UniProtKB - P09131 (P3_HUMAN)
Protein
P3 protein
Gene
SLC10A3
Organism
Homo sapiens (Human)
Status
Functioni
The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.
GO - Molecular functioni
- bile acid:sodium symporter activity Source: GO_Central
GO - Biological processi
- bile acid and bile salt transport Source: GO_Central
- response to retinoic acid Source: Ensembl
Keywordsi
Biological process | Symport, Transport |
Enzyme and pathway databases
PathwayCommonsi | P09131 |
Protein family/group databases
TCDBi | 2.A.28.1.8, the bile acid:na(+) symporter (bass) family |
Names & Taxonomyi
Protein namesi | Recommended name: P3 proteinAlternative name(s): Solute carrier family 10 member 3 |
Gene namesi | Name:SLC10A3 Synonyms:DXS253E, P3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000126903.15 |
HGNCi | HGNC:22979, SLC10A3 |
MIMi | 312090, gene |
neXtProti | NX_P09131 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 225 – 245 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 253 – 273 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 281 – 301 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 320 – 340 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 361 – 381 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 383 – 403 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 417 – 437 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 450 – 470 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000126903 |
PharmGKBi | PA134886398 |
Miscellaneous databases
Pharosi | P09131, Tdark |
Polymorphism and mutation databases
BioMutai | SLC10A3 |
DMDMi | 129356 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000052343 | 1 – 477 | P3 proteinAdd BLAST | 477 |
Proteomic databases
MassIVEi | P09131 |
PaxDbi | P09131 |
PeptideAtlasi | P09131 |
PRIDEi | P09131 |
ProteomicsDBi | 52201 [P09131-1] 52202 [P09131-2] |
PTM databases
iPTMneti | P09131 |
PhosphoSitePlusi | P09131 |
Expressioni
Gene expression databases
Bgeei | ENSG00000126903, Expressed in right ovary and 192 other tissues |
ExpressionAtlasi | P09131, baseline and differential |
Genevisiblei | P09131, HS |
Organism-specific databases
HPAi | ENSG00000126903, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 113889, 3 interactors |
IntActi | P09131, 1 interactor |
STRINGi | 9606.ENSP00000263512 |
Miscellaneous databases
RNActi | P09131, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2718, Eukaryota |
GeneTreei | ENSGT00950000182808 |
HOGENOMi | CLU_034788_2_0_1 |
InParanoidi | P09131 |
OrthoDBi | 1148347at2759 |
PhylomeDBi | P09131 |
TreeFami | TF315811 |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit |
InterProi | View protein in InterPro IPR002657, BilAc:Na_symport/Acr3 IPR004710, Bilac:Na_transpt IPR038770, Na+/solute_symporter_sf IPR030210, SLC10A3 |
PANTHERi | PTHR10361, PTHR10361, 1 hit PTHR10361:SF3, PTHR10361:SF3, 1 hit |
Pfami | View protein in Pfam PF01758, SBF, 1 hit |
TIGRFAMsi | TIGR00841, bass, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P09131-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVLMQDKGSS QQWPGLGGEG GGTGPLSMLR AALLLISLPW GAQGTASTSL
60 70 80 90 100
STAGGHTVPP TGGRYLSIGD GSVMEFEFPE DSEGIIVISS QYPGQANRTA
110 120 130 140 150
PGPMLRVTSL DTEVLTIKNV SAITWGGGGG FVVSIHSGLA GLAPLHIQLV
160 170 180 190 200
DAHEAPPTLI EERRDFCIKV SPAEDTPATL SADLAHFSEN PILYLLLPLI
210 220 230 240 250
FVNKCSFGCK VELEVLKGLM QSPQPMLLGL LGQFLVMPLY AFLMAKVFML
260 270 280 290 300
PKALALGLII TCSSPGGGGS YLFSLLLGGD VTLAISMTFL STVAATGFLP
310 320 330 340 350
LSSAIYSRLL SIHETLHVPI SKILGTLLFI AIPIAVGVLI KSKLPKFSQL
360 370 380 390 400
LLQVVKPFSF VLLLGGLFLA YRMGVFILAG IRLPIVLVGI TVPLVGLLVG
410 420 430 440 450
YCLATCLKLP VAQRRTVSIE VGVQNSLLAL AMLQLSLRRL QADYASQAPF
460 470
IVALSGTSEM LALVIGHFIY SSLFPVP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MS43 | A0A0A0MS43_HUMAN | P3 protein | SLC10A3 | 532 | Annotation score: | ||
Q5HY78 | Q5HY78_HUMAN | P3 protein | SLC10A3 | 218 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050229 | 354 | V → I. Corresponds to variant dbSNP:rs35381503Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043669 | 120 – 148 | Missing in isoform 2. 1 PublicationAdd BLAST | 29 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12458 Genomic DNA Translation: CAA30998.1 L44140 Genomic DNA Translation: AAA92651.1 BX664739 Genomic DNA No translation available. CH471172 Genomic DNA Translation: EAW72697.1 CH471172 Genomic DNA Translation: EAW72698.1 CH471172 Genomic DNA Translation: EAW72699.1 BC004966 mRNA Translation: AAH04966.1 |
CCDSi | CCDS14755.1 [P09131-1] CCDS48195.1 [P09131-2] |
PIRi | S01696 |
RefSeqi | NP_001135863.1, NM_001142391.2 [P09131-2] NP_001135864.1, NM_001142392.2 [P09131-1] NP_062822.1, NM_019848.4 [P09131-1] XP_011529503.1, XM_011531201.2 [P09131-1] |
Genome annotation databases
Ensembli | ENST00000263512; ENSP00000263512; ENSG00000126903 [P09131-1] ENST00000369649; ENSP00000358663; ENSG00000126903 [P09131-2] ENST00000393587; ENSP00000377212; ENSG00000126903 [P09131-1] ENST00000651600; ENSP00000499188; ENSG00000126903 [P09131-1] |
GeneIDi | 8273 |
KEGGi | hsa:8273 |
UCSCi | uc004flp.4, human [P09131-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12458 Genomic DNA Translation: CAA30998.1 L44140 Genomic DNA Translation: AAA92651.1 BX664739 Genomic DNA No translation available. CH471172 Genomic DNA Translation: EAW72697.1 CH471172 Genomic DNA Translation: EAW72698.1 CH471172 Genomic DNA Translation: EAW72699.1 BC004966 mRNA Translation: AAH04966.1 |
CCDSi | CCDS14755.1 [P09131-1] CCDS48195.1 [P09131-2] |
PIRi | S01696 |
RefSeqi | NP_001135863.1, NM_001142391.2 [P09131-2] NP_001135864.1, NM_001142392.2 [P09131-1] NP_062822.1, NM_019848.4 [P09131-1] XP_011529503.1, XM_011531201.2 [P09131-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 113889, 3 interactors |
IntActi | P09131, 1 interactor |
STRINGi | 9606.ENSP00000263512 |
Protein family/group databases
TCDBi | 2.A.28.1.8, the bile acid:na(+) symporter (bass) family |
PTM databases
iPTMneti | P09131 |
PhosphoSitePlusi | P09131 |
Polymorphism and mutation databases
BioMutai | SLC10A3 |
DMDMi | 129356 |
Proteomic databases
MassIVEi | P09131 |
PaxDbi | P09131 |
PeptideAtlasi | P09131 |
PRIDEi | P09131 |
ProteomicsDBi | 52201 [P09131-1] 52202 [P09131-2] |
Protocols and materials databases
Antibodypediai | 17715, 59 antibodies |
DNASUi | 8273 |
Genome annotation databases
Ensembli | ENST00000263512; ENSP00000263512; ENSG00000126903 [P09131-1] ENST00000369649; ENSP00000358663; ENSG00000126903 [P09131-2] ENST00000393587; ENSP00000377212; ENSG00000126903 [P09131-1] ENST00000651600; ENSP00000499188; ENSG00000126903 [P09131-1] |
GeneIDi | 8273 |
KEGGi | hsa:8273 |
UCSCi | uc004flp.4, human [P09131-1] |
Organism-specific databases
CTDi | 8273 |
EuPathDBi | HostDB:ENSG00000126903.15 |
GeneCardsi | SLC10A3 |
HGNCi | HGNC:22979, SLC10A3 |
HPAi | ENSG00000126903, Low tissue specificity |
MIMi | 312090, gene |
neXtProti | NX_P09131 |
OpenTargetsi | ENSG00000126903 |
PharmGKBi | PA134886398 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2718, Eukaryota |
GeneTreei | ENSGT00950000182808 |
HOGENOMi | CLU_034788_2_0_1 |
InParanoidi | P09131 |
OrthoDBi | 1148347at2759 |
PhylomeDBi | P09131 |
TreeFami | TF315811 |
Enzyme and pathway databases
PathwayCommonsi | P09131 |
Miscellaneous databases
BioGRID-ORCSi | 8273, 3 hits in 469 CRISPR screens |
GeneWikii | SLC10A3 |
GenomeRNAii | 8273 |
Pharosi | P09131, Tdark |
PROi | PR:P09131 |
RNActi | P09131, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000126903, Expressed in right ovary and 192 other tissues |
ExpressionAtlasi | P09131, baseline and differential |
Genevisiblei | P09131, HS |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit |
InterProi | View protein in InterPro IPR002657, BilAc:Na_symport/Acr3 IPR004710, Bilac:Na_transpt IPR038770, Na+/solute_symporter_sf IPR030210, SLC10A3 |
PANTHERi | PTHR10361, PTHR10361, 1 hit PTHR10361:SF3, PTHR10361:SF3, 1 hit |
Pfami | View protein in Pfam PF01758, SBF, 1 hit |
TIGRFAMsi | TIGR00841, bass, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | P3_HUMAN | |
Accessioni | P09131Primary (citable) accession number: P09131 Secondary accession number(s): Q5HY79, Q9BSL2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations