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Protein

Homeobox protein Hox-B5

Gene

HOXB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi194 – 253HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B5
Alternative name(s):
Homeobox protein HHO.C10
Homeobox protein Hox-2A
Homeobox protein Hu-1
Gene namesi
Name:HOXB5
Synonyms:HOX2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000120075.5
HGNCiHGNC:5116 HOXB5
MIMi142960 gene
neXtProtiNX_P09067

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3215
OpenTargetsiENSG00000120075
PharmGKBiPA29392

Polymorphism and mutation databases

BioMutaiHOXB5
DMDMi400000

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001281 – 269Homeobox protein Hox-B5Add BLAST269

Proteomic databases

MaxQBiP09067
PaxDbiP09067
PeptideAtlasiP09067
PRIDEiP09067
ProteomicsDBi52191

PTM databases

iPTMnetiP09067
PhosphoSitePlusiP09067

Expressioni

Tissue specificityi

Spinal cord.

Developmental stagei

Embryo.

Gene expression databases

BgeeiENSG00000120075 Expressed in 169 organ(s), highest expression level in sigmoid colon
CleanExiHS_HOXB5
GenevisibleiP09067 HS

Organism-specific databases

HPAiHPA043851
HPA074454

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi109455, 53 interactors
ELMiP09067
IntActiP09067, 59 interactors
STRINGi9606.ENSP00000239151

Structurei

3D structure databases

ProteinModelPortaliP09067
SMRiP09067
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi176 – 181Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231178
HOVERGENiHBG016849
InParanoidiP09067
KOiK09305
OMAiCATASRE
OrthoDBiEOG091G09XD
PhylomeDBiP09067
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P09067-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYFVNSFS GRYPNGPDYQ LLNYGSGSSL SGSYRDPAAM HTGSYGYNYN
60 70 80 90 100
GMDLSVNRSS ASSSHFGAVG ESSRAFPAPA QEPRFRQAAS SCSLSSPESL
110 120 130 140 150
PCTNGDSHGA KPSASSPSDQ ATSASSSANF TEIDEASASS EPEEAASQLS
160 170 180 190 200
SPSLARAQPE PMATSTAAPE GQTPQIFPWM RKLHISHDMT GPDGKRARTA
210 220 230 240 250
YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI WFQNRRMKWK
260
KDNKLKSMSL ATAGSAFQP
Length:269
Mass (Da):29,434
Last modified:July 1, 1993 - v3
Checksum:i58197F105DB0F8C4
GO

Sequence cautioni

The sequence AAA52681 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92299 mRNA Translation: AAA52682.1
AF287967 Genomic DNA Translation: AAG31553.1
AK314964 mRNA Translation: BAG37466.1
BC117247 mRNA Translation: AAI17248.1
X03794 mRNA Translation: CAA27420.1
K02572 Genomic DNA Translation: AAA52681.1 Different initiation.
M86726 mRNA Translation: AAB59430.1
CCDSiCCDS11530.1
PIRiA24777
A45578
RefSeqiNP_002138.1, NM_002147.3
UniGeneiHs.654456

Genome annotation databases

EnsembliENST00000239151; ENSP00000239151; ENSG00000120075
GeneIDi3215
KEGGihsa:3215
UCSCiuc002inr.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92299 mRNA Translation: AAA52682.1
AF287967 Genomic DNA Translation: AAG31553.1
AK314964 mRNA Translation: BAG37466.1
BC117247 mRNA Translation: AAI17248.1
X03794 mRNA Translation: CAA27420.1
K02572 Genomic DNA Translation: AAA52681.1 Different initiation.
M86726 mRNA Translation: AAB59430.1
CCDSiCCDS11530.1
PIRiA24777
A45578
RefSeqiNP_002138.1, NM_002147.3
UniGeneiHs.654456

3D structure databases

ProteinModelPortaliP09067
SMRiP09067
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109455, 53 interactors
ELMiP09067
IntActiP09067, 59 interactors
STRINGi9606.ENSP00000239151

PTM databases

iPTMnetiP09067
PhosphoSitePlusiP09067

Polymorphism and mutation databases

BioMutaiHOXB5
DMDMi400000

Proteomic databases

MaxQBiP09067
PaxDbiP09067
PeptideAtlasiP09067
PRIDEiP09067
ProteomicsDBi52191

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239151; ENSP00000239151; ENSG00000120075
GeneIDi3215
KEGGihsa:3215
UCSCiuc002inr.4 human

Organism-specific databases

CTDi3215
DisGeNETi3215
EuPathDBiHostDB:ENSG00000120075.5
GeneCardsiHOXB5
HGNCiHGNC:5116 HOXB5
HPAiHPA043851
HPA074454
MIMi142960 gene
neXtProtiNX_P09067
OpenTargetsiENSG00000120075
PharmGKBiPA29392
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231178
HOVERGENiHBG016849
InParanoidiP09067
KOiK09305
OMAiCATASRE
OrthoDBiEOG091G09XD
PhylomeDBiP09067
TreeFamiTF316310

Miscellaneous databases

GeneWikiiHOXB5
GenomeRNAii3215
PROiPR:P09067
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120075 Expressed in 169 organ(s), highest expression level in sigmoid colon
CleanExiHS_HOXB5
GenevisibleiP09067 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXB5_HUMAN
AccessioniPrimary (citable) accession number: P09067
Secondary accession number(s): B2RC69, P09069, Q17RP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1993
Last modified: September 12, 2018
This is version 179 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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