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Protein

P3 protein

Gene

SLC10A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Protein family/group databases

TCDBi2.A.28.1.8 the bile acid:na(+) symporter (bass) family

Names & Taxonomyi

Protein namesi
Recommended name:
P3 protein
Alternative name(s):
Solute carrier family 10 member 3
Gene namesi
Name:SLC10A3
Synonyms:DXS253E, P3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000126903.15
HGNCiHGNC:22979 SLC10A3
MIMi312090 gene
neXtProtiNX_P09131

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Transmembranei383 – 403HelicalSequence analysisAdd BLAST21
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000126903
PharmGKBiPA134886398

Polymorphism and mutation databases

BioMutaiSLC10A3
DMDMi129356

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000523431 – 477P3 proteinAdd BLAST477

Proteomic databases

PaxDbiP09131
PeptideAtlasiP09131
PRIDEiP09131
ProteomicsDBi52201
52202 [P09131-2]

PTM databases

iPTMnetiP09131
PhosphoSitePlusiP09131

Expressioni

Gene expression databases

BgeeiENSG00000126903
CleanExiHS_SLC10A3
ExpressionAtlasiP09131 baseline and differential
GenevisibleiP09131 HS

Organism-specific databases

HPAiHPA021656

Interactioni

Protein-protein interaction databases

BioGridi113889, 2 interactors
IntActiP09131, 1 interactor
STRINGi9606.ENSP00000263512

Structurei

3D structure databases

ProteinModelPortaliP09131
SMRiP09131
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2718 Eukaryota
COG0385 LUCA
GeneTreeiENSGT00550000074505
HOGENOMiHOG000037944
HOVERGENiHBG002872
InParanoidiP09131
KOiK14343
PhylomeDBiP09131
TreeFamiTF315811

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
InterProiView protein in InterPro
IPR002657 BilAc:Na_symport/Acr3
IPR004710 Bilac:Na_transpt
IPR038770 Na+/solute_symporter_sf
IPR030210 SLC10A3
PANTHERiPTHR10361 PTHR10361, 1 hit
PTHR10361:SF3 PTHR10361:SF3, 1 hit
PfamiView protein in Pfam
PF01758 SBF, 1 hit
TIGRFAMsiTIGR00841 bass, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P09131-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLMQDKGSS QQWPGLGGEG GGTGPLSMLR AALLLISLPW GAQGTASTSL
60 70 80 90 100
STAGGHTVPP TGGRYLSIGD GSVMEFEFPE DSEGIIVISS QYPGQANRTA
110 120 130 140 150
PGPMLRVTSL DTEVLTIKNV SAITWGGGGG FVVSIHSGLA GLAPLHIQLV
160 170 180 190 200
DAHEAPPTLI EERRDFCIKV SPAEDTPATL SADLAHFSEN PILYLLLPLI
210 220 230 240 250
FVNKCSFGCK VELEVLKGLM QSPQPMLLGL LGQFLVMPLY AFLMAKVFML
260 270 280 290 300
PKALALGLII TCSSPGGGGS YLFSLLLGGD VTLAISMTFL STVAATGFLP
310 320 330 340 350
LSSAIYSRLL SIHETLHVPI SKILGTLLFI AIPIAVGVLI KSKLPKFSQL
360 370 380 390 400
LLQVVKPFSF VLLLGGLFLA YRMGVFILAG IRLPIVLVGI TVPLVGLLVG
410 420 430 440 450
YCLATCLKLP VAQRRTVSIE VGVQNSLLAL AMLQLSLRRL QADYASQAPF
460 470
IVALSGTSEM LALVIGHFIY SSLFPVP
Length:477
Mass (Da):50,333
Last modified:July 1, 1989 - v1
Checksum:i49CB363EB3B66A1D
GO
Isoform 2 (identifier: P09131-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-148: Missing.

Note: No experimental confirmation available.
Show »
Length:448
Mass (Da):47,549
Checksum:i47A1263CF8EFFF91
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050229354V → I. Corresponds to variant dbSNP:rs35381503Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043669120 – 148Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12458 Genomic DNA Translation: CAA30998.1
L44140 Genomic DNA Translation: AAA92651.1
BX664739 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72697.1
CH471172 Genomic DNA Translation: EAW72698.1
CH471172 Genomic DNA Translation: EAW72699.1
BC004966 mRNA Translation: AAH04966.1
CCDSiCCDS14755.1 [P09131-1]
CCDS48195.1 [P09131-2]
PIRiS01696
RefSeqiNP_001135863.1, NM_001142391.2 [P09131-2]
NP_001135864.1, NM_001142392.2 [P09131-1]
NP_062822.1, NM_019848.4 [P09131-1]
XP_011529503.1, XM_011531201.2 [P09131-1]
UniGeneiHs.522826

Genome annotation databases

EnsembliENST00000263512; ENSP00000263512; ENSG00000126903 [P09131-1]
ENST00000369649; ENSP00000358663; ENSG00000126903 [P09131-2]
ENST00000393587; ENSP00000377212; ENSG00000126903 [P09131-1]
GeneIDi8273
KEGGihsa:8273
UCSCiuc004flp.4 human [P09131-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiP3_HUMAN
AccessioniPrimary (citable) accession number: P09131
Secondary accession number(s): Q5HY79, Q9BSL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 20, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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