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Protein

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

Pde6g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processSensory transduction, Vision
LigandcGMP

Enzyme and pathway databases

ReactomeiR-MMU-2485179 Activation of the phototransduction cascade
R-MMU-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-MMU-4086398 Ca2+ pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
Short name:
GMP-PDE gamma
Gene namesi
Name:Pde6g
Synonyms:Pdeg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:97526 Pde6g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Deficiency in GMP-PDE activity cause accumulation of cGMP in visual cells. The elevated cGMP levels are associated with degeneration of the photoreceptors and blindness.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001661181 – 87Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaAdd BLAST87

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP09174
PRIDEiP09174

PTM databases

iPTMnetiP09174
PhosphoSitePlusiP09174

Expressioni

Gene expression databases

BgeeiENSMUSG00000025386 Expressed in 102 organ(s), highest expression level in retina
CleanExiMM_PDE6G
ExpressionAtlasiP09174 baseline and differential
GenevisibleiP09174 MM

Interactioni

Subunit structurei

Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202085, 1 interactor
STRINGi10090.ENSMUSP00000026452

Structurei

3D structure databases

ProteinModelPortaliP09174
SMRiP09174
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 45Arg/Lys-rich (basic)Add BLAST22

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IZA8 Eukaryota
ENOG410YN07 LUCA
GeneTreeiENSGT00390000013260
HOGENOMiHOG000261673
HOVERGENiHBG000447
InParanoidiP09174
KOiK13759
OMAiTRVMGGP
OrthoDBiEOG091G14J5
PhylomeDBiP09174
TreeFamiTF333297

Family and domain databases

Gene3Di4.10.1120.10, 1 hit
InterProiView protein in InterPro
IPR006952 PDE6_gamma
IPR037030 PDE6_gamma_sf
PANTHERiPTHR12122 PTHR12122, 1 hit
PfamiView protein in Pfam
PF04868 PDE6_gamma, 1 hit
PIRSFiPIRSF000969 35-cGMP_Pdiase_g, 1 hit

Sequencei

Sequence statusi: Complete.

P09174-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLEPPKGEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF
60 70 80
GDDIPGMEGL GTDITVICPW EAFNHLELHE LAQYGII
Length:87
Mass (Da):9,637
Last modified:July 1, 1989 - v1
Checksum:i415CE37E2CF14B99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00746 mRNA Translation: CAA68714.1
BC082288 mRNA Translation: AAH82288.1
CCDSiCCDS36389.1
PIRiS00612 ESMSGM
RefSeqiNP_036197.1, NM_012065.3
XP_006532518.1, XM_006532455.3
UniGeneiMm.39200

Genome annotation databases

EnsembliENSMUST00000026452; ENSMUSP00000026452; ENSMUSG00000025386
GeneIDi18588
KEGGimmu:18588
UCSCiuc007mss.2 mouse

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00746 mRNA Translation: CAA68714.1
BC082288 mRNA Translation: AAH82288.1
CCDSiCCDS36389.1
PIRiS00612 ESMSGM
RefSeqiNP_036197.1, NM_012065.3
XP_006532518.1, XM_006532455.3
UniGeneiMm.39200

3D structure databases

ProteinModelPortaliP09174
SMRiP09174
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202085, 1 interactor
STRINGi10090.ENSMUSP00000026452

PTM databases

iPTMnetiP09174
PhosphoSitePlusiP09174

Proteomic databases

PaxDbiP09174
PRIDEiP09174

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026452; ENSMUSP00000026452; ENSMUSG00000025386
GeneIDi18588
KEGGimmu:18588
UCSCiuc007mss.2 mouse

Organism-specific databases

CTDi5148
MGIiMGI:97526 Pde6g

Phylogenomic databases

eggNOGiENOG410IZA8 Eukaryota
ENOG410YN07 LUCA
GeneTreeiENSGT00390000013260
HOGENOMiHOG000261673
HOVERGENiHBG000447
InParanoidiP09174
KOiK13759
OMAiTRVMGGP
OrthoDBiEOG091G14J5
PhylomeDBiP09174
TreeFamiTF333297

Enzyme and pathway databases

ReactomeiR-MMU-2485179 Activation of the phototransduction cascade
R-MMU-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-MMU-4086398 Ca2+ pathway

Miscellaneous databases

PROiPR:P09174
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025386 Expressed in 102 organ(s), highest expression level in retina
CleanExiMM_PDE6G
ExpressionAtlasiP09174 baseline and differential
GenevisibleiP09174 MM

Family and domain databases

Gene3Di4.10.1120.10, 1 hit
InterProiView protein in InterPro
IPR006952 PDE6_gamma
IPR037030 PDE6_gamma_sf
PANTHERiPTHR12122 PTHR12122, 1 hit
PfamiView protein in Pfam
PF04868 PDE6_gamma, 1 hit
PIRSFiPIRSF000969 35-cGMP_Pdiase_g, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCNRG_MOUSE
AccessioniPrimary (citable) accession number: P09174
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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