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Protein

Chymotrypsin-like elastase family member 3A

Gene

CELA3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Efficient protease with alanine specificity but only little elastolytic activity.

Catalytic activityi

Preferential cleavage: Ala-|-Xaa. Does not hydrolyze elastin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Charge relay systemBy similarity1
Active sitei123Charge relay systemBy similarity1
Active sitei217Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.154

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-like elastase family member 3A (EC:3.4.21.70)
Alternative name(s):
Elastase IIIA
Elastase-3A
Protease E
Gene namesi
Name:CELA3A
Synonyms:ELA3, ELA3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142789.19
HGNCiHGNC:15944 CELA3A
neXtProtiNX_P09093

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000142789
PharmGKBiPA27736

Polymorphism and mutation databases

BioMutaiCELA3A
DMDMi288558842

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Or 16Sequence analysisAdd BLAST15
PropeptideiPRO_000002769716 – 28Activation peptideSequence analysisAdd BLAST13
ChainiPRO_000002769829 – 270Chymotrypsin-like elastase family member 3AAdd BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 74PROSITE-ProRule annotation
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi117 ↔ 120Curated
Disulfide bondi157 ↔ 223PROSITE-ProRule annotation
Disulfide bondi188 ↔ 204PROSITE-ProRule annotation
Disulfide bondi213 ↔ 244PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP09093
PeptideAtlasiP09093
PRIDEiP09093
ProteomicsDBi52197

Expressioni

Gene expression databases

BgeeiENSG00000142789 Expressed in 95 organ(s), highest expression level in duodenum
CleanExiHS_ELA3A
ExpressionAtlasiP09093 baseline and differential
GenevisibleiP09093 HS

Organism-specific databases

HPAiHPA028086
HPA045650

Interactioni

Protein-protein interaction databases

BioGridi115439, 15 interactors
IntActiP09093, 2 interactors
MINTiP09093
STRINGi9606.ENSP00000290122

Structurei

3D structure databases

ProteinModelPortaliP09093
SMRiP09093
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 268Peptidase S1PROSITE-ProRule annotationAdd BLAST240

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
InParanoidiP09093
KOiK01345
OMAiKSACHGD
OrthoDBiEOG091G0DF7
PhylomeDBiP09093
TreeFamiTF330455

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P09093-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLRLLSSLL LVAVASGYGP PSSHSSSRVV HGEDAVPYSW PWQVSLQYEK
60 70 80 90 100
SGSFYHTCGG SLIAPDWVVT AGHCISRDLT YQVVLGEYNL AVKEGPEQVI
110 120 130 140 150
PINSEELFVH PLWNRSCVAC GNDIALIKLS RSAQLGDAVQ LASLPPAGDI
160 170 180 190 200
LPNKTPCYIT GWGRLYTNGP LPDKLQQARL PVVDYKHCSR WNWWGSTVKK
210 220 230 240 250
TMVCAGGYIR SGCNGDSGGP LNCPTEDGGW QVHGVTSFVS AFGCNFIWKP
260 270
TVFTRVSAFI DWIEETIASH
Length:270
Mass (Da):29,489
Last modified:February 9, 2010 - v3
Checksum:i576DDB255A4C71EA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AQ52B1AQ52_HUMAN
Chymotrypsin-like elastase family m...
CELA3A
121Annotation score:
B1AQ55B1AQ55_HUMAN
Chymotrypsin-like elastase family m...
CELA3A
75Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63I → T in AAH05918 (PubMed:15489334).Curated1
Sequence conflicti106Missing in AAA66350 (PubMed:2826474).Curated1
Sequence conflicti174K → E in AAH05918 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05978324H → R. Corresponds to variant dbSNP:rs7531336Ensembl.1
Natural variantiVAR_05978425S → P. Corresponds to variant dbSNP:rs7533776Ensembl.1
Natural variantiVAR_05978531H → N. Corresponds to variant dbSNP:rs7519660Ensembl.1
Natural variantiVAR_051838241A → G3 PublicationsCorresponds to variant dbSNP:rs3820285Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18700
, M18693, M18694, M18695, M18696, M18697, M18698, M18699 Genomic DNA Translation: AAA66350.1
D00306 mRNA Translation: BAA00212.1
AL590556 Genomic DNA No translation available.
BC005918 mRNA Translation: AAH05918.1
BC007028 mRNA Translation: AAH07028.1
BC015103 mRNA Translation: AAH15103.1
CCDSiCCDS220.1
PIRiA29934
RefSeqiNP_005738.4, NM_005747.4
UniGeneiHs.181289

Genome annotation databases

EnsembliENST00000290122; ENSP00000290122; ENSG00000142789
GeneIDi10136
KEGGihsa:10136
UCSCiuc001bfl.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18700
, M18693, M18694, M18695, M18696, M18697, M18698, M18699 Genomic DNA Translation: AAA66350.1
D00306 mRNA Translation: BAA00212.1
AL590556 Genomic DNA No translation available.
BC005918 mRNA Translation: AAH05918.1
BC007028 mRNA Translation: AAH07028.1
BC015103 mRNA Translation: AAH15103.1
CCDSiCCDS220.1
PIRiA29934
RefSeqiNP_005738.4, NM_005747.4
UniGeneiHs.181289

3D structure databases

ProteinModelPortaliP09093
SMRiP09093
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115439, 15 interactors
IntActiP09093, 2 interactors
MINTiP09093
STRINGi9606.ENSP00000290122

Protein family/group databases

MEROPSiS01.154

Polymorphism and mutation databases

BioMutaiCELA3A
DMDMi288558842

Proteomic databases

PaxDbiP09093
PeptideAtlasiP09093
PRIDEiP09093
ProteomicsDBi52197

Protocols and materials databases

DNASUi10136
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290122; ENSP00000290122; ENSG00000142789
GeneIDi10136
KEGGihsa:10136
UCSCiuc001bfl.4 human

Organism-specific databases

CTDi10136
EuPathDBiHostDB:ENSG00000142789.19
GeneCardsiCELA3A
H-InvDBiHIX0000228
HGNCiHGNC:15944 CELA3A
HPAiHPA028086
HPA045650
neXtProtiNX_P09093
OpenTargetsiENSG00000142789
PharmGKBiPA27736
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
InParanoidiP09093
KOiK01345
OMAiKSACHGD
OrthoDBiEOG091G0DF7
PhylomeDBiP09093
TreeFamiTF330455

Miscellaneous databases

GeneWikiiCELA3A
GenomeRNAii10136
PROiPR:P09093

Gene expression databases

BgeeiENSG00000142789 Expressed in 95 organ(s), highest expression level in duodenum
CleanExiHS_ELA3A
ExpressionAtlasiP09093 baseline and differential
GenevisibleiP09093 HS

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCEL3A_HUMAN
AccessioniPrimary (citable) accession number: P09093
Secondary accession number(s): B1AQ53, Q9BRW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 9, 2010
Last modified: November 7, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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