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Protein

Homeobox protein Hox-D3

Gene

Hoxd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi195 – 254HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein Hox-D3
Alternative name(s):
Homeobox protein Hox-4.1
Homeobox protein MH-19
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hoxd3
Synonyms:Hox-4.1, Hoxd-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:96207 Hoxd3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002002051 – 433Homeobox protein Hox-D3Add BLAST433

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P09027

PRoteomics IDEntifications database

More...
PRIDEi
P09027

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P09027

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in adult kidney, but not in other adult tissues tested.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in 12-, 14-, and 17-day-old mouse embryos in the posterior half of the myelencephalon, spinal cord, dorsal root ganglia, first cervical vertebra, thyroid gland, kidney tubules, esophagus, stomach, and intestines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000079277 Expressed in 72 organ(s), highest expression level in hindbrain

CleanEx database of gene expression profiles

More...
CleanExi
MM_HOXD3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P09027 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P09027 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
200396, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000044809

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P09027

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P09027

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi161 – 166Antp-type hexapeptide6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0489 Eukaryota
ENOG410ZTBY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160027

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000252944

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107984

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P09027

KEGG Orthology (KO)

More...
KOi
K09303

Identification of Orthologs from Complete Genome Data

More...
OMAi
PSFAKPQ

Database of Orthologous Groups

More...
OrthoDBi
934469at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P09027

TreeFam database of animal gene trees

More...
TreeFami
TF315938

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025281 DUF4074
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13293 DUF4074, 1 hit
PF00046 Homeodomain, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00024 HOMEOBOX

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389 HOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P09027-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLFEQGQLTL ELPECTMQKA AYYENPGLFG GYGYSKATDT YGYSTPHQPY
60 70 80 90 100
PPPAAANSLD SDYPSSACSI QSSAPLRAPA HKGAELNGSC MRPGTGNSQG
110 120 130 140 150
GGGGNQPPGL NSEQQPPQPP PPPPPTLPPS SPTNPGSGVP AKKTKGGLSA
160 170 180 190 200
SSSSSTISKQ IFPWMKESRQ NSKQKNSCAT SGENCEDKSP PGPASKRVRT
210 220 230 240 250
AYTSAQLVEL EKEFHFNRYL CRPRRVEMAN LLNLTERQIK IWFQNRRMKY
260 270 280 290 300
KKDQKAKGIL HSPAGQSPER SPPLGGAAGH VAYSGQLPPV PGLAYDAPSP
310 320 330 340 350
PAFAKSQPNM YGLAAYTAPL SSCLPQQKRY PAPEFEPHPM ASNGGGFASA
360 370 380 390 400
NLQGSPVYVG GNFVDSMAPT SGPVFNLGHL SHPSSASVDY SCAAQIPGNH
410 420 430
HHGPCDPHPT YTDLSAHHSS QGRLPEAPKL THL
Length:433
Mass (Da):45,976
Last modified:March 3, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0BA0409A7F32F9E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZS5G3UZS5_MOUSE
Homeobox protein Hox-D3
Hoxd3
113Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZU1G3UZU1_MOUSE
Homeobox protein Hox-D3
Hoxd3
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB60683 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC52779 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC52780 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE23694 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA51975 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti187D → N (PubMed:2890503).Curated1
Sequence conflicti187D → N in AAA37846 (Ref. 6) Curated1
Sequence conflicti192G → D (PubMed:2890503).Curated1
Sequence conflicti192G → D in AAA37846 (Ref. 6) Curated1
Sequence conflicti201A → T (PubMed:2890503).Curated1
Sequence conflicti201A → T in AAA37846 (Ref. 6) Curated1
Sequence conflicti289Missing in CAA51975 (PubMed:7710686).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U03485, U03496 Genomic DNA Translation: AAB60683.1 Different initiation.
X73573 mRNA Translation: CAA51975.1 Sequence problems.
L24363 Genomic DNA Translation: AAA37855.1
U56400 mRNA Translation: AAC52779.1 Different initiation.
U56401 Genomic DNA Translation: AAC52780.1 Different initiation.
AK138525 mRNA Translation: BAE23694.1 Different initiation.
M18169 Genomic DNA Translation: AAA37846.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38149.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D29585
S34164
S47539

NCBI Reference Sequences

More...
RefSeqi
NP_034598.2, NM_010468.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.430708

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000047830; ENSMUSP00000044809; ENSMUSG00000079277
ENSMUST00000111982; ENSMUSP00000107613; ENSMUSG00000079277
ENSMUST00000111983; ENSMUSP00000107614; ENSMUSG00000079277

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
15434

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:15434

UCSC genome browser

More...
UCSCi
uc008kee.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03485, U03496 Genomic DNA Translation: AAB60683.1 Different initiation.
X73573 mRNA Translation: CAA51975.1 Sequence problems.
L24363 Genomic DNA Translation: AAA37855.1
U56400 mRNA Translation: AAC52779.1 Different initiation.
U56401 Genomic DNA Translation: AAC52780.1 Different initiation.
AK138525 mRNA Translation: BAE23694.1 Different initiation.
M18169 Genomic DNA Translation: AAA37846.1 Sequence problems.
CCDSiCCDS38149.1
PIRiD29585
S34164
S47539
RefSeqiNP_034598.2, NM_010468.2
UniGeneiMm.430708

3D structure databases

ProteinModelPortaliP09027
SMRiP09027
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200396, 4 interactors
STRINGi10090.ENSMUSP00000044809

PTM databases

PhosphoSitePlusiP09027

Proteomic databases

PaxDbiP09027
PRIDEiP09027

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047830; ENSMUSP00000044809; ENSMUSG00000079277
ENSMUST00000111982; ENSMUSP00000107613; ENSMUSG00000079277
ENSMUST00000111983; ENSMUSP00000107614; ENSMUSG00000079277
GeneIDi15434
KEGGimmu:15434
UCSCiuc008kee.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3232
MGIiMGI:96207 Hoxd3

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00940000160027
HOGENOMiHOG000252944
HOVERGENiHBG107984
InParanoidiP09027
KOiK09303
OMAiPSFAKPQ
OrthoDBi934469at2759
PhylomeDBiP09027
TreeFamiTF315938

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P09027

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000079277 Expressed in 72 organ(s), highest expression level in hindbrain
CleanExiMM_HOXD3
ExpressionAtlasiP09027 baseline and differential
GenevisibleiP09027 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR025281 DUF4074
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF13293 DUF4074, 1 hit
PF00046 Homeodomain, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHXD3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09027
Secondary accession number(s): Q3UUD3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: March 3, 2009
Last modified: January 16, 2019
This is version 168 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
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