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Protein

Hemoglobin subunit theta-1

Gene

HBQ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)1
Metal bindingi88Iron (heme proximal ligand)1

GO - Molecular functioni

GO - Biological processi

  • oxygen transport Source: ProtInc

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit theta-1
Alternative name(s):
Hemoglobin theta-1 chain
Theta-1-globin
Gene namesi
Name:HBQ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000086506.2
HGNCiHGNC:4833 HBQ1
MIMi142240 gene
neXtProtiNX_P09105

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi3049
OpenTargetsiENSG00000086506
PharmGKBiPA29208

Polymorphism and mutation databases

BioMutaiHBQ1
DMDMi122330

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000528461 – 142Hemoglobin subunit theta-1Add BLAST142

Proteomic databases

MaxQBiP09105
PaxDbiP09105
PeptideAtlasiP09105
PRIDEiP09105
ProteomicsDBi52199

PTM databases

iPTMnetiP09105
PhosphoSitePlusiP09105

Expressioni

Gene expression databases

BgeeiENSG00000086506 Expressed in 76 organ(s), highest expression level in blood
CleanExiHS_HBQ1
ExpressionAtlasiP09105 baseline and differential
GenevisibleiP09105 HS

Organism-specific databases

HPAiHPA062473

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi109299, 2 interactors
IntActiP09105, 9 interactors
STRINGi9606.ENSP00000199708

Structurei

3D structure databases

ProteinModelPortaliP09105
SMRiP09105
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00760000119197
HOGENOMiHOG000036867
HOVERGENiHBG009709
InParanoidiP09105
KOiK13827
OMAiVGVYTTE
OrthoDBiEOG091G0S0X
PhylomeDBiP09105
TreeFamiTF332328

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
IPR002339 Haemoglobin_pi
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
PR00815 PIHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

P09105-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSAEDRAL VRALWKKLGS NVGVYTTEAL ERTFLAFPAT KTYFSHLDLS
60 70 80 90 100
PGSSQVRAHG QKVADALSLA VERLDDLPHA LSALSHLHAC QLRVDPASFQ
110 120 130 140
LLGHCLLVTL ARHYPGDFSP ALQASLDKFL SHVISALVSE YR
Length:142
Mass (Da):15,508
Last modified:January 23, 2007 - v2
Checksum:i9D4F103D758694D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06482 Genomic DNA Translation: CAA29776.1
M33022 Genomic DNA Translation: AAA52640.1
DQ431198 Genomic DNA Translation: ABD95912.1
AE006462 Genomic DNA Translation: AAK61217.1
BC056686 mRNA Translation: AAH56686.1
M91453 Genomic DNA Translation: AAA58362.1
CCDSiCCDS10400.1
PIRiI52337 HTHU
RefSeqiNP_005322.1, NM_005331.4
UniGeneiHs.247921

Genome annotation databases

EnsembliENST00000199708; ENSP00000199708; ENSG00000086506
GeneIDi3049
KEGGihsa:3049
UCSCiuc002cfz.4 human

Similar proteinsi

Entry informationi

Entry nameiHBAT_HUMAN
AccessioniPrimary (citable) accession number: P09105
Secondary accession number(s): Q13723, Q1W6G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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