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UniProtKB - P09174 (CNRG_MOUSE)
Protein
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Gene
Pde6g
Organism
Mus musculus (Mouse)
Status
Functioni
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Catalytic activityi
- EC:3.1.4.35
GO - Molecular functioni
- 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
- cGMP binding Source: InterPro
- spectrin binding Source: MGI
GO - Biological processi
- positive regulation of epidermal growth factor receptor signaling pathway Source: MGI
- positive regulation of G protein-coupled receptor signaling pathway Source: MGI
- positive regulation of MAPK cascade Source: MGI
- response to stimulus Source: UniProtKB-KW
- visual perception Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Sensory transduction, Vision |
Ligand | cGMP |
Enzyme and pathway databases
Reactomei | R-MMU-2485179, Activation of the phototransduction cascade R-MMU-2514859, Inactivation, recovery and regulation of the phototransduction cascade R-MMU-4086398, Ca2+ pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)Short name: GMP-PDE gamma |
Gene namesi | Name:Pde6g Synonyms:Pdeg |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97526, Pde6g |
VEuPathDBi | HostDB:ENSMUSG00000025386 |
Subcellular locationi
Plasma Membrane
- photoreceptor outer segment membrane Source: GO_Central
- plasma membrane Source: Reactome
Pathology & Biotechi
Involvement in diseasei
Deficiency in GMP-PDE activity cause accumulation of cGMP in visual cells. The elevated cGMP levels are associated with degeneration of the photoreceptors and blindness.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000166118 | 1 – 87 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaAdd BLAST | 87 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | P09174 |
PRIDEi | P09174 |
ProteomicsDBi | 283467 |
PTM databases
iPTMneti | P09174 |
PhosphoSitePlusi | P09174 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000025386, Expressed in retina and 136 other tissues |
ExpressionAtlasi | P09174, baseline and differential |
Genevisiblei | P09174, MM |
Interactioni
Subunit structurei
Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.
GO - Molecular functioni
- spectrin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 202085, 1 interactor |
STRINGi | 10090.ENSMUSP00000026452 |
Miscellaneous databases
RNActi | P09174, protein |
Structurei
3D structure databases
AlphaFoldDBi | P09174 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 55 | DisorderedSequence analysisAdd BLAST | 55 |
Sequence similaritiesi
Belongs to the rod/cone cGMP-PDE gamma subunit family.Curated
Phylogenomic databases
eggNOGi | ENOG502S20G, Eukaryota |
GeneTreei | ENSGT00390000013260 |
HOGENOMi | CLU_170469_0_0_1 |
InParanoidi | P09174 |
OMAi | KGRGWHP |
OrthoDBi | 1574918at2759 |
PhylomeDBi | P09174 |
TreeFami | TF333297 |
Family and domain databases
Gene3Di | 4.10.1120.10, 1 hit |
InterProi | View protein in InterPro IPR006952, PDE6_gamma IPR037030, PDE6_gamma_sf |
PANTHERi | PTHR12122, PTHR12122, 1 hit |
Pfami | View protein in Pfam PF04868, PDE6_gamma, 1 hit |
PIRSFi | PIRSF000969, 35-cGMP_Pdiase_g, 1 hit |
i Sequence
Sequence statusi: Complete.
P09174-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLEPPKGEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF
60 70 80
GDDIPGMEGL GTDITVICPW EAFNHLELHE LAQYGII
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00746 mRNA Translation: CAA68714.1 BC082288 mRNA Translation: AAH82288.1 |
CCDSi | CCDS36389.1 |
PIRi | S00612, ESMSGM |
RefSeqi | NP_036197.1, NM_012065.3 XP_006532518.1, XM_006532455.3 |
Genome annotation databases
Ensembli | ENSMUST00000026452; ENSMUSP00000026452; ENSMUSG00000025386 |
GeneIDi | 18588 |
KEGGi | mmu:18588 |
UCSCi | uc007mss.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00746 mRNA Translation: CAA68714.1 BC082288 mRNA Translation: AAH82288.1 |
CCDSi | CCDS36389.1 |
PIRi | S00612, ESMSGM |
RefSeqi | NP_036197.1, NM_012065.3 XP_006532518.1, XM_006532455.3 |
3D structure databases
AlphaFoldDBi | P09174 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 202085, 1 interactor |
STRINGi | 10090.ENSMUSP00000026452 |
PTM databases
iPTMneti | P09174 |
PhosphoSitePlusi | P09174 |
Proteomic databases
PaxDbi | P09174 |
PRIDEi | P09174 |
ProteomicsDBi | 283467 |
Protocols and materials databases
Antibodypediai | 57116, 118 antibodies from 19 providers |
DNASUi | 18588 |
Genome annotation databases
Ensembli | ENSMUST00000026452; ENSMUSP00000026452; ENSMUSG00000025386 |
GeneIDi | 18588 |
KEGGi | mmu:18588 |
UCSCi | uc007mss.2, mouse |
Organism-specific databases
CTDi | 5148 |
MGIi | MGI:97526, Pde6g |
VEuPathDBi | HostDB:ENSMUSG00000025386 |
Phylogenomic databases
eggNOGi | ENOG502S20G, Eukaryota |
GeneTreei | ENSGT00390000013260 |
HOGENOMi | CLU_170469_0_0_1 |
InParanoidi | P09174 |
OMAi | KGRGWHP |
OrthoDBi | 1574918at2759 |
PhylomeDBi | P09174 |
TreeFami | TF333297 |
Enzyme and pathway databases
Reactomei | R-MMU-2485179, Activation of the phototransduction cascade R-MMU-2514859, Inactivation, recovery and regulation of the phototransduction cascade R-MMU-4086398, Ca2+ pathway |
Miscellaneous databases
BioGRID-ORCSi | 18588, 3 hits in 70 CRISPR screens |
PROi | PR:P09174 |
RNActi | P09174, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025386, Expressed in retina and 136 other tissues |
ExpressionAtlasi | P09174, baseline and differential |
Genevisiblei | P09174, MM |
Family and domain databases
Gene3Di | 4.10.1120.10, 1 hit |
InterProi | View protein in InterPro IPR006952, PDE6_gamma IPR037030, PDE6_gamma_sf |
PANTHERi | PTHR12122, PTHR12122, 1 hit |
Pfami | View protein in Pfam PF04868, PDE6_gamma, 1 hit |
PIRSFi | PIRSF000969, 35-cGMP_Pdiase_g, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CNRG_MOUSE | |
Accessioni | P09174Primary (citable) accession number: P09174 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | May 25, 2022 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families