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UniProtKB - P09087 (ABDB_DROME)
Protein
Homeobox protein abdominal-B
Gene
Abd-B
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 387 – 446 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: FlyBase
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: FlyBase
- transcription cis-regulatory region binding Source: FlyBase
GO - Biological processi
- determination of genital disc primordium Source: FlyBase
- external genitalia morphogenesis Source: FlyBase
- female genitalia development Source: FlyBase
- genital disc anterior/posterior pattern formation Source: FlyBase
- genital disc sexually dimorphic development Source: FlyBase
- germ cell migration Source: FlyBase
- gonadal mesoderm development Source: FlyBase
- imaginal disc-derived female genitalia development Source: FlyBase
- male genitalia development Source: FlyBase
- male gonad development Source: FlyBase
- male pigmentation Source: FlyBase
- midgut development Source: FlyBase
- negative regulation of cardioblast cell fate specification Source: FlyBase
- negative regulation of female receptivity Source: FlyBase
- negative regulation of salivary gland boundary specification Source: FlyBase
- negative regulation of striated muscle tissue development Source: FlyBase
- neuroendocrine cell differentiation Source: FlyBase
- open tracheal system development Source: FlyBase
- pole cell migration Source: FlyBase
- positive regulation of apoptotic process involved in morphogenesis Source: FlyBase
- positive regulation of transcription by RNA polymerase II Source: FlyBase
- regulation of transcription by RNA polymerase II Source: GO_Central
- segment specification Source: FlyBase
- specification of segmental identity, abdomen Source: FlyBase
- sperm storage Source: FlyBase
- spiracle morphogenesis, open tracheal system Source: FlyBase
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Enzyme and pathway databases
SignaLinki | P09087 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein abdominal-BAlternative name(s): Infraabdominal 7 Short name: IAB-7 P3 PH189 |
Gene namesi | Name:Abd-B ORF Names:CG10291 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0000015, Abd-B |
VEuPathDBi | VectorBase:FBgn0000015 |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: FlyBase
Other locations
- polytene chromosome band Source: FlyBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200258 | 1 – 493 | Homeobox protein abdominal-BAdd BLAST | 493 |
Proteomic databases
PaxDbi | P09087 |
Expressioni
Tissue specificityi
Isoform M and isoform R are expressed in ectodermal and mesodermal tissues and central nervous system of fourth to ninth embryonic abdominal segments. Later in embryogenesis, expression is seen in visceral mesoderm surrounding hindgut and in two Malpighian tubules.1 Publication
Developmental stagei
Highly expressed during embryogenesis, lower expression in larvae, pupae and adults.1 Publication
Gene expression databases
Bgeei | FBgn0000015, Expressed in oviduct (Drosophila) and 49 other tissues |
ExpressionAtlasi | P09087, baseline and differential |
Genevisiblei | P09087, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 70921, 61 interactors |
DIPi | DIP-19566N |
IntActi | P09087, 3 interactors |
STRINGi | 7227.FBpp0082826 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P09087 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 199 | DisorderedSequence analysisAdd BLAST | 199 | |
Regioni | 322 – 360 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 438 – 475 | DisorderedSequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 28 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 31 – 51 | Basic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 52 – 93 | Polar residuesSequence analysisAdd BLAST | 42 | |
Compositional biasi | 111 – 199 | Polar residuesSequence analysisAdd BLAST | 89 | |
Compositional biasi | 325 – 360 | Polar residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 446 – 475 | Polar residuesSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Belongs to the Abd-B homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000168206 |
HOGENOMi | CLU_545455_0_0_1 |
InParanoidi | P09087 |
OMAi | APWPYND |
PhylomeDBi | P09087 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform M (identifier: P09087-1) [UniParc]FASTAAdd to basket
Also known as: Morphogenetic, Abd-BI
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQQHHLQQQQ QQQQQQEQQH LQEQQQHLQQ LHHHAHHHLP QPLHTTSHHH
60 70 80 90 100
SAHPHLQQQQ QQQQHAVVAS SPSSVLQQQQ QQSTPTTHST PTHAVMYEDP
110 120 130 140 150
PPVPLVAVQQ QHLPAPQQQQ QLQQQQQQQQ QQLATTPVAG ALSPAQTPTG
160 170 180 190 200
PSAQQQQHLT SPHHQQLPQQ QTPNSVASGA SSNLQQQQQQ QNAAVAPGQT
210 220 230 240 250
QIVAPTTASV SPSSVSSQKE DINMSIQLAP LHIPAIRAGP GFETDTSAAV
260 270 280 290 300
KRHTAHWAYN DEGFNQHYGS GYYDRKHMFA YPYPETQFPV GQYWGPNYRP
310 320 330 340 350
DQTTSAAAAA AYMNEAERHV SAAARQSVEG TSTSSYEPPT YSSPGGLRGY
360 370 380 390 400
PSENYSSSGA SGGLSVGAVG PCTPNPGLHE WTGQVSVRKK RKPYSKFQTL
410 420 430 440 450
ELEKEFLFNA YVSKQKRWEL ARNLQLTERQ VKIWFQNRRM KNKKNSQRQA
460 470 480 490
NQQNNNNNSS SNHNHAQATQ QHHSGHHLNL SLNMGHHAAK MHQ
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A126GUV3 | A0A126GUV3_DROME | Abdominal B, isoform H | Abd-B 9, Abd B, ABD-B, Abd-b, abd-B | 493 | Annotation score: | ||
A4V304 | A4V304_DROME | Abdominal B, isoform C | Abd-B 9, Abd B, ABD-B, Abd-b, abd-B | 270 | Annotation score: | ||
A0A0B4KGT1 | A0A0B4KGT1_DROME | Abdominal B, isoform F | Abd-B 9, Abd B, ABD-B, Abd-b, abd-B | 323 | Annotation score: | ||
A0A126GUV9 | A0A126GUV9_DROME | Abdominal B, isoform G | Abd-B 9, Abd B, ABD-B, Abd-b, abd-B | 286 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 15 | Q → H in CAB57859 (PubMed:2482824).Curated | 1 | |
Sequence conflicti | 74 | Missing in CAA34260 (PubMed:2575066).Curated | 1 | |
Sequence conflicti | 177 – 180 | ASGA → PVR in CAA34260 (PubMed:2575066).Curated | 4 | |
Sequence conflicti | 317 – 318 | ER → DG in CAA34260 (PubMed:2575066).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002396 | 1 – 223 | Missing in isoform R. CuratedAdd BLAST | 223 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U31961 Genomic DNA Translation: AAA84402.1 U31961 Genomic DNA Translation: AAA84403.1 M21173 mRNA Translation: AAA28400.1 X16134 mRNA Translation: CAA34260.1 X51663 mRNA Translation: CAB57859.1 AE014297 Genomic DNA Translation: AAF55362.1 AE014297 Genomic DNA Translation: AAF55363.1 X15080 mRNA Translation: CAA33187.1 |
PIRi | A32584 A34220 B24780 |
RefSeqi | NP_001303471.1, NM_001316542.1 [P09087-2] NP_001303472.1, NM_001316543.1 [P09087-1] NP_001303474.1, NM_001316545.1 [P09087-2] NP_524896.2, NM_080157.3 [P09087-1] NP_650577.1, NM_142320.2 [P09087-2] NP_732180.1, NM_169735.2 [P09087-2] NP_732181.1, NM_169736.2 [P09087-2] NP_996220.1, NM_206498.2 [P09087-2] |
Genome annotation databases
EnsemblMetazoai | FBtr0083381; FBpp0082823; FBgn0000015 [P09087-2] FBtr0083382; FBpp0082824; FBgn0000015 [P09087-2] FBtr0083383; FBpp0082825; FBgn0000015 [P09087-2] FBtr0083384; FBpp0082826; FBgn0000015 [P09087-1] FBtr0083385; FBpp0089276; FBgn0000015 [P09087-2] FBtr0415463; FBpp0373669; FBgn0000015 [P09087-1] FBtr0415464; FBpp0373670; FBgn0000015 [P09087-2] FBtr0415465; FBpp0373671; FBgn0000015 [P09087-2] |
GeneIDi | 47763 |
KEGGi | dme:Dmel_CG11648 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U31961 Genomic DNA Translation: AAA84402.1 U31961 Genomic DNA Translation: AAA84403.1 M21173 mRNA Translation: AAA28400.1 X16134 mRNA Translation: CAA34260.1 X51663 mRNA Translation: CAB57859.1 AE014297 Genomic DNA Translation: AAF55362.1 AE014297 Genomic DNA Translation: AAF55363.1 X15080 mRNA Translation: CAA33187.1 |
PIRi | A32584 A34220 B24780 |
RefSeqi | NP_001303471.1, NM_001316542.1 [P09087-2] NP_001303472.1, NM_001316543.1 [P09087-1] NP_001303474.1, NM_001316545.1 [P09087-2] NP_524896.2, NM_080157.3 [P09087-1] NP_650577.1, NM_142320.2 [P09087-2] NP_732180.1, NM_169735.2 [P09087-2] NP_732181.1, NM_169736.2 [P09087-2] NP_996220.1, NM_206498.2 [P09087-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5ZJQ | X-ray | 2.44 | A | 369-452 | [»] | |
5ZJR | X-ray | 3.03 | A | 369-452 | [»] | |
5ZJS | X-ray | 2.90 | A | 369-452 | [»] | |
5ZJT | X-ray | 2.40 | A/E | 369-452 | [»] | |
SMRi | P09087 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 70921, 61 interactors |
DIPi | DIP-19566N |
IntActi | P09087, 3 interactors |
STRINGi | 7227.FBpp0082826 |
Proteomic databases
PaxDbi | P09087 |
Protocols and materials databases
DNASUi | 47763 |
Genome annotation databases
EnsemblMetazoai | FBtr0083381; FBpp0082823; FBgn0000015 [P09087-2] FBtr0083382; FBpp0082824; FBgn0000015 [P09087-2] FBtr0083383; FBpp0082825; FBgn0000015 [P09087-2] FBtr0083384; FBpp0082826; FBgn0000015 [P09087-1] FBtr0083385; FBpp0089276; FBgn0000015 [P09087-2] FBtr0415463; FBpp0373669; FBgn0000015 [P09087-1] FBtr0415464; FBpp0373670; FBgn0000015 [P09087-2] FBtr0415465; FBpp0373671; FBgn0000015 [P09087-2] |
GeneIDi | 47763 |
KEGGi | dme:Dmel_CG11648 |
Organism-specific databases
CTDi | 47763 |
FlyBasei | FBgn0000015, Abd-B |
VEuPathDBi | VectorBase:FBgn0000015 |
Phylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000168206 |
HOGENOMi | CLU_545455_0_0_1 |
InParanoidi | P09087 |
OMAi | APWPYND |
PhylomeDBi | P09087 |
Enzyme and pathway databases
SignaLinki | P09087 |
Miscellaneous databases
BioGRID-ORCSi | 47763, 0 hits in 3 CRISPR screens |
GenomeRNAii | 47763 |
PROi | PR:P09087 |
Gene expression databases
Bgeei | FBgn0000015, Expressed in oviduct (Drosophila) and 49 other tissues |
ExpressionAtlasi | P09087, baseline and differential |
Genevisiblei | P09087, DM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ABDB_DROME | |
Accessioni | P09087Primary (citable) accession number: P09087 Secondary accession number(s): Q9VEQ8, Q9VEQ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 207 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries - Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families