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Protein

Homeobox protein Hox-A5

Gene

Hoxa5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi195 – 254HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A5
Alternative name(s):
Homeobox protein Hox-1.3
Homeobox protein M2
Gene namesi
Name:Hoxa5
Synonyms:Hox-1.3, Hoxa-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96177 Hoxa5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000581 – 270Homeobox protein Hox-A5Add BLAST270

Proteomic databases

MaxQBiP09021
PaxDbiP09021
PeptideAtlasiP09021
PRIDEiP09021

PTM databases

PhosphoSitePlusiP09021

Expressioni

Developmental stagei

Expressed during embryogenesis and in adult kidney.

Gene expression databases

BgeeiENSMUSG00000038253 Expressed in 223 organ(s), highest expression level in efferent duct
CleanExiMM_HOXA5
GenevisibleiP09021 MM

Interactioni

Protein-protein interaction databases

BioGridi200370, 1 interactor
IntActiP09021, 3 interactors
MINTiP09021
STRINGi10090.ENSMUSP00000039012

Structurei

3D structure databases

ProteinModelPortaliP09021
SMRiP09021
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi176 – 181Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231178
HOVERGENiHBG016849
InParanoidiP09021
KOiK09305
OMAiLKSMNMA
OrthoDBiEOG091G09XD
PhylomeDBiP09021
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P09021-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN
60 70 80 90 100
GMDLSVGRSG SGHFGSGERA RSYAAGASAA PAEPRYSQPA TSTHSPPPDP
110 120 130 140 150
LPCSAVAPSP GSDSHHGGKN SLGNSSGASA NAGSTHISSR EGVGTASAAE
160 170 180 190 200
EDAPASSEQA GAQSEPSPAP PAQPQIYPWM RKLHISHDNI GGPEGKRART
210 220 230 240 250
AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK IWFQNRRMKW
260 270
KKDNKLKSMS MAAAGGAFRP
Length:270
Mass (Da):29,237
Last modified:November 1, 1988 - v1
Checksum:iDC4BDDA8FE62766E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70A → V in AAH11063 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36604 mRNA Translation: AAA37838.1
Y00208 Genomic DNA Translation: CAA68364.1
X16840 mRNA Translation: CAA34738.1
M28021 mRNA Translation: AAA37837.1
BC011063 mRNA Translation: AAH11063.1
CCDSiCCDS20143.1
PIRiS07812 WJMS13
RefSeqiNP_034583.1, NM_010453.5
UniGeneiMm.173

Genome annotation databases

EnsembliENSMUST00000048794; ENSMUSP00000039012; ENSMUSG00000038253
GeneIDi15402
KEGGimmu:15402
UCSCiuc009byh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36604 mRNA Translation: AAA37838.1
Y00208 Genomic DNA Translation: CAA68364.1
X16840 mRNA Translation: CAA34738.1
M28021 mRNA Translation: AAA37837.1
BC011063 mRNA Translation: AAH11063.1
CCDSiCCDS20143.1
PIRiS07812 WJMS13
RefSeqiNP_034583.1, NM_010453.5
UniGeneiMm.173

3D structure databases

ProteinModelPortaliP09021
SMRiP09021
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200370, 1 interactor
IntActiP09021, 3 interactors
MINTiP09021
STRINGi10090.ENSMUSP00000039012

PTM databases

PhosphoSitePlusiP09021

Proteomic databases

MaxQBiP09021
PaxDbiP09021
PeptideAtlasiP09021
PRIDEiP09021

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048794; ENSMUSP00000039012; ENSMUSG00000038253
GeneIDi15402
KEGGimmu:15402
UCSCiuc009byh.1 mouse

Organism-specific databases

CTDi3202
MGIiMGI:96177 Hoxa5

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231178
HOVERGENiHBG016849
InParanoidiP09021
KOiK09305
OMAiLKSMNMA
OrthoDBiEOG091G09XD
PhylomeDBiP09021
TreeFamiTF316310

Miscellaneous databases

PROiPR:P09021
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038253 Expressed in 223 organ(s), highest expression level in efferent duct
CleanExiMM_HOXA5
GenevisibleiP09021 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXA5_MOUSE
AccessioniPrimary (citable) accession number: P09021
Secondary accession number(s): Q91VQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: September 12, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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