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Protein

Homeobox protein Hox-B3

Gene

Hoxb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi191 – 250HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA-binding transcription factor activity Source: GO_Central
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B3
Alternative name(s):
Homeobox protein Hox-2.7
Homeobox protein MH-23
Gene namesi
Name:Hoxb3
Synonyms:Hox-2.7, Hoxb-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96184 Hoxb3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001181 – 433Homeobox protein Hox-B3Add BLAST433

Proteomic databases

PaxDbiP09026
PRIDEiP09026

PTM databases

iPTMnetiP09026
PhosphoSitePlusiP09026

Expressioni

Gene expression databases

BgeeiENSMUSG00000048763 Expressed in 240 organ(s), highest expression level in head
CleanExiMM_HOXB3
ExpressionAtlasiP09026 baseline and differential
GenevisibleiP09026 MM

Interactioni

Protein-protein interaction databases

IntActiP09026, 1 interactor
MINTiP09026
STRINGi10090.ENSMUSP00000053426

Structurei

3D structure databases

ProteinModelPortaliP09026
SMRiP09026
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi129 – 134Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 181Gly-richAdd BLAST28

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000252944
HOVERGENiHBG107984
InParanoidiP09026
KOiK09303
OMAiKCGPGTN
OrthoDBiEOG091G09XD
PhylomeDBiP09026
TreeFamiTF315938

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR025281 DUF4074
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF13293 DUF4074, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P09026-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKATYYDNT AAALFGGYSS YPGSNGFGYD GPPQPPFQAA THLEGDYQRS
60 70 80 90 100
ACSLQSLGNA APHAKSKELN GSCMRPGLAP EPLPAPPGSP PPSAAPTSTT
110 120 130 140 150
SNSNNGGGPS KSGPPKCGAG SNSTLTKQIF PWMKESRQTS KLKNSSPGTA
160 170 180 190 200
EGCGGGGGGG GGGGGGGGGS SGGGGGGGGG GDKSPPGSAA SKRARTAYTS
210 220 230 240 250
AQLVELEKEF HFNRYLCRPR RVEMANLLNL SERQIKIWFQ NRRMKYKKDQ
260 270 280 290 300
KAKGLASSSG GPSPAGSPPQ PMQSTAGFMN ALHSMTPSYD SPSPPAFGKG
310 320 330 340 350
HQNAYALPSN YQPPLKGCGA PQKYPPTPAS EYEPHVLQAN GGAYGTPTMQ
360 370 380 390 400
GSPVYVGGGG YADPLPPPAG PSLYGLNHLS HHPSGNLDYN GAAPMGPNQH
410 420 430
HGPCDPHPTY TDLSSHHAPP QGRIQEAPKL THL
Length:433
Mass (Da):44,353
Last modified:October 1, 1996 - v4
Checksum:i9AD3C922663612A6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZC2G3UZC2_MOUSE
Homeobox protein Hox-B3
Hoxb3
18Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113G → C in CAA46951 (PubMed:1582411).Curated1
Sequence conflicti113G → C in AAA08719 (PubMed:1582411).Curated1
Sequence conflicti119A → S in CAA46951 (PubMed:1582411).Curated1
Sequence conflicti119A → S in AAA08719 (PubMed:1582411).Curated1
Sequence conflicti152 – 168GCGGG…GGGGG → RLWWWRPAVVAAAAAVR in AAA37840 (PubMed:2890503).CuratedAdd BLAST17
Sequence conflicti182D → N (PubMed:2463210).Curated1
Sequence conflicti216 – 217LC → FV in AAA37840 (PubMed:2890503).Curated2
Sequence conflicti330S → L in AAA37840 (PubMed:2890503).Curated1
Sequence conflicti342 – 361GAYGT…GGGGY → APTGRPPCRAVRCMWAGVAT (PubMed:2890503).CuratedAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66177 mRNA Translation: CAA46951.1
S35628 mRNA Translation: AAA08719.1
U02278 Genomic DNA Translation: AAB60496.1
M18168 Genomic DNA Translation: AAA37840.1
CCDSiCCDS25299.1
PIRiS20963
RefSeqiNP_001073338.1, NM_001079869.1
NP_034588.2, NM_010458.2
XP_006532346.1, XM_006532283.3
XP_006532347.1, XM_006532284.3
XP_006532348.1, XM_006532285.3
XP_006532349.1, XM_006532286.3
XP_006532351.1, XM_006532288.1
XP_006532352.1, XM_006532289.3
XP_006532353.1, XM_006532290.3
XP_011247059.1, XM_011248757.2
UniGeneiMm.342481

Genome annotation databases

EnsembliENSMUST00000055334; ENSMUSP00000053426; ENSMUSG00000048763
ENSMUST00000093944; ENSMUSP00000091476; ENSMUSG00000048763
GeneIDi15410
KEGGimmu:15410
UCSCiuc007lbw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66177 mRNA Translation: CAA46951.1
S35628 mRNA Translation: AAA08719.1
U02278 Genomic DNA Translation: AAB60496.1
M18168 Genomic DNA Translation: AAA37840.1
CCDSiCCDS25299.1
PIRiS20963
RefSeqiNP_001073338.1, NM_001079869.1
NP_034588.2, NM_010458.2
XP_006532346.1, XM_006532283.3
XP_006532347.1, XM_006532284.3
XP_006532348.1, XM_006532285.3
XP_006532349.1, XM_006532286.3
XP_006532351.1, XM_006532288.1
XP_006532352.1, XM_006532289.3
XP_006532353.1, XM_006532290.3
XP_011247059.1, XM_011248757.2
UniGeneiMm.342481

3D structure databases

ProteinModelPortaliP09026
SMRiP09026
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP09026, 1 interactor
MINTiP09026
STRINGi10090.ENSMUSP00000053426

PTM databases

iPTMnetiP09026
PhosphoSitePlusiP09026

Proteomic databases

PaxDbiP09026
PRIDEiP09026

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055334; ENSMUSP00000053426; ENSMUSG00000048763
ENSMUST00000093944; ENSMUSP00000091476; ENSMUSG00000048763
GeneIDi15410
KEGGimmu:15410
UCSCiuc007lbw.1 mouse

Organism-specific databases

CTDi3213
MGIiMGI:96184 Hoxb3

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000252944
HOVERGENiHBG107984
InParanoidiP09026
KOiK09303
OMAiKCGPGTN
OrthoDBiEOG091G09XD
PhylomeDBiP09026
TreeFamiTF315938

Miscellaneous databases

PROiPR:P09026
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048763 Expressed in 240 organ(s), highest expression level in head
CleanExiMM_HOXB3
ExpressionAtlasiP09026 baseline and differential
GenevisibleiP09026 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR025281 DUF4074
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF13293 DUF4074, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXB3_MOUSE
AccessioniPrimary (citable) accession number: P09026
Secondary accession number(s): P10285, Q4PJ06, Q61680
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 160 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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