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UniProtKB - P09110 (THIK_HUMAN)

Entry version 215 (07 Oct 2020)
Sequence version 2 (01 Oct 1989)
Previous versions | rss
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Protein

3-ketoacyl-CoA thiolase, peroxisomal

Gene

ACAA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid metabolism

This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei123Acyl-thioester intermediateBy similarity1
Active sitei377Proton acceptorPROSITE-ProRule annotation1
Active sitei408Proton acceptorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS00752-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P09110

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2046106, alpha-linolenic acid (ALA) metabolism
R-HSA-390247, Beta-oxidation of very long chain fatty acids
R-HSA-6798695, Neutrophil degranulation
R-HSA-9033241, Peroxisomal protein import
R-HSA-9033500, TYSND1 cleaves peroxisomal proteins

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00199

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3-ketoacyl-CoA thiolase, peroxisomal (EC:2.3.1.16)
Alternative name(s):
Acetyl-CoA acyltransferase
Beta-ketothiolase
Peroxisomal 3-oxoacyl-CoA thiolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACAA1
Synonyms:ACAA, PTHIO
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000060971.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:82, ACAA1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604054, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P09110

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		30

Open Targets

More...OpenTargetsi		ENSG00000060971

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24419

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P09110, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB09069, Trimetazidine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ACAA1

Domain mapping of disease mutations (DMDM)

More...DMDMi		135751

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 26PeroxisomeCombined sourcesAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003406727 – 4243-ketoacyl-CoA thiolase, peroxisomalAdd BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei59PhosphothreonineCombined sources1
Modified residuei60PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P09110

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P09110

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P09110

MaxQB - The MaxQuant DataBase

More...MaxQBi		P09110

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P09110

PeptideAtlas

More...PeptideAtlasi		P09110

PRoteomics IDEntifications database

More...PRIDEi		P09110

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		33816
52200 [P09110-1]

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00012828

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P09110

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P09110

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P09110

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P09110

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P09110

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P09110

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Peroxisomal thiolase is markedly induced (at the level of transcription) by various hypolipidemic compounds in parallel with the other two enzymes of the peroxisomal beta-oxidation system.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000060971, Expressed in nephron tubule and 248 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P09110, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P09110, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000060971, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106548, 46 interactors

Protein interaction database and analysis system

More...IntActi		P09110, 14 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000333664

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P09110, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1424
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P09110

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P09110

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thiolase-like superfamily. Thiolase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1389, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182771

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P09110

KEGG Orthology (KO)

More...KOi		K07513

Identification of Orthologs from Complete Genome Data

More...OMAi		YHETRAD

Database for complete collections of gene phylogenies

More...PhylomeDBi		P09110

TreeFam database of animal gene trees

More...TreeFami		TF332308

Family and domain databases

Conserved Domains Database

More...CDDi		cd00751, thiolase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.47.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002155, Thiolase
IPR016039, Thiolase-like
IPR020615, Thiolase_acyl_enz_int_AS
IPR020610, Thiolase_AS
IPR020617, Thiolase_C
IPR020613, Thiolase_CS
IPR020616, Thiolase_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02803, Thiolase_C, 1 hit
PF00108, Thiolase_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000429, Ac-CoA_Ac_transf, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53901, SSF53901, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01930, AcCoA-C-Actrans, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00098, THIOLASE_1, 1 hit
PS00737, THIOLASE_2, 1 hit
PS00099, THIOLASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P09110-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQRLQVVLGH LRGPADSGWM PQAAPCLSGA PQASAADVVV VHGRRTAICR 
        60         70         80         90        100
AGRGGFKDTT PDELLSAVMT AVLKDVNLRP EQLGDICVGN VLQPGAGAIM 
       110        120        130        140        150
ARIAQFLSDI PETVPLSTVN RQCSSGLQAV ASIAGGIRNG SYDIGMACGV 
       160        170        180        190        200
ESMSLADRGN PGNITSRLME KEKARDCLIP MGITSENVAE RFGISREKQD 
       210        220        230        240        250
TFALASQQKA ARAQSKGCFQ AEIVPVTTTV HDDKGTKRSI TVTQDEGIRP 
       260        270        280        290        300
STTMEGLAKL KPAFKKDGST TAGNSSQVSD GAAAILLARR SKAEELGLPI 
       310        320        330        340        350
LGVLRSYAVV GVPPDIMGIG PAYAIPVALQ KAGLTVSDVD IFEINEAFAS 
       360        370        380        390        400
QAAYCVEKLR LPPEKVNPLG GAVALGHPLG CTGARQVITL LNELKRRGKR 
       410        420 
AYGVVSMCIG TGMGAAAVFE YPGN
Length:424
Mass (Da):44,292
Last modified:October 1, 1989 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71B2BBAFA06AE412
GO
Isoform 2 (identifier: P09110-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-181: Missing.
     272-331: Missing.

Show »
Length:331
Mass (Da):34,665
Checksum:i8137A0AC448FBA24
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JDE9C9JDE9_HUMAN
3-ketoacyl-CoA thiolase, peroxisoma...
ACAA1
383Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C131H7C131_HUMAN
3-ketoacyl-CoA thiolase, peroxisoma...
ACAA1
290Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4D4H0Y4D4_HUMAN
3-ketoacyl-CoA thiolase, peroxisoma...
ACAA1
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DVF4B4DVF4_HUMAN
3-ketoacyl-CoA thiolase, peroxisoma...
ACAA1
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2Q6F2Z2Q6_HUMAN
3-ketoacyl-CoA thiolase, peroxisoma...
ACAA1
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3P7F2Z3P7_HUMAN
3-ketoacyl-CoA thiolase, peroxisoma...
ACAA1
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_011904172E → D. Corresponds to variant dbSNP:rs156265Ensembl.1
Natural variantiVAR_069148387V → A1 PublicationCorresponds to variant dbSNP:rs2229528Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_046195149 – 181Missing in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_046196272 – 331Missing in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X12966 mRNA Translation: CAA31412.1
X14813 mRNA Translation: CAA32918.1
X65140 Genomic DNA Translation: CAA46270.1
X65148 Genomic DNA Translation: CAA46271.1
AP006309 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64516.1
BC000635 mRNA Translation: AAH00635.1
BC011977 mRNA Translation: AAH11977.1
BC014474 mRNA Translation: AAH14474.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2673.1 [P09110-1]
CCDS46794.1 [P09110-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S17515, XUHUAB

NCBI Reference Sequences

More...RefSeqi		NP_001123882.1, NM_001130410.1 [P09110-2]
NP_001598.1, NM_001607.3 [P09110-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000301810; ENSP00000301810; ENSG00000060971 [P09110-2]
ENST00000333167; ENSP00000333664; ENSG00000060971 [P09110-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		30

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:30

UCSC genome browser

More...UCSCi		uc003cht.4, human [P09110-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12966 mRNA Translation: CAA31412.1
X14813 mRNA Translation: CAA32918.1
X65140 Genomic DNA Translation: CAA46270.1
X65148 Genomic DNA Translation: CAA46271.1
AP006309 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64516.1
BC000635 mRNA Translation: AAH00635.1
BC011977 mRNA Translation: AAH11977.1
BC014474 mRNA Translation: AAH14474.1
CCDSiCCDS2673.1 [P09110-1]
CCDS46794.1 [P09110-2]
PIRiS17515, XUHUAB
RefSeqiNP_001123882.1, NM_001130410.1 [P09110-2]
NP_001598.1, NM_001607.3 [P09110-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IIKX-ray2.55A/B30-423[»]
SMRiP09110
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106548, 46 interactors
IntActiP09110, 14 interactors
STRINGi9606.ENSP00000333664

Chemistry databases

DrugBankiDB09069, Trimetazidine

PTM databases

CarbonylDBiP09110
iPTMnetiP09110
MetOSiteiP09110
PhosphoSitePlusiP09110
SwissPalmiP09110

Polymorphism and mutation databases

BioMutaiACAA1
DMDMi135751

2D gel databases

REPRODUCTION-2DPAGEiIPI00012828
UCD-2DPAGEiP09110

Proteomic databases

EPDiP09110
jPOSTiP09110
MassIVEiP09110
MaxQBiP09110
PaxDbiP09110
PeptideAtlasiP09110
PRIDEiP09110
ProteomicsDBi33816
52200 [P09110-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1631, 309 antibodies

The DNASU plasmid repository

More...DNASUi		30

Genome annotation databases

EnsembliENST00000301810; ENSP00000301810; ENSG00000060971 [P09110-2]
ENST00000333167; ENSP00000333664; ENSG00000060971 [P09110-1]
GeneIDi30
KEGGihsa:30
UCSCiuc003cht.4, human [P09110-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		30
DisGeNETi30
EuPathDBiHostDB:ENSG00000060971.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		ACAA1
HGNCiHGNC:82, ACAA1
HPAiENSG00000060971, Tissue enhanced (liver)
MIMi604054, gene
neXtProtiNX_P09110
OpenTargetsiENSG00000060971
PharmGKBiPA24419

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1389, Eukaryota
GeneTreeiENSGT00950000182771
InParanoidiP09110
KOiK07513
OMAiYHETRAD
PhylomeDBiP09110
TreeFamiTF332308

Enzyme and pathway databases

UniPathwayiUPA00199
BioCyciMetaCyc:HS00752-MONOMER
PathwayCommonsiP09110
ReactomeiR-HSA-2046106, alpha-linolenic acid (ALA) metabolism
R-HSA-390247, Beta-oxidation of very long chain fatty acids
R-HSA-6798695, Neutrophil degranulation
R-HSA-9033241, Peroxisomal protein import
R-HSA-9033500, TYSND1 cleaves peroxisomal proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		30, 7 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ACAA1, human
EvolutionaryTraceiP09110

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ACAA1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		30
PharosiP09110, Tbio

Protein Ontology

More...PROi		PR:P09110
RNActiP09110, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000060971, Expressed in nephron tubule and 248 other tissues
ExpressionAtlasiP09110, baseline and differential
GenevisibleiP09110, HS

Family and domain databases

CDDicd00751, thiolase, 1 hit
Gene3Di3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR002155, Thiolase
IPR016039, Thiolase-like
IPR020615, Thiolase_acyl_enz_int_AS
IPR020610, Thiolase_AS
IPR020617, Thiolase_C
IPR020613, Thiolase_CS
IPR020616, Thiolase_N
PfamiView protein in Pfam
PF02803, Thiolase_C, 1 hit
PF00108, Thiolase_N, 1 hit
PIRSFiPIRSF000429, Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901, SSF53901, 2 hits
TIGRFAMsiTIGR01930, AcCoA-C-Actrans, 1 hit
PROSITEiView protein in PROSITE
PS00098, THIOLASE_1, 1 hit
PS00737, THIOLASE_2, 1 hit
PS00099, THIOLASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHIK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09110
Secondary accession number(s): G5E935, Q96CA6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1989
Last modified: October 7, 2020
This is version 215 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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