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Protein

60S ribosomal protein L4

Gene

RpL4

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L4
Alternative name(s):
L1
Gene namesi
Name:RpL4
Synonyms:RpL1
ORF Names:CG5502
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0003279 RpL4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001293591 – 40160S ribosomal protein L4Add BLAST401

Proteomic databases

PaxDbiP09180
PRIDEiP09180

Expressioni

Gene expression databases

BgeeiFBgn0003279
ExpressionAtlasiP09180 baseline and differential
GenevisibleiP09180 DM

Interactioni

Protein-protein interaction databases

BioGridi68230, 28 interactors
IntActiP09180, 2 interactors
MINTiP09180
STRINGi7227.FBpp0084617

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CC1-401[»]
ProteinModelPortaliP09180
SMRiP09180
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1475 Eukaryota
COG0088 LUCA
InParanoidiP09180
KOiK02930
OMAiGRGKMRN
OrthoDBiEOG091G0A2I
PhylomeDBiP09180

Family and domain databases

Gene3Di3.40.1370.10, 1 hit
InterProiView protein in InterPro
IPR025755 Ribos_L4_C_dom
IPR002136 Ribosomal_L4/L1e
IPR013000 Ribosomal_L4/L1e_euk/arc_CS
IPR023574 Ribosomal_L4_dom_sf
PfamiView protein in Pfam
PF14374 Ribos_L4_asso_C, 1 hit
PF00573 Ribosomal_L4, 1 hit
SUPFAMiSSF52166 SSF52166, 1 hit
PROSITEiView protein in PROSITE
PS00939 RIBOSOMAL_L1E, 1 hit

Sequencei

Sequence statusi: Complete.

P09180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLGNARPLV SVYTEKNEPA KDKNICLPAV FKAPIRPDVV NEVHQLLRRN
60 70 80 90 100
NRQAYAVSEL AGHQTSAESW GTGRAVARIP RVRGGGTHRS GQGAFGNMCR
110 120 130 140 150
GGRMFAPTKT FRRWHRKVNV NQRRYALVSA IAASGVPALV QSKGHVIDGV
160 170 180 190 200
SEFPLVVSDE VQKVQKTKQA VIFLRRLKIW ADIQKVYKSQ RFRAGRGTMR
210 220 230 240 250
DRRRIARRGP LVVYDKDEGL RKAFRNIPGI ETINVDKLNL LKLAPGGHVG
260 270 280 290 300
RFVIWTESAF ARLNDLFGTW KKPSTLKKGY NLPQPKMANT DLSRLLKSEE
310 320 330 340 350
IRKVLRDPRK RVFRSVRRLN PLTNVRQLIK LNPYAEVLKR RAALAAEKRT
360 370 380 390 400
VAKVLAKAKK QNVELAKSHF ANVATKAAAN RAKLLAARKK KVAAKKPAAK

K
Length:401
Mass (Da):45,026
Last modified:December 7, 2004 - v2
Checksum:iC8B7EF9F732EF497
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117K → R in CAA29998 (PubMed:3133637).Curated1
Sequence conflicti240L → V in CAA31759 (PubMed:2492096).Curated1
Sequence conflicti378 – 401AANRA…PAAKK → RPIAPSSGRPQEEGRRQEAS GQEVNLLSPE in CAA31759 (PubMed:2492096).CuratedAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13382 mRNA Translation: CAA31759.1
AE014297 Genomic DNA Translation: AAG22173.1
AY069485 mRNA Translation: AAL39630.1
X06881 Genomic DNA Translation: CAA29998.1
PIRiS02209 R5FFL1
RefSeqiNP_524538.2, NM_079814.3
UniGeneiDm.2104

Genome annotation databases

EnsemblMetazoaiFBtr0085248; FBpp0084617; FBgn0003279
GeneIDi43349
KEGGidme:Dmel_CG5502

Similar proteinsi

Entry informationi

Entry nameiRL4_DROME
AccessioniPrimary (citable) accession number: P09180
Secondary accession number(s): Q9I7H6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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