ACAA1

Functionⁱ

Catalytic activityⁱ

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.

Pathwayⁱ: fatty acid metabolism

This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	123	Acyl-thioester intermediateBy similarity	1
Active siteⁱ	377	Proton acceptorPROSITE-ProRule annotation	1
Active siteⁱ	408	Proton acceptorPROSITE-ProRule annotation	1

GO - Molecular functionⁱ

acetate CoA-transferase activity
Source: Reactome
Inferred from experimentⁱ
- 11734571
acetyl-CoA C-acyltransferase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
palmitoyl-CoA oxidase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 2882519

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

alpha-linolenic acid metabolic process Source: Reactome
bile acid metabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 2318981
fatty acid beta-oxidation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 2365812
- 2882519
fatty acid beta-oxidation using acyl-CoA oxidase Source: Reactome
neutrophil degranulation Source: Reactome
phenylacetate catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein targeting to peroxisome Source: Reactome
very long-chain fatty acid metabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 2318981

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase
Biological process	Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS00752-MONOMER
Reactomeⁱ	R-HSA-2046106 alpha-linolenic acid (ALA) metabolism R-HSA-390247 Beta-oxidation of very long chain fatty acids R-HSA-6798695 Neutrophil degranulation R-HSA-9033241 Peroxisomal protein import R-HSA-9033500 TYSND1 cleaves peroxisomal proteins
UniPathwayⁱ	UPA00199

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 3-ketoacyl-CoA thiolase, peroxisomal (EC:2.3.1.16) Alternative name(s): Acetyl-CoA acyltransferase Beta-ketothiolase Peroxisomal 3-oxoacyl-CoA thiolase
Gene namesⁱ	Name:ACAA1 Synonyms:ACAA, PTHIO
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000060971.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:82 ACAA1
MIMⁱ	604054 gene
neXtProtⁱ	NX_P09110

Keywords - Cellular componentⁱ

Peroxisome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	30
Open Targets More...OpenTargetsⁱ	ENSG00000060971
PharmGKBⁱ	PA24419

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB09069 Trimetazidine

DrugBankⁱ

DB09069 Trimetazidine

Polymorphism and mutation databases

BioMutaⁱ	ACAA1
DMDMⁱ	135751

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 26	PeroxisomeCombined sourcesAdd BLAST		26
ChainⁱPRO_0000034067	27 – 424	3-ketoacyl-CoA thiolase, peroxisomalAdd BLAST		398

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	59	PhosphothreonineCombined sources		1
Modified residueⁱ	60	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P09110
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P09110
PaxDbⁱ	P09110
PeptideAtlas More...PeptideAtlasⁱ	P09110
PRIDEⁱ	P09110
ProteomicsDBⁱ	52200

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00012828
UCD-2DPAGEⁱ	P09110

PTM databases

CarbonylDBⁱ	P09110
iPTMnetⁱ	P09110
PhosphoSitePlusⁱ	P09110
SwissPalmⁱ	P09110

Expressionⁱ

Inductionⁱ

Peroxisomal thiolase is markedly induced (at the level of transcription) by various hypolipidemic compounds in parallel with the other two enzymes of the peroxisomal beta-oxidation system.

Gene expression databases

Bgeeⁱ	ENSG00000060971 Expressed in 236 organ(s), highest expression level in nephron tubule
CleanExⁱ	HS_ACAA1
ExpressionAtlasⁱ	P09110 baseline and differential
Genevisibleⁱ	P09110 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA006764 HPA007244

HPAⁱ

HPA006764
HPA007244

Interactionⁱ

Subunit structureⁱ

Homodimer.1 Publication

Protein-protein interaction databases

BioGridⁱ	106548, 32 interactors
IntActⁱ	P09110, 7 interactors
STRINGⁱ	9606.ENSP00000333664

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	38 – 45	Combined sources	8
Turnⁱ	51 – 53	Combined sources	3
Turnⁱ	55 – 58	Combined sources	4
Helixⁱ	61 – 76	Combined sources	16
Helixⁱ	80 – 82	Combined sources	3
Beta strandⁱ	86 – 89	Combined sources	4
Beta strandⁱ	91 – 94	Combined sources	4
Helixⁱ	95 – 97	Combined sources	3
Helixⁱ	98 – 107	Combined sources	10
Beta strandⁱ	116 – 120	Combined sources	5
Helixⁱ	122 – 124	Combined sources	3
Helixⁱ	125 – 138	Combined sources	14
Beta strandⁱ	143 – 152	Combined sources	10
Turnⁱ	153 – 155	Combined sources	3
Helixⁱ	168 – 170	Combined sources	3
Helixⁱ	172 – 175	Combined sources	4
Helixⁱ	176 – 178	Combined sources	3
Helixⁱ	181 – 191	Combined sources	11
Helixⁱ	196 – 216	Combined sources	21
Turnⁱ	217 – 222	Combined sources	6
Beta strandⁱ	226 – 231	Combined sources	6
Beta strandⁱ	237 – 242	Combined sources	6
Helixⁱ	254 – 259	Combined sources	6
Beta strandⁱ	263 – 265	Combined sources	3
Beta strandⁱ	279 – 289	Combined sources	11
Helixⁱ	290 – 296	Combined sources	7
Beta strandⁱ	302 – 311	Combined sources	10
Helixⁱ	314 – 319	Combined sources	6
Helixⁱ	320 – 332	Combined sources	13
Helixⁱ	336 – 338	Combined sources	3
Beta strandⁱ	339 – 344	Combined sources	6
Helixⁱ	349 – 359	Combined sources	11
Helixⁱ	363 – 365	Combined sources	3
Helixⁱ	372 – 375	Combined sources	4
Turnⁱ	379 – 381	Combined sources	3
Helixⁱ	382 – 397	Combined sources	16
Beta strandⁱ	401 – 409	Combined sources	9
Turnⁱ	410 – 412	Combined sources	3
Beta strandⁱ	413 – 421	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P09110
SMRⁱ	P09110
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P09110

EvolutionaryTraceⁱ

P09110

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the thiolase family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG1389 Eukaryota COG0183 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000151024
HOGENOMⁱ	HOG000012239
HOVERGENⁱ	HBG003112
InParanoidⁱ	P09110
KEGG Orthology (KO) More...KOⁱ	K07513
OMAⁱ	RYGLTTM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09C6
PhylomeDBⁱ	P09110
TreeFamⁱ	TF332308

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00751 thiolase, 1 hit
Gene3Dⁱ	3.40.47.10, 1 hit
InterProⁱ	View protein in InterPro IPR002155 Thiolase IPR016039 Thiolase-like IPR020615 Thiolase_acyl_enz_int_AS IPR020610 Thiolase_AS IPR020617 Thiolase_C IPR020613 Thiolase_CS IPR020616 Thiolase_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02803 Thiolase_C, 1 hit PF00108 Thiolase_N, 1 hit
PIRSFⁱ	PIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMⁱ	SSF53901 SSF53901, 2 hits
TIGRFAMsⁱ	TIGR01930 AcCoA-C-Actrans, 1 hit
PROSITEⁱ	View protein in PROSITE PS00098 THIOLASE_1, 1 hit PS00737 THIOLASE_2, 1 hit PS00099 THIOLASE_3, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P09110-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRLQVVLGH LRGPADSGWM PQAAPCLSGA PQASAADVVV VHGRRTAICR 
        60         70         80         90        100
AGRGGFKDTT PDELLSAVMT AVLKDVNLRP EQLGDICVGN VLQPGAGAIM 
       110        120        130        140        150
ARIAQFLSDI PETVPLSTVN RQCSSGLQAV ASIAGGIRNG SYDIGMACGV 
       160        170        180        190        200
ESMSLADRGN PGNITSRLME KEKARDCLIP MGITSENVAE RFGISREKQD 
       210        220        230        240        250
TFALASQQKA ARAQSKGCFQ AEIVPVTTTV HDDKGTKRSI TVTQDEGIRP 
       260        270        280        290        300
STTMEGLAKL KPAFKKDGST TAGNSSQVSD GAAAILLARR SKAEELGLPI 
       310        320        330        340        350
LGVLRSYAVV GVPPDIMGIG PAYAIPVALQ KAGLTVSDVD IFEINEAFAS 
       360        370        380        390        400
QAAYCVEKLR LPPEKVNPLG GAVALGHPLG CTGARQVITL LNELKRRGKR 
       410        420 
AYGVVSMCIG TGMGAAAVFE YPGN

Length:424

Mass (Da):44,292

Last modified:October 1, 1989 - v2

Checksum:ⁱ71B2BBAFA06AE412

GO

Isoform 2 (identifier: P09110-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
149-181: Missing.
272-331: Missing.

« Hide

        10         20         30         40         50
MQRLQVVLGH LRGPADSGWM PQAAPCLSGA PQASAADVVV VHGRRTAICR 
        60         70         80         90        100
AGRGGFKDTT PDELLSAVMT AVLKDVNLRP EQLGDICVGN VLQPGAGAIM 
       110        120        130        140        150
ARIAQFLSDI PETVPLSTVN RQCSSGLQAV ASIAGGIRNG SYDIGMACGI 
       160        170        180        190        200
TSENVAERFG ISREKQDTFA LASQQKAARA QSKGCFQAEI VPVTTTVHDD 
       210        220        230        240        250
KGTKRSITVT QDEGIRPSTT MEGLAKLKPA FKKDGSTTAG LTVSDVDIFE 
       260        270        280        290        300
INEAFASQAA YCVEKLRLPP EKVNPLGGAV ALGHPLGCTG ARQVITLLNE 
       310        320        330 
LKRRGKRAYG VVSMCIGTGM GAAAVFEYPG N

Note: No experimental confirmation available.

Show »

Length:331

Mass (Da):34,665

Checksum:ⁱ8137A0AC448FBA24

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JDE9	C9JDE9_HUMAN	3-ketoacyl-CoA thiolase, peroxisoma... 3-ketoacyl-CoA thiolase, peroxisomal	ACAA1	383	Annotation score:
H7C131	H7C131_HUMAN	3-ketoacyl-CoA thiolase, peroxisoma... 3-ketoacyl-CoA thiolase, peroxisomal	ACAA1	290	Annotation score:
H0Y4D4	H0Y4D4_HUMAN	3-ketoacyl-CoA thiolase, peroxisoma... 3-ketoacyl-CoA thiolase, peroxisomal	ACAA1	237	Annotation score:
B4DVF4	B4DVF4_HUMAN	3-ketoacyl-CoA thiolase, peroxisoma... 3-ketoacyl-CoA thiolase, peroxisomal (cDNA FLJ54941, highly similar to 3-ketoacyl-CoA thiolase, peroxisomal) (cDNA, FLJ79450, highly similar to 3-ketoacyl-CoA thiolase, peroxisomal)	ACAA1	153	Annotation score:
F2Z2Q6	F2Z2Q6_HUMAN	3-ketoacyl-CoA thiolase, peroxisoma... 3-ketoacyl-CoA thiolase, peroxisomal	ACAA1	113	Annotation score:
F2Z3P7	F2Z3P7_HUMAN	3-ketoacyl-CoA thiolase, peroxisoma... 3-ketoacyl-CoA thiolase, peroxisomal	ACAA1	121	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_011904	172	E → D. Corresponds to variant dbSNP:rs156265Ensembl.		1
Natural variantⁱVAR_069148	387	V → A1 PublicationCorresponds to variant dbSNP:rs2229528Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046195	149 – 181	Missing in isoform 2. 1 PublicationAdd BLAST		33
Alternative sequenceⁱVSP_046196	272 – 331	Missing in isoform 2. 1 PublicationAdd BLAST		60

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X12966 mRNA Translation: CAA31412.1 X14813 mRNA Translation: CAA32918.1 X65140 Genomic DNA Translation: CAA46270.1 X65148 Genomic DNA Translation: CAA46271.1 AP006309 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64516.1 BC000635 mRNA Translation: AAH00635.1 BC011977 mRNA Translation: AAH11977.1 BC014474 mRNA Translation: AAH14474.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2673.1 [P09110-1] CCDS46794.1 [P09110-2]
PIRⁱ	S17515 XUHUAB
NCBI Reference Sequences More...RefSeqⁱ	NP_001123882.1, NM_001130410.1 [P09110-2] NP_001598.1, NM_001607.3 [P09110-1]
UniGeneⁱ	Hs.643487

Genome annotation databases

Ensemblⁱ	ENST00000301810; ENSP00000301810; ENSG00000060971 [P09110-2] ENST00000333167; ENSP00000333664; ENSG00000060971 [P09110-1]
GeneIDⁱ	30
KEGGⁱ	hsa:30
UCSC genome browser More...UCSCⁱ	uc003cht.4 human [P09110-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P09110	Acetyl-Coenzyme A acyltransferase 1 (Peroxisomal 3-oxoacyl-Coenzyme A thiolase), isoform CRA_a		HUMAN		424	UniRef100_P09110
ACAA1 isoform 2		PANTR		424
Uncharacterized protein		PANPA		171
3-oxoacyl-CoA thiolase (Fragment)		HUMAN		326
UPI0005D00E36		HUMAN		279
+1
P09110-2	Testicular tissue protein Li 197		HUMAN		331	UniRef100_A0A140VJX0
ACAA1 isoform 4		PANTR		331

Protein	Similar proteins		Species	Score	Length	Source
P09110	Acetyl-Coenzyme A acyltransferase 1 (Peroxisomal 3-oxoacyl-Coenzyme A thiolase), isoform CRA_a		HUMAN		424	UniRef90_P09110
ACAA1 isoform 2		PANTR		424
Uncharacterized protein		PANPA		171
3-ketoacyl-CoA thiolase, peroxisomal isoform X1		ODORO		426
Uncharacterized protein		FELCA		426
+54
P09110-2	Uncharacterized protein		MACMU		331	UniRef90_F6SR84
Uncharacterized protein		MANLE		274
Uncharacterized protein		CERAT		331
Uncharacterized protein		PAPAN		331
Uncharacterized protein		MACFA		331
+25

Protein	Similar proteins		Species	Score	Length	Source
P09110	Acetyl-Coenzyme A acyltransferase 1 (Peroxisomal 3-oxoacyl-Coenzyme A thiolase), isoform CRA_a		HUMAN		424	UniRef50_P09110
ACAA1 isoform 2		PANTR		424
Uncharacterized protein		PANPA		171
Uncharacterized protein		FELCA		426
3-ketoacyl-CoA thiolase, peroxisomal isoform X1		ODORO		426
+55
P09110-2	Acetyl-CoA acyltransferase 1		PANTR		380	UniRef50_A0A2I3TGQ8
Uncharacterized protein		PROCO		331
3-ketoacyl-CoA thiolase, peroxisomal isoform X2		TARSY		339
3-ketoacyl-CoA thiolase, peroxisomal isoform X3		Enhydra lutris kenyoni		333
Uncharacterized protein		FELCA		333
+27

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X12966 mRNA Translation: CAA31412.1 X14813 mRNA Translation: CAA32918.1 X65140 Genomic DNA Translation: CAA46270.1 X65148 Genomic DNA Translation: CAA46271.1 AP006309 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64516.1 BC000635 mRNA Translation: AAH00635.1 BC011977 mRNA Translation: AAH11977.1 BC014474 mRNA Translation: AAH14474.1
CCDSⁱ	CCDS2673.1 [P09110-1] CCDS46794.1 [P09110-2]
PIRⁱ	S17515 XUHUAB
RefSeqⁱ	NP_001123882.1, NM_001130410.1 [P09110-2] NP_001598.1, NM_001607.3 [P09110-1]
UniGeneⁱ	Hs.643487

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2IIK	X-ray	2.55	A/B	30-423	[»]
ProteinModelPortalⁱ	P09110
SMRⁱ	P09110
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106548, 32 interactors
IntActⁱ	P09110, 7 interactors
STRINGⁱ	9606.ENSP00000333664

Chemistry databases

DrugBankⁱ	DB09069 Trimetazidine

DrugBankⁱ

DB09069 Trimetazidine

PTM databases

CarbonylDBⁱ	P09110
iPTMnetⁱ	P09110
PhosphoSitePlusⁱ	P09110
SwissPalmⁱ	P09110

Polymorphism and mutation databases

BioMutaⁱ	ACAA1
DMDMⁱ	135751

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00012828
UCD-2DPAGEⁱ	P09110

Proteomic databases

EPDⁱ	P09110
MaxQBⁱ	P09110
PaxDbⁱ	P09110
PeptideAtlasⁱ	P09110
PRIDEⁱ	P09110
ProteomicsDBⁱ	52200

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	30
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000301810; ENSP00000301810; ENSG00000060971 [P09110-2] ENST00000333167; ENSP00000333664; ENSG00000060971 [P09110-1]
GeneIDⁱ	30
KEGGⁱ	hsa:30
UCSCⁱ	uc003cht.4 human [P09110-1]

Organism-specific databases

CTDⁱ	30
DisGeNETⁱ	30
EuPathDBⁱ	HostDB:ENSG00000060971.17
GeneCardsⁱ	ACAA1
HGNCⁱ	HGNC:82 ACAA1
HPAⁱ	HPA006764 HPA007244
MIMⁱ	604054 gene
neXtProtⁱ	NX_P09110
OpenTargetsⁱ	ENSG00000060971
PharmGKBⁱ	PA24419
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1389 Eukaryota COG0183 LUCA
GeneTreeⁱ	ENSGT00930000151024
HOGENOMⁱ	HOG000012239
HOVERGENⁱ	HBG003112
InParanoidⁱ	P09110
KOⁱ	K07513
OMAⁱ	RYGLTTM
OrthoDBⁱ	EOG091G09C6
PhylomeDBⁱ	P09110
TreeFamⁱ	TF332308

Enzyme and pathway databases

UniPathwayⁱ	UPA00199
BioCycⁱ	MetaCyc:HS00752-MONOMER
Reactomeⁱ	R-HSA-2046106 alpha-linolenic acid (ALA) metabolism R-HSA-390247 Beta-oxidation of very long chain fatty acids R-HSA-6798695 Neutrophil degranulation R-HSA-9033241 Peroxisomal protein import R-HSA-9033500 TYSND1 cleaves peroxisomal proteins

Miscellaneous databases

ChiTaRSⁱ	ACAA1 human
EvolutionaryTraceⁱ	P09110
GeneWikiⁱ	ACAA1
GenomeRNAiⁱ	30
Protein Ontology More...PROⁱ	PR:P09110
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000060971 Expressed in 236 organ(s), highest expression level in nephron tubule
CleanExⁱ	HS_ACAA1
ExpressionAtlasⁱ	P09110 baseline and differential
Genevisibleⁱ	P09110 HS

Family and domain databases

CDDⁱ	cd00751 thiolase, 1 hit
Gene3Dⁱ	3.40.47.10, 1 hit
InterProⁱ	View protein in InterPro IPR002155 Thiolase IPR016039 Thiolase-like IPR020615 Thiolase_acyl_enz_int_AS IPR020610 Thiolase_AS IPR020617 Thiolase_C IPR020613 Thiolase_CS IPR020616 Thiolase_N
Pfamⁱ	View protein in Pfam PF02803 Thiolase_C, 1 hit PF00108 Thiolase_N, 1 hit
PIRSFⁱ	PIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMⁱ	SSF53901 SSF53901, 2 hits
TIGRFAMsⁱ	TIGR01930 AcCoA-C-Actrans, 1 hit
PROSITEⁱ	View protein in PROSITE PS00098 THIOLASE_1, 1 hit PS00737 THIOLASE_2, 1 hit PS00099 THIOLASE_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	THIK_HUMAN
Accessionⁱ	P09110Primary (citable) accession number: P09110 Secondary accession number(s): G5E935, Q96CA6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	October 1, 1989
	Last modified:	November 7, 2018
	This is version 201 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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UniRef

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Supporting data

UniProtKB - P09110 (THIK_HUMAN)

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3-ketoacyl-CoA thiolase, peroxisomal

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid metabolism

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Peroxisome

Cytosol

Extracellular region or secreted

Peroxisome

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: fatty acid metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ