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Protein

Homeobox protein Hox-C4

Gene

HOXC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi156 – 215HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C4
Alternative name(s):
Homeobox protein CP19
Homeobox protein Hox-3E
Gene namesi
Name:HOXC4
Synonyms:HOX3E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000198353.7
HGNCiHGNC:5126 HOXC4
MIMi142974 gene
neXtProtiNX_P09017

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3221
OpenTargetsiENSG00000198353
PharmGKBiPA29401

Polymorphism and mutation databases

BioMutaiHOXC4
DMDMi281185468

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001641 – 264Homeobox protein Hox-C4Add BLAST264

Proteomic databases

MaxQBiP09017
PaxDbiP09017
PeptideAtlasiP09017
PRIDEiP09017
ProteomicsDBi52186

PTM databases

iPTMnetiP09017
PhosphoSitePlusiP09017

Expressioni

Gene expression databases

BgeeiENSG00000198353 Expressed in 203 organ(s), highest expression level in right uterine tube
ExpressionAtlasiP09017 baseline and differential
GenevisibleiP09017 HS

Organism-specific databases

HPAiHPA053910

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109461, 24 interactors
IntActiP09017, 13 interactors
MINTiP09017
STRINGi9606.ENSP00000305973

Structurei

3D structure databases

ProteinModelPortaliP09017
SMRiP09017
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi135 – 140Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 60Poly-Pro7
Compositional biasi183 – 186Poly-Arg4

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231179
HOVERGENiHBG016849
InParanoidiP09017
KOiK09304
OMAiPPRASYQ
OrthoDBiEOG091G09XD
PhylomeDBiP09017
TreeFamiTF352857

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P09017-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIMSSYLMDS NYIDPKFPPC EEYSQNSYIP EHSPEYYGRT RESGFQHHHQ
60 70 80 90 100
ELYPPPPPRP SYPERQYSCT SLQGPGNSRG HGPAQAGHHH PEKSQSLCEP
110 120 130 140 150
APLSGASASP SPAPPACSQP APDHPSSAAS KQPIVYPWMK KIHVSTVNPN
160 170 180 190 200
YNGGEPKRSR TAYTRQQVLE LEKEFHYNRY LTRRRRIEIA HSLCLSERQI
210 220 230 240 250
KIWFQNRRMK WKKDHRLPNT KVRSAPPAGA APSTLSAATP GTSEDHSQSA
260
TPPEQQRAED ITRL
Length:264
Mass (Da):29,811
Last modified:December 15, 2009 - v2
Checksum:i5CCD13995574226E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161T → A in CAA30376 (PubMed:2898768).Curated1
Sequence conflicti161T → A in AAG42145 (PubMed:11857506).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055961158R → L. Corresponds to variant dbSNP:rs11835301Ensembl.1
Natural variantiVAR_055962178N → S. Corresponds to variant dbSNP:rs35406888Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07495 mRNA Translation: CAA30376.1
AY014298, AY014297 Genomic DNA Translation: AAG42145.1
AC023794 Genomic DNA No translation available.
CCDSiCCDS8873.1
PIRiS01030 WJHU3E
RefSeqiNP_055435.2, NM_014620.5
NP_705897.1, NM_153633.2
UniGeneiHs.549040

Genome annotation databases

EnsembliENST00000303406; ENSP00000305973; ENSG00000198353
ENST00000430889; ENSP00000399808; ENSG00000198353
GeneIDi3221
KEGGihsa:3221
UCSCiuc001seu.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07495 mRNA Translation: CAA30376.1
AY014298, AY014297 Genomic DNA Translation: AAG42145.1
AC023794 Genomic DNA No translation available.
CCDSiCCDS8873.1
PIRiS01030 WJHU3E
RefSeqiNP_055435.2, NM_014620.5
NP_705897.1, NM_153633.2
UniGeneiHs.549040

3D structure databases

ProteinModelPortaliP09017
SMRiP09017
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109461, 24 interactors
IntActiP09017, 13 interactors
MINTiP09017
STRINGi9606.ENSP00000305973

PTM databases

iPTMnetiP09017
PhosphoSitePlusiP09017

Polymorphism and mutation databases

BioMutaiHOXC4
DMDMi281185468

Proteomic databases

MaxQBiP09017
PaxDbiP09017
PeptideAtlasiP09017
PRIDEiP09017
ProteomicsDBi52186

Protocols and materials databases

DNASUi3221
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303406; ENSP00000305973; ENSG00000198353
ENST00000430889; ENSP00000399808; ENSG00000198353
GeneIDi3221
KEGGihsa:3221
UCSCiuc001seu.5 human

Organism-specific databases

CTDi3221
DisGeNETi3221
EuPathDBiHostDB:ENSG00000198353.7
GeneCardsiHOXC4
H-InvDBiHIX0079410
HIX0079484
HIX0171647
HGNCiHGNC:5126 HOXC4
HPAiHPA053910
MIMi142974 gene
neXtProtiNX_P09017
OpenTargetsiENSG00000198353
PharmGKBiPA29401
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231179
HOVERGENiHBG016849
InParanoidiP09017
KOiK09304
OMAiPPRASYQ
OrthoDBiEOG091G09XD
PhylomeDBiP09017
TreeFamiTF352857

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis

Miscellaneous databases

ChiTaRSiHOXC4 human
GeneWikiiHOXC4
GenomeRNAii3221
PROiPR:P09017
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198353 Expressed in 203 organ(s), highest expression level in right uterine tube
ExpressionAtlasiP09017 baseline and differential
GenevisibleiP09017 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXC4_HUMAN
AccessioniPrimary (citable) accession number: P09017
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: December 15, 2009
Last modified: November 7, 2018
This is version 180 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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