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Protein

Fibroblast growth factor 2

Gene

FGF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677). Functions as a potent mitogen in vitro (PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677).6 Publications

Miscellaneous

This protein binds heparin more strongly than does aFGF.

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Retains almost half of its activity after treatment at pH 2.0 for 3 hours at 20 degrees Celsius.1 Publication

Temperature dependencei

Inactivated after 3 minutes at 60 degrees Celsius or 1 minute at 80 degrees Celsius.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei169HeparinBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei261Important for interaction with integrin1 Publication1
Sitei262Important for interaction with integrin1 Publication1
Sitei267Important for interaction with integrin1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Growth factor, Heparin-binding, Mitogen
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1839122 Signaling by activated point mutants of FGFR1
R-HSA-1839130 Signaling by activated point mutants of FGFR3
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-190370 FGFR1b ligand binding and activation
R-HSA-190372 FGFR3c ligand binding and activation
R-HSA-190373 FGFR1c ligand binding and activation
R-HSA-190375 FGFR2c ligand binding and activation
R-HSA-190377 FGFR2b ligand binding and activation
R-HSA-2033514 FGFR3 mutant receptor activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
R-HSA-3000170 Syndecan interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8851708 Signaling by FGFR2 IIIa TM
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P09038

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P09038

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.108.1.1 the fibroblast growth factor 2 (fgf2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibroblast growth factor 2
Short name:
FGF-2
Alternative name(s):
Basic fibroblast growth factor
Short name:
bFGF
Heparin-binding growth factor 2
Short name:
HBGF-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FGF2
Synonyms:FGFB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000138685.12

Human Gene Nomenclature Database

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HGNCi
HGNC:3676 FGF2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
134920 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P09038

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi181R → E: No effect on integrin binding. 1 Publication1
Mutagenesisi186R → E: No effect on integrin binding. 1 Publication1
Mutagenesisi188K → E: No effect on integrin binding. 1 Publication1
Mutagenesisi261 – 262KR → EE: Abolishes binding to integrin ITGAV:ITGB3 and suppresses FGF2 signaling with loss of ERK1/2 activation and reduced ability to induce DNA synthesis, cell migration and angiogenesis. Acts as a potent antagonist of FGF2-mediated angiogenesis. 1 Publication2
Mutagenesisi267K → E: Reduces binding to integrin ITGAV:ITGB3 and suppresses FGF2 signaling with reduced ERK1/2 activation and reduced ability to induce DNA synthesis, cell migration and angiogenesis. Acts as a potent antagonist of FGF2-mediated angiogenesis. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
2247

Open Targets

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OpenTargetsi
ENSG00000138685

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28115

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3107

Drug and drug target database

More...
DrugBanki
DB05434 ABT-510
DB00686 Pentosan Polysulfate
DB00877 Sirolimus
DB00364 Sucralfate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FGF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
261260095

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000089321 – 142Or 93, or 124, or 125, or 131, or 161Add BLAST142
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000008933143 – 288Fibroblast growth factor 2Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei108Omega-N-methylarginine; alternateBy similarity1
Modified residuei108Symmetric dimethylarginine; alternateBy similarity1
Modified residuei110Omega-N-methylarginine; alternateBy similarity1
Modified residuei110Symmetric dimethylarginine; alternateBy similarity1
Modified residuei112Omega-N-methylarginine; alternateBy similarity1
Modified residuei112Symmetric dimethylarginine; alternateBy similarity1
Modified residuei215Phosphotyrosine; by TEC1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.1 Publication
Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P09038

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P09038

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P09038

PeptideAtlas

More...
PeptideAtlasi
P09038

PRoteomics IDEntifications database

More...
PRIDEi
P09038

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52187
52188 [P09038-1]
52189 [P09038-2]
52190 [P09038-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P09038

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P09038

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000138685 Expressed in 185 organ(s), highest expression level in cartilage tissue

CleanEx database of gene expression profiles

More...
CleanExi
HS_FGF2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P09038 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P09038 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000125

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP3 (PubMed:18669637). Interacts with integrin ITGAV:ITGB3; the interaction is required for FGF2 signaling (PubMed:28302677). Interacts with SNORC (via the extracellular domain) (By similarity). Interacts with glypican GPC3 (By similarity).By similarity10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108538, 33 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P09038

Database of interacting proteins

More...
DIPi
DIP-4012N

Protein interaction database and analysis system

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IntActi
P09038, 14 interactors

Molecular INTeraction database

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MINTi
P09038

STRING: functional protein association networks

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STRINGi
9606.ENSP00000264498

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P09038

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1288
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BASX-ray1.90A135-288[»]
1BFBX-ray1.90A142-288[»]
1BFCX-ray2.20A142-288[»]
1BFFX-ray2.00A160-288[»]
1BFGX-ray1.60A143-288[»]
1BLANMR-A134-288[»]
1BLDNMR-A134-288[»]
1CVSX-ray2.80A/B157-288[»]
1EV2X-ray2.20A/B/C/D157-288[»]
1FGAX-ray2.20A143-288[»]
1FQ9X-ray3.00A/B157-288[»]
1II4X-ray2.70A/B/C/D134-288[»]
1IILX-ray2.30A/B/C/D134-288[»]
2BFHX-ray2.50A161-288[»]
2FGFX-ray1.77A143-288[»]
2M49NMR-A/C161-286[»]
4FGFX-ray1.60A143-288[»]
4OEEX-ray1.50A134-288[»]
4OEFX-ray1.80A134-288[»]
4OEGX-ray1.60A134-288[»]
5X1OX-ray1.90A/B143-288[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P09038

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P09038

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P09038

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni261 – 277Heparin-bindingBy similarityAdd BLAST17

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi179 – 181Cell attachment site; atypicalSequence analysis3
Motifi221 – 223Cell attachment site; atypicalSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3885 Eukaryota
ENOG4111IPH LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161583

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG107917

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P09038

KEGG Orthology (KO)

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KOi
K18497

Database of Orthologous Groups

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OrthoDBi
1157770at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P09038

TreeFam database of animal gene trees

More...
TreeFami
TF317805

Family and domain databases

Conserved Domains Database

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CDDi
cd00058 FGF, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028223 FGF2
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF

The PANTHER Classification System

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PANTHERi
PTHR11486 PTHR11486, 1 hit
PTHR11486:SF83 PTHR11486:SF83, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00167 FGF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00263 HBGFFGF

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00442 FGF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50353 SSF50353, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00247 HBGF_FGF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P09038-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MVGVGGGDVE DVTPRPGGCQ ISGRGARGCN GIPGAAAWEA ALPRRRPRRH
60 70 80 90 100
PSVNPRSRAA GSPRTRGRRT EERPSGSRLG DRGRGRALPG GRLGGRGRGR
110 120 130 140 150
APERVGGRGR GRGTAAPRAA PAARGSRPGP AGTMAAGSIT TLPALPEDGG
160 170 180 190 200
SGAFPPGHFK DPKRLYCKNG GFFLRIHPDG RVDGVREKSD PHIKLQLQAE
210 220 230 240 250
ERGVVSIKGV CANRYLAMKE DGRLLASKCV TDECFFFERL ESNNYNTYRS
260 270 280
RKYTSWYVAL KRTGQYKLGS KTGPGQKAIL FLPMSAKS
Note: Starts at an alternative CUG codon.
Length:288
Mass (Da):30,770
Last modified:October 13, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEAE98552A39D5E19
GO
Isoform 2 (identifier: P09038-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.
     79-79: L → M

Note: Starts at an alternative CUG codon.
Show »
Length:210
Mass (Da):22,623
Checksum:iA21C7A6E82E4F5BD
GO
Isoform 3 (identifier: P09038-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.

Show »
Length:155
Mass (Da):17,254
Checksum:iBE6CE13373007129
GO
Isoform 4 (identifier: P09038-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.
     93-93: L → M

Note: Starts at an alternative CUG codon.
Show »
Length:196
Mass (Da):21,203
Checksum:iD6B5447137E60343
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUF6A0A087WUF6_HUMAN
Fibroblast growth factor
FGF2
288Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQV6A0A0A0MQV6_HUMAN
Fibroblast growth factor
FGF2
288Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA52448 differs from that shown. Reason: Frameshift at positions 25, 82, 98 and 133.Curated
The sequence AAB21432 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.Curated
The sequence AAB21432 differs from that shown. Reason: Frameshift at position 25.Curated
The sequence ABO43041 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.Curated
The sequence ABO43041 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA28027 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.Curated
The sequence CAA28027 differs from that shown. Reason: Frameshift at positions 25 and 102.Curated
The sequence CAA73868 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.Curated
The sequence CAA73868 differs from that shown. Reason: Frameshift at position 25.Curated
The sequence EAX05222 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.Curated
The sequence EAX05222 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25G → R in AAA52448 (PubMed:2435575).Curated1
Sequence conflicti50H → Q in AAA52448 (PubMed:2435575).Curated1
Sequence conflicti59A → R in AAA52448 (PubMed:2435575).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0373831 – 133Missing in isoform 3. 2 PublicationsAdd BLAST133
Alternative sequenceiVSP_0373841 – 92Missing in isoform 4. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_0382361 – 78Missing in isoform 2. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_03823779L → M in isoform 2. 1 Publication1
Alternative sequenceiVSP_03738593L → M in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X04431 Genomic DNA Translation: CAA28027.1 Sequence problems.
X04432 Genomic DNA Translation: CAA28028.1
X04433 Genomic DNA Translation: CAA28029.1
J04513 mRNA Translation: AAA52531.1
J04513 mRNA Translation: AAA52532.1
J04513 mRNA Translation: AAA52533.1
AB451321 mRNA Translation: BAG70135.1
AB451450 mRNA Translation: BAG70264.1
EF506888 Genomic DNA Translation: ABO43041.1 Sequence problems.
AC021205 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05222.1 Sequence problems.
S81809 Genomic DNA Translation: AAB21432.2 Sequence problems.
Y13468 Genomic DNA Translation: CAA73868.1 Sequence problems.
M27968 mRNA Translation: AAA52448.1 Frameshift.
M17599 mRNA Translation: AAA52534.1
AY820133 mRNA Translation: AAV70487.1
S47380 mRNA Translation: AAD13853.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34059.1 [P09038-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
A32398

NCBI Reference Sequences

More...
RefSeqi
NP_001997.5, NM_002006.4 [P09038-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.284244

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000608478; ENSP00000477134; ENSG00000138685 [P09038-2]
ENST00000614010; ENSP00000478620; ENSG00000138685 [P09038-4]
ENST00000644866; ENSP00000494222; ENSG00000138685 [P09038-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2247

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2247

UCSC genome browser

More...
UCSCi
uc062zki.1 human [P09038-4]

Keywords - Coding sequence diversityi

Alternative initiation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04431 Genomic DNA Translation: CAA28027.1 Sequence problems.
X04432 Genomic DNA Translation: CAA28028.1
X04433 Genomic DNA Translation: CAA28029.1
J04513 mRNA Translation: AAA52531.1
J04513 mRNA Translation: AAA52532.1
J04513 mRNA Translation: AAA52533.1
AB451321 mRNA Translation: BAG70135.1
AB451450 mRNA Translation: BAG70264.1
EF506888 Genomic DNA Translation: ABO43041.1 Sequence problems.
AC021205 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05222.1 Sequence problems.
S81809 Genomic DNA Translation: AAB21432.2 Sequence problems.
Y13468 Genomic DNA Translation: CAA73868.1 Sequence problems.
M27968 mRNA Translation: AAA52448.1 Frameshift.
M17599 mRNA Translation: AAA52534.1
AY820133 mRNA Translation: AAV70487.1
S47380 mRNA Translation: AAD13853.1
CCDSiCCDS34059.1 [P09038-4]
PIRiA32398
RefSeqiNP_001997.5, NM_002006.4 [P09038-4]
UniGeneiHs.284244

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BASX-ray1.90A135-288[»]
1BFBX-ray1.90A142-288[»]
1BFCX-ray2.20A142-288[»]
1BFFX-ray2.00A160-288[»]
1BFGX-ray1.60A143-288[»]
1BLANMR-A134-288[»]
1BLDNMR-A134-288[»]
1CVSX-ray2.80A/B157-288[»]
1EV2X-ray2.20A/B/C/D157-288[»]
1FGAX-ray2.20A143-288[»]
1FQ9X-ray3.00A/B157-288[»]
1II4X-ray2.70A/B/C/D134-288[»]
1IILX-ray2.30A/B/C/D134-288[»]
2BFHX-ray2.50A161-288[»]
2FGFX-ray1.77A143-288[»]
2M49NMR-A/C161-286[»]
4FGFX-ray1.60A143-288[»]
4OEEX-ray1.50A134-288[»]
4OEFX-ray1.80A134-288[»]
4OEGX-ray1.60A134-288[»]
5X1OX-ray1.90A/B143-288[»]
ProteinModelPortaliP09038
SMRiP09038
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108538, 33 interactors
CORUMiP09038
DIPiDIP-4012N
IntActiP09038, 14 interactors
MINTiP09038
STRINGi9606.ENSP00000264498

Chemistry databases

BindingDBiP09038
ChEMBLiCHEMBL3107
DrugBankiDB05434 ABT-510
DB00686 Pentosan Polysulfate
DB00877 Sirolimus
DB00364 Sucralfate

Protein family/group databases

TCDBi1.A.108.1.1 the fibroblast growth factor 2 (fgf2) family

PTM databases

iPTMnetiP09038
PhosphoSitePlusiP09038

Polymorphism and mutation databases

BioMutaiFGF2
DMDMi261260095

Proteomic databases

EPDiP09038
jPOSTiP09038
PaxDbiP09038
PeptideAtlasiP09038
PRIDEiP09038
ProteomicsDBi52187
52188 [P09038-1]
52189 [P09038-2]
52190 [P09038-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2247
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000608478; ENSP00000477134; ENSG00000138685 [P09038-2]
ENST00000614010; ENSP00000478620; ENSG00000138685 [P09038-4]
ENST00000644866; ENSP00000494222; ENSG00000138685 [P09038-2]
GeneIDi2247
KEGGihsa:2247
UCSCiuc062zki.1 human [P09038-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2247
DisGeNETi2247
EuPathDBiHostDB:ENSG00000138685.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FGF2
HGNCiHGNC:3676 FGF2
HPAiCAB000125
MIMi134920 gene
neXtProtiNX_P09038
OpenTargetsiENSG00000138685
PharmGKBiPA28115

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00940000161583
HOVERGENiHBG107917
InParanoidiP09038
KOiK18497
OrthoDBi1157770at2759
PhylomeDBiP09038
TreeFamiTF317805

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1839122 Signaling by activated point mutants of FGFR1
R-HSA-1839130 Signaling by activated point mutants of FGFR3
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-190370 FGFR1b ligand binding and activation
R-HSA-190372 FGFR3c ligand binding and activation
R-HSA-190373 FGFR1c ligand binding and activation
R-HSA-190375 FGFR2c ligand binding and activation
R-HSA-190377 FGFR2b ligand binding and activation
R-HSA-2033514 FGFR3 mutant receptor activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
R-HSA-3000170 Syndecan interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8851708 Signaling by FGFR2 IIIa TM
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
SignaLinkiP09038
SIGNORiP09038

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FGF2 human
EvolutionaryTraceiP09038

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Basic_fibroblast_growth_factor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2247

Protein Ontology

More...
PROi
PR:P09038

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138685 Expressed in 185 organ(s), highest expression level in cartilage tissue
CleanExiHS_FGF2
ExpressionAtlasiP09038 baseline and differential
GenevisibleiP09038 HS

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028223 FGF2
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF83 PTHR11486:SF83, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFGF2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09038
Secondary accession number(s): A4LBB8
, O00527, P78443, Q16443, Q5PY50, Q7KZ11, Q7KZ72, Q9UC54, Q9UCS5, Q9UCS6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 13, 2009
Last modified: January 16, 2019
This is version 224 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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