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Protein

Homeobox protein Hox-C8

Gene

Hoxc8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi149 – 208HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C8
Alternative name(s):
Homeobox protein Hox-3.1
Homeobox protein M31
Gene namesi
Name:Hoxc8
Synonyms:Hox-3.1, Hoxc-8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96198 Hoxc8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001811 – 242Homeobox protein Hox-C8Add BLAST242

Proteomic databases

MaxQBiP09025
PaxDbiP09025
PRIDEiP09025

PTM databases

iPTMnetiP09025
PhosphoSitePlusiP09025

Expressioni

Developmental stagei

Initially found in all tissues of the posterior region in 8.5 and 9.5 dpc. Embryos, it eventually become specifically located in neural tissue.

Gene expression databases

BgeeiENSMUSG00000001657 Expressed in 172 organ(s), highest expression level in brown adipose tissue
CleanExiMM_HOXC8
GenevisibleiP09025 MM

Interactioni

Subunit structurei

Interacts with HOMEZ.By similarity

Protein-protein interaction databases

BioGridi200389, 2 interactors
IntActiP09025, 1 interactor
STRINGi10090.ENSMUSP00000001703

Structurei

3D structure databases

ProteinModelPortaliP09025
SMRiP09025
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi138 – 143Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP09025
KOiK09308
OMAiFHHGTSS
OrthoDBiEOG091G09XD
PhylomeDBiP09025
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P09025-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYFVNPLF SKYKGGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ
60 70 80 90 100
HASHHVQDFF HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY
110 120 130 140 150
GAQQEASVVQ YPDCKSSANT NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR
160 170 180 190 200
SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI EVSHALGLTE RQVKIWFQNR
210 220 230 240
RMKWKKENNK DKLPGARDEE KVEEEGNEEE EKEEEEKEEN KD
Length:242
Mass (Da):27,740
Last modified:July 1, 1989 - v2
Checksum:i4A2A53BDA4CFA878
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151S → T in CAA27294 (PubMed:3007994).Curated1
Sequence conflicti181E → Q in CAA27294 (PubMed:3007994).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07439 mRNA Translation: CAA30319.1
X07646 mRNA Translation: CAA30486.1
M35603 Genomic DNA Translation: AAA37857.1
X03659 Genomic DNA Translation: CAA27294.1 Sequence problems.
CCDSiCCDS27894.1
PIRiB25180 A25180
B36023 WJMSX3
S13785
RefSeqiNP_034596.1, NM_010466.2
UniGeneiMm.6167

Genome annotation databases

EnsembliENSMUST00000001703; ENSMUSP00000001703; ENSMUSG00000001657
GeneIDi15426
KEGGimmu:15426
UCSCiuc012aaf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07439 mRNA Translation: CAA30319.1
X07646 mRNA Translation: CAA30486.1
M35603 Genomic DNA Translation: AAA37857.1
X03659 Genomic DNA Translation: CAA27294.1 Sequence problems.
CCDSiCCDS27894.1
PIRiB25180 A25180
B36023 WJMSX3
S13785
RefSeqiNP_034596.1, NM_010466.2
UniGeneiMm.6167

3D structure databases

ProteinModelPortaliP09025
SMRiP09025
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200389, 2 interactors
IntActiP09025, 1 interactor
STRINGi10090.ENSMUSP00000001703

PTM databases

iPTMnetiP09025
PhosphoSitePlusiP09025

Proteomic databases

MaxQBiP09025
PaxDbiP09025
PRIDEiP09025

Protocols and materials databases

DNASUi15426
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001703; ENSMUSP00000001703; ENSMUSG00000001657
GeneIDi15426
KEGGimmu:15426
UCSCiuc012aaf.1 mouse

Organism-specific databases

CTDi3224
MGIiMGI:96198 Hoxc8

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP09025
KOiK09308
OMAiFHHGTSS
OrthoDBiEOG091G09XD
PhylomeDBiP09025
TreeFamiTF316310

Miscellaneous databases

PROiPR:P09025
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001657 Expressed in 172 organ(s), highest expression level in brown adipose tissue
CleanExiMM_HOXC8
GenevisibleiP09025 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXC8_MOUSE
AccessioniPrimary (citable) accession number: P09025
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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