UniProtKB - P09172 (DOPO_HUMAN)
Protein
Dopamine beta-hydroxylase
Gene
DBH
Organism
Homo sapiens (Human)
Status
Functioni
Conversion of dopamine to noradrenaline.4 Publications
Catalytic activityi
- dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical3 PublicationsEC:1.14.17.13 Publications
Cofactori
Cu2+1 Publication1 PublicationNote: Binds 2 copper ions per subunit.1 Publication
Kineticsi
- KM=1.8 mM for tyramine1 Publication
pH dependencei
Optimum pH is 5.2.1 Publication
: (R)-noradrenaline biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes (R)-noradrenaline from dopamine.3 PublicationsProteins known to be involved in this subpathway in this organism are:
- Dopamine beta-hydroxylase (DBH), Dopamine beta-hydroxylase (DBH)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-noradrenaline from dopamine, the pathway (R)-noradrenaline biosynthesis and in Catecholamine biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 230 | Sequence analysis | 1 | |
Metal bindingi | 262 | Copper ABy similarity | 1 | |
Metal bindingi | 263 | Copper ABy similarity | 1 | |
Metal bindingi | 333 | Copper ABy similarity | 1 | |
Active sitei | 412 | Sequence analysis | 1 | |
Metal bindingi | 412 | Copper BCombined sources1 Publication | 1 | |
Metal bindingi | 414 | Copper BCombined sources1 Publication | 1 | |
Metal bindingi | 487 | Copper BCombined sources1 Publication | 1 |
GO - Molecular functioni
- catalytic activity Source: ProtInc
- copper ion binding Source: UniProtKB
- dopamine beta-monooxygenase activity Source: UniProtKB
- L-ascorbic acid binding Source: UniProtKB-KW
GO - Biological processi
- behavioral response to ethanol Source: Ensembl
- blood vessel remodeling Source: Ensembl
- catecholamine biosynthetic process Source: Reactome
- chemical synaptic transmission Source: ProtInc
- dopamine catabolic process Source: UniProtKB
- fear response Source: Ensembl
- glucose homeostasis Source: Ensembl
- homoiothermy Source: Ensembl
- leukocyte mediated immunity Source: Ensembl
- leukocyte migration Source: Ensembl
- locomotory behavior Source: Ensembl
- maternal behavior Source: Ensembl
- memory Source: Ensembl
- norepinephrine biosynthetic process Source: UniProtKB
- octopamine biosynthetic process Source: GO_Central
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of vasoconstriction Source: Ensembl
- regulation of cell population proliferation Source: Ensembl
- regulation of extrinsic apoptotic signaling pathway Source: Ensembl
- response to amphetamine Source: Ensembl
- response to pain Source: Ensembl
- visual learning Source: Ensembl
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Biological process | Catecholamine biosynthesis |
Ligand | Copper, Metal-binding, Vitamin C |
Enzyme and pathway databases
BioCyci | MetaCyc:MONOMER66-381 |
BRENDAi | 1.14.17.1, 2681 |
PathwayCommonsi | P09172 |
Reactomei | R-HSA-209905, Catecholamine biosynthesis |
SignaLinki | P09172 |
SIGNORi | P09172 |
UniPathwayi | UPA00748;UER00735 |
Names & Taxonomyi
Protein namesi | Recommended name: Dopamine beta-hydroxylase (EC:1.14.17.13 Publications)Alternative name(s): Dopamine beta-monooxygenase Cleaved into the following chain: |
Gene namesi | Name:DBH |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2689, DBH |
MIMi | 609312, gene |
neXtProti | NX_P09172 |
VEuPathDBi | HostDB:ENSG00000123454.10 |
Subcellular locationi
Extracellular region or secreted
- Secreted 2 Publications
Other locations
- secretory vesicle lumen 1 Publication
- chromaffin granule lumen 1 Publication
Other locations
- secretory vesicle membrane 1 Publication; Single-pass type II membrane protein Curated
- chromaffin granule membrane 1 Publication; Single-pass type II membrane protein Curated
Cytoskeleton
- centriolar satellite Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
Extracellular region or secreted
- extracellular region Source: UniProtKB
- extracellular space Source: UniProtKB
Other locations
- chromaffin granule lumen Source: UniProtKB-SubCell
- chromaffin granule membrane Source: UniProtKB-SubCell
- cytoplasm Source: ProtInc
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: HPA
- membrane Source: ProtInc
- secretory granule lumen Source: UniProtKB
- secretory granule membrane Source: UniProtKB
- synapse Source: GOC
- transport vesicle membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 16 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 17 – 37 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 38 – 617 | IntragranularSequence analysisAdd BLAST | 580 |
Keywords - Cellular componenti
Cytoplasmic vesicle, Membrane, SecretedPathology & Biotechi
Involvement in diseasei
Orthostatic hypotension 1 (ORTHYP1)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of orthostatic hypotension due to congenital dopamine beta-hydroxylase deficiency. Orthostatic hypotension, also known as postural hypotension, is a finding defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure occurring 3 minutes after a person has risen from supine to standing. Symptoms include dizziness, blurred vision, and sometimes syncope. ORTHYP1 is an autosomal recessive condition apparent from infancy or early childhood and characterized by low plasma and urinary levels of norepinephrine and epinephrine, and episodic hypoglycemia.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022758 | 101 | V → M in ORTHYP1. 1 PublicationCorresponds to variant dbSNP:rs267606760EnsemblClinVar. | 1 | |
Natural variantiVAR_022759 | 114 | D → E in ORTHYP1. 1 PublicationCorresponds to variant dbSNP:rs77576840EnsemblClinVar. | 1 | |
Natural variantiVAR_022760 | 345 | D → N in ORTHYP1. 1 PublicationCorresponds to variant dbSNP:rs267606761EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 1621 |
GeneReviewsi | DBH |
MalaCardsi | DBH |
MIMi | 223360, phenotype |
OpenTargetsi | ENSG00000123454 |
Orphaneti | 230, Dopamine beta-hydroxylase deficiency |
PharmGKBi | PA136 |
Miscellaneous databases
Pharosi | P09172, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3102 |
DrugBanki | DB00126, Ascorbic acid DB06774, Capsaicin DB09130, Copper DB05394, Corticorelin DB00822, Disulfiram DB00988, Dopamine DB00550, Propylthiouracil |
DrugCentrali | P09172 |
GuidetoPHARMACOLOGYi | 2486 |
Genetic variation databases
BioMutai | DBH |
DMDMi | 158517849 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000006356 | 1 – 617 | Dopamine beta-hydroxylaseAdd BLAST | 617 | |
ChainiPRO_0000308209 | 40 – 617 | Soluble dopamine beta-hydroxylaseAdd BLAST | 578 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 64 | N-linked (GlcNAc...) asparagineSequence analysisCombined sources1 Publication | 1 | |
Disulfide bondi | 154 ↔ 596 | Combined sources1 Publication | ||
Glycosylationi | 184 | N-linked (GlcNAc...) (complex) asparagineCombined sources3 Publications | 1 | |
Disulfide bondi | 232 ↔ 283 | Combined sources1 Publication | ||
Disulfide bondi | 269 ↔ 295 | Combined sources1 Publication | ||
Disulfide bondi | 390 ↔ 503 | Combined sources1 Publication | ||
Disulfide bondi | 394 ↔ 565 | Combined sources1 Publication | ||
Disulfide bondi | 466 ↔ 488 | Combined sources1 Publication | ||
Disulfide bondi | 528 | Interchain (with C-530)Combined sources1 Publication | ||
Disulfide bondi | 530 | Interchain (with C-528)Combined sources1 Publication | ||
Glycosylationi | 566 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 |
Post-translational modificationi
N-glycosylated.2 Publications
Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 39 – 40 | CleavageBy similarity | 2 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P09172 |
PaxDbi | P09172 |
PeptideAtlasi | P09172 |
PRIDEi | P09172 |
ProteomicsDBi | 52205 |
PTM databases
GlyConnecti | 1933, 9 N-Linked glycans (1 site) |
GlyGeni | P09172, 4 sites |
iPTMneti | P09172 |
PhosphoSitePlusi | P09172 |
Expressioni
Inductioni
Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids.
Gene expression databases
Bgeei | ENSG00000123454, Expressed in adrenal gland and 114 other tissues |
ExpressionAtlasi | P09172, baseline and differential |
Genevisiblei | P09172, HS |
Organism-specific databases
HPAi | ENSG00000123454, Group enriched (adrenal gland, brain, liver) |
Interactioni
Subunit structurei
Homotetramer; composed of two disulfide-linked dimers.
1 PublicationBinary interactionsi
Hide detailsP09172
Protein-protein interaction databases
BioGRIDi | 107989, 13 interactors |
IntActi | P09172, 21 interactors |
MINTi | P09172 |
STRINGi | 9606.ENSP00000376776 |
Chemistry databases
BindingDBi | P09172 |
Miscellaneous databases
RNActi | P09172, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P09172 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 57 – 173 | DOMONPROSITE-ProRule annotationAdd BLAST | 117 |
Sequence similaritiesi
Belongs to the copper type II ascorbate-dependent monooxygenase family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3568, Eukaryota |
GeneTreei | ENSGT00530000063085 |
HOGENOMi | CLU_017939_3_0_1 |
InParanoidi | P09172 |
OMAi | QCAPEMD |
OrthoDBi | 1472750at2759 |
PhylomeDBi | P09172 |
TreeFami | TF320698 |
Family and domain databases
Gene3Di | 2.60.120.230, 1 hit 2.60.120.310, 1 hit |
InterProi | View protein in InterPro IPR014784, Cu2_ascorb_mOase-like_C IPR020611, Cu2_ascorb_mOase_CS-1 IPR014783, Cu2_ascorb_mOase_CS-2 IPR000323, Cu2_ascorb_mOase_N IPR036939, Cu2_ascorb_mOase_N_sf IPR024548, Cu2_monoox_C IPR000945, DBH-like IPR005018, DOMON_domain IPR008977, PHM/PNGase_F_dom_sf IPR028460, Tbh/DBH |
PANTHERi | PTHR10157, PTHR10157, 1 hit |
Pfami | View protein in Pfam PF03712, Cu2_monoox_C, 1 hit PF01082, Cu2_monooxygen, 1 hit PF03351, DOMON, 1 hit |
PRINTSi | PR00767, DBMONOXGNASE |
SMARTi | View protein in SMART SM00664, DoH, 1 hit |
SUPFAMi | SSF49742, SSF49742, 2 hits |
PROSITEi | View protein in PROSITE PS00084, CU2_MONOOXYGENASE_1, 1 hit PS00085, CU2_MONOOXYGENASE_2, 1 hit PS50836, DOMON, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P09172-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPALSRWASL PGPSMREAAF MYSTAVAIFL VILVAALQGS APRESPLPYH
60 70 80 90 100
IPLDPEGSLE LSWNVSYTQE AIHFQLLVRR LKAGVLFGMS DRGELENADL
110 120 130 140 150
VVLWTDGDTA YFADAWSDQK GQIHLDPQQD YQLLQVQRTP EGLTLLFKRP
160 170 180 190 200
FGTCDPKDYL IEDGTVHLVY GILEEPFRSL EAINGSGLQM GLQRVQLLKP
210 220 230 240 250
NIPEPELPSD ACTMEVQAPN IQIPSQETTY WCYIKELPKG FSRHHIIKYE
260 270 280 290 300
PIVTKGNEAL VHHMEVFQCA PEMDSVPHFS GPCDSKMKPD RLNYCRHVLA
310 320 330 340 350
AWALGAKAFY YPEEAGLAFG GPGSSRYLRL EVHYHNPLVI EGRNDSSGIR
360 370 380 390 400
LYYTAKLRRF NAGIMELGLV YTPVMAIPPR ETAFILTGYC TDKCTQLALP
410 420 430 440 450
PSGIHIFASQ LHTHLTGRKV VTVLVRDGRE WEIVNQDNHY SPHFQEIRML
460 470 480 490 500
KKVVSVHPGD VLITSCTYNT EDRELATVGG FGILEEMCVN YVHYYPQTQL
510 520 530 540 550
ELCKSAVDAG FLQKYFHLIN RFNNEDVCTC PQASVSQQFT SVPWNSFNRD
560 570 580 590 600
VLKALYSFAP ISMHCNKSSA VRFQGEWNLQ PLPKVISTLE EPTPQCPTSQ
610
GRSPAGPTVV SIGGGKG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5T382 | Q5T382_HUMAN | Dopamine beta-hydroxylase | DBH | 256 | Annotation score: |
Sequence cautioni
The sequence AAH17174 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA31631 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA31632 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA68285 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 505 | S → T in CAA68285 (PubMed:3443096).Curated | 1 | |
Sequence conflicti | 505 | S → T in CAA31631 (PubMed:2922261).Curated | 1 | |
Sequence conflicti | 505 | S → T in CAA31632 (PubMed:2922261).Curated | 1 |
Polymorphismi
There are two main alleles of DBH: DBH-A with Ala-318 and DBH-B with Ser-318 (PubMed:10490716, PubMed:10391209, PubMed:10391210).3 Publications
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048838 | 12 | G → S. Corresponds to variant dbSNP:rs5318Ensembl. | 1 | |
Natural variantiVAR_022758 | 101 | V → M in ORTHYP1. 1 PublicationCorresponds to variant dbSNP:rs267606760EnsemblClinVar. | 1 | |
Natural variantiVAR_022759 | 114 | D → E in ORTHYP1. 1 PublicationCorresponds to variant dbSNP:rs77576840EnsemblClinVar. | 1 | |
Natural variantiVAR_014706 | 181 | E → Q. Corresponds to variant dbSNP:rs5319Ensembl. | 1 | |
Natural variantiVAR_013947 | 211 | A → T2 PublicationsCorresponds to variant dbSNP:rs5320EnsemblClinVar. | 1 | |
Natural variantiVAR_014707 | 239 | K → N. Corresponds to variant dbSNP:rs5321Ensembl. | 1 | |
Natural variantiVAR_014708 | 250 | E → Q. Corresponds to variant dbSNP:rs5323Ensembl. | 1 | |
Natural variantiVAR_014709 | 290 | D → N. Corresponds to variant dbSNP:rs5324EnsemblClinVar. | 1 | |
Natural variantiVAR_014710 | 317 | L → P. Corresponds to variant dbSNP:rs5325Ensembl. | 1 | |
Natural variantiVAR_002196 | 318 | A → S in allele DBH-B. 3 PublicationsCorresponds to variant dbSNP:rs4531EnsemblClinVar. | 1 | |
Natural variantiVAR_022760 | 345 | D → N in ORTHYP1. 1 PublicationCorresponds to variant dbSNP:rs267606761EnsemblClinVar. | 1 | |
Natural variantiVAR_013948 | 549 | R → C2 PublicationsCorresponds to variant dbSNP:rs6271EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL365494 Genomic DNA No translation available. Y00096 mRNA Translation: CAA68285.1 Different initiation. BC017174 mRNA Translation: AAH17174.1 Different initiation. X13255 mRNA Translation: CAA31631.1 Different initiation. X13256 mRNA Translation: CAA31632.1 Different initiation. |
CCDSi | CCDS6977.2 |
PIRi | S03020 |
RefSeqi | NP_000778.3, NM_000787.3 |
Genome annotation databases
Ensembli | ENST00000393056; ENSP00000376776; ENSG00000123454 |
GeneIDi | 1621 |
KEGGi | hsa:1621 |
UCSCi | uc004cel.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Dopamine beta hydroxylase entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL365494 Genomic DNA No translation available. Y00096 mRNA Translation: CAA68285.1 Different initiation. BC017174 mRNA Translation: AAH17174.1 Different initiation. X13255 mRNA Translation: CAA31631.1 Different initiation. X13256 mRNA Translation: CAA31632.1 Different initiation. |
CCDSi | CCDS6977.2 |
PIRi | S03020 |
RefSeqi | NP_000778.3, NM_000787.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4ZEL | X-ray | 2.90 | A/B | 40-617 | [»] | |
SMRi | P09172 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107989, 13 interactors |
IntActi | P09172, 21 interactors |
MINTi | P09172 |
STRINGi | 9606.ENSP00000376776 |
Chemistry databases
BindingDBi | P09172 |
ChEMBLi | CHEMBL3102 |
DrugBanki | DB00126, Ascorbic acid DB06774, Capsaicin DB09130, Copper DB05394, Corticorelin DB00822, Disulfiram DB00988, Dopamine DB00550, Propylthiouracil |
DrugCentrali | P09172 |
GuidetoPHARMACOLOGYi | 2486 |
PTM databases
GlyConnecti | 1933, 9 N-Linked glycans (1 site) |
GlyGeni | P09172, 4 sites |
iPTMneti | P09172 |
PhosphoSitePlusi | P09172 |
Genetic variation databases
BioMutai | DBH |
DMDMi | 158517849 |
Proteomic databases
MassIVEi | P09172 |
PaxDbi | P09172 |
PeptideAtlasi | P09172 |
PRIDEi | P09172 |
ProteomicsDBi | 52205 |
Protocols and materials databases
Antibodypediai | 881, 527 antibodies |
DNASUi | 1621 |
Genome annotation databases
Ensembli | ENST00000393056; ENSP00000376776; ENSG00000123454 |
GeneIDi | 1621 |
KEGGi | hsa:1621 |
UCSCi | uc004cel.4, human |
Organism-specific databases
CTDi | 1621 |
DisGeNETi | 1621 |
GeneCardsi | DBH |
GeneReviewsi | DBH |
HGNCi | HGNC:2689, DBH |
HPAi | ENSG00000123454, Group enriched (adrenal gland, brain, liver) |
MalaCardsi | DBH |
MIMi | 223360, phenotype 609312, gene |
neXtProti | NX_P09172 |
OpenTargetsi | ENSG00000123454 |
Orphaneti | 230, Dopamine beta-hydroxylase deficiency |
PharmGKBi | PA136 |
VEuPathDBi | HostDB:ENSG00000123454.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3568, Eukaryota |
GeneTreei | ENSGT00530000063085 |
HOGENOMi | CLU_017939_3_0_1 |
InParanoidi | P09172 |
OMAi | QCAPEMD |
OrthoDBi | 1472750at2759 |
PhylomeDBi | P09172 |
TreeFami | TF320698 |
Enzyme and pathway databases
UniPathwayi | UPA00748;UER00735 |
BioCyci | MetaCyc:MONOMER66-381 |
BRENDAi | 1.14.17.1, 2681 |
PathwayCommonsi | P09172 |
Reactomei | R-HSA-209905, Catecholamine biosynthesis |
SignaLinki | P09172 |
SIGNORi | P09172 |
Miscellaneous databases
BioGRID-ORCSi | 1621, 2 hits in 984 CRISPR screens |
ChiTaRSi | DBH, human |
GeneWikii | Dopamine_beta_hydroxylase |
GenomeRNAii | 1621 |
Pharosi | P09172, Tchem |
PROi | PR:P09172 |
RNActi | P09172, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000123454, Expressed in adrenal gland and 114 other tissues |
ExpressionAtlasi | P09172, baseline and differential |
Genevisiblei | P09172, HS |
Family and domain databases
Gene3Di | 2.60.120.230, 1 hit 2.60.120.310, 1 hit |
InterProi | View protein in InterPro IPR014784, Cu2_ascorb_mOase-like_C IPR020611, Cu2_ascorb_mOase_CS-1 IPR014783, Cu2_ascorb_mOase_CS-2 IPR000323, Cu2_ascorb_mOase_N IPR036939, Cu2_ascorb_mOase_N_sf IPR024548, Cu2_monoox_C IPR000945, DBH-like IPR005018, DOMON_domain IPR008977, PHM/PNGase_F_dom_sf IPR028460, Tbh/DBH |
PANTHERi | PTHR10157, PTHR10157, 1 hit |
Pfami | View protein in Pfam PF03712, Cu2_monoox_C, 1 hit PF01082, Cu2_monooxygen, 1 hit PF03351, DOMON, 1 hit |
PRINTSi | PR00767, DBMONOXGNASE |
SMARTi | View protein in SMART SM00664, DoH, 1 hit |
SUPFAMi | SSF49742, SSF49742, 2 hits |
PROSITEi | View protein in PROSITE PS00084, CU2_MONOOXYGENASE_1, 1 hit PS00085, CU2_MONOOXYGENASE_2, 1 hit PS50836, DOMON, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DOPO_HUMAN | |
Accessioni | P09172Primary (citable) accession number: P09172 Secondary accession number(s): Q5T381, Q96AG2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 24, 2007 | |
Last modified: | April 7, 2021 | |
This is version 217 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families