Homeobox protein abdominal-B

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Regulation of body pigmentation by the Abdominal-B Hox protein and its gain and loss in Drosophila evolution."
    Jeong S., Rokas A., Carroll S.B.
    Cell 125:1387-1399(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: FlyBaseInferred from direct assayⁱ
  • "A regulatory element of the empty spiracles homeobox gene is composed of three distinct conserved regions that bind regulatory proteins."
    Taylor H.S.
    Mol Reprod Dev 49:246-253(1998) [PubMed] [Europe PMC] [Abstract]
• transcription cis-regulatory region binding Source: FlyBaseInferred from direct assayⁱ
  • "Functional dissection of the Hox protein Abdominal-B in Drosophila cell culture."
    Zhai Z., Yang X., Lohmann I.
    Biochem Biophys Res Commun 414:761-766(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• determination of genital disc primordium Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Allocation and specification of the genital disc precursor cells in Drosophila."
    Chen E.H., Christiansen A.E., Baker B.S.
    Dev Biol 281:270-285(2005) [PubMed] [Europe PMC] [Abstract]
• external genitalia morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Requirement of Abdominal-A and Abdominal-B in the developing genitalia of Drosophila breaks the posterior downregulation rule."
    Foronda D., Estrada B., de Navas L., Sanchez-Herrero E.
    Development 133:117-127(2006) [PubMed] [Europe PMC] [Abstract]
• female genitalia development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Requirement of Abdominal-A and Abdominal-B in the developing genitalia of Drosophila breaks the posterior downregulation rule."
    Foronda D., Estrada B., de Navas L., Sanchez-Herrero E.
    Development 133:117-127(2006) [PubMed] [Europe PMC] [Abstract]
• genital disc anterior/posterior pattern formation Source: FlyBase <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Expression patterns of developmental genes reveal segment and parasegment organization of D. melanogaster genital discs."
    Freeland D.E., Kuhn D.T.
    Mech Dev 56:61-72(1996) [PubMed] [Europe PMC] [Abstract]
• genital disc sexually dimorphic development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Allocation and specification of the genital disc precursor cells in Drosophila."
    Chen E.H., Christiansen A.E., Baker B.S.
    Dev Biol 281:270-285(2005) [PubMed] [Europe PMC] [Abstract]
• germ cell migration Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Identification of genes controlling germ cell migration and embryonic gonad formation in Drosophila."
    Moore L.A., Broihier H.T., Van Doren M., Lunsford L.B., Lehmann R.
    Development 125:667-678(1998) [PubMed] [Europe PMC] [Abstract]
• gonadal mesoderm development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Abdominal-B is essential for proper sexually dimorphic development of the Drosophila gonad."
    DeFalco T., Le Bras S., Van Doren M.
    Mech Dev 121:1323-1333(2004) [PubMed] [Europe PMC] [Abstract]
  • "Identification of genes controlling germ cell migration and embryonic gonad formation in Drosophila."
    Moore L.A., Broihier H.T., Van Doren M., Lunsford L.B., Lehmann R.
    Development 125:667-678(1998) [PubMed] [Europe PMC] [Abstract]
• imaginal disc-derived female genitalia development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A simple and efficient method to identify replacements of P-lacZ by P-Gal4 lines allows obtaining Gal4 insertions in the bithorax complex of Drosophila."
    de Navas L., Foronda D., Suzanne M., Sanchez-Herrero E.
    Mech Dev 123:860-867(2006) [PubMed] [Europe PMC] [Abstract]
• male genitalia development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Requirement of Abdominal-A and Abdominal-B in the developing genitalia of Drosophila breaks the posterior downregulation rule."
    Foronda D., Estrada B., de Navas L., Sanchez-Herrero E.
    Development 133:117-127(2006) [PubMed] [Europe PMC] [Abstract]
• male gonad development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Abdominal-B is essential for proper sexually dimorphic development of the Drosophila gonad."
    DeFalco T., Le Bras S., Van Doren M.
    Mech Dev 121:1323-1333(2004) [PubMed] [Europe PMC] [Abstract]
• male pigmentation Source: FlyBaseInferred from direct assayⁱ
  • "Regulation of body pigmentation by the Abdominal-B Hox protein and its gain and loss in Drosophila evolution."
    Jeong S., Rokas A., Carroll S.B.
    Cell 125:1387-1399(2006) [PubMed] [Europe PMC] [Abstract]
• midgut development Source: FlyBase <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Developmental genetics of the Drosophila gut: specification of primordia, subdivision and overt-differentiation."
    Murakami R., Takashima S., Hamaguchi T.
    Cell Mol Biol (Noisy-le-grand) 45:661-676(1999) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cardioblast cell fate specification Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Homeotic genes autonomously specify the anteroposterior subdivision of the Drosophila dorsal vessel into aorta and heart."
    Lo P.C., Skeath J.B., Gajewski K., Schulz R.A., Frasch M.
    Dev Biol 251:307-319(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of female receptivity Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A novel function for the Hox gene Abd-B in the male accessory gland regulates the long-term female post-mating response in Drosophila."
    Gligorov D., Sitnik J.L., Maeda R.K., Wolfner M.F., Karch F.
    PLoS Genet 9:e1003395-e1003395(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of salivary gland boundary specification Source: FlyBaseTraceable author statementⁱ
  • "Organ formation in Drosophila: specification and morphogenesis of the salivary gland."
    Bradley P.L., Haberman A.S., Andrew D.J.
    Bioessays 23:901-911(2001) [PubMed] [Europe PMC] [Abstract]
  • "Constructing an organ: the Drosophila salivary gland as a model for tube formation."
    Abrams E.W., Vining M.S., Andrew D.J.
    Trends Cell Biol 13:247-254(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of striated muscle tissue development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel."
    Lovato T.L., Nguyen T.P., Molina M.R., Cripps R.M.
    Development 129:5019-5027(2002) [PubMed] [Europe PMC] [Abstract]
• neuroendocrine cell differentiation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Postmitotic specification of Drosophila insulinergic neurons from pioneer neurons."
    Miguel-Aliaga I., Thor S., Gould A.P.
    PLoS Biol 6:e58-e58(2008) [PubMed] [Europe PMC] [Abstract]
• open tracheal system development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Coordinated control of cell adhesion, polarity, and cytoskeleton underlies Hox-induced organogenesis in Drosophila."
    Lovegrove B., Simoes S., Rivas M.L., Sotillos S., Johnson K., Knust E., Jacinto A., Hombria J.C.
    Curr. Biol. 16:2206-2216(2006) [PubMed] [Europe PMC] [Abstract]
• pole cell migration Source: FlyBaseTraceable author statementⁱ
  • "Organogenesis: Drosophila goes gonadal."
    Howard K.
    Curr Biol 8:R415-7(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process involved in morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Drosophila Hox gene deformed sculpts head morphology via direct regulation of the apoptosis activator reaper."
    Lohmann I., McGinnis N., Bodmer M., McGinnis W.
    Cell 110:457-466(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: FlyBaseInferred from direct assayⁱ
  • "Regulation of body pigmentation by the Abdominal-B Hox protein and its gain and loss in Drosophila evolution."
    Jeong S., Rokas A., Carroll S.B.
    Cell 125:1387-1399(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• segment specification Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Drosophila Hox gene deformed sculpts head morphology via direct regulation of the apoptosis activator reaper."
    Lohmann I., McGinnis N., Bodmer M., McGinnis W.
    Cell 110:457-466(2002) [PubMed] [Europe PMC] [Abstract]
• specification of segmental identity, abdomen Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Dissecting the regulatory landscape of the Abd-B gene of the bithorax complex."
    Mihaly J., Barges S., Sipos L., Maeda R., Cleard F., Hogga I., Bender W., Gyurkovics H., Karch F.
    Development 133:2983-2993(2006) [PubMed] [Europe PMC] [Abstract]
  • "A simple and efficient method to identify replacements of P-lacZ by P-Gal4 lines allows obtaining Gal4 insertions in the bithorax complex of Drosophila."
    de Navas L., Foronda D., Suzanne M., Sanchez-Herrero E.
    Mech Dev 123:860-867(2006) [PubMed] [Europe PMC] [Abstract]
• sperm storage Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A novel function for the Hox gene Abd-B in the male accessory gland regulates the long-term female post-mating response in Drosophila."
    Gligorov D., Sitnik J.L., Maeda R.K., Wolfner M.F., Karch F.
    PLoS Genet 9:e1003395-e1003395(2013) [PubMed] [Europe PMC] [Abstract]
• spiracle morphogenesis, open tracheal system Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Study of the posterior spiracles of Drosophila as a model to understand the genetic and cellular mechanisms controlling morphogenesis."
    Hu N., Castelli-Gair J.
    Dev Biol 214:197-210(1999) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MQQHHLQQQQ QQQQQQEQQH LQEQQQHLQQ LHHHAHHHLP QPLHTTSHHH 
        60         70         80         90        100
SAHPHLQQQQ QQQQHAVVAS SPSSVLQQQQ QQSTPTTHST PTHAVMYEDP 
       110        120        130        140        150
PPVPLVAVQQ QHLPAPQQQQ QLQQQQQQQQ QQLATTPVAG ALSPAQTPTG 
       160        170        180        190        200
PSAQQQQHLT SPHHQQLPQQ QTPNSVASGA SSNLQQQQQQ QNAAVAPGQT 
       210        220        230        240        250
QIVAPTTASV SPSSVSSQKE DINMSIQLAP LHIPAIRAGP GFETDTSAAV 
       260        270        280        290        300
KRHTAHWAYN DEGFNQHYGS GYYDRKHMFA YPYPETQFPV GQYWGPNYRP 
       310        320        330        340        350
DQTTSAAAAA AYMNEAERHV SAAARQSVEG TSTSSYEPPT YSSPGGLRGY 
       360        370        380        390        400
PSENYSSSGA SGGLSVGAVG PCTPNPGLHE WTGQVSVRKK RKPYSKFQTL 
       410        420        430        440        450
ELEKEFLFNA YVSKQKRWEL ARNLQLTERQ VKIWFQNRRM KNKKNSQRQA 
       460        470        480        490 
NQQNNNNNSS SNHNHAQATQ QHHSGHHLNL SLNMGHHAAK MHQ        

        10         20         30         40         50
MSIQLAPLHI PAIRAGPGFE TDTSAAVKRH TAHWAYNDEG FNQHYGSGYY 
        60         70         80         90        100
DRKHMFAYPY PETQFPVGQY WGPNYRPDQT TSAAAAAAYM NEAERHVSAA 
       110        120        130        140        150
ARQSVEGTST SSYEPPTYSS PGGLRGYPSE NYSSSGASGG LSVGAVGPCT 
       160        170        180        190        200
PNPGLHEWTG QVSVRKKRKP YSKFQTLELE KEFLFNAYVS KQKRWELARN 
       210        220        230        240        250
LQLTERQVKI WFQNRRMKNK KNSQRQANQQ NNNNNSSSNH NHAQATQQHH 
       260        270
SGHHLNLSLN MGHHAAKMHQ                                  

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Vertebrate homeotic Hox proteins
   Nomenclature of vertebrate homeotic Hox proteins and list of entries
2. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
4. SIMILARITY comments
   Index of protein domains and families