UniProtKB - P09108 (RAPSN_TETCF)
43 kDa receptor-associated protein of the synapse
RAPSN
Functioni
Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 363 – 403 | RING-typePROSITE-ProRule annotationAdd BLAST | 41 |
GO - Molecular functioni
- acetylcholine receptor binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
- protein-membrane adaptor activity Source: InterPro
GO - Biological processi
- chemical synaptic transmission Source: InterPro
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: 43 kDa receptor-associated protein of the synapseShort name: RAPsyn Alternative name(s): 43 kDa postsynaptic protein Acetylcholine receptor-associated 43 kDa protein |
Gene namesi | Name:RAPSN |
Organismi | Tetronarce californica (Pacific electric ray) (Torpedo californica) |
Taxonomic identifieri | 7787 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Chondrichthyes › Elasmobranchii › Batoidea › Torpediniformes › Torpedinidae › Tetronarce |
Subcellular locationi
Plasma membrane
Cytoskeleton
Note: Cytoplasmic surface of postsynaptic membranes.
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Plasma Membrane
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed | |||
ChainiPRO_0000167594 | 2 – 412 | 43 kDa receptor-associated protein of the synapseAdd BLAST | 411 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycine1 Publication | 1 | |
Modified residuei | 196 | PhosphotyrosineSequence analysis | 1 | |
Modified residuei | 405 | PhosphoserineSequence analysis | 1 |
Keywords - PTMi
Lipoprotein, Myristate, PhosphoproteinPTM databases
iPTMneti | P09108 |
Interactioni
GO - Molecular functioni
- acetylcholine receptor binding Source: InterPro
Protein-protein interaction databases
MINTi | P09108 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 6 – 39 | TPR 1Add BLAST | 34 | |
Repeati | 83 – 116 | TPR 2Add BLAST | 34 | |
Repeati | 123 – 156 | TPR 3Add BLAST | 34 | |
Repeati | 163 – 196 | TPR 4Add BLAST | 34 | |
Repeati | 206 – 239 | TPR 5Add BLAST | 34 | |
Repeati | 246 – 279 | TPR 6Add BLAST | 34 | |
Repeati | 286 – 319 | TPR 7Add BLAST | 34 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 363 – 403 | RING-typePROSITE-ProRule annotationAdd BLAST | 41 |
Keywords - Domaini
Repeat, TPR repeat, Zinc-fingerFamily and domain databases
Gene3Di | 1.25.40.10, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001237, Postsynaptic IPR018293, Postsynaptic_CS IPR019568, Rapsyn_myristoylation/link_N IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF10579, Rapsyn_N, 1 hit PF13176, TPR_7, 2 hits PF13639, zf-RING_2, 1 hit |
PRINTSi | PR00217, POSTSYNAPTIC |
SMARTi | View protein in SMART SM00184, RING, 1 hit SM00028, TPR, 7 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS00405, 43_KD_POSTSYNAPTIC, 1 hit PS50005, TPR, 4 hits PS50293, TPR_REGION, 1 hit PS50089, ZF_RING_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGQDQTKQQI EKGLQLYQAN ETGKALEIWQ QVVERSTELP GRFRALGCLI
60 70 80 90 100
TAHSEMGKYE DMLRFAVAQS EAARQMGDPE RVTEAYLNLA RGHEKLCEFS
110 120 130 140 150
EAVAYCRTCL GAEGGPLRLQ FNGQVCLSMG NAFLGLSAFQ KALECFEKAL
160 170 180 190 200
RYAHGNDDKM LECRVCCSLG AFYVQLKDYE KALFFPCKSA ELVADYGRGW
210 220 230 240 250
SLKYKAMSRY HMAAAYRKLG RMDDAMECCE ESMKIALQHQ DRPLQALCLL
260 270 280 290 300
CFADIHRHRS DIGKALPRYE SSLNIMTEIG NRLGQAHVLL NIAKCWMTEK
310 320 330 340 350
KLDKTLGVVQ KAEELADAVG NKLVLLKAHC LYETIYREMG SDQLLRDHVV
360 370 380 390 400
KFHECMEDME LYCGLCGESI GDQNSQLQAL PCSHLFHLKC LQTNGNRGCP
410
NCKRSSVKPG YV
The sequence of this isoform differs from the canonical sequence as follows:
390-412: Missing.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 362 | Y → T AA sequence (PubMed:3427060).Curated | 1 | |
Sequence conflicti | 394 | N → D AA sequence (PubMed:3427060).Curated | 1 | |
Sequence conflicti | 411 | Y → T AA sequence (PubMed:3427060).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005534 | 390 – 412 | Missing in isoform Short. 1 PublicationAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02952 mRNA Translation: AAA49282.1 J02953 mRNA Translation: AAA49283.1 |
PIRi | A28009 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02952 mRNA Translation: AAA49282.1 J02953 mRNA Translation: AAA49283.1 |
PIRi | A28009 |
3D structure databases
SMRi | P09108 |
ModBasei | Search... |
Protein-protein interaction databases
MINTi | P09108 |
PTM databases
iPTMneti | P09108 |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001237, Postsynaptic IPR018293, Postsynaptic_CS IPR019568, Rapsyn_myristoylation/link_N IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF10579, Rapsyn_N, 1 hit PF13176, TPR_7, 2 hits PF13639, zf-RING_2, 1 hit |
PRINTSi | PR00217, POSTSYNAPTIC |
SMARTi | View protein in SMART SM00184, RING, 1 hit SM00028, TPR, 7 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS00405, 43_KD_POSTSYNAPTIC, 1 hit PS50005, TPR, 4 hits PS50293, TPR_REGION, 1 hit PS50089, ZF_RING_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RAPSN_TETCF | |
Accessioni | P09108Primary (citable) accession number: P09108 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 144 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families