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Protein

POU domain, class 2, transcription factor 2

Gene

POU2F2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi297 – 356HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6807505 RNA polymerase II transcribes snRNA genes

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P09086

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
POU domain, class 2, transcription factor 2
Alternative name(s):
Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
Octamer-binding protein 2
Short name:
Oct-2
Octamer-binding transcription factor 2
Short name:
OTF-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POU2F2
Synonyms:OCT2, OTF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000028277.20

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9213 POU2F2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
164176 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P09086

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi340 – 342VIR → FNP: Suppresses DNA-binding ability. 3

Organism-specific databases

DisGeNET

More...
DisGeNETi
5452

Open Targets

More...
OpenTargetsi
ENSG00000028277

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33537

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3509582

Drug and drug target database

More...
DrugBanki
DB08930 Dolutegravir

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
POU2F2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
123402

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001007141 – 479POU domain, class 2, transcription factor 2Add BLAST479

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P09086

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P09086

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P09086

PeptideAtlas

More...
PeptideAtlasi
P09086

PRoteomics IDEntifications database

More...
PRIDEi
P09086

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52192
52193 [P09086-2]
52194 [P09086-3]
52195 [P09086-4]
52196 [P09086-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P09086

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P09086

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000028277 Expressed in 206 organ(s), highest expression level in buccal mucosa cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_POU2F2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P09086 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P09086 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002513
HPA049056
HPA062096
HPA064404

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NR3C1, AR and PGR.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111448, 19 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P09086

Database of interacting proteins

More...
DIPi
DIP-51N

Protein interaction database and analysis system

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IntActi
P09086, 6 interactors

Molecular INTeraction database

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MINTi
P09086

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000431603

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P09086

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1479
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P09086

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P09086

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P09086

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini195 – 269POU-specificPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni389 – 410Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi417 – 424Gly-rich8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3802 Eukaryota
ENOG410XQ7X LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160115

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220842

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052783

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P09086

KEGG Orthology (KO)

More...
KOi
K09364

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P09086

TreeFam database of animal gene trees

More...
TreeFami
TF316413

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
IPR000972 TF_octamer

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046 Homeodomain, 1 hit
PF00157 Pou, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00029 OCTAMER
PR00028 POUDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P09086-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVHSSMGAPE IRMSKPLEAE KQGLDSPSEH TDTERNGPDT NHQNPQNKTS
60 70 80 90 100
PFSVSPTGPS TKIKAEDPSG DSAPAAPLPP QPAQPHLPQA QLMLTGSQLA
110 120 130 140 150
GDIQQLLQLQ QLVLVPGHHL QPPAQFLLPQ AQQSQPGLLP TPNLFQLPQQ
160 170 180 190 200
TQGALLTSQP RAGLPTQAVT RPTLPDPHLS HPQPPKCLEP PSHPEEPSDL
210 220 230 240 250
EELEQFARTF KQRRIKLGFT QGDVGLAMGK LYGNDFSQTT ISRFEALNLS
260 270 280 290 300
FKNMCKLKPL LEKWLNDAET MSVDSSLPSP NQLSSPSLGF DGLPGRRRKK
310 320 330 340 350
RTSIETNVRF ALEKSFLANQ KPTSEEILLI AEQLHMEKEV IRVWFCNRRQ
360 370 380 390 400
KEKRINPCSA APMLPSPGKP ASYSPHMVTP QGGAGTLPLS QASSSLSTTV
410 420 430 440 450
TTLSSAVGTL HPSRTAGGGG GGGGAAPPLN SIPSVTPPPP ATTNSTNPSP
460 470
QGSHSAIGLS GLNPSTGPGL WWNPAPYQP
Length:479
Mass (Da):51,209
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8DA661DC07644D43
GO
Isoform 2 (identifier: P09086-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     468-479: Missing.

Show »
Length:467
Mass (Da):49,801
Checksum:i444B5AB65B950050
GO
Isoform 3 (identifier: P09086-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-183: Missing.

Show »
Length:463
Mass (Da):49,461
Checksum:i5DCCA37A76A65AB9
GO
Isoform 4 (identifier: P09086-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-183: Missing.
     400-416: VTTLSSAVGTLHPSRTA → AQTPALKAATRLSACQA
     417-479: Missing.

Show »
Length:400
Mass (Da):43,528
Checksum:i074B384660350FCE
GO
Isoform 5 (identifier: P09086-5) [UniParc]FASTAAdd to basket
Also known as: Oct-2B

The sequence of this isoform differs from the canonical sequence as follows:
     468-479: PGLWWNPAPYQP → STMVGLSSGL...GGPEAGSKAE

Note: Incomplete sequence.
Show »
Length:602
Mass (Da):62,172
Checksum:iF5E4E2B0D206FC15
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5ME60B5ME60_HUMAN
POU domain protein
POU2F2
586Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLL6H0YLL6_HUMAN
POU domain protein
POU2F2
485Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKT2H0YKT2_HUMAN
POU domain protein
POU2F2
618Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNW1H0YNW1_HUMAN
POU domain protein
POU2F2
424Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQ96U3KQ96_HUMAN
POU domain, class 2, transcription ...
POU2F2
262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQN1U3KQN1_HUMAN
POU domain, class 2, transcription ...
POU2F2
320Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1I6M0R1I6_HUMAN
POU domain, class 2, transcription ...
POU2F2
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SF23A0A0D9SF23_HUMAN
POU domain, class 2, transcription ...
POU2F2
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PR37E9PR37_HUMAN
POU domain, class 2, transcription ...
POU2F2
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNG1H0YNG1_HUMAN
POU domain, class 2, transcription ...
POU2F2
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA32039 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002324168 – 183Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_007848400 – 416VTTLS…PSRTA → AQTPALKAATRLSACQA in isoform 4. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_007849417 – 479Missing in isoform 4. 2 PublicationsAdd BLAST63
Alternative sequenceiVSP_002325468 – 479Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_032187468 – 479PGLWW…APYQP → STMVGLSSGLSPALMSNNPL ATIQALASGGTLPLTSLDGS GNLVLGAAGAAPGSPSLVTS PLFLNHTGLPLLSAPPGVGL VSAAAAAVAASISSKSPGLS SSSSSSSSSSSSTCSDVAAQ TPGGPGGPEAGSKAE in isoform 5. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M36653 mRNA Translation: AAA36389.1
X53468 mRNA Translation: CAA37562.1
X53469 mRNA Translation: CAA37565.1
M36542 mRNA Translation: AAA36732.1
X13810 mRNA Translation: CAA32040.1
BT007438 mRNA Translation: AAP36106.1
BC006101 mRNA Translation: AAH06101.1
M36718 mRNA Translation: AAA59978.1
X13809 mRNA Translation: CAA32039.1 Different initiation.
X81030 Genomic DNA Translation: CAA56933.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33035.1 [P09086-3]
CCDS56094.1 [P09086-2]
CCDS56095.1 [P09086-1]
CCDS58665.1 [P09086-4]

Protein sequence database of the Protein Information Resource

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PIRi
A31753
A42098

NCBI Reference Sequences

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RefSeqi
NP_001193954.1, NM_001207025.2 [P09086-1]
NP_001193955.1, NM_001207026.1 [P09086-2]
NP_001234923.1, NM_001247994.1 [P09086-4]
NP_002689.1, NM_002698.4 [P09086-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.147381

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000389341; ENSP00000373992; ENSG00000028277 [P09086-3]
ENST00000526816; ENSP00000431603; ENSG00000028277 [P09086-1]
ENST00000529067; ENSP00000437224; ENSG00000028277 [P09086-4]
ENST00000529952; ENSP00000436988; ENSG00000028277 [P09086-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5452

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5452

UCSC genome browser

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UCSCi
uc002osn.4 human [P09086-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36653 mRNA Translation: AAA36389.1
X53468 mRNA Translation: CAA37562.1
X53469 mRNA Translation: CAA37565.1
M36542 mRNA Translation: AAA36732.1
X13810 mRNA Translation: CAA32040.1
BT007438 mRNA Translation: AAP36106.1
BC006101 mRNA Translation: AAH06101.1
M36718 mRNA Translation: AAA59978.1
X13809 mRNA Translation: CAA32039.1 Different initiation.
X81030 Genomic DNA Translation: CAA56933.1
CCDSiCCDS33035.1 [P09086-3]
CCDS56094.1 [P09086-2]
CCDS56095.1 [P09086-1]
CCDS58665.1 [P09086-4]
PIRiA31753
A42098
RefSeqiNP_001193954.1, NM_001207025.2 [P09086-1]
NP_001193955.1, NM_001207026.1 [P09086-2]
NP_001234923.1, NM_001247994.1 [P09086-4]
NP_002689.1, NM_002698.4 [P09086-3]
UniGeneiHs.147381

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HDPNMR-A297-359[»]
ProteinModelPortaliP09086
SMRiP09086
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111448, 19 interactors
CORUMiP09086
DIPiDIP-51N
IntActiP09086, 6 interactors
MINTiP09086
STRINGi9606.ENSP00000431603

Chemistry databases

BindingDBiP09086
ChEMBLiCHEMBL3509582
DrugBankiDB08930 Dolutegravir

PTM databases

iPTMnetiP09086
PhosphoSitePlusiP09086

Polymorphism and mutation databases

BioMutaiPOU2F2
DMDMi123402

Proteomic databases

EPDiP09086
MaxQBiP09086
PaxDbiP09086
PeptideAtlasiP09086
PRIDEiP09086
ProteomicsDBi52192
52193 [P09086-2]
52194 [P09086-3]
52195 [P09086-4]
52196 [P09086-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5452
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389341; ENSP00000373992; ENSG00000028277 [P09086-3]
ENST00000526816; ENSP00000431603; ENSG00000028277 [P09086-1]
ENST00000529067; ENSP00000437224; ENSG00000028277 [P09086-4]
ENST00000529952; ENSP00000436988; ENSG00000028277 [P09086-2]
GeneIDi5452
KEGGihsa:5452
UCSCiuc002osn.4 human [P09086-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5452
DisGeNETi5452
EuPathDBiHostDB:ENSG00000028277.20

GeneCards: human genes, protein and diseases

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GeneCardsi
POU2F2
HGNCiHGNC:9213 POU2F2
HPAiCAB002513
HPA049056
HPA062096
HPA064404
MIMi164176 gene
neXtProtiNX_P09086
OpenTargetsiENSG00000028277
PharmGKBiPA33537

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
GeneTreeiENSGT00940000160115
HOGENOMiHOG000220842
HOVERGENiHBG052783
InParanoidiP09086
KOiK09364
PhylomeDBiP09086
TreeFamiTF316413

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes
SIGNORiP09086

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
POU2F2 human
EvolutionaryTraceiP09086

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5452

Protein Ontology

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PROi
PR:P09086

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000028277 Expressed in 206 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_POU2F2
ExpressionAtlasiP09086 baseline and differential
GenevisibleiP09086 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
IPR000972 TF_octamer
PfamiView protein in Pfam
PF00046 Homeodomain, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00029 OCTAMER
PR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPO2F2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09086
Secondary accession number(s): Q16648, Q7M4M8, Q9BRS4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 203 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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