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Protein

Fibroblast growth factor 2

Gene

FGF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677). Functions as a potent mitogen in vitro (PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677).6 Publications

Miscellaneous

This protein binds heparin more strongly than does aFGF.

pH dependencei

Retains almost half of its activity after treatment at pH 2.0 for 3 hours at 20 degrees Celsius.1 Publication

Temperature dependencei

Inactivated after 3 minutes at 60 degrees Celsius or 1 minute at 80 degrees Celsius.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei169HeparinBy similarity1
Sitei261Important for interaction with integrin1 Publication1
Sitei262Important for interaction with integrin1 Publication1
Sitei267Important for interaction with integrin1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Heparin-binding, Mitogen
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1839122 Signaling by activated point mutants of FGFR1
R-HSA-1839130 Signaling by activated point mutants of FGFR3
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-190370 FGFR1b ligand binding and activation
R-HSA-190372 FGFR3c ligand binding and activation
R-HSA-190373 FGFR1c ligand binding and activation
R-HSA-190375 FGFR2c ligand binding and activation
R-HSA-190377 FGFR2b ligand binding and activation
R-HSA-2033514 FGFR3 mutant receptor activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
R-HSA-3000170 Syndecan interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8851708 Signaling by FGFR2 IIIa TM
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
SignaLinkiP09038
SIGNORiP09038

Protein family/group databases

TCDBi1.A.108.1.1 the fibroblast growth factor 2 (fgf2) family

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 2
Short name:
FGF-2
Alternative name(s):
Basic fibroblast growth factor
Short name:
bFGF
Heparin-binding growth factor 2
Short name:
HBGF-2
Gene namesi
Name:FGF2
Synonyms:FGFB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000138685.12
HGNCiHGNC:3676 FGF2
MIMi134920 gene
neXtProtiNX_P09038

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi181R → E: No effect on integrin binding. 1 Publication1
Mutagenesisi186R → E: No effect on integrin binding. 1 Publication1
Mutagenesisi188K → E: No effect on integrin binding. 1 Publication1
Mutagenesisi261 – 262KR → EE: Abolishes binding to integrin ITGAV:ITGB3 and suppresses FGF2 signaling with loss of ERK1/2 activation and reduced ability to induce DNA synthesis, cell migration and angiogenesis. Acts as a potent antagonist of FGF2-mediated angiogenesis. 1 Publication2
Mutagenesisi267K → E: Reduces binding to integrin ITGAV:ITGB3 and suppresses FGF2 signaling with reduced ERK1/2 activation and reduced ability to induce DNA synthesis, cell migration and angiogenesis. Acts as a potent antagonist of FGF2-mediated angiogenesis. 1 Publication1

Organism-specific databases

DisGeNETi2247
OpenTargetsiENSG00000138685
PharmGKBiPA28115

Chemistry databases

ChEMBLiCHEMBL3107
DrugBankiDB05434 ABT-510
DB00686 Pentosan Polysulfate
DB00877 Sirolimus
DB00364 Sucralfate

Polymorphism and mutation databases

BioMutaiFGF2
DMDMi261260095

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000089321 – 142Or 93, or 124, or 125, or 131, or 161Add BLAST142
ChainiPRO_0000008933143 – 288Fibroblast growth factor 2Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108Omega-N-methylarginine; alternateBy similarity1
Modified residuei108Symmetric dimethylarginine; alternateBy similarity1
Modified residuei110Omega-N-methylarginine; alternateBy similarity1
Modified residuei110Symmetric dimethylarginine; alternateBy similarity1
Modified residuei112Omega-N-methylarginine; alternateBy similarity1
Modified residuei112Symmetric dimethylarginine; alternateBy similarity1
Modified residuei215Phosphotyrosine; by TEC1 Publication1
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources

Post-translational modificationi

Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.1 Publication
Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP09038
PaxDbiP09038
PeptideAtlasiP09038
PRIDEiP09038
ProteomicsDBi52187
52188 [P09038-1]
52189 [P09038-2]
52190 [P09038-3]

PTM databases

iPTMnetiP09038
PhosphoSitePlusiP09038

Expressioni

Tissue specificityi

Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.2 Publications

Gene expression databases

BgeeiENSG00000138685 Expressed in 185 organ(s), highest expression level in cartilage tissue
CleanExiHS_FGF2
ExpressionAtlasiP09038 baseline and differential
GenevisibleiP09038 HS

Organism-specific databases

HPAiCAB000125

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP3 (PubMed:18669637). Interacts with integrin ITGAV:ITGB3; the interaction is required for FGF2 signaling (PubMed:28302677). Interacts with SNORC (via the extracellular domain) (By similarity). Interacts with glypican GPC3 (By similarity).By similarity10 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108538, 29 interactors
CORUMiP09038
DIPiDIP-4012N
IntActiP09038, 14 interactors
MINTiP09038
STRINGi9606.ENSP00000264498

Chemistry databases

BindingDBiP09038

Structurei

Secondary structure

1288
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP09038
SMRiP09038
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09038

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni261 – 277Heparin-bindingBy similarityAdd BLAST17

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi179 – 181Cell attachment site; atypicalSequence analysis3
Motifi221 – 223Cell attachment site; atypicalSequence analysis3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00730000110923
HOVERGENiHBG107917
InParanoidiP09038
KOiK18497
PhylomeDBiP09038
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028223 FGF2
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF83 PTHR11486:SF83, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative initiation. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P09038-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVGVGGGDVE DVTPRPGGCQ ISGRGARGCN GIPGAAAWEA ALPRRRPRRH
60 70 80 90 100
PSVNPRSRAA GSPRTRGRRT EERPSGSRLG DRGRGRALPG GRLGGRGRGR
110 120 130 140 150
APERVGGRGR GRGTAAPRAA PAARGSRPGP AGTMAAGSIT TLPALPEDGG
160 170 180 190 200
SGAFPPGHFK DPKRLYCKNG GFFLRIHPDG RVDGVREKSD PHIKLQLQAE
210 220 230 240 250
ERGVVSIKGV CANRYLAMKE DGRLLASKCV TDECFFFERL ESNNYNTYRS
260 270 280
RKYTSWYVAL KRTGQYKLGS KTGPGQKAIL FLPMSAKS
Note: Starts at an alternative CUG codon.
Length:288
Mass (Da):30,770
Last modified:October 13, 2009 - v3
Checksum:iEAE98552A39D5E19
GO
Isoform 2 (identifier: P09038-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.
     79-79: L → M

Note: Starts at an alternative CUG codon.
Show »
Length:210
Mass (Da):22,623
Checksum:iA21C7A6E82E4F5BD
GO
Isoform 3 (identifier: P09038-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.

Show »
Length:155
Mass (Da):17,254
Checksum:iBE6CE13373007129
GO
Isoform 4 (identifier: P09038-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.
     93-93: L → M

Note: Starts at an alternative CUG codon.
Show »
Length:196
Mass (Da):21,203
Checksum:iD6B5447137E60343
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUF6A0A087WUF6_HUMAN
Fibroblast growth factor
FGF2
288Annotation score:
A0A0A0MQV6A0A0A0MQV6_HUMAN
Fibroblast growth factor
FGF2
288Annotation score:

Sequence cautioni

The sequence AAA52448 differs from that shown. Reason: Frameshift at positions 25, 82, 98 and 133.Curated
The sequence AAB21432 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.Curated
The sequence AAB21432 differs from that shown. Reason: Frameshift at position 25.Curated
The sequence ABO43041 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.Curated
The sequence ABO43041 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA28027 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.Curated
The sequence CAA28027 differs from that shown. Reason: Frameshift at positions 25 and 102.Curated
The sequence CAA73868 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.Curated
The sequence CAA73868 differs from that shown. Reason: Frameshift at position 25.Curated
The sequence EAX05222 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.Curated
The sequence EAX05222 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25G → R in AAA52448 (PubMed:2435575).Curated1
Sequence conflicti50H → Q in AAA52448 (PubMed:2435575).Curated1
Sequence conflicti59A → R in AAA52448 (PubMed:2435575).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0373831 – 133Missing in isoform 3. 2 PublicationsAdd BLAST133
Alternative sequenceiVSP_0373841 – 92Missing in isoform 4. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_0382361 – 78Missing in isoform 2. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_03823779L → M in isoform 2. 1 Publication1
Alternative sequenceiVSP_03738593L → M in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04431 Genomic DNA Translation: CAA28027.1 Sequence problems.
X04432 Genomic DNA Translation: CAA28028.1
X04433 Genomic DNA Translation: CAA28029.1
J04513 mRNA Translation: AAA52531.1
J04513 mRNA Translation: AAA52532.1
J04513 mRNA Translation: AAA52533.1
AB451321 mRNA Translation: BAG70135.1
AB451450 mRNA Translation: BAG70264.1
EF506888 Genomic DNA Translation: ABO43041.1 Sequence problems.
AC021205 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05222.1 Sequence problems.
S81809 Genomic DNA Translation: AAB21432.2 Sequence problems.
Y13468 Genomic DNA Translation: CAA73868.1 Sequence problems.
M27968 mRNA Translation: AAA52448.1 Frameshift.
M17599 mRNA Translation: AAA52534.1
AY820133 mRNA Translation: AAV70487.1
S47380 mRNA Translation: AAD13853.1
CCDSiCCDS34059.1 [P09038-4]
PIRiA32398
RefSeqiNP_001997.5, NM_002006.4 [P09038-4]
UniGeneiHs.284244

Genome annotation databases

EnsembliENST00000608478; ENSP00000477134; ENSG00000138685 [P09038-2]
ENST00000614010; ENSP00000478620; ENSG00000138685 [P09038-4]
ENST00000644866; ENSP00000494222; ENSG00000138685 [P09038-2]
GeneIDi2247
KEGGihsa:2247
UCSCiuc062zki.1 human [P09038-4]

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04431 Genomic DNA Translation: CAA28027.1 Sequence problems.
X04432 Genomic DNA Translation: CAA28028.1
X04433 Genomic DNA Translation: CAA28029.1
J04513 mRNA Translation: AAA52531.1
J04513 mRNA Translation: AAA52532.1
J04513 mRNA Translation: AAA52533.1
AB451321 mRNA Translation: BAG70135.1
AB451450 mRNA Translation: BAG70264.1
EF506888 Genomic DNA Translation: ABO43041.1 Sequence problems.
AC021205 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05222.1 Sequence problems.
S81809 Genomic DNA Translation: AAB21432.2 Sequence problems.
Y13468 Genomic DNA Translation: CAA73868.1 Sequence problems.
M27968 mRNA Translation: AAA52448.1 Frameshift.
M17599 mRNA Translation: AAA52534.1
AY820133 mRNA Translation: AAV70487.1
S47380 mRNA Translation: AAD13853.1
CCDSiCCDS34059.1 [P09038-4]
PIRiA32398
RefSeqiNP_001997.5, NM_002006.4 [P09038-4]
UniGeneiHs.284244

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BASX-ray1.90A135-288[»]
1BFBX-ray1.90A142-288[»]
1BFCX-ray2.20A142-288[»]
1BFFX-ray2.00A160-288[»]
1BFGX-ray1.60A143-288[»]
1BLANMR-A134-288[»]
1BLDNMR-A134-288[»]
1CVSX-ray2.80A/B157-288[»]
1EV2X-ray2.20A/B/C/D157-288[»]
1FGAX-ray2.20A143-288[»]
1FQ9X-ray3.00A/B157-288[»]
1II4X-ray2.70A/B/C/D134-288[»]
1IILX-ray2.30A/B/C/D134-288[»]
2BFHX-ray2.50A161-288[»]
2FGFX-ray1.77A143-288[»]
2M49NMR-A/C161-286[»]
4FGFX-ray1.60A143-288[»]
4OEEX-ray1.50A134-288[»]
4OEFX-ray1.80A134-288[»]
4OEGX-ray1.60A134-288[»]
5X1OX-ray1.90A/B143-288[»]
ProteinModelPortaliP09038
SMRiP09038
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108538, 29 interactors
CORUMiP09038
DIPiDIP-4012N
IntActiP09038, 14 interactors
MINTiP09038
STRINGi9606.ENSP00000264498

Chemistry databases

BindingDBiP09038
ChEMBLiCHEMBL3107
DrugBankiDB05434 ABT-510
DB00686 Pentosan Polysulfate
DB00877 Sirolimus
DB00364 Sucralfate

Protein family/group databases

TCDBi1.A.108.1.1 the fibroblast growth factor 2 (fgf2) family

PTM databases

iPTMnetiP09038
PhosphoSitePlusiP09038

Polymorphism and mutation databases

BioMutaiFGF2
DMDMi261260095

Proteomic databases

EPDiP09038
PaxDbiP09038
PeptideAtlasiP09038
PRIDEiP09038
ProteomicsDBi52187
52188 [P09038-1]
52189 [P09038-2]
52190 [P09038-3]

Protocols and materials databases

DNASUi2247
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000608478; ENSP00000477134; ENSG00000138685 [P09038-2]
ENST00000614010; ENSP00000478620; ENSG00000138685 [P09038-4]
ENST00000644866; ENSP00000494222; ENSG00000138685 [P09038-2]
GeneIDi2247
KEGGihsa:2247
UCSCiuc062zki.1 human [P09038-4]

Organism-specific databases

CTDi2247
DisGeNETi2247
EuPathDBiHostDB:ENSG00000138685.12
GeneCardsiFGF2
HGNCiHGNC:3676 FGF2
HPAiCAB000125
MIMi134920 gene
neXtProtiNX_P09038
OpenTargetsiENSG00000138685
PharmGKBiPA28115
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00730000110923
HOVERGENiHBG107917
InParanoidiP09038
KOiK18497
PhylomeDBiP09038
TreeFamiTF317805

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1839122 Signaling by activated point mutants of FGFR1
R-HSA-1839130 Signaling by activated point mutants of FGFR3
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-190370 FGFR1b ligand binding and activation
R-HSA-190372 FGFR3c ligand binding and activation
R-HSA-190373 FGFR1c ligand binding and activation
R-HSA-190375 FGFR2c ligand binding and activation
R-HSA-190377 FGFR2b ligand binding and activation
R-HSA-2033514 FGFR3 mutant receptor activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
R-HSA-3000170 Syndecan interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8851708 Signaling by FGFR2 IIIa TM
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
SignaLinkiP09038
SIGNORiP09038

Miscellaneous databases

ChiTaRSiFGF2 human
EvolutionaryTraceiP09038
GeneWikiiBasic_fibroblast_growth_factor
GenomeRNAii2247
PROiPR:P09038
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138685 Expressed in 185 organ(s), highest expression level in cartilage tissue
CleanExiHS_FGF2
ExpressionAtlasiP09038 baseline and differential
GenevisibleiP09038 HS

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028223 FGF2
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF83 PTHR11486:SF83, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGF2_HUMAN
AccessioniPrimary (citable) accession number: P09038
Secondary accession number(s): A4LBB8
, O00527, P78443, Q16443, Q5PY50, Q7KZ11, Q7KZ72, Q9UC54, Q9UCS5, Q9UCS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 13, 2009
Last modified: October 10, 2018
This is version 222 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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