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UniProtKB - P09131 (P3_HUMAN)

Protein

P3 protein

Gene

SLC10A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processSymport, Transport

Protein family/group databases

TCDBi2.A.28.1.8 the bile acid:na(+) symporter (bass) family

Names & Taxonomyi

Protein namesi
Recommended name:
P3 protein
Alternative name(s):
Solute carrier family 10 member 3
Gene namesi
Name:SLC10A3
Synonyms:DXS253E, P3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000126903.15
HGNCiHGNC:22979 SLC10A3
MIMi312090 gene
neXtProtiNX_P09131

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Transmembranei383 – 403HelicalSequence analysisAdd BLAST21
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000126903
PharmGKBiPA134886398

Polymorphism and mutation databases

BioMutaiSLC10A3
DMDMi129356

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000523431 – 477P3 proteinAdd BLAST477

Proteomic databases

PaxDbiP09131
PeptideAtlasiP09131
PRIDEiP09131
ProteomicsDBi52201
52202 [P09131-2]

PTM databases

iPTMnetiP09131
PhosphoSitePlusiP09131

Expressioni

Gene expression databases

BgeeiENSG00000126903 Expressed in 177 organ(s), highest expression level in right ovary
CleanExiHS_SLC10A3
ExpressionAtlasiP09131 baseline and differential
GenevisibleiP09131 HS

Organism-specific databases

HPAiHPA021656

Interactioni

Protein-protein interaction databases

BioGridi113889, 2 interactors
IntActiP09131, 1 interactor
STRINGi9606.ENSP00000263512

Structurei

3D structure databases

ProteinModelPortaliP09131
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2718 Eukaryota
COG0385 LUCA
GeneTreeiENSGT00550000074505
HOGENOMiHOG000037944
HOVERGENiHBG002872
InParanoidiP09131
KOiK14343
PhylomeDBiP09131
TreeFamiTF315811

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
InterProiView protein in InterPro
IPR002657 BilAc:Na_symport/Acr3
IPR004710 Bilac:Na_transpt
IPR038770 Na+/solute_symporter_sf
IPR030210 SLC10A3
PANTHERiPTHR10361 PTHR10361, 1 hit
PTHR10361:SF3 PTHR10361:SF3, 1 hit
PfamiView protein in Pfam
PF01758 SBF, 1 hit
TIGRFAMsiTIGR00841 bass, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P09131-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLMQDKGSS QQWPGLGGEG GGTGPLSMLR AALLLISLPW GAQGTASTSL 
        60         70         80         90        100
STAGGHTVPP TGGRYLSIGD GSVMEFEFPE DSEGIIVISS QYPGQANRTA 
       110        120        130        140        150
PGPMLRVTSL DTEVLTIKNV SAITWGGGGG FVVSIHSGLA GLAPLHIQLV 
       160        170        180        190        200
DAHEAPPTLI EERRDFCIKV SPAEDTPATL SADLAHFSEN PILYLLLPLI 
       210        220        230        240        250
FVNKCSFGCK VELEVLKGLM QSPQPMLLGL LGQFLVMPLY AFLMAKVFML 
       260        270        280        290        300
PKALALGLII TCSSPGGGGS YLFSLLLGGD VTLAISMTFL STVAATGFLP 
       310        320        330        340        350
LSSAIYSRLL SIHETLHVPI SKILGTLLFI AIPIAVGVLI KSKLPKFSQL 
       360        370        380        390        400
LLQVVKPFSF VLLLGGLFLA YRMGVFILAG IRLPIVLVGI TVPLVGLLVG 
       410        420        430        440        450
YCLATCLKLP VAQRRTVSIE VGVQNSLLAL AMLQLSLRRL QADYASQAPF 
       460        470 
IVALSGTSEM LALVIGHFIY SSLFPVP
Length:477
Mass (Da):50,333
Last modified:July 1, 1989 - v1
Checksum:i49CB363EB3B66A1D
GO
Isoform 2 (identifier: P09131-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-148: Missing.

Note: No experimental confirmation available.
Show »
Length:448
Mass (Da):47,549
Checksum:i47A1263CF8EFFF91
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5HY78Q5HY78_HUMAN
P3 protein
SLC10A3
218Annotation score:
A0A0A0MS43A0A0A0MS43_HUMAN
P3 protein
SLC10A3
532Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050229354V → I. Corresponds to variant dbSNP:rs35381503Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043669120 – 148Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12458 Genomic DNA Translation: CAA30998.1
L44140 Genomic DNA Translation: AAA92651.1
BX664739 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72697.1
CH471172 Genomic DNA Translation: EAW72698.1
CH471172 Genomic DNA Translation: EAW72699.1
BC004966 mRNA Translation: AAH04966.1
CCDSiCCDS14755.1 [P09131-1]
CCDS48195.1 [P09131-2]
PIRiS01696
RefSeqiNP_001135863.1, NM_001142391.2 [P09131-2]
NP_001135864.1, NM_001142392.2 [P09131-1]
NP_062822.1, NM_019848.4 [P09131-1]
XP_011529503.1, XM_011531201.2 [P09131-1]
UniGeneiHs.522826

Genome annotation databases

EnsembliENST00000263512; ENSP00000263512; ENSG00000126903 [P09131-1]
ENST00000369649; ENSP00000358663; ENSG00000126903 [P09131-2]
ENST00000393587; ENSP00000377212; ENSG00000126903 [P09131-1]
GeneIDi8273
KEGGihsa:8273
UCSCiuc004flp.4 human [P09131-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12458 Genomic DNA Translation: CAA30998.1
L44140 Genomic DNA Translation: AAA92651.1
BX664739 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72697.1
CH471172 Genomic DNA Translation: EAW72698.1
CH471172 Genomic DNA Translation: EAW72699.1
BC004966 mRNA Translation: AAH04966.1
CCDSiCCDS14755.1 [P09131-1]
CCDS48195.1 [P09131-2]
PIRiS01696
RefSeqiNP_001135863.1, NM_001142391.2 [P09131-2]
NP_001135864.1, NM_001142392.2 [P09131-1]
NP_062822.1, NM_019848.4 [P09131-1]
XP_011529503.1, XM_011531201.2 [P09131-1]
UniGeneiHs.522826

3D structure databases

ProteinModelPortaliP09131
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113889, 2 interactors
IntActiP09131, 1 interactor
STRINGi9606.ENSP00000263512

Protein family/group databases

TCDBi2.A.28.1.8 the bile acid:na(+) symporter (bass) family

PTM databases

iPTMnetiP09131
PhosphoSitePlusiP09131

Polymorphism and mutation databases

BioMutaiSLC10A3
DMDMi129356

Proteomic databases

PaxDbiP09131
PeptideAtlasiP09131
PRIDEiP09131
ProteomicsDBi52201
52202 [P09131-2]

Protocols and materials databases

DNASUi8273
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263512; ENSP00000263512; ENSG00000126903 [P09131-1]
ENST00000369649; ENSP00000358663; ENSG00000126903 [P09131-2]
ENST00000393587; ENSP00000377212; ENSG00000126903 [P09131-1]
GeneIDi8273
KEGGihsa:8273
UCSCiuc004flp.4 human [P09131-1]

Organism-specific databases

CTDi8273
EuPathDBiHostDB:ENSG00000126903.15
GeneCardsiSLC10A3
HGNCiHGNC:22979 SLC10A3
HPAiHPA021656
MIMi312090 gene
neXtProtiNX_P09131
OpenTargetsiENSG00000126903
PharmGKBiPA134886398
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2718 Eukaryota
COG0385 LUCA
GeneTreeiENSGT00550000074505
HOGENOMiHOG000037944
HOVERGENiHBG002872
InParanoidiP09131
KOiK14343
PhylomeDBiP09131
TreeFamiTF315811

Miscellaneous databases

GeneWikiiSLC10A3
GenomeRNAii8273
PROiPR:P09131
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126903 Expressed in 177 organ(s), highest expression level in right ovary
CleanExiHS_SLC10A3
ExpressionAtlasiP09131 baseline and differential
GenevisibleiP09131 HS

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
InterProiView protein in InterPro
IPR002657 BilAc:Na_symport/Acr3
IPR004710 Bilac:Na_transpt
IPR038770 Na+/solute_symporter_sf
IPR030210 SLC10A3
PANTHERiPTHR10361 PTHR10361, 1 hit
PTHR10361:SF3 PTHR10361:SF3, 1 hit
PfamiView protein in Pfam
PF01758 SBF, 1 hit
TIGRFAMsiTIGR00841 bass, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiP3_HUMAN
AccessioniPrimary (citable) accession number: P09131
Secondary accession number(s): Q5HY79, Q9BSL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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