UniProtKB - P09055 (ITB1_MOUSE)
Integrin beta-1
Itgb1
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 152 | MagnesiumBy similarity | 1 | |
Metal bindingi | 154 | Calcium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 156 | Calcium 1By similarity | 1 | |
Metal bindingi | 157 | Calcium 1By similarity | 1 | |
Metal bindingi | 189 | Calcium 2By similarity | 1 | |
Metal bindingi | 244 | Calcium 2By similarity | 1 | |
Metal bindingi | 246 | Calcium 2By similarity | 1 | |
Metal bindingi | 248 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 249 | Calcium 2By similarity | 1 | |
Metal bindingi | 249 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- actin binding Source: MGI
- alpha-actinin binding Source: MGI
- cell adhesion molecule binding Source: MGI
- collagen binding Source: MGI
- collagen binding involved in cell-matrix adhesion Source: MGI
- fibronectin binding Source: MGI
- integrin binding Source: MGI
- kinase binding Source: MGI
- laminin binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- protease binding Source: MGI
- protein-containing complex binding Source: MGI
- protein domain specific binding Source: MGI
- protein heterodimerization activity Source: UniProtKB
- protein kinase binding Source: MGI
- protein tyrosine kinase binding Source: MGI
- signaling receptor activity Source: InterPro
- signaling receptor binding Source: MGI
GO - Biological processi
- axon extension Source: MGI
- basement membrane organization Source: CAFA
- bicellular tight junction assembly Source: MGI
- calcium-independent cell-matrix adhesion Source: MGI
- cardiac muscle cell differentiation Source: MGI
- cardiac muscle tissue development Source: MGI
- CD40 signaling pathway Source: MGI
- cell adhesion Source: MGI
- cell adhesion mediated by integrin Source: UniProtKB
- cell fate specification Source: MGI
- cell-matrix adhesion Source: MGI
- cell migration Source: MGI
- cell migration involved in sprouting angiogenesis Source: MGI
- cell projection organization Source: MGI
- cell-substrate adhesion Source: MGI
- cellular response to low-density lipoprotein particle stimulus Source: UniProtKB
- dendrite morphogenesis Source: MGI
- establishment of mitotic spindle orientation Source: MGI
- formation of radial glial scaffolds Source: MGI
- G1/S transition of mitotic cell cycle Source: MGI
- germ cell migration Source: MGI
- heterotypic cell-cell adhesion Source: MGI
- integrin-mediated signaling pathway Source: MGI
- in utero embryonic development Source: MGI
- lamellipodium assembly Source: MGI
- leukocyte cell-cell adhesion Source: MGI
- leukocyte tethering or rolling Source: MGI
- modulation of chemical synaptic transmission Source: SynGO
- negative regulation of anoikis Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of cell differentiation Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of cell projection organization Source: MGI
- negative regulation of neuron differentiation Source: MGI
- negative regulation of Rho protein signal transduction Source: MGI
- neuron projection development Source: MGI
- phagocytosis Source: MGI
- positive regulation of angiogenesis Source: MGI
- positive regulation of apoptotic process Source: MGI
- positive regulation of cell migration Source: UniProtKB
- positive regulation of cell population proliferation Source: MGI
- positive regulation of cell-substrate adhesion Source: MGI
- positive regulation of endocytosis Source: MGI
- positive regulation of fibroblast migration Source: MGI
- positive regulation of glutamate uptake involved in transmission of nerve impulse Source: ARUK-UCL
- positive regulation of GTPase activity Source: MGI
- positive regulation of neuron differentiation Source: MGI
- positive regulation of neuron projection development Source: MGI
- positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
- positive regulation of protein kinase B signaling Source: MGI
- positive regulation of protein localization to plasma membrane Source: UniProtKB
- positive regulation of signaling receptor activity Source: MGI
- positive regulation of wound healing Source: MGI
- protein transport within lipid bilayer Source: MGI
- reactive gliosis Source: ARUK-UCL
- receptor internalization Source: UniProtKB
- regulation of cell cycle Source: MGI
- regulation of collagen catabolic process Source: UniProtKB
- regulation of G protein-coupled receptor signaling pathway Source: MGI
- regulation of inward rectifier potassium channel activity Source: ARUK-UCL
- regulation of spontaneous synaptic transmission Source: ARUK-UCL
- sarcomere organization Source: MGI
- tissue homeostasis Source: MGI
- visual learning Source: MGI
Keywordsi
Molecular function | Integrin, Receptor |
Biological process | Cell adhesion |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-MMU-1566948, Elastic fibre formation R-MMU-1566977, Fibronectin matrix formation R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-202733, Cell surface interactions at the vascular wall R-MMU-210991, Basigin interactions R-MMU-2129379, Molecules associated with elastic fibres R-MMU-216083, Integrin cell surface interactions R-MMU-3000157, Laminin interactions R-MMU-3000170, Syndecan interactions R-MMU-3000178, ECM proteoglycans R-MMU-445144, Signal transduction by L1 R-MMU-446343, Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-MMU-8874081, MET activates PTK2 signaling R-MMU-8875513, MET interacts with TNS proteins |
Names & Taxonomyi
Protein namesi | Recommended name: Integrin beta-1CuratedAlternative name(s): Fibronectin receptor subunit beta VLA-4 subunit beta CD_antigen: CD29 |
Gene namesi | Name:Itgb1Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96610, Itgb1 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein Sequence analysis
- invadopodium membrane By similarity; Single-pass type I membrane protein Sequence analysis
- ruffle membrane By similarity; Single-pass type I membrane protein Sequence analysis
Endosome
- Recycling endosome 2 Publications
Other locations
- Melanosome By similarity
- lamellipodium By similarity
- ruffle By similarity
- focal adhesion By similarity
- Cell surface By similarity
Note: Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions to fibrillar adhesions in an ITGB1BP1-dependent manner. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner.By similarity
Plasma membrane
Other locations
Note: In cardiac muscle, isoform 2 is found in costameres and intercalated disks.
Endosome
- recycling endosome Source: UniProtKB-SubCell
Extracellular region or secreted
- basement membrane Source: MGI
Plasma Membrane
- external side of plasma membrane Source: MGI
- integral component of postsynaptic membrane Source: MGI
- integral component of synaptic membrane Source: SynGO
- integrin alpha1-beta1 complex Source: MGI
- integrin alpha10-beta1 complex Source: MGI
- integrin alpha11-beta1 complex Source: MGI
- integrin alpha2-beta1 complex Source: MGI
- integrin alpha3-beta1 complex Source: MGI
- integrin alpha5-beta1 complex Source: MGI
- integrin alpha7-beta1 complex Source: MGI
- integrin alpha9-beta1 complex Source: MGI
- integrin complex Source: MGI
- invadopodium membrane Source: UniProtKB
- plasma membrane Source: MGI
- postsynaptic membrane Source: MGI
- ruffle membrane Source: UniProtKB-SubCell
- sarcolemma Source: MGI
- synaptic membrane Source: MGI
Other locations
- acrosomal vesicle Source: MGI
- adherens junction Source: MGI
- cell surface Source: UniProtKB
- cell-cell junction Source: MGI
- cytoplasm Source: MGI
- dendritic spine Source: MGI
- filopodium Source: MGI
- focal adhesion Source: UniProtKB
- glial cell projection Source: MGI
- glutamatergic synapse Source: SynGO
- hemidesmosome Source: MGI
- intercalated disc Source: MGI
- lamellipodium Source: UniProtKB-SubCell
- melanosome Source: UniProtKB-SubCell
- membrane Source: UniProtKB
- membrane raft Source: MGI
- myelin sheath abaxonal region Source: BHF-UCL
- neuromuscular junction Source: MGI
- receptor complex Source: MGI
- Schaffer collateral - CA1 synapse Source: SynGO
- synapse Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 728 | ExtracellularSequence analysisAdd BLAST | 708 | |
Transmembranei | 729 – 751 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 752 – 798 | CytoplasmicSequence analysisAdd BLAST | 47 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Endosome, MembranePathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 783 | Y → F: Reduced endocytosis; when associated with F-795. 1 Publication | 1 | |
Mutagenesisi | 795 | Y → F: Reduced endocytosis; when associated with F-783. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Add BLAST | 20 | |
ChainiPRO_0000016335 | 21 – 798 | Integrin beta-1Add BLAST | 778 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 27 ↔ 45 | By similarity | ||
Disulfide bondi | 35 ↔ 464 | By similarity | ||
Disulfide bondi | 38 ↔ 75 | By similarity | ||
Disulfide bondi | 48 ↔ 64 | By similarity | ||
Glycosylationi | 50 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 94 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 97 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 207 ↔ 213 | By similarity | ||
Glycosylationi | 212 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 261 ↔ 301 | By similarity | ||
Glycosylationi | 269 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 363 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 401 ↔ 415 | By similarity | ||
Glycosylationi | 406 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 417 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 435 ↔ 462 | By similarity | ||
Disulfide bondi | 466 ↔ 691 | By similarity | ||
Disulfide bondi | 477 ↔ 489 | By similarity | ||
Glycosylationi | 481 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 486 ↔ 525 | By similarity | ||
Disulfide bondi | 491 ↔ 500 | By similarity | ||
Disulfide bondi | 502 ↔ 516 | By similarity | ||
Glycosylationi | 520 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 531 ↔ 536 | By similarity | ||
Disulfide bondi | 533 ↔ 568 | By similarity | ||
Disulfide bondi | 538 ↔ 553 | By similarity | ||
Disulfide bondi | 555 ↔ 560 | By similarity | ||
Disulfide bondi | 574 ↔ 579 | By similarity | ||
Disulfide bondi | 576 ↔ 607 | By similarity | ||
Disulfide bondi | 581 ↔ 590 | By similarity | ||
Glycosylationi | 584 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 592 ↔ 599 | By similarity | ||
Disulfide bondi | 613 ↔ 618 | By similarity | ||
Disulfide bondi | 615 ↔ 661 | By similarity | ||
Disulfide bondi | 620 ↔ 630 | By similarity | ||
Disulfide bondi | 633 ↔ 636 | By similarity | ||
Disulfide bondi | 640 ↔ 649 | By similarity | ||
Disulfide bondi | 646 ↔ 723 | By similarity | ||
Disulfide bondi | 665 ↔ 699 | By similarity | ||
Glycosylationi | 669 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 777 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 783 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 785 | PhosphoserineBy similarity | 1 | |
Modified residuei | 789 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 794 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 794 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity |
Post-translational modificationi
Keywords - PTMi
Acetylation, Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P09055 |
jPOSTi | P09055 |
MaxQBi | P09055 |
PaxDbi | P09055 |
PeptideAtlasi | P09055 |
PRIDEi | P09055 |
PTM databases
GlyConnecti | 2403, 8 N-Linked glycans (3 sites) |
GlyGeni | P09055, 12 sites |
iPTMneti | P09055 |
PhosphoSitePlusi | P09055 |
SwissPalmi | P09055 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000025809, Expressed in trachea and 342 other tissues |
ExpressionAtlasi | P09055, baseline and differential |
Genevisiblei | P09055, MM |
Interactioni
Subunit structurei
Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner (By similarity). Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. ITGA6:ITGB1 is found in a complex with CD9; interaction takes place in oocytes and is involved in sperm-egg fusion (PubMed:10634791). Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5.
Interacts with FLNA, FLNB, FLNC and RANBP9.
Interacts with KRT1 in the presence of RACK1 and SRC.
Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization.
Interacts with RAB21.
Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region).
Interacts with MYO10.
Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly.
Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1.
Interacts with ACAP1; required for ITGB1 recycling.
Interacts with ASAP3.
Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1.
Interacts with DAB2.
Interacts with FGR and HCK.
Isoform 2 interacts with alpha-7A and alpha-7B in adult skeletal muscle.
Isoform 2 interacts with alpha-7B in cardiomyocytes of adult heart.
Interacts with EMP2; the interaction may be direct or indirect and ITGB1 has a heterodimer form (PubMed:12189152). ITGA5:ITGB1 interacts with CCN3 (By similarity). ITGA4:ITGB1 is found in a ternary complex with CX3CR1 and CX3CL1 (By similarity). ITGA5:ITGB1 interacts with FBN1 (By similarity). ITGA5:ITGB1 interacts with IL1B.
Interacts with MDK (PubMed:15466886). ITGA4:ITGB1 interacts with MDK; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). ITGA6:ITGB1 interacts with MDK; this interaction mediates MDK-induced neurite-outgrowth (PubMed:15466886). ITGA5:ITGB1 interacts with ACE2 (By similarity).
By similarity9 PublicationsBinary interactionsi
Hide detailsP09055
With | #Exp. | IntAct |
---|---|---|
Csf2rb [P26955] | 2 | EBI-644224,EBI-1810026 |
Nme2 [Q01768] | 3 | EBI-644224,EBI-642573 |
Tmem158 [Q6F5E0] | 3 | EBI-644224,EBI-645317 |
Wasl [Q91YD9] | 2 | EBI-644224,EBI-642417 |
GO - Molecular functioni
- actin binding Source: MGI
- alpha-actinin binding Source: MGI
- cell adhesion molecule binding Source: MGI
- collagen binding involved in cell-matrix adhesion Source: MGI
- fibronectin binding Source: MGI
- integrin binding Source: MGI
- kinase binding Source: MGI
- laminin binding Source: MGI
- protease binding Source: MGI
- protein domain specific binding Source: MGI
- protein heterodimerization activity Source: UniProtKB
- protein kinase binding Source: MGI
- protein tyrosine kinase binding Source: MGI
- signaling receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 200826, 120 interactors |
ComplexPortali | CPX-3027, Integrin alpha5-beta1 complex CPX-3114, Integrin alpha1-beta1 complex CPX-3115, Integrin alpha2-beta1 complex CPX-3117, Integrin alpha3-beta1 complex CPX-3118, integrin alpha4-beta1 complex CPX-3119, Integrin alpha6-beta1 complex CPX-3121, Integrin alpha7-beta1 complex CPX-3122, Integrin alpha8-beta1 complex CPX-3123, Integrin alpha9-beta1 complex CPX-3124, Integrin alpha10-beta1 complex CPX-3125, Integrin alpha11-beta1 complex CPX-3130, Integrin alphav-beta1 complex |
CORUMi | P09055 |
DIPi | DIP-46247N |
IntActi | P09055, 62 interactors |
MINTi | P09055 |
STRINGi | 10090.ENSMUSP00000087457 |
Miscellaneous databases
RNActi | P09055, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P09055 |
SMRi | P09055 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 140 – 378 | VWFAAdd BLAST | 239 | |
Repeati | 466 – 515 | IAdd BLAST | 50 | |
Repeati | 516 – 559 | IIAdd BLAST | 44 | |
Repeati | 560 – 598 | IIIAdd BLAST | 39 | |
Repeati | 599 – 635 | IVAdd BLAST | 37 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 207 – 213 | CX3CL1-bindingBy similarity | 7 | |
Regioni | 295 – 314 | CX3CL1-bindingBy similarityAdd BLAST | 20 | |
Regioni | 466 – 635 | Cysteine-rich tandem repeatsAdd BLAST | 170 | |
Regioni | 762 – 767 | Signal for sorting from recycling endosomes; interaction with ACAP1By similarity | 6 | |
Regioni | 785 – 792 | Interaction with ITGB1BP1By similarity | 8 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1226, Eukaryota |
GeneTreei | ENSGT01010000222340 |
HOGENOMi | CLU_011772_2_1_1 |
InParanoidi | P09055 |
OMAi | DEQMCTF |
OrthoDBi | 473040at2759 |
PhylomeDBi | P09055 |
TreeFami | TF105392 |
Family and domain databases
Gene3Di | 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR013111, EGF_extracell IPR040622, I-EGF_1 IPR027071, Integrin_beta-1 IPR033760, Integrin_beta_N IPR015812, Integrin_bsu IPR014836, Integrin_bsu_cyt_dom IPR012896, Integrin_bsu_tail IPR036349, Integrin_bsu_tail_dom_sf IPR002369, Integrin_bsu_VWA IPR032695, Integrin_dom_sf IPR016201, PSI IPR036465, vWFA_dom_sf |
PANTHERi | PTHR10082, PTHR10082, 1 hit PTHR10082:SF28, PTHR10082:SF28, 1 hit |
Pfami | View protein in Pfam PF07974, EGF_2, 1 hit PF18372, I-EGF_1, 1 hit PF08725, Integrin_b_cyt, 1 hit PF07965, Integrin_B_tail, 1 hit PF00362, Integrin_beta, 1 hit PF17205, PSI_integrin, 1 hit |
PIRSFi | PIRSF002512, Integrin_B, 1 hit |
PRINTSi | PR01186, INTEGRINB |
SMARTi | View protein in SMART SM00187, INB, 1 hit SM01241, Integrin_b_cyt, 1 hit SM01242, Integrin_B_tail, 1 hit SM00423, PSI, 1 hit |
SUPFAMi | SSF53300, SSF53300, 1 hit SSF69179, SSF69179, 1 hit SSF69687, SSF69687, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 2 hits PS00243, INTEGRIN_BETA, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNLQLVSWIG LISLICSVFG QTDKNRCLKA NAKSCGECIQ AGPNCGWCTN
60 70 80 90 100
TTFLQEGMPT SARCDDLEAL KKKGCQPSDI ENPRGSQTIK KNKNVTNRSK
110 120 130 140 150
GMAEKLRPED ITQIQPQQLL LKLRSGEPQK FTLKFKRAED YPIDLYYLMD
160 170 180 190 200
LSYSMKDDLE NVKSLGTDLM NEMRRITSDF RIGFGSFVEK TVMPYISTTP
210 220 230 240 250
AKLRNPCTSE QNCTSPFSYK NVLSLTDRGE FFNELVGQQR ISGNLDSPEG
260 270 280 290 300
GFDAIMQVAV CGSLIGWRNV TRLLVFSTDA GFHFAGDGKL GGIVLPNDGQ
310 320 330 340 350
CHLENNVYTM SHYYDYPSIA HLVQKLSENN IQTIFAVTEE FQPVYKELKN
360 370 380 390 400
LIPKSAVGTL SGNSSNVIQL IIDAYNSLSS EVILENSKLP DGVTINYKSY
410 420 430 440 450
CKNGVNGTGE NGRKCSNISI GDEVQFEISI TANKCPNKES ETIKIKPLGF
460 470 480 490 500
TEEVEVVLQF ICKCNCQSHG IPASPKCHEG NGTFECGACR CNEGRVGRHC
510 520 530 540 550
ECSTDEVNSE DMDAYCRKEN SSEICSNNGE CVCGQCVCRK RDNTNEIYSG
560 570 580 590 600
KFCECDNFNC DRSNGLICGG NGVCRCRVCE CYPNYTGSAC DCSLDTGPCL
610 620 630 640 650
ASNGQICNGR GICECGACKC TDPKFQGPTC ETCQTCLGVC AEHKECVQCR
660 670 680 690 700
AFNKGEKKDT CAQECSHFNL TKVESREKLP QPVQVDPVTH CKEKDIDDCW
710 720 730 740 750
FYFTYSVNGN NEAIVHVVET PDCPTGPDII PIVAGVVAGI VLIGLALLLI
760 770 780 790
WKLLMIIHDR REFAKFEKEK MNAKWDTGEN PIYKSAVTTV VNPKYEGK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RJL5 | D6RJL5_MOUSE | Integrin beta-1 | Itgb1 | 58 | Annotation score: | ||
A0A0A0MQJ3 | A0A0A0MQJ3_MOUSE | Integrin beta-1 | Itgb1 | 112 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5 | L → Q in BAC40532 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 72 | K → E in BAE35290 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 385 | E → D in BAC36379 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 385 | E → P in CAA33272 (PubMed:2523953).Curated | 1 | |
Sequence conflicti | 392 | G → A in CAA33272 (PubMed:2523953).Curated | 1 | |
Sequence conflicti | 407 | G → E in BAC36379 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 443 – 445 | IKI → HSKL in CAA33272 (PubMed:2523953).Curated | 3 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053581 | 778 | G → Q in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_053582 | 786 – 798 | AVTTV…KYEGK → PINNFKNPNYGRKAGL in isoform 2. 1 PublicationAdd BLAST | 13 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00769 mRNA Translation: CAA68738.1 AK076526 mRNA Translation: BAC36379.1 Different initiation. AK088729 mRNA Translation: BAC40532.1 AK159689 mRNA Translation: BAE35290.1 AK167682 mRNA Translation: BAE39731.1 AC156608 Genomic DNA No translation available. CH466525 Genomic DNA Translation: EDL11832.1 BC050906 mRNA Translation: AAH50906.1 X15202 mRNA Translation: CAA33272.1 U37029 mRNA Translation: AAA80243.1 U47283 Genomic DNA Translation: AAA88821.1 |
CCDSi | CCDS22791.1 [P09055-1] |
PIRi | PL0104, IJMSFB S01659 |
RefSeqi | NP_034708.1, NM_010578.2 [P09055-1] |
Genome annotation databases
Ensembli | ENSMUST00000090006; ENSMUSP00000087457; ENSMUSG00000025809 [P09055-1] |
GeneIDi | 16412 |
KEGGi | mmu:16412 |
UCSCi | uc009nzv.2, mouse [P09055-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00769 mRNA Translation: CAA68738.1 AK076526 mRNA Translation: BAC36379.1 Different initiation. AK088729 mRNA Translation: BAC40532.1 AK159689 mRNA Translation: BAE35290.1 AK167682 mRNA Translation: BAE39731.1 AC156608 Genomic DNA No translation available. CH466525 Genomic DNA Translation: EDL11832.1 BC050906 mRNA Translation: AAH50906.1 X15202 mRNA Translation: CAA33272.1 U37029 mRNA Translation: AAA80243.1 U47283 Genomic DNA Translation: AAA88821.1 |
CCDSi | CCDS22791.1 [P09055-1] |
PIRi | PL0104, IJMSFB S01659 |
RefSeqi | NP_034708.1, NM_010578.2 [P09055-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5XQ0 | X-ray | 2.75 | A/B | 784-798 | [»] | |
BMRBi | P09055 | |||||
SMRi | P09055 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 200826, 120 interactors |
ComplexPortali | CPX-3027, Integrin alpha5-beta1 complex CPX-3114, Integrin alpha1-beta1 complex CPX-3115, Integrin alpha2-beta1 complex CPX-3117, Integrin alpha3-beta1 complex CPX-3118, integrin alpha4-beta1 complex CPX-3119, Integrin alpha6-beta1 complex CPX-3121, Integrin alpha7-beta1 complex CPX-3122, Integrin alpha8-beta1 complex CPX-3123, Integrin alpha9-beta1 complex CPX-3124, Integrin alpha10-beta1 complex CPX-3125, Integrin alpha11-beta1 complex CPX-3130, Integrin alphav-beta1 complex |
CORUMi | P09055 |
DIPi | DIP-46247N |
IntActi | P09055, 62 interactors |
MINTi | P09055 |
STRINGi | 10090.ENSMUSP00000087457 |
PTM databases
GlyConnecti | 2403, 8 N-Linked glycans (3 sites) |
GlyGeni | P09055, 12 sites |
iPTMneti | P09055 |
PhosphoSitePlusi | P09055 |
SwissPalmi | P09055 |
Proteomic databases
EPDi | P09055 |
jPOSTi | P09055 |
MaxQBi | P09055 |
PaxDbi | P09055 |
PeptideAtlasi | P09055 |
PRIDEi | P09055 |
Protocols and materials databases
Antibodypediai | 3126, 2825 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000090006; ENSMUSP00000087457; ENSMUSG00000025809 [P09055-1] |
GeneIDi | 16412 |
KEGGi | mmu:16412 |
UCSCi | uc009nzv.2, mouse [P09055-1] |
Organism-specific databases
CTDi | 3688 |
MGIi | MGI:96610, Itgb1 |
Phylogenomic databases
eggNOGi | KOG1226, Eukaryota |
GeneTreei | ENSGT01010000222340 |
HOGENOMi | CLU_011772_2_1_1 |
InParanoidi | P09055 |
OMAi | DEQMCTF |
OrthoDBi | 473040at2759 |
PhylomeDBi | P09055 |
TreeFami | TF105392 |
Enzyme and pathway databases
Reactomei | R-MMU-1566948, Elastic fibre formation R-MMU-1566977, Fibronectin matrix formation R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-202733, Cell surface interactions at the vascular wall R-MMU-210991, Basigin interactions R-MMU-2129379, Molecules associated with elastic fibres R-MMU-216083, Integrin cell surface interactions R-MMU-3000157, Laminin interactions R-MMU-3000170, Syndecan interactions R-MMU-3000178, ECM proteoglycans R-MMU-445144, Signal transduction by L1 R-MMU-446343, Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-MMU-8874081, MET activates PTK2 signaling R-MMU-8875513, MET interacts with TNS proteins |
Miscellaneous databases
BioGRID-ORCSi | 16412, 2 hits in 18 CRISPR screens |
ChiTaRSi | Itgb1, mouse |
PROi | PR:P09055 |
RNActi | P09055, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025809, Expressed in trachea and 342 other tissues |
ExpressionAtlasi | P09055, baseline and differential |
Genevisiblei | P09055, MM |
Family and domain databases
Gene3Di | 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR013111, EGF_extracell IPR040622, I-EGF_1 IPR027071, Integrin_beta-1 IPR033760, Integrin_beta_N IPR015812, Integrin_bsu IPR014836, Integrin_bsu_cyt_dom IPR012896, Integrin_bsu_tail IPR036349, Integrin_bsu_tail_dom_sf IPR002369, Integrin_bsu_VWA IPR032695, Integrin_dom_sf IPR016201, PSI IPR036465, vWFA_dom_sf |
PANTHERi | PTHR10082, PTHR10082, 1 hit PTHR10082:SF28, PTHR10082:SF28, 1 hit |
Pfami | View protein in Pfam PF07974, EGF_2, 1 hit PF18372, I-EGF_1, 1 hit PF08725, Integrin_b_cyt, 1 hit PF07965, Integrin_B_tail, 1 hit PF00362, Integrin_beta, 1 hit PF17205, PSI_integrin, 1 hit |
PIRSFi | PIRSF002512, Integrin_B, 1 hit |
PRINTSi | PR01186, INTEGRINB |
SMARTi | View protein in SMART SM00187, INB, 1 hit SM01241, Integrin_b_cyt, 1 hit SM01242, Integrin_B_tail, 1 hit SM00423, PSI, 1 hit |
SUPFAMi | SSF53300, SSF53300, 1 hit SSF69179, SSF69179, 1 hit SSF69687, SSF69687, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 2 hits PS00243, INTEGRIN_BETA, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ITB1_MOUSE | |
Accessioni | P09055Primary (citable) accession number: P09055 Secondary accession number(s): F6R105 Q8BVU1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | November 1, 1988 | |
Last modified: | February 10, 2021 | |
This is version 221 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families