Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein engrailed-1

Gene

En1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi312 – 371HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein engrailed-1
Short name:
Homeobox protein en-1
Short name:
Mo-En-1
Gene namesi
Name:En1
Synonyms:En-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:95389 En1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001960631 – 401Homeobox protein engrailed-1Add BLAST401

Proteomic databases

PaxDbiP09065
PRIDEiP09065

PTM databases

iPTMnetiP09065
PhosphoSitePlusiP09065

Expressioni

Gene expression databases

BgeeiENSMUSG00000058665 Expressed in 119 organ(s), highest expression level in spinal cord
CleanExiMM_EN1
GenevisibleiP09065 MM

Interactioni

Protein-protein interaction databases

BioGridi199444, 2 interactors
STRINGi10090.ENSMUSP00000078659

Structurei

3D structure databases

ProteinModelPortaliP09065
SMRiP09065
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi52 – 87Pro-richAdd BLAST36
Compositional biasi73 – 87Poly-ProAdd BLAST15
Compositional biasi207 – 228Poly-AlaAdd BLAST22

Sequence similaritiesi

Belongs to the engrailed homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0493 Eukaryota
ENOG4111P06 LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000247054
HOVERGENiHBG005975
InParanoidiP09065
KOiK09319
OMAiNCGPPDG
OrthoDBiEOG091G0XBB
TreeFamiTF106461

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR019549 Homeobox-engrailed_C-terminal
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR000747 Homeobox_engrailed
IPR020479 Homeobox_metazoa
IPR019737 Homoebox-engrailed_CS
PfamiView protein in Pfam
PF10525 Engrail_1_C_sig, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00026 ENGRAILED
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00033 ENGRAILED, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P09065-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEQQPEPKS QRDSGLGAVA AAAPSGLSLS LSPGASGSSG SDGDSVPVSP
60 70 80 90 100
QPAPPSPPAA PCLPPLAHHP HLPPHPPPPP PPPPPPPQHL AAPAHQPQPA
110 120 130 140 150
AQLHRTTNFF IDNILRPDFG CKKEQPLPQL LVASAAAGGG AAAGGGSRVE
160 170 180 190 200
RDRGQTGAGR DPVHSLGTRA SGAASLLCAP DANCGPPDGS QPATAVSAGA
210 220 230 240 250
SKAGNPAAAA AAAAAAAAAA VAAAAAAASK PSDSGGGSGG NAGSPGAQGA
260 270 280 290 300
KFPEHNPAIL LMGSANGGPV VKTDSQQPLV WPAWVYCTRY SDRPSSGPRT
310 320 330 340 350
RKLKKKKNEK EDKRPRTAFT AEQLQRLKAE FQANRYITEQ RRQTLAQELS
360 370 380 390 400
LNESQIKIWF QNKRAKIKKA TGIKNGLALH LMAQGLYNHS TTTVQDKDES

E
Length:401
Mass (Da):40,981
Last modified:July 27, 2011 - v3
Checksum:i05456FD3815AA02A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197S → G in AAA03660 (PubMed:1363401).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12703 mRNA Translation: AAA03660.2
AK140408 mRNA Translation: BAE24375.1
Y00201 Genomic DNA Translation: CAA68361.1
CCDSiCCDS15235.1
PIRiA48423
RefSeqiNP_034263.2, NM_010133.2
UniGeneiMm.2657

Genome annotation databases

EnsembliENSMUST00000079721; ENSMUSP00000078659; ENSMUSG00000058665
GeneIDi13798
KEGGimmu:13798
UCSCiuc007cjm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12703 mRNA Translation: AAA03660.2
AK140408 mRNA Translation: BAE24375.1
Y00201 Genomic DNA Translation: CAA68361.1
CCDSiCCDS15235.1
PIRiA48423
RefSeqiNP_034263.2, NM_010133.2
UniGeneiMm.2657

3D structure databases

ProteinModelPortaliP09065
SMRiP09065
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199444, 2 interactors
STRINGi10090.ENSMUSP00000078659

PTM databases

iPTMnetiP09065
PhosphoSitePlusiP09065

Proteomic databases

PaxDbiP09065
PRIDEiP09065

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079721; ENSMUSP00000078659; ENSMUSG00000058665
GeneIDi13798
KEGGimmu:13798
UCSCiuc007cjm.2 mouse

Organism-specific databases

CTDi2019
MGIiMGI:95389 En1

Phylogenomic databases

eggNOGiKOG0493 Eukaryota
ENOG4111P06 LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000247054
HOVERGENiHBG005975
InParanoidiP09065
KOiK09319
OMAiNCGPPDG
OrthoDBiEOG091G0XBB
TreeFamiTF106461

Miscellaneous databases

PROiPR:P09065
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058665 Expressed in 119 organ(s), highest expression level in spinal cord
CleanExiMM_EN1
GenevisibleiP09065 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR019549 Homeobox-engrailed_C-terminal
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR000747 Homeobox_engrailed
IPR020479 Homeobox_metazoa
IPR019737 Homoebox-engrailed_CS
PfamiView protein in Pfam
PF10525 Engrail_1_C_sig, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00026 ENGRAILED
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00033 ENGRAILED, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHME1_MOUSE
AccessioniPrimary (citable) accession number: P09065
Secondary accession number(s): Q3USF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 163 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again