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Protein

Homeobox protein Hox-B6

Gene

Hoxb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi146 – 205HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • embryonic skeletal system development Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • erythrocyte homeostasis Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B6
Alternative name(s):
Homeobox protein Hox-2.2
Homeobox protein MH-22A
Gene namesi
Name:Hoxb6
Synonyms:Hox-2.2, Hoxb-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96187 Hoxb6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001361 – 224Homeobox protein Hox-B6Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei214PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP09023
PaxDbiP09023
PeptideAtlasiP09023
PRIDEiP09023

PTM databases

iPTMnetiP09023
PhosphoSitePlusiP09023

Expressioni

Gene expression databases

BgeeiENSMUSG00000000690 Expressed in 152 organ(s), highest expression level in head
CleanExiMM_HOXB6
GenevisibleiP09023 MM

Interactioni

Protein-protein interaction databases

BioGridi200380, 1 interactor
DIPiDIP-59870N
IntActiP09023, 1 interactor
STRINGi10090.ENSMUSP00000000704

Structurei

3D structure databases

ProteinModelPortaliP09023
SMRiP09023
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 132Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi216 – 220Poly-Glu5

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP09023
KOiK09306
OMAiPLRHYSA
OrthoDBiEOG091G09XD
PhylomeDBiP09023
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P09023-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD
60 70 80 90 100
KGFAASSYYP PAGGGYGRAA PCDYGPAPAF YREKDAACAL SGADEPPPFH
110 120 130 140 150
PEPRKSDCAQ DKSVFGETEE QKCSTPVYPW MQRMNSCNSS SFGPSGRRGR
160 170 180 190 200
QTYTRYQTLE LEKEFHYNRY LTRRRRIEIA HALCLTERQI KIWFQNRRMK
210 220
WKKESKLLSA SQLSAEEEEE KPAE
Length:224
Mass (Da):25,310
Last modified:July 1, 1989 - v2
Checksum:iE8FC0BDEB57F5C3D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186T → P in AAA37844 (PubMed:2890503).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18166 Genomic DNA Translation: AAA37844.1
X56459 mRNA Translation: CAA39834.1
BC016893 mRNA Translation: AAH16893.1
M18401 Genomic DNA Translation: AAC27130.1 Sequence problems.
J03782 Genomic DNA Translation: AAA37843.1
CCDSiCCDS25295.1
PIRiA31324
B29585
C27176
RefSeqiNP_032295.1, NM_008269.1
UniGeneiMm.215

Genome annotation databases

EnsembliENSMUST00000000704; ENSMUSP00000000704; ENSMUSG00000000690
ENSMUST00000173432; ENSMUSP00000133281; ENSMUSG00000000690
GeneIDi15414
KEGGimmu:15414
UCSCiuc007lbt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18166 Genomic DNA Translation: AAA37844.1
X56459 mRNA Translation: CAA39834.1
BC016893 mRNA Translation: AAH16893.1
M18401 Genomic DNA Translation: AAC27130.1 Sequence problems.
J03782 Genomic DNA Translation: AAA37843.1
CCDSiCCDS25295.1
PIRiA31324
B29585
C27176
RefSeqiNP_032295.1, NM_008269.1
UniGeneiMm.215

3D structure databases

ProteinModelPortaliP09023
SMRiP09023
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200380, 1 interactor
DIPiDIP-59870N
IntActiP09023, 1 interactor
STRINGi10090.ENSMUSP00000000704

PTM databases

iPTMnetiP09023
PhosphoSitePlusiP09023

Proteomic databases

MaxQBiP09023
PaxDbiP09023
PeptideAtlasiP09023
PRIDEiP09023

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000704; ENSMUSP00000000704; ENSMUSG00000000690
ENSMUST00000173432; ENSMUSP00000133281; ENSMUSG00000000690
GeneIDi15414
KEGGimmu:15414
UCSCiuc007lbt.1 mouse

Organism-specific databases

CTDi3216
MGIiMGI:96187 Hoxb6

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP09023
KOiK09306
OMAiPLRHYSA
OrthoDBiEOG091G09XD
PhylomeDBiP09023
TreeFamiTF316310

Miscellaneous databases

PROiPR:P09023
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000690 Expressed in 152 organ(s), highest expression level in head
CleanExiMM_HOXB6
GenevisibleiP09023 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXB6_MOUSE
AccessioniPrimary (citable) accession number: P09023
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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