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Protein

Homeobox protein engrailed-2

Gene

En2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi235 – 294HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
  • embryonic brain development Source: ParkinsonsUK-UCL
  • hindbrain development Source: MGI
  • midbrain development Source: MGI
  • negative regulation of neuron apoptotic process Source: ParkinsonsUK-UCL
  • neuron development Source: MGI
  • neuron differentiation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein engrailed-2
Short name:
Homeobox protein en-2
Short name:
Mo-En-2
Gene namesi
Name:En2
Synonyms:En-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:95390 En2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001960681 – 324Homeobox protein engrailed-2Add BLAST324

Proteomic databases

PaxDbiP09066
PeptideAtlasiP09066
PRIDEiP09066

PTM databases

iPTMnetiP09066
PhosphoSitePlusiP09066

Expressioni

Tissue specificityi

Cerebellar granule cells.

Developmental stagei

In the adult brain it is found in the cerebellar granule cell layer while the expression during the gestation period is region specific, at the junction of the midbrain and hindbrain.

Gene expression databases

BgeeiENSMUSG00000039095 Expressed in 93 organ(s), highest expression level in cerebellum
CleanExiMM_EN2
ExpressionAtlasiP09066 baseline and differential
GenevisibleiP09066 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036761

Structurei

3D structure databases

ProteinModelPortaliP09066
SMRiP09066
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 30Poly-Gly7
Compositional biasi103 – 110Poly-Gly8

Sequence similaritiesi

Belongs to the engrailed homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0493 Eukaryota
ENOG4111P06 LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000247054
HOVERGENiHBG005975
InParanoidiP09066
KOiK09319
OMAiHRVTNFF
OrthoDBiEOG091G0XBB
PhylomeDBiP09066
TreeFamiTF106461

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR019549 Homeobox-engrailed_C-terminal
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR000747 Homeobox_engrailed
IPR020479 Homeobox_metazoa
IPR019737 Homoebox-engrailed_CS
PfamiView protein in Pfam
PF10525 Engrail_1_C_sig, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00026 ENGRAILED
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00033 ENGRAILED, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P09066-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEKDSKPSE TAAEAQRQPE PSSGGGSGGG SSPSDSDTGR RRALMLPEVL
60 70 80 90 100
QAPGNHQHPH RITNFFIDNI LRPEFGRRKD AGTCCAGAGG ARGGEGGAGT
110 120 130 140 150
TEGGGGGAGG AEQLLGARES RPNPACAPSA GGTLSAAAGD PAVDGEGGSK
160 170 180 190 200
TLSLHGGAKK PGDPGGSLDG VLKARGLGGG DLSVSSDSDS SQASATLGAQ
210 220 230 240 250
PMLWPAWVYC TRYSDRPSSG PRSRKPKKKN PNKEDKRPRT AFTAEQLQRL
260 270 280 290 300
KAEFQTNRYL TEQRRQSLAQ ELSLNESQIK IWFQNKRAKI KKATGNKNTL
310 320
AVHLMAQGLY NHSTTAKEGK SDSE
Length:324
Mass (Da):33,817
Last modified:February 1, 1994 - v2
Checksum:iD1D9D602A1225A53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12704 Genomic DNA No translation available.
L12705 mRNA Translation: AAA53527.1
Y00203 Genomic DNA Translation: CAA68362.1
CCDSiCCDS19143.1
PIRiD48423
RefSeqiNP_034264.1, NM_010134.3
UniGeneiMm.4298

Genome annotation databases

EnsembliENSMUST00000036177; ENSMUSP00000036761; ENSMUSG00000039095
GeneIDi13799
KEGGimmu:13799
UCSCiuc008wtv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12704 Genomic DNA No translation available.
L12705 mRNA Translation: AAA53527.1
Y00203 Genomic DNA Translation: CAA68362.1
CCDSiCCDS19143.1
PIRiD48423
RefSeqiNP_034264.1, NM_010134.3
UniGeneiMm.4298

3D structure databases

ProteinModelPortaliP09066
SMRiP09066
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036761

PTM databases

iPTMnetiP09066
PhosphoSitePlusiP09066

Proteomic databases

PaxDbiP09066
PeptideAtlasiP09066
PRIDEiP09066

Protocols and materials databases

DNASUi13799
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036177; ENSMUSP00000036761; ENSMUSG00000039095
GeneIDi13799
KEGGimmu:13799
UCSCiuc008wtv.1 mouse

Organism-specific databases

CTDi2020
MGIiMGI:95390 En2

Phylogenomic databases

eggNOGiKOG0493 Eukaryota
ENOG4111P06 LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000247054
HOVERGENiHBG005975
InParanoidiP09066
KOiK09319
OMAiHRVTNFF
OrthoDBiEOG091G0XBB
PhylomeDBiP09066
TreeFamiTF106461

Miscellaneous databases

PROiPR:P09066
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039095 Expressed in 93 organ(s), highest expression level in cerebellum
CleanExiMM_EN2
ExpressionAtlasiP09066 baseline and differential
GenevisibleiP09066 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR019549 Homeobox-engrailed_C-terminal
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR000747 Homeobox_engrailed
IPR020479 Homeobox_metazoa
IPR019737 Homoebox-engrailed_CS
PfamiView protein in Pfam
PF10525 Engrail_1_C_sig, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00026 ENGRAILED
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00033 ENGRAILED, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHME2_MOUSE
AccessioniPrimary (citable) accession number: P09066
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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