4ACS | X-ray | 2.10 | A/B/C/D | 1-221 | [»] | |
AlphaFoldDBi | P09210 | |||||
SMRi | P09210 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109194, 9 interactors |
IntActi | P09210, 5 interactors |
STRINGi | 9606.ENSP00000420168 |
Chemistry databases
BindingDBi | P09210 |
ChEMBLi | CHEMBL2241 |
DrugBanki | DB14001, alpha-Tocopherol succinate DB00993, Azathioprine DB01008, Busulfan DB00608, Chloroquine DB00636, Clofibrate DB14002, D-alpha-Tocopherol acetate DB00903, Etacrynic acid DB00143, Glutathione DB03310, Glutathione disulfide DB00163, Vitamin E |
PTM databases
GlyGeni | P09210, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P09210 |
PhosphoSitePlusi | P09210 |
Genetic variation databases
BioMutai | GSTA2 |
DMDMi | 126302551 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00745233 |
Proteomic databases
jPOSTi | P09210 |
MassIVEi | P09210 |
MaxQBi | P09210 |
PaxDbi | P09210 |
PeptideAtlasi | P09210 |
PRIDEi | P09210 |
ProteomicsDBi | 52206 |
Protocols and materials databases
Antibodypediai | 30929, 228 antibodies from 28 providers |
DNASUi | 2939 |
Genome annotation databases
Ensembli | ENST00000493422.3; ENSP00000420168.1; ENSG00000244067.3 |
GeneIDi | 2939 |
KEGGi | hsa:2939 |
MANE-Selecti | ENST00000493422.3; ENSP00000420168.1; NM_000846.5; NP_000837.3 |
UCSCi | uc003pay.4, human |
Organism-specific databases
CTDi | 2939 |
DisGeNETi | 2939 |
GeneCardsi | GSTA2 |
HGNCi | HGNC:4627, GSTA2 |
HPAi | ENSG00000244067, Group enriched (kidney, liver) |
MIMi | 138360, gene |
neXtProti | NX_P09210 |
OpenTargetsi | ENSG00000244067 |
PharmGKBi | PA29017 |
VEuPathDBi | HostDB:ENSG00000244067 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1695, Eukaryota |
GeneTreei | ENSGT00940000164034 |
HOGENOMi | CLU_039475_4_0_1 |
InParanoidi | P09210 |
OMAi | KERAXID |
OrthoDBi | 1162336at2759 |
PhylomeDBi | P09210 |
TreeFami | TF105321 |
Enzyme and pathway databases
BRENDAi | 2.5.1.18, 2681 |
PathwayCommonsi | P09210 |
Reactomei | R-HSA-156590, Glutathione conjugation R-HSA-8950505, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
SABIO-RKi | P09210 |
SignaLinki | P09210 |
Miscellaneous databases
BioGRID-ORCSi | 2939, 19 hits in 983 CRISPR screens |
ChiTaRSi | GSTA2, human |
EvolutionaryTracei | P09210 |
GeneWikii | GSTA2 |
GenomeRNAii | 2939 |
Pharosi | P09210, Tbio |
PROi | PR:P09210 |
RNActi | P09210, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000244067, Expressed in adult mammalian kidney and 71 other tissues |
ExpressionAtlasi | P09210, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR003080, GST_alpha IPR004046, GST_C IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF14497, GST_C_3, 1 hit PF02798, GST_N, 1 hit |
PRINTSi | PR01266, GSTRNSFRASEA |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GSTA2_HUMAN | |
Accessioni | P09210Primary (citable) accession number: P09210 Secondary accession number(s): Q12759, Q16491, Q9NTY6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | February 20, 2007 | |
Last modified: | May 25, 2022 | |
This is version 217 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families