Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Hox-B7

Gene

Hoxb7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi137 – 196HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B7
Alternative name(s):
Homeobox protein Hox-2.3
Homeobox protein MH-22B
Homeobox protein MuB1
Gene namesi
Name:Hoxb7
Synonyms:Hox-2.3, Hoxb-7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96188 Hoxb7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001431 – 217Homeobox protein Hox-B7Add BLAST217

Proteomic databases

MaxQBiP09024
PaxDbiP09024
PRIDEiP09024

PTM databases

iPTMnetiP09024
PhosphoSitePlusiP09024

Expressioni

Gene expression databases

BgeeiENSMUSG00000038721 Expressed in 77 organ(s), highest expression level in embryo
CleanExiMM_HOXB7
GenevisibleiP09024 MM

Interactioni

Protein-protein interaction databases

BioGridi200381, 1 interactor
IntActiP09024, 1 interactor
STRINGi10090.ENSMUSP00000040121

Structurei

3D structure databases

ProteinModelPortaliP09024
SMRiP09024
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi126 – 131Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi210 – 217Glu-rich (acidic)8

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP09024
KOiK09307
OMAiWMRSTGT
OrthoDBiEOG091G09XD
PhylomeDBiP09024
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P09024-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLYYANAL FSKYPAASSV FAPGAFPEQT SCAFASNPQR PGYGAGPGAP
60 70 80 90 100
FSASVQGLYS GGGAMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC
110 120 130 140 150
PGDPAKAAGA KEQRDSDLAA ESNFRIYPWM RSSGPDRKRG RQTYTRYQTL
160 170 180 190 200
ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ IKIWFQNRRM KWKKENKTSG
210
PGTTGQDKAE AEEEEEE
Length:217
Mass (Da):23,967
Last modified:September 5, 2006 - v2
Checksum:i074AEB9D57EE88D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104P → A (PubMed:2889183).Curated1
Sequence conflicti104P → A (PubMed:2896332).Curated1
Sequence conflicti108A → G (PubMed:2889183).Curated1
Sequence conflicti108A → G (PubMed:2896332).Curated1
Sequence conflicti144Y → S in BAE23104 (PubMed:16141072).Curated1
Sequence conflicti206Q → H in AAA37845 (PubMed:2890503).Curated1
Sequence conflicti211A → G (PubMed:2889183).Curated1
Sequence conflicti211A → G (PubMed:2896332).Curated1
Sequence conflicti211A → R in AAA88245 (PubMed:2891608).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00436 Genomic DNA Translation: CAA68494.1
X06762 mRNA Translation: CAA29934.1
AK136706 mRNA Translation: BAE23104.1
AL645478 Genomic DNA Translation: CAM27142.1
M18167 Genomic DNA Translation: AAA37845.1 Sequence problems.
M18400 Genomic DNA Translation: AAA88245.1
X14570 mRNA Translation: CAA32708.1
CCDSiCCDS25294.1
PIRiA26846 WJMSX2
RefSeqiNP_034590.2, NM_010460.2
UniGeneiMm.390366

Genome annotation databases

EnsembliENSMUST00000049352; ENSMUSP00000040121; ENSMUSG00000038721
GeneIDi15415
KEGGimmu:15415
UCSCiuc007lbr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00436 Genomic DNA Translation: CAA68494.1
X06762 mRNA Translation: CAA29934.1
AK136706 mRNA Translation: BAE23104.1
AL645478 Genomic DNA Translation: CAM27142.1
M18167 Genomic DNA Translation: AAA37845.1 Sequence problems.
M18400 Genomic DNA Translation: AAA88245.1
X14570 mRNA Translation: CAA32708.1
CCDSiCCDS25294.1
PIRiA26846 WJMSX2
RefSeqiNP_034590.2, NM_010460.2
UniGeneiMm.390366

3D structure databases

ProteinModelPortaliP09024
SMRiP09024
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200381, 1 interactor
IntActiP09024, 1 interactor
STRINGi10090.ENSMUSP00000040121

PTM databases

iPTMnetiP09024
PhosphoSitePlusiP09024

Proteomic databases

MaxQBiP09024
PaxDbiP09024
PRIDEiP09024

Protocols and materials databases

DNASUi15415
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049352; ENSMUSP00000040121; ENSMUSG00000038721
GeneIDi15415
KEGGimmu:15415
UCSCiuc007lbr.1 mouse

Organism-specific databases

CTDi3217
MGIiMGI:96188 Hoxb7

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP09024
KOiK09307
OMAiWMRSTGT
OrthoDBiEOG091G09XD
PhylomeDBiP09024
TreeFamiTF316310

Miscellaneous databases

PROiPR:P09024
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038721 Expressed in 77 organ(s), highest expression level in embryo
CleanExiMM_HOXB7
GenevisibleiP09024 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXB7_MOUSE
AccessioniPrimary (citable) accession number: P09024
Secondary accession number(s): A2A9Z9, Q3UW15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: September 5, 2006
Last modified: November 7, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again