UniProtKB - P09127 (HEMX_ECOLI)
Protein
Protein HemX
Gene
hemX
Organism
Escherichia coli (strain K12)
Status
Functioni
Miscellaneous
Was suggested to be a uroporphyrinogen-III methyltransferase, but the function of the protein has not been experimentally determined.1 Publication
Enzyme and pathway databases
BioCyci | EcoCyc:HEMX-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Protein HemXCuratedAlternative name(s): ORF XImported |
Gene namesi | Name:hemX1 Publication Ordered Locus Names:b3803, JW3775 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Single-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 37 – 57 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000135255 | 1 – 393 | Protein HemXAdd BLAST | 393 |
Proteomic databases
jPOSTi | P09127 |
PaxDbi | P09127 |
PRIDEi | P09127 |
Interactioni
Subunit structurei
Homooligomer, possibly a homopentamer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 4259707, 160 interactors |
DIPi | DIP-9888N |
IntActi | P09127, 3 interactors |
STRINGi | 511145.b3803 |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2959, Bacteria |
HOGENOMi | CLU_036381_1_0_6 |
InParanoidi | P09127 |
PhylomeDBi | P09127 |
Family and domain databases
InterProi | View protein in InterPro IPR007470, HemX |
PANTHERi | PTHR38043, PTHR38043, 1 hit |
Pfami | View protein in Pfam PF04375, HemX, 1 hit |
i Sequence
Sequence statusi: Complete.
P09127-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEQEKTSAV VEETREAVDT TSQPVATEKK SKNNTALILS AVAIAIALAA
60 70 80 90 100
GIGLYGWGKQ QAVNQTATSD ALANQLTALQ KAQESQKAEL EGIIKQQAAQ
110 120 130 140 150
LKQANRQQET LAKQLDEVQQ KVATISGSDA KTWLLAQADF LVKLAGRKLW
160 170 180 190 200
SDQDVTTAAA LLKSADASLA DMNDPSLITV RRAITDDIAS LSAVSQVDYD
210 220 230 240 250
GIILKLNQLS NQVDNLRLAD NDSDGSPMDS DGEELSSSIS EWRINLQKSW
260 270 280 290 300
QNFMDNFITI RRRDDTAVPL LAPNQDIYLR ENIRSRLLVA AQAVPRHQEE
310 320 330 340 350
TYRQALENVS TWVRAYYDTD DATTKAFLDE VDQLSQQNIS MDLPETLQSQ
360 370 380 390
AMLEKLMQTR VRNLLAQPAA GTTEAKPAPA PQADTPAAAP QGE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13406 Genomic DNA Translation: CAA31772.1 X12614 Genomic DNA Translation: CAA31134.1 M87049 Genomic DNA Translation: AAA67599.1 U00096 Genomic DNA Translation: AAC76806.1 AP009048 Genomic DNA Translation: BAE77498.1 |
PIRi | S02185 |
RefSeqi | NP_418247.1, NC_000913.3 WP_000138997.1, NZ_SSZK01000025.1 |
Genome annotation databases
EnsemblBacteriai | AAC76806; AAC76806; b3803 BAE77498; BAE77498; BAE77498 |
GeneIDi | 948446 |
KEGGi | ecj:JW3775 eco:b3803 |
PATRICi | fig|1411691.4.peg.2905 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13406 Genomic DNA Translation: CAA31772.1 X12614 Genomic DNA Translation: CAA31134.1 M87049 Genomic DNA Translation: AAA67599.1 U00096 Genomic DNA Translation: AAC76806.1 AP009048 Genomic DNA Translation: BAE77498.1 |
PIRi | S02185 |
RefSeqi | NP_418247.1, NC_000913.3 WP_000138997.1, NZ_SSZK01000025.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4259707, 160 interactors |
DIPi | DIP-9888N |
IntActi | P09127, 3 interactors |
STRINGi | 511145.b3803 |
Proteomic databases
jPOSTi | P09127 |
PaxDbi | P09127 |
PRIDEi | P09127 |
Genome annotation databases
EnsemblBacteriai | AAC76806; AAC76806; b3803 BAE77498; BAE77498; BAE77498 |
GeneIDi | 948446 |
KEGGi | ecj:JW3775 eco:b3803 |
PATRICi | fig|1411691.4.peg.2905 |
Organism-specific databases
EchoBASEi | EB0428 |
Phylogenomic databases
eggNOGi | COG2959, Bacteria |
HOGENOMi | CLU_036381_1_0_6 |
InParanoidi | P09127 |
PhylomeDBi | P09127 |
Enzyme and pathway databases
BioCyci | EcoCyc:HEMX-MONOMER |
Miscellaneous databases
PROi | PR:P09127 |
Family and domain databases
InterProi | View protein in InterPro IPR007470, HemX |
PANTHERi | PTHR38043, PTHR38043, 1 hit |
Pfami | View protein in Pfam PF04375, HemX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HEMX_ECOLI | |
Accessioni | P09127Primary (citable) accession number: P09127 Secondary accession number(s): Q2M8A8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |