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Protein

Homeobox protein Hox-A6

Gene

Hoxa6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi154 – 213HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • embryonic skeletal system development Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A6
Alternative name(s):
Homeobox protein Hox-1.2
Homeobox protein M5-4
Gene namesi
Name:Hoxa6
Synonyms:Hox-1.2, Hoxa-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96178 Hoxa6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000681 – 232Homeobox protein Hox-A6Add BLAST232

Proteomic databases

PaxDbiP09092
PRIDEiP09092

PTM databases

PhosphoSitePlusiP09092

Expressioni

Gene expression databases

BgeeiENSMUSG00000043219 Expressed in 40 organ(s), highest expression level in mesonephros
CleanExiMM_HOXA6
ExpressionAtlasiP09092 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi200371, 6 interactors
STRINGi10090.ENSMUSP00000058755

Structurei

3D structure databases

ProteinModelPortaliP09092
SMRiP09092
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi135 – 140Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP09092
KOiK09306
OMAiIACNRAS
OrthoDBiEOG091G09XD
PhylomeDBiP09092
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P09092-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYFVNPTF PGSLPSGQDS FLGQLPLYPA GYDALRPFPA SYGASSLPDK
60 70 80 90 100
TYTSPCFYQQ SNSVLACNRA SYEYGASCFY SDKDLSGASP SGNNKQRGPG
110 120 130 140 150
DYLHFSPEQQ YKPDGSVQGK ALHEEGTDRK YTSPVYPWMQ RMNSCAGAVY
160 170 180 190 200
GSHGRRGRQT YTRYQTLELE KEFHFNRYLT RRRRIEIANA LCLTERQIKI
210 220 230
WFQNRRMKWK KENKLINSTQ ASGEDSEAKA GE
Length:232
Mass (Da):26,335
Last modified:January 23, 2002 - v2
Checksum:i7E29499428BBA8A7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136 – 146YPWMQRMNSCA → ASLIRTSFLPT (PubMed:2416462).CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247663 Genomic DNA Translation: AAF97512.1
M11988 Genomic DNA Translation: AAA37830.1
CCDSiCCDS20144.1
PIRiA24779
RefSeqiNP_034584.1, NM_010454.1
UniGeneiMm.222030

Genome annotation databases

EnsembliENSMUST00000062829; ENSMUSP00000058755; ENSMUSG00000043219
GeneIDi15403
KEGGimmu:15403
UCSCiuc009byi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247663 Genomic DNA Translation: AAF97512.1
M11988 Genomic DNA Translation: AAA37830.1
CCDSiCCDS20144.1
PIRiA24779
RefSeqiNP_034584.1, NM_010454.1
UniGeneiMm.222030

3D structure databases

ProteinModelPortaliP09092
SMRiP09092
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200371, 6 interactors
STRINGi10090.ENSMUSP00000058755

PTM databases

PhosphoSitePlusiP09092

Proteomic databases

PaxDbiP09092
PRIDEiP09092

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062829; ENSMUSP00000058755; ENSMUSG00000043219
GeneIDi15403
KEGGimmu:15403
UCSCiuc009byi.1 mouse

Organism-specific databases

CTDi3203
MGIiMGI:96178 Hoxa6

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP09092
KOiK09306
OMAiIACNRAS
OrthoDBiEOG091G09XD
PhylomeDBiP09092
TreeFamiTF316310

Miscellaneous databases

PROiPR:P09092
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043219 Expressed in 40 organ(s), highest expression level in mesonephros
CleanExiMM_HOXA6
ExpressionAtlasiP09092 baseline and differential

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXA6_MOUSE
AccessioniPrimary (citable) accession number: P09092
Secondary accession number(s): Q9JI98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2002
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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