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Protein

Homeobox protein Hox-D4

Gene

HOXD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi154 – 213HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • activating transcription factor binding Source: GO_Central
  • DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D4
Alternative name(s):
Homeobox protein HHO.C13
Homeobox protein Hox-4B
Homeobox protein Hox-5.1
Gene namesi
Name:HOXD4
Synonyms:HOX4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000170166.5
HGNCiHGNC:5138 HOXD4
MIMi142981 gene+phenotype
neXtProtiNX_P09016

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3233
MIMi142981 gene+phenotype
OpenTargetsiENSG00000170166
PharmGKBiPA29412

Polymorphism and mutation databases

BioMutaiHOXD4
DMDMi20141491

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002101 – 255Homeobox protein Hox-D4Add BLAST255

Proteomic databases

MaxQBiP09016
PaxDbiP09016
PeptideAtlasiP09016
PRIDEiP09016
ProteomicsDBi52185

PTM databases

iPTMnetiP09016
PhosphoSitePlusiP09016

Expressioni

Gene expression databases

BgeeiENSG00000170166 Expressed in 65 organ(s), highest expression level in myometrium
CleanExiHS_HOXD4
GenevisibleiP09016 HS

Organism-specific databases

HPAiHPA054383
HPA070349

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109473, 22 interactors
ELMiP09016
IntActiP09016, 2 interactors
STRINGi9606.ENSP00000302548

Structurei

3D structure databases

ProteinModelPortaliP09016
SMRiP09016
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi133 – 138Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi222 – 234Poly-SerAdd BLAST13

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231179
HOVERGENiHBG016849
InParanoidiP09016
KOiK09304
OMAiPDFGEQT
OrthoDBiEOG091G09XD
PhylomeDBiP09016
TreeFamiTF352857

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P09016-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVMSSYMVNS KYVDPKFPPC EEYLQGGYLG EQGADYYGGG AQGADFQPPG
60 70 80 90 100
LYPRPDFGEQ PFGGSGPGPG SALPARGHGQ EPGGPGGHYA APGEPCPAPP
110 120 130 140 150
APPPAPLPGA RAYSQSDPKQ PPSGTALKQP AVVYPWMKKV HVNSVNPNYT
160 170 180 190 200
GGEPKRSRTA YTRQQVLELE KEFHFNRYLT RRRRIEIAHT LCLSERQIKI
210 220 230 240 250
WFQNRRMKWK KDHKLPNTKG RSSSSSSSSS CSSSVAPSQH LQPMAKDHHT

DLTTL
Length:255
Mass (Da):27,885
Last modified:January 23, 2002 - v3
Checksum:i39205343CDB0142F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142V → A in CAA28411 (PubMed:2879245).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067445123S → P2 PublicationsCorresponds to variant dbSNP:rs34727427Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17360 Genomic DNA Translation: CAA35237.1
X04706 mRNA Translation: CAA28411.1
AK313885 mRNA Translation: BAG36610.1
BC016763 mRNA Translation: AAH16763.1
BC074797 mRNA Translation: AAH74797.1
CCDSiCCDS2269.1
PIRiS10985 WJHU4B
RefSeqiNP_055436.2, NM_014621.2
UniGeneiHs.591609

Genome annotation databases

EnsembliENST00000306324; ENSP00000302548; ENSG00000170166
GeneIDi3233
KEGGihsa:3233
UCSCiuc002uks.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17360 Genomic DNA Translation: CAA35237.1
X04706 mRNA Translation: CAA28411.1
AK313885 mRNA Translation: BAG36610.1
BC016763 mRNA Translation: AAH16763.1
BC074797 mRNA Translation: AAH74797.1
CCDSiCCDS2269.1
PIRiS10985 WJHU4B
RefSeqiNP_055436.2, NM_014621.2
UniGeneiHs.591609

3D structure databases

ProteinModelPortaliP09016
SMRiP09016
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109473, 22 interactors
ELMiP09016
IntActiP09016, 2 interactors
STRINGi9606.ENSP00000302548

PTM databases

iPTMnetiP09016
PhosphoSitePlusiP09016

Polymorphism and mutation databases

BioMutaiHOXD4
DMDMi20141491

Proteomic databases

MaxQBiP09016
PaxDbiP09016
PeptideAtlasiP09016
PRIDEiP09016
ProteomicsDBi52185

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306324; ENSP00000302548; ENSG00000170166
GeneIDi3233
KEGGihsa:3233
UCSCiuc002uks.4 human

Organism-specific databases

CTDi3233
DisGeNETi3233
EuPathDBiHostDB:ENSG00000170166.5
GeneCardsiHOXD4
HGNCiHGNC:5138 HOXD4
HPAiHPA054383
HPA070349
MIMi142981 gene+phenotype
neXtProtiNX_P09016
OpenTargetsiENSG00000170166
PharmGKBiPA29412
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231179
HOVERGENiHBG016849
InParanoidiP09016
KOiK09304
OMAiPDFGEQT
OrthoDBiEOG091G09XD
PhylomeDBiP09016
TreeFamiTF352857

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis

Miscellaneous databases

GeneWikiiHOXD4
GenomeRNAii3233
PROiPR:P09016
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170166 Expressed in 65 organ(s), highest expression level in myometrium
CleanExiHS_HOXD4
GenevisibleiP09016 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXD4_HUMAN
AccessioniPrimary (citable) accession number: P09016
Secondary accession number(s): B2R9R3, Q96AU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2002
Last modified: November 7, 2018
This is version 184 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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