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Protein

Homeobox protein Hox-B5

Gene

Hoxb5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi194 – 253HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B5
Alternative name(s):
Homeobox protein H24.1
Homeobox protein Hox-2.1
Homeobox protein Mu-1
Gene namesi
Name:Hoxb5
Synonyms:Hox-2.1, Hoxb-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96186 Hoxb5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001291 – 269Homeobox protein Hox-B5Add BLAST269

Proteomic databases

MaxQBiP09079
PaxDbiP09079
PRIDEiP09079

PTM databases

iPTMnetiP09079
PhosphoSitePlusiP09079

Expressioni

Tissue specificityi

Expressed in a broad spectrum of tissues.

Developmental stagei

Embryo.

Gene expression databases

BgeeiENSMUSG00000038700 Expressed in 141 organ(s), highest expression level in head
CleanExiMM_HOXB5
GenevisibleiP09079 MM

Interactioni

Protein-protein interaction databases

BioGridi200379, 1 interactor
STRINGi10090.ENSMUSP00000035423

Structurei

3D structure databases

ProteinModelPortaliP09079
SMRiP09079
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi176 – 181Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231178
HOVERGENiHBG016849
InParanoidiP09079
KOiK09305
OMAiAHFTEIE
OrthoDBiEOG091G09XD
PhylomeDBiP09079
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P09079-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYFVNSFS GRYPNGPDYQ LLNYGSGSSL SGSYRDPAAM HTGSYGYNYN
60 70 80 90 100
GMDLSVNRSS ASSSHFGAVG ESSRAFPASA QEPRFRQATS SCSLSSPESL
110 120 130 140 150
PCTNGDSHGA KPSASSPSDQ ATPASSSANF TEIDEASASS EPEEAASQLS
160 170 180 190 200
SPSLARAQPE PMATSTAAPE GQTPQIFPWM RKLHISHDMT GPDGKRARTA
210 220 230 240 250
YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI WFQNRRMKWK
260
KDNKLKSMSL ATAGSAFQP
Length:269
Mass (Da):29,464
Last modified:September 5, 2006 - v3
Checksum:iB3508345236FB6A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81Q → K in AAA37842 (PubMed:2889591).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26283 mRNA Translation: AAA37842.1
AK133512 mRNA Translation: BAE21695.1
BC103595 mRNA Translation: AAI03596.1
BC103596 mRNA Translation: AAI03597.1
BC103604 mRNA Translation: AAI03605.1
BC103607 mRNA Translation: AAI03608.1
L36070 Genomic DNA Translation: AAA50294.1
X03033 Genomic DNA Translation: CAB57812.1
CCDSiCCDS25296.1
PIRiA43551
B24777
RefSeqiNP_032294.2, NM_008268.2
UniGeneiMm.207

Genome annotation databases

EnsembliENSMUST00000049272; ENSMUSP00000035423; ENSMUSG00000038700
GeneIDi15413
KEGGimmu:15413
UCSCiuc007lbu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26283 mRNA Translation: AAA37842.1
AK133512 mRNA Translation: BAE21695.1
BC103595 mRNA Translation: AAI03596.1
BC103596 mRNA Translation: AAI03597.1
BC103604 mRNA Translation: AAI03605.1
BC103607 mRNA Translation: AAI03608.1
L36070 Genomic DNA Translation: AAA50294.1
X03033 Genomic DNA Translation: CAB57812.1
CCDSiCCDS25296.1
PIRiA43551
B24777
RefSeqiNP_032294.2, NM_008268.2
UniGeneiMm.207

3D structure databases

ProteinModelPortaliP09079
SMRiP09079
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200379, 1 interactor
STRINGi10090.ENSMUSP00000035423

PTM databases

iPTMnetiP09079
PhosphoSitePlusiP09079

Proteomic databases

MaxQBiP09079
PaxDbiP09079
PRIDEiP09079

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049272; ENSMUSP00000035423; ENSMUSG00000038700
GeneIDi15413
KEGGimmu:15413
UCSCiuc007lbu.2 mouse

Organism-specific databases

CTDi3215
MGIiMGI:96186 Hoxb5

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231178
HOVERGENiHBG016849
InParanoidiP09079
KOiK09305
OMAiAHFTEIE
OrthoDBiEOG091G09XD
PhylomeDBiP09079
TreeFamiTF316310

Miscellaneous databases

PROiPR:P09079
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038700 Expressed in 141 organ(s), highest expression level in head
CleanExiMM_HOXB5
GenevisibleiP09079 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXB5_MOUSE
AccessioniPrimary (citable) accession number: P09079
Secondary accession number(s): Q3ZAY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: September 5, 2006
Last modified: November 7, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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