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Protein

Paired box protein Pax-1

Gene

Pax1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column.

GO - Molecular functioni

  • DNA-binding transcription factor activity Source: MGI
  • proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-1
Gene namesi
Name:Pax1
Synonyms:Pax-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:97485 Pax1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Undulated (un) homozygous mice exhibits vertebral malformations along the entire rostro-caudal axis. This is due to a single mutation in the paired box region.1 Publication

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501731 – 446Paired box protein Pax-1Add BLAST446

Proteomic databases

MaxQBiP09084
PaxDbiP09084
PRIDEiP09084

PTM databases

PhosphoSitePlusiP09084

Expressioni

Gene expression databases

BgeeiENSMUSG00000037034 Expressed in 138 organ(s), highest expression level in caudal region of vertebral column
CleanExiMM_PAX1
ExpressionAtlasiP09084 baseline and differential
GenevisibleiP09084 MM

Interactioni

Protein-protein interaction databases

BioGridi202028, 2 interactors
STRINGi10090.ENSMUSP00000105594

Structurei

3D structure databases

ProteinModelPortaliP09084
SMRiP09084
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 215PairedPROSITE-ProRule annotationAdd BLAST127

Keywords - Domaini

Paired box

Phylogenomic databases

eggNOGiKOG3517 Eukaryota
ENOG4111FI9 LUCA
GeneTreeiENSGT00680000099553
HOGENOMiHOG000230938
HOVERGENiHBG009115
InParanoidiP09084
KOiK09382
OMAiKMGSHHG
OrthoDBiEOG091G0S4E
PhylomeDBiP09084
TreeFamiTF315397

Family and domain databases

CDDicd00131 PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001523 Paired_dom
IPR033206 PAX1
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR24329:SF262 PTHR24329:SF262, 1 hit
PfamiView protein in Pfam
PF00292 PAX, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P09084-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFTLGLGSR AWRVSWERAA AAAAGPGAGG ALGSGSLRVS SRRGPRLARA
60 70 80 90 100
LPLCLSGGGG ARALPDCAGP SPRRSGARQL AGPRAMEQTY GEVNQLGGVF
110 120 130 140 150
VNGRPLPNAI RLRIVELAQL GIRPCDISRQ LRVSHGCVSK ILARYNETGS
160 170 180 190 200
ILPGAIGGSK PRVTTPNVVK HIRDYKQGDP GIFAWEIRDR LLADGVCDKY
210 220 230 240 250
NVPSVSSISR ILRNKIGSLA QPGPYEASKQ PPPQPALPYN HIYQYPYPSP
260 270 280 290 300
VSPTGTKMGT HPGVPGSAGH VSIPRSWPSA HSVSNILGIR TFMEQTGALA
310 320 330 340 350
GSEGAAYSPK MEDWAGVNRA AFPTSPAVNG LEKPALEADI KYTQSASSLS
360 370 380 390 400
AVGGFLPACA YPASNQHGVY SAPAAGYLSP GPPWPPAQAP PLTPHGAGVA
410 420 430 440
VHGGELAAAM TFKHREGTDR KPPSPGGKAT DALGSLHGLP IPASTS
Length:446
Mass (Da):46,263
Last modified:May 18, 2010 - v4
Checksum:i635FE7318A946D6C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ALK0A2ALK0_MOUSE
Paired box protein Pax-1
Pax1
384Annotation score:

Sequence cautioni

The sequence AAA37793 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAA39888 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141I → M in AAA37793 (PubMed:2453291).Curated1
Sequence conflicti300A → T in AAA39888 (PubMed:1889089).Curated1
Sequence conflicti345S → L in AAA39888 (PubMed:1889089).Curated1
Sequence conflicti367H → Q in AAA39888 (PubMed:1889089).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti103G → S in un. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133503, AJ133504, AJ133505 Genomic DNA Translation: CAB38370.1
AL805918 Genomic DNA Translation: CAM17060.2
M69222 mRNA Translation: AAA39888.1 Different initiation.
M20978 Genomic DNA Translation: AAA37793.1 Sequence problems.
CCDSiCCDS16835.2
PIRiA29902
A40023
RefSeqiNP_032806.2, NM_008780.2
UniGeneiMm.315502
Mm.483524

Genome annotation databases

EnsembliENSMUST00000109968; ENSMUSP00000105594; ENSMUSG00000037034
GeneIDi18503
KEGGimmu:18503
UCSCiuc008msx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133503, AJ133504, AJ133505 Genomic DNA Translation: CAB38370.1
AL805918 Genomic DNA Translation: CAM17060.2
M69222 mRNA Translation: AAA39888.1 Different initiation.
M20978 Genomic DNA Translation: AAA37793.1 Sequence problems.
CCDSiCCDS16835.2
PIRiA29902
A40023
RefSeqiNP_032806.2, NM_008780.2
UniGeneiMm.315502
Mm.483524

3D structure databases

ProteinModelPortaliP09084
SMRiP09084
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202028, 2 interactors
STRINGi10090.ENSMUSP00000105594

PTM databases

PhosphoSitePlusiP09084

Proteomic databases

MaxQBiP09084
PaxDbiP09084
PRIDEiP09084

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109968; ENSMUSP00000105594; ENSMUSG00000037034
GeneIDi18503
KEGGimmu:18503
UCSCiuc008msx.2 mouse

Organism-specific databases

CTDi5075
MGIiMGI:97485 Pax1

Phylogenomic databases

eggNOGiKOG3517 Eukaryota
ENOG4111FI9 LUCA
GeneTreeiENSGT00680000099553
HOGENOMiHOG000230938
HOVERGENiHBG009115
InParanoidiP09084
KOiK09382
OMAiKMGSHHG
OrthoDBiEOG091G0S4E
PhylomeDBiP09084
TreeFamiTF315397

Miscellaneous databases

PROiPR:P09084
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037034 Expressed in 138 organ(s), highest expression level in caudal region of vertebral column
CleanExiMM_PAX1
ExpressionAtlasiP09084 baseline and differential
GenevisibleiP09084 MM

Family and domain databases

CDDicd00131 PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001523 Paired_dom
IPR033206 PAX1
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR24329:SF262 PTHR24329:SF262, 1 hit
PfamiView protein in Pfam
PF00292 PAX, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAX1_MOUSE
AccessioniPrimary (citable) accession number: P09084
Secondary accession number(s): A2ALJ9, Q9R2B1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 152 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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