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Protein

Homeotic protein bicoid

Gene

bcd

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Segment polarity protein that provides positional cues for the development of head and thoracic segments. Regulates the expression of zygotic genes, possibly through its homeodomain, and inhibits the activity of other maternal gene products. May also bind RNA. Interacts with Bin1 to repress transcription of bicoid target genes in the anterior tip of the embryo; a process known as retraction.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi97 – 156HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA-binding transcription factor activity Source: FlyBase
  • mRNA 3'-UTR binding Source: FlyBase
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: GO_Central
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: FlyBase
  • translation regulator activity Source: FlyBase
  • translation repressor activity Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, RNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P09081

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeotic protein bicoid
Alternative name(s):
PRD-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:bcd
ORF Names:CG1034
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0000166 bcd

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000490141 – 494Homeotic protein bicoidAdd BLAST494

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P09081

PRoteomics IDEntifications database

More...
PRIDEi
P09081

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Maternal expression is an anterior cap concentrated in the cortical cytoplasm.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0000166 Expressed in 13 organ(s), highest expression level in cleaving embryo

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P09081 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Bin1; in vitro and yeast cells. Interacts with bin3.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
66028, 79 interactors

Protein interaction database and analysis system

More...
IntActi
P09081, 31 interactors

Molecular INTeraction database

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MINTi
P09081

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0081168

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1494
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P09081

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P09081

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P09081

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni433 – 440RNA-bindingBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 40His/Pro-rich (PRD motif)Add BLAST29
Compositional biasi260 – 294Gln/His-rich (OPA repeat)Add BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KBMY Eukaryota
ENOG4110N46 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000172642

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P09081

KEGG Orthology (KO)

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KOi
K18659

Identification of Orthologs from Complete Genome Data

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OMAi
NTQFAYC

Database of Orthologous Groups

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OrthoDBi
EOG091G0CRZ

Database for complete collections of gene phylogenies

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PhylomeDBi
P09081

Family and domain databases

Conserved Domains Database

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CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046 Homeodomain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389 HOX, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform G (identifier: P09081-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQPPPDQNF YHHPLPHTHT HPHPHSHPHP HSHPHPHHQH PQLQLPPQFR
60 70 80 90 100
NPFDLLFDER TGAINYNYIR PYLPNQMPKP DVFPSEELPD SLVMRRPRRT
110 120 130 140 150
RTTFTSSQIA ELEQHFLQGR YLTAPRLADL SAKLALGTAQ VKIWFKNRRR
160 170 180 190 200
RHKIQSDQHK DQSYEGMPLS PGMKQSDGDP PSLQTLSLGG GATPNALTPS
210 220 230 240 250
PTPSTPTAHM TEHYSESFNA YYNYNGGHNH AQANRHMHMQ YPSGGGPGPG
260 270 280 290 300
STNVNGGQFF QQQQVHNHQQ QLHHQGNHVP HQMQQQQQQA QQQQYHHFDF
310 320 330 340 350
QQKQASACRV LVKDEPEADY NFNSSYYMRS GMSGATASAS AVARGAASPG
360 370 380 390 400
SEVYEPLTPK NDESPSLCGI GIGGPCAIAV GETEAADDMD DGTSKKTTLQ
410 420 430 440 450
ILEPLKGLDK SCDDGSSDDM STGIRALAGT GNRGAAFAKF GKPSPPQGPQ
460 470 480 490
PPLGMGGVAM GESNQYQCTM DTIMQAYNPH RNAAGNSQFA YCFN
Length:494
Mass (Da):54,511
Last modified:May 10, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i561D8509D5C11FD3
GO
Isoform A (identifier: P09081-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-400: Missing.

Show »
Length:149
Mass (Da):16,363
Checksum:i9ECE6842A7DB862A
GO
Isoform D (identifier: P09081-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-85: Missing.

Show »
Length:489
Mass (Da):53,966
Checksum:i81829ACF03419B86
GO
Isoform E (identifier: P09081-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: No experimental confirmation available.
Show »
Length:418
Mass (Da):45,438
Checksum:i04D4C70D6750DB39
GO
Isoform F (identifier: P09081-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.
     81-85: Missing.

Note: No experimental confirmation available.
Show »
Length:413
Mass (Da):44,893
Checksum:i204670A1A666802F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti298F → S in CAB37631 (PubMed:2901954).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti284Q → H in strain: Z362. 1
Natural varianti317E → K in strain: Z229. 1
Natural varianti337A → S in strain: Z95, Z197 and Z229. 1
Natural varianti438A → P in strain: Z184, Z210 and Z216. 1
Natural varianti458V → L in strain: Z157. 1
Natural varianti460M → L in strain: Oregon-R, Z145, Z266, Z346 and Z398. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0272031 – 76Missing in isoform E and isoform F. CuratedAdd BLAST76
Alternative sequenceiVSP_00223556 – 400Missing in isoform A. 1 PublicationAdd BLAST345
Alternative sequenceiVSP_00223481 – 85Missing in isoform D and isoform F. 2 Publications5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X07870 Genomic DNA Translation: CAA30720.1
X14458 mRNA Translation: CAA32627.1
X14459 mRNA Translation: CAB37631.1
X14460 mRNA Translation: CAA32629.1
AF466621 Genomic DNA Translation: AAL77008.1
AF466622 Genomic DNA Translation: AAL77009.1
AF466623 Genomic DNA Translation: AAL77010.1
AF466624 Genomic DNA Translation: AAL77011.1
AF466625 Genomic DNA Translation: AAL77012.1
AF466626 Genomic DNA Translation: AAL77013.1
AF466627 Genomic DNA Translation: AAL77014.1
AF466628 Genomic DNA Translation: AAL77015.1
AF466629 Genomic DNA Translation: AAL77016.1
AF466630 Genomic DNA Translation: AAL77017.1
AF466631 Genomic DNA Translation: AAL77018.1
AF466632 Genomic DNA Translation: AAL77019.1
AF466633 Genomic DNA Translation: AAL77020.1
AF466634 Genomic DNA Translation: AAL77021.1
AF466635 Genomic DNA Translation: AAL77022.1
AF466636 Genomic DNA Translation: AAL77023.1
AF466637 Genomic DNA Translation: AAL77024.1
AF466638 Genomic DNA Translation: AAL77025.1
AF466639 Genomic DNA Translation: AAL77026.1
AF466640 Genomic DNA Translation: AAL77027.1
AF466641 Genomic DNA Translation: AAL77028.1
AF466642 Genomic DNA Translation: AAL77029.1
AF466643 Genomic DNA Translation: AAL77030.1
AF466644 Genomic DNA Translation: AAL77031.1
AF466645 Genomic DNA Translation: AAL77032.1
AE001572 Genomic DNA Translation: AAD19798.1
AE014297 Genomic DNA Translation: AAF54085.2
AE014297 Genomic DNA Translation: AAN13368.1
AE014297 Genomic DNA Translation: AAN13369.1
AE014297 Genomic DNA Translation: AAN13371.2
AE014297 Genomic DNA Translation: AAO41514.1
AY058658 mRNA Translation: AAL13887.1
BT021332 mRNA Translation: AAX33480.1
M14549 Genomic DNA Translation: AAA28385.1
K03517 mRNA Translation: AAA28391.1

Protein sequence database of the Protein Information Resource

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PIRi
S00835 WJFFBC

NCBI Reference Sequences

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RefSeqi
NP_476825.1, NM_057477.5 [P09081-3]
NP_731111.1, NM_169157.3 [P09081-2]
NP_731113.2, NM_169159.4 [P09081-4]
NP_788587.1, NM_176410.3 [P09081-1]
NP_788588.1, NM_176411.3 [P09081-5]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Dm.3237

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0081664; FBpp0081164; FBgn0000166 [P09081-3]
FBtr0081665; FBpp0081165; FBgn0000166 [P09081-2]
FBtr0081666; FBpp0081166; FBgn0000166 [P09081-4]
FBtr0081667; FBpp0081167; FBgn0000166 [P09081-5]
FBtr0081668; FBpp0081168; FBgn0000166 [P09081-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
40830

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG1034

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07870 Genomic DNA Translation: CAA30720.1
X14458 mRNA Translation: CAA32627.1
X14459 mRNA Translation: CAB37631.1
X14460 mRNA Translation: CAA32629.1
AF466621 Genomic DNA Translation: AAL77008.1
AF466622 Genomic DNA Translation: AAL77009.1
AF466623 Genomic DNA Translation: AAL77010.1
AF466624 Genomic DNA Translation: AAL77011.1
AF466625 Genomic DNA Translation: AAL77012.1
AF466626 Genomic DNA Translation: AAL77013.1
AF466627 Genomic DNA Translation: AAL77014.1
AF466628 Genomic DNA Translation: AAL77015.1
AF466629 Genomic DNA Translation: AAL77016.1
AF466630 Genomic DNA Translation: AAL77017.1
AF466631 Genomic DNA Translation: AAL77018.1
AF466632 Genomic DNA Translation: AAL77019.1
AF466633 Genomic DNA Translation: AAL77020.1
AF466634 Genomic DNA Translation: AAL77021.1
AF466635 Genomic DNA Translation: AAL77022.1
AF466636 Genomic DNA Translation: AAL77023.1
AF466637 Genomic DNA Translation: AAL77024.1
AF466638 Genomic DNA Translation: AAL77025.1
AF466639 Genomic DNA Translation: AAL77026.1
AF466640 Genomic DNA Translation: AAL77027.1
AF466641 Genomic DNA Translation: AAL77028.1
AF466642 Genomic DNA Translation: AAL77029.1
AF466643 Genomic DNA Translation: AAL77030.1
AF466644 Genomic DNA Translation: AAL77031.1
AF466645 Genomic DNA Translation: AAL77032.1
AE001572 Genomic DNA Translation: AAD19798.1
AE014297 Genomic DNA Translation: AAF54085.2
AE014297 Genomic DNA Translation: AAN13368.1
AE014297 Genomic DNA Translation: AAN13369.1
AE014297 Genomic DNA Translation: AAN13371.2
AE014297 Genomic DNA Translation: AAO41514.1
AY058658 mRNA Translation: AAL13887.1
BT021332 mRNA Translation: AAX33480.1
M14549 Genomic DNA Translation: AAA28385.1
K03517 mRNA Translation: AAA28391.1
PIRiS00835 WJFFBC
RefSeqiNP_476825.1, NM_057477.5 [P09081-3]
NP_731111.1, NM_169157.3 [P09081-2]
NP_731113.2, NM_169159.4 [P09081-4]
NP_788587.1, NM_176410.3 [P09081-1]
NP_788588.1, NM_176411.3 [P09081-5]
UniGeneiDm.3237

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZQ3NMR-P97-163[»]
ProteinModelPortaliP09081
SMRiP09081
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66028, 79 interactors
IntActiP09081, 31 interactors
MINTiP09081
STRINGi7227.FBpp0081168

Proteomic databases

PaxDbiP09081
PRIDEiP09081

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0081664; FBpp0081164; FBgn0000166 [P09081-3]
FBtr0081665; FBpp0081165; FBgn0000166 [P09081-2]
FBtr0081666; FBpp0081166; FBgn0000166 [P09081-4]
FBtr0081667; FBpp0081167; FBgn0000166 [P09081-5]
FBtr0081668; FBpp0081168; FBgn0000166 [P09081-1]
GeneIDi40830
KEGGidme:Dmel_CG1034

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
40830
FlyBaseiFBgn0000166 bcd

Phylogenomic databases

eggNOGiENOG410KBMY Eukaryota
ENOG4110N46 LUCA
GeneTreeiENSGT00940000172642
InParanoidiP09081
KOiK18659
OMAiNTQFAYC
OrthoDBiEOG091G0CRZ
PhylomeDBiP09081

Enzyme and pathway databases

SignaLinkiP09081

Miscellaneous databases

EvolutionaryTraceiP09081

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
40830

Protein Ontology

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PROi
PR:P09081

Gene expression databases

BgeeiFBgn0000166 Expressed in 13 organ(s), highest expression level in cleaving embryo
GenevisibleiP09081 DM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeodomain, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCD_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09081
Secondary accession number(s): Q5BI92
, Q86BA9, Q86BP2, Q8INR7, Q8ST46, Q8STB1, Q8T9S9, Q8T9T0, Q8T9T1, Q95TN3, Q9UAM0, Q9VI47
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: May 10, 2004
Last modified: December 5, 2018
This is version 193 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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